GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSR | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of GSR mRNA | PMID:33736254 | GSR | multiple interactions | EXP | | 6480464 | CTD | [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSR protein; [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of GSR protein; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of GSR mRNA; [Palmitic Acid co-treated with Arsenic] results in increased expression of GSR mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GSR protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GSR protein | PMID:33434570 PMID:33736254 PMID:35809665 | GSR | decreases activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Arsenic results in decreased activity of GSR protein | PMID:20114059 PMID:21219961 PMID:21864513 PMID:22120977 PMID:22229868 PMID:36813806 PMID:36850985 | GSR | decreases activity | ISO | Gsr (Mus musculus) | 6480464 | CTD | Arsenic results in decreased activity of GSR protein | PMID:10930056 | GSR | increases expression | ISO | Gsr (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of GSR mRNA; Arsenic results in increased expression of GSR protein | PMID:35523338 | GSR | multiple interactions | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein; [Arsenic co-treated with quinalphos] results in decreased activity of GSR protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of GSR protein; Acetaminophen promotes the reaction [Arsenic results in decreased activity of GSR protein]; fisetin inhibits the reaction [Arsenic results in decreased activity of GSR protein]; nobiletin inhibits the reaction [Arsenic results in decreased activity of GSR protein]; Silybin inhibits the reaction [Arsenic results in decreased activity of GSR protein]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of GSR protein] | PMID:17176674 PMID:21219961 PMID:22120977 PMID:22229868 PMID:30835071 PMID:32270456 PMID:36813806 PMID:36850985 | GSR | multiple interactions | ISO | Gsr (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of GSR protein; epigallocatechin gallate inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of GSR protein]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GSR protein] | PMID:31350662 PMID:35523338 | | ||||||||||||||||||||||
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