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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:15891
Term: taurine
Definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
Chemical ID: MESH:D013654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDTaurine inhibits the reaction [potassium bromate results in decreased activity of GSR protein]; Taurine inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Taurine inhibits the reaction [sodium arsenite results in decreased expression of GSR protein]; Taurine inhibits the reaction [sodium arsenite results in increased activity of GSR protein]PMID:19429265 PMID:19616567 PMID:19672740 PMID:25213677
GSRmultiple interactionsISOGsr (Mus musculus)6480464CTDTaurine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Taurine inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]PMID:17624716 PMID:18414974 PMID:18548748 PMID:18561905
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