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Gene: GSR (glutathione-disulfide reductase) Homo sapiens
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Symbol: GSR
Name: glutathione-disulfide reductase
Description: Predicted to have flavin adenine dinucleotide binding activity and glutathione-disulfide reductase activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Localizes to the extracellular exosome. Implicated in macular degeneration. Biomarker of several diseases, including artery disease (multiple); beta thalassemia; cataract (multiple); diabetic angiopathy; and hematologic cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase; glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase; HEL-75; HEL-S-122m; MGC78522
Orthologs:
Mus musculus (house mouse) : Gsr (glutathione reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsr (glutathione-disulfide reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsr (glutathione-disulfide reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GSR (glutathione-disulfide reductase)
Canis lupus familiaris (dog) : GSR (glutathione-disulfide reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsr (glutathione-disulfide reductase)
Sus scrofa (pig) : GSR (glutathione-disulfide reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,678,061 - 30,727,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37830,535,578 - 30,585,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,655,977 - 30,704,985 (-)NCBINCBI36hg18NCBI36
Build 34830,655,976 - 30,704,985NCBI
Celera829,494,968 - 29,543,967 (-)NCBI
Cytogenetic Map8p12NCBI
HuRef829,080,197 - 29,130,251 (-)NCBIHuRef
CHM1_1830,737,741 - 30,787,638 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GSR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732221
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.