Gsr (glutathione-disulfide reductase) - Rat Genome Database

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Gene: Gsr (glutathione-disulfide reductase) Rattus norvegicus
Symbol: Gsr
Name: glutathione-disulfide reductase
RGD ID: 621747
Description: Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADP) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Predicted to be located in external side of plasma membrane. Predicted to be active in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including Parkinsonism; acute kidney failure (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (+)-sesamin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione reductase; glutathione reductase, mitochondrial; GR; GRase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21658,482,209 - 58,525,256 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,820,015 - 63,862,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,233,692 - 67,276,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,454,254 - 62,496,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
acute kidney tubular necrosis  (IEP,ISO)
Acute Lung Injury  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
alcohol-induced mental disorder  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
anemia  (ISO)
Arsenic Poisoning  (IEP)
beta thalassemia  (ISO)
Cadmium Poisoning  (IEP)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP)
cataract  (IDA,ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Cognitive Dysfunction  (ISO)
congenital hemolytic anemia  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
diabetic cataract  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
genetic disease  (ISO)
Heinz body anemia  (ISO)
hemolytic anemia  (ISO)
Hemolytic Anemia due to Glutathione Reductase Deficiency  (ISO)
hemorrhagic cystitis  (IEP)
Huntington's disease  (IEP)
Hypercholesterolemia  (IDA,IEP)
hypertension  (IEP,ISO)
hyperthyroidism  (IEP,ISO)
hypoglycemia  (ISO)
iron deficiency anemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Knee Osteoarthritis  (ISO)
Liver Injury  (IEP)
Lung Injury  (IEP)
lymphoid leukemia  (ISO)
macular degeneration  (ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IEP)
myoglobinuria  (IEP)
nephrolithiasis  (IEP)
neurodegenerative disease  (ISO)
non-alcoholic fatty liver disease  (IEP)
Organophosphate Poisoning  (IEP)
osteoporosis  (ISO)
Parkinsonism  (IEP,ISO)
peptic ulcer disease  (IEP)
polycythemia vera  (ISO)
Premature Aging  (ISO)
Protein Deficiency  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
senile cataract  (ISO)
sickle cell anemia  (ISO)
Sleep Deprivation  (IEP)
Testicular Injury  (IEP)
transient cerebral ischemia  (IDA)
Ureteral Calculi  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP,ISO)
(+)-sesamin  (EXP)
(+)-taxifolin  (EXP)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-(-)-perillyl alcohol  (EXP,ISO)
(S)-coclaurine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (EXP)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hexylbenzene-1,3-diol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methoxycinnamic acid  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
9,11,13-octadecatrienoic acid  (EXP)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alloxan  (EXP)
allyl isothiocyanate  (EXP,ISO)
alpha,alpha-trehalose  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
AM-251  (ISO)
aminoacetone  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amoxicillin  (ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP)
Anetholtrithion  (ISO)
anthocyanin  (EXP)
apigenin  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arjunolic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspartame  (EXP)
astaxanthin  (EXP)
atrazine  (EXP,ISO)
Augmentin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bacoside a  (EXP)
Bandrowski's base  (ISO)
benfotiamine  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
benzopyran  (EXP)
Benzoyl peroxide  (ISO)
benzyl isothiocyanate  (EXP,ISO)
berberine  (EXP)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bis-4-nitrophenyl phosphate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
bromoacetate  (ISO)
brucine  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cadmium sulfide  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium silicate  (EXP)
calcium(0)  (EXP)
camphene  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP)
carmustine  (EXP,ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
cefaloridine  (EXP)
cefazolin  (ISO)
celastrol  (EXP,ISO)
chalcones  (EXP)
chitosan  (EXP)
chloric acid  (ISO)
chlorite  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (ISO)
chlorogenic acid  (EXP,ISO)
chloroprene  (EXP,ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (EXP)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
citral  (EXP)
clavulanic acid  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
coumarin  (EXP)
crocidolite asbestos  (EXP)
cumene hydroperoxide  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloartenol  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
daidzein  (EXP)
dapsone  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
delta-hexachlorocyclohexane  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
dichlorvos  (EXP)
dieckol  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digoxin  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (EXP)
dimethyl fumarate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP,ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
elemental selenium  (EXP)
ellagic acid  (EXP)
emodin  (ISO)
endosulfan  (EXP)
endrin  (EXP)
enilconazole  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
eugenol  (ISO)
EUK-134  (EXP)
farnesol  (EXP)
fenitrothion  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferulic acid  (EXP,ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fructose  (EXP)
furan  (EXP)
furans  (ISO)
furosemide  (EXP)
galangin  (EXP)
gallic acid  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geranial  (EXP)
geraniol  (EXP,ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP,ISO)
glyburide  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
hemin  (ISO)
Heptachlor epoxide  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
hexane  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
hypochlorous acid  (ISO)
iberin  (EXP)
idarubicin  (ISO)
ifosfamide  (ISO)
Illudin S  (ISO)
imidacloprid  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irofulven  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
isocyanates  (ISO)
isoeugenol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kainic acid  (EXP)
ketoconazole  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
leflunomide  (EXP)
Leonurine  (EXP)
letrozole  (EXP)
limonin  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium carbonate  (EXP)
lupeol  (EXP)
lutein  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
maculosin  (ISO)
magnesium sulfate  (EXP)
malathion  (EXP,ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP,ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
methyl salicylate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
microcystin  (EXP)
microcystin-LR  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotaline  (EXP)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
motexafin gadolinium  (ISO)
myricetin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (EXP)
N,N-dimethylglycine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (EXP,ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nilotinib  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofurantoin  (EXP,ISO)
nitrogen dioxide  (EXP)
O-acetyl-L-carnitine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (EXP)
oridonin  (EXP)
orlistat  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
patulin  (ISO)
pentachlorophenol  (ISO)
pentetrazol  (EXP)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perillyl alcohol  (EXP,ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytol  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium bromate  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
prodigiosin  (EXP)
propan-2-ol  (ISO)
propiconazole  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
purpurin  (EXP)
Pyridostigmine bromide  (EXP)
pyridoxamine  (EXP)
pyrogallol  (ISO)
pyrovalerone  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinalphos  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salubrinal  (EXP)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP)
selenomethionine  (ISO)
serotonin  (ISO)
silibinin  (EXP)
silicon atom  (EXP)
silicon carbide  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sodium nitrite  (ISO)
spironolactone  (EXP)
squalene  (EXP)
streptozocin  (EXP)
sucrose  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
taurine  (EXP,ISO)
tebuconazole  (EXP)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP)
tetrathiomolybdate(2-)  (ISO)
thallium  (EXP)
thapsigargin  (ISO)
theophylline  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (EXP)
thyroxine  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
trans-caffeic acid  (EXP,ISO)
trans-isoeugenol  (ISO)
triadimefon  (EXP)
tributyl phosphate  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(picolinato)chromium  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (EXP,ISO)
water  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
zinc acetate  (EXP,ISO)
zinc atom  (EXP)
zinc dichloride  (EXP,ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO,TAS)
external side of plasma membrane  (IEA,ISO)
mitochondrion  (IBA)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Abd El Tawab AM, etal., Chem Biol Interact. 2014 Nov 11;224C:196-205. doi: 10.1016/j.cbi.2014.11.001.
2. Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat. Abraham P, etal., Cell Biochem Funct. 2009 Jan;27(1):56-62. doi: 10.1002/cbf.1534.
3. Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Adem S and Ciftci M, Protein Expr Purif. 2012 Jan;81(1):1-4. doi: 10.1016/j.pep.2011.08.031. Epub 2011 Sep 10.
4. The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. Aksenov MY, etal., J Mol Neurosci. 1998 Oct;11(2):151-64.
5. Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis. Ali N, etal., Mol Cell Biochem. 2014 Jan;385(1-2):215-23. doi: 10.1007/s11010-013-1830-4. Epub 2013 Oct 24.
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8. Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells. Banerjee T and Kuypers FA, Br J Haematol. 2004 Feb;124(3):391-402.
9. The effect of a minor constituent of essential oil from Citrus aurantium: the role of beta-myrcene in preventing peptic ulcer disease. Bonamin F, etal., Chem Biol Interact. 2014 Apr 5;212:11-9. doi: 10.1016/j.cbi.2014.01.009. Epub 2014 Jan 27.
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11. Antioxidant capacity responsible for a hypocholesterolemia is independent of dietary cholesterol in adult rats fed rice protein. Cai J, etal., Gene. 2014 Jan 1;533(1):57-66. doi: 10.1016/j.gene.2013.09.124. Epub 2013 Oct 10.
12. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. Carlberg I and Mannervik B, J Biol Chem. 1975 Jul 25;250(14):5475-80.
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14. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Casado A, etal., Neurochem Res. 2008 Mar;33(3):450-8. Epub 2007 Aug 25.
15. Non-haem iron-mediated oxidative stress in haemoglobin E beta-thalassaemia. Chakraborty I, etal., Ann Acad Med Singapore. 2010 Jan;39(1):13-6.
16. Reversal of experimental myoglobinuric acute renal failure in rats by quercetin, a bioflavonoid. Chander V, etal., Pharmacology. 2005 Jan;73(1):49-56. Epub 2004 Sep 27.
17. Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension. Chaves FJ, etal., Am J Hypertens. 2007 Jan;20(1):62-9.
18. Low glutathione reductase and peroxidase activity in age-related macular degeneration. Cohen SM, etal., Br J Ophthalmol. 1994 Oct;78(10):791-4.
19. Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications. Colak E, etal., Ann Med. 2005;37(8):613-20.
20. Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease. Cruz-Aguado R, etal., Restor Neurol Neurosci. 2000;17(4):217-221.
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26. Ameliorative effect of acetyl-L-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats. Farghaly LM, etal., Eur J Pharmacol. 2014 Apr 15;729:1-9. doi: 10.1016/j.ejphar.2014.02.005. Epub 2014 Feb 14.
27. Rapid neutrophil accumulation and protein oxidation in irradiated rat lungs. Fliss H and Menard M, J Appl Physiol. 1994 Dec;77(6):2727-33.
28. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Beneficial effect of xylo-oligosaccharides and fructo-oligosaccharides in streptozotocin-induced diabetic rats. Gobinath D, etal., Br J Nutr. 2010 Jul;104(1):40-7. doi: 10.1017/S0007114510000243. Epub 2010 Feb 26.
31. Long-term treatment with a beta-blocker timolol attenuates renal-damage in diabetic rats via enhancing kidney antioxidant-defense system. Gokturk H, etal., Mol Cell Biochem. 2014 Oct;395(1-2):177-86. doi: 10.1007/s11010-014-2123-2. Epub 2014 Jun 20.
32. Alterations in trace elements and oxidative stress in uremic patients with dementia. Guo CH, etal., Biol Trace Elem Res. 2009 Oct;131(1):13-24. doi: 10.1007/s12011-009-8342-9. Epub 2009 Feb 26.
33. Catechins attenuate eccentric exercise-induced inflammation and loss of force production in muscle in senescence-accelerated mice. Haramizu S, etal., J Appl Physiol (1985). 2011 Dec;111(6):1654-63. doi: 10.1152/japplphysiol.01434.2010. Epub 2011 Sep 8.
34. Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Ishrat T, etal., Brain Res. 2009 Jul 24;1281:117-27. doi: 10.1016/j.brainres.2009.04.010. Epub 2009 Apr 15.
35. Expression of Glutathione Peroxidase and Glutathione Reductase and Level of Free Radical Processes under Toxic Hepatitis in Rats. Iskusnykh IY, etal., J Toxicol. 2013;2013:870628. doi: 10.1155/2013/870628. Epub 2013 Mar 11.
36. Protective effects of different antioxidants against cadmium induced oxidative damage in rat testis and prostate tissues. Jahan S, etal., Syst Biol Reprod Med. 2014 Aug;60(4):199-205. doi: 10.3109/19396368.2014.912363. Epub 2014 Apr 23.
37. Oleuropein offers cardioprotection in rats with acute myocardial infarction. Janahmadi Z, etal., Cardiovasc Toxicol. 2015 Jan;15(1):61-8. doi: 10.1007/s12012-014-9271-1.
38. S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Javed H, etal., Brain Res. 2011 May 10;1389:133-42. doi: 10.1016/j.brainres.2011.02.072. Epub 2011 Mar 1.
39. The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. Kaneko T, etal., Eur J Biochem 2002 Mar;269(5):1570-8.
40. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Khuwaja G, etal., Brain Res. 2011 Jan 12;1368:254-63. Epub 2010 Oct 15.
41. Antioxidant Enzymes and Lipid Peroxidation in Type 2 Diabetes Mellitus Patients with and without Nephropathy. Kumawat M, etal., N Am J Med Sci. 2013 Mar;5(3):213-9. doi: 10.4103/1947-2714.109193.
42. The activity of glucose-6-phosphate dehydroxygenase and glutathione enzymes in red blood cells in patients with haemoblastoses. Kumerova A, etal., Mater Med Pol. 1995 Jan-Mar;27(1):7-9.
43. Amyloid Abeta1-40 preconditions non-apoptotic signals in vivo and protects fetal rat brain from intrauterine ischemic stress. Kuperstein F, etal., J Neurochem. 2004 Nov;91(4):965-74.
44. Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium. Lan Z, etal., Food Chem Toxicol. 2014 Jan;63:62-8. doi: 10.1016/j.fct.2013.10.038. Epub 2013 Nov 5.
45. Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats. Lee IC, etal., Hum Exp Toxicol. 2015 Mar;34(3):227-39. doi: 10.1177/0960327114537095. Epub 2014 Jun 27.
46. Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-kappaB p65 signal pathway. Li YW, etal., Gene. 2014 May 25;542(1):46-51. doi: 10.1016/j.gene.2014.03.021. Epub 2014 Mar 12.
47. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Liu H, etal., Gene. 2014 Jul 15;545(1):149-55. doi: 10.1016/j.gene.2014.04.043. Epub 2014 Apr 24.
48. Familial deficiency of glutathione reductase in human blood cells. Loos H, etal., Blood. 1976 Jul;48(1):53-62.
49. Acetaminophen increases the risk of arsenic-mediated development of hepatic damage in rats by enhancing redox-signaling mechanism. Majhi CR, etal., Environ Toxicol. 2014 Feb;29(2):187-98. doi: 10.1002/tox.20785. Epub 2011 Nov 25.
50. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Maldonado PD, etal., Free Radic Biol Med. 2003 Aug 1;35(3):317-24.
51. Renal oxidative vulnerability due to changes in mitochondrial-glutathione and energy homeostasis in a rat model of calcium oxalate urolithiasis. Meimaridou E, etal., Am J Physiol Renal Physiol. 2006 Oct;291(4):F731-40. Epub 2006 May 2.
52. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
53. Partial glutathione reductase deficiency as a cause of diverse clinical manifestations in a family with unstable hemoglobin (Hemoglobin Hana, beta63(E7) His-Asn). Mojzikova R, etal., Blood Cells Mol Dis. 2010 Oct 15;45(3):219-22. doi: 10.1016/j.bcmd.2010.07.003. Epub 2010 Aug 9.
54. Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system. Nakanishi K, etal., J Thorac Cardiovasc Surg. 1997 Dec;114(6):1088-96.
55. Oxidative stress and total antioxidant status in acute leukemia at diagnosis and post remission induction phase. Naz A, etal., Pak J Pharm Sci. 2013 Nov;26(6):1123-30.
56. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
57. Lutein derived fragments exhibit higher antioxidant and anti-inflammatory properties than lutein in lipopolysaccharide induced inflammation in rats. Nidhi B, etal., Food Funct. 2015 Feb;6(2):450-60. doi: 10.1039/c4fo00606b.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint. Ostalowska A, etal., Osteoarthritis Cartilage. 2006 Feb;14(2):139-45. Epub 2005 Nov 10.
60. The investigation of plasma glucose-6-phosphate dehydrogenase, 6-phoshogluconate dehydrogenase, glutathione reductase in premenauposal patients with iron deficiency anemia. Ozcicek F, etal., Pak J Med Sci. 2014 Jul;30(4):809-913.
61. Effect of clofibrate on intracellular enzyme distribution in the rat liver Panchenko LF, etal., Tsitologiia. 1983 Nov;25(11):1302-8.
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
64. Altered antioxidant capacity in human renal cell carcinoma: role of glutathione associated enzymes. Pljesa-Ercegovac M, etal., Urol Oncol. 2008 Mar-Apr;26(2):175-81. doi: 10.1016/j.urolonc.2007.02.007. Epub 2007 Nov 26.
65. Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency. Ponce IT, etal., Biol Rhythm Res. 2012 Jul 1;43(4):351-372. Epub 2011 Aug 1.
66. Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid. Rehman MU, etal., Mol Cell Biochem. 2012 Jun;365(1-2):119-27. doi: 10.1007/s11010-012-1250-x.
67. GOA pipeline RGD automated data pipeline
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice. Rogers LK, etal., Toxicol Appl Pharmacol. 2006 Dec 15;217(3):289-98. Epub 2006 Sep 26.
70. Evaluation of oxidative stress biomarkers in patients with chronic renal failure: a case control study. Romeu M, etal., BMC Res Notes. 2010 Jan 25;3:20. doi: 10.1186/1756-0500-3-20.
71. Effects of Carissa opaca fruits extracts on oxidative pulmonary damages and fibrosis in rats. Sahreen S, etal., BMC Complement Altern Med. 2014 Jan 30;14:40. doi: 10.1186/1472-6882-14-40.
72. Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Salim S, etal., Brain Res. 2011 Aug 2;1404:63-71. doi: 10.1016/j.brainres.2011.06.024. Epub 2011 Jun 16.
73. Effects of development and ageing on pulmonary NADPH-cytochrome c reductase, glutathione peroxidase, glutathione reductase and thioredoxin reductase activities in male and female rats. Santa Maria C and Machado A, Mech Ageing Dev. 1986-1987 Jan;37(3):183-95.
74. Antioxidant status in patients with osteoporosis: a controlled study. Sendur OF, etal., Joint Bone Spine. 2009 Oct;76(5):514-8. doi: 10.1016/j.jbspin.2009.02.005. Epub 2009 May 21.
75. Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. Sengupta A and Ghosh M, J Oleo Sci. 2014;63(5):439-47.
76. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
77. Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment. Sultana R, etal., Neurochem Res. 2008 Dec;33(12):2540-6. doi: 10.1007/s11064-008-9593-0. Epub 2008 Mar 6.
78. Comparative effect of pioglitazone, quercetin and hydroxy citric acid on the status of lipid peroxidation and antioxidants in experimental non-alcoholic steatohepatitis. Surapaneni KM and Jainu M, J Physiol Pharmacol. 2014 Feb;65(1):67-74.
79. Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8. Sureda FX, etal., Exp Gerontol. 2006 Apr;41(4):360-7. Epub 2006 Mar 20.
80. Similarities between rat liver mitochondrial and cytosolic glutathione reductases and their apoenzyme accumulation in riboflavin deficiency. Taniguchi M, etal., Biochem Int. 1986 Sep;13(3):447-54.
81. Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: potential role of oxidative stress mechanisms. Vollert C, etal., Behav Brain Res. 2011 Oct 31;224(2):233-40. doi: 10.1016/j.bbr.2011.05.010. Epub 2011 May 19.
82. The effect of oxidative stress on human red cells glutathione peroxidase, glutathione reductase level, and prevalence of anemia among diabetics. Waggiallah H and Alzohairy M, N Am J Med Sci. 2011 Jul;3(7):344-7. doi: 10.4297/najms.2011.3344.
83. Subchronic arsenic exposure through drinking water alters vascular redox homeostasis and affects physical health in rats. Waghe P, etal., Biol Trace Elem Res. 2014 Dec;162(1-3):234-41. doi: 10.1007/s12011-014-0116-3. Epub 2014 Sep 11.
84. Bilateral ovarian ischemia/reperfusion injury and treatment options in rats with an induced model of diabetes. Yapca OE, etal., Iran J Basic Med Sci. 2014;17(4):294-302.
85. Effects of glycerol-induced acute renal failure on tissue glutathione and glutathione-dependent enzymes in the rat. Yeung JH Methods Find Exp Clin Pharmacol. 1991 Jan-Feb;13(1):23-8.
86. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
Additional References at PubMed
PMID:204065   PMID:1235912   PMID:2139228   PMID:7323947   PMID:8417789   PMID:12516874   PMID:12967637   PMID:14651853   PMID:16189290   PMID:17382203   PMID:18614015   PMID:19056867  
PMID:23376485   PMID:23533145   PMID:24029230   PMID:26316444   PMID:34825649  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21658,482,209 - 58,525,256 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,820,015 - 63,862,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,233,692 - 67,276,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,454,254 - 62,496,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38830,678,066 - 30,727,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,678,066 - 30,727,846 (-)EnsemblGRCh38hg38GRCh38
GRCh37830,535,583 - 30,585,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,655,977 - 30,704,985 (-)NCBINCBI36Build 36hg18NCBI36
Build 34830,655,976 - 30,704,985NCBI
Celera829,494,968 - 29,543,967 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,080,197 - 29,130,251 (-)NCBIHuRef
CHM1_1830,737,741 - 30,787,638 (-)NCBICHM1_1
T2T-CHM13v2.0830,957,535 - 31,007,300 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39834,143,266 - 34,188,190 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl834,142,551 - 34,188,191 (+)EnsemblGRCm39 Ensembl
GRCm38833,653,238 - 33,698,162 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,652,523 - 33,698,163 (+)EnsemblGRCm38mm10GRCm38
MGSCv37834,763,710 - 34,808,634 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36835,119,173 - 35,164,097 (+)NCBIMGSCv36mm8
MGSCv36832,569,577 - 32,614,657 (+)NCBIMGSCv36mm8
Celera836,289,529 - 36,337,457 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map820.69NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554637,131,364 - 7,153,583 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,130,459 - 7,153,631 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1824,965,772 - 25,015,466 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0829,990,543 - 30,040,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,180,294 - 27,229,557 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,180,300 - 27,229,557 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11633,633,949 - 33,680,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,633,968 - 33,679,752 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1634,093,319 - 34,142,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,660,075 - 35,709,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,659,426 - 35,709,550 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,758,663 - 33,808,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01634,330,564 - 34,379,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01634,449,530 - 34,498,911 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494356,784,705 - 56,832,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792531,756 - 579,166 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936792531,076 - 579,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1554,382,567 - 54,433,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11554,382,564 - 54,433,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,755,038 - 61,806,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1828,778,713 - 28,851,907 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605213,248,221 - 13,308,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478013,440,235 - 13,496,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,440,269 - 13,497,435 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gsr
376 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:232
Interacting mature miRNAs:269
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,482,315 - 58,482,498 (+)MAPPERmRatBN7.2
Rnor_6.01662,197,428 - 62,197,610NCBIRnor6.0
Rnor_5.01661,859,412 - 61,859,594UniSTSRnor5.0
RGSC_v3.41662,254,812 - 62,254,994UniSTSRGSC3.4
Celera1656,518,367 - 56,518,549UniSTS
RH 3.4 Map16560.71UniSTS
Cytogenetic Map16q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,518,859 - 58,519,012 (+)MAPPERmRatBN7.2
Rnor_6.01662,233,971 - 62,234,123NCBIRnor6.0
Rnor_5.01661,895,955 - 61,896,107UniSTSRnor5.0
RGSC_v3.41662,291,124 - 62,291,276UniSTSRGSC3.4
Celera1656,554,903 - 56,555,055UniSTS
RH 3.4 Map16541.6UniSTS
Cytogenetic Map16q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,482,498 - 58,482,689 (+)MAPPERmRatBN7.2
Rnor_6.01662,197,611 - 62,197,801NCBIRnor6.0
Rnor_5.01661,859,595 - 61,859,785UniSTSRnor5.0
RGSC_v3.41662,254,995 - 62,255,185UniSTSRGSC3.4
Celera1656,518,550 - 56,518,740UniSTS
RH 3.4 Map16542.51UniSTS
Cytogenetic Map16q12.3UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff


RefSeq Acc Id: ENSRNOT00000020252   ⟹   ENSRNOP00000020252
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,517,057 (-)Ensembl
Rnor_6.0 Ensembl1662,197,617 - 62,239,987 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090036   ⟹   ENSRNOP00000068989
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,511,298 (-)Ensembl
Rnor_6.0 Ensembl1662,198,178 - 62,241,361 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094128   ⟹   ENSRNOP00000084963
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)Ensembl
RefSeq Acc Id: NM_053906   ⟹   NP_446358
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21658,482,505 - 58,524,909 (-)NCBI
Rnor_6.01662,197,617 - 62,239,987 (-)NCBI
Rnor_5.01661,859,601 - 61,901,971 (-)NCBI
RGSC_v3.41662,255,562 - 62,298,458 (-)RGD
Celera1656,518,556 - 56,560,956 (-)NCBI
RefSeq Acc Id: XR_005494529
Rat AssemblyChrPosition (strand)Source
mRatBN7.21658,482,209 - 58,525,256 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446358 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB18132 (Get FASTA)   NCBI Sequence Viewer  
  EDM09143 (Get FASTA)   NCBI Sequence Viewer  
  P70619 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446358   ⟸   NM_053906
- UniProtKB: F1LRE1 (UniProtKB/TrEMBL),   A6IVS9 (UniProtKB/TrEMBL),   A0A0G2JU71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068989   ⟸   ENSRNOT00000090036