GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSR | decreases activity | EXP | | 6480464 | CTD | Acetaminophen results in decreased activity of GSR protein | PMID:28984147 | GSR | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of GSR mRNA | PMID:31059760 | GSR | multiple interactions | EXP | | 6480464 | CTD | [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA; celastrol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] | PMID:28984147 PMID:31059760 | GSR | affects expression | ISO | Gsr (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of GSR mRNA | PMID:17562736 | GSR | decreases activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in decreased activity of GSR protein | PMID:15707775 PMID:19932728 PMID:22093918 | GSR | decreases activity | ISO | Gsr (Mus musculus) | 6480464 | CTD | Acetaminophen results in decreased activity of GSR protein | PMID:22683606 PMID:26602168 PMID:27161652 PMID:27866976 PMID:37458150 | GSR | decreases expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in decreased expression of GSR mRNA | PMID:33387578 | GSR | decreases expression | ISO | Gsr (Mus musculus) | 6480464 | CTD | Acetaminophen results in decreased expression of GSR protein | PMID:26265018 | GSR | increases expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Acetaminophen results in increased expression of GSR mRNA | PMID:17202758 PMID:17202762 | GSR | increases expression | ISO | Gsr (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of GSR mRNA; Acetaminophen results in increased expression of GSR protein | PMID:20933533 PMID:29325178 | GSR | multiple interactions | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Acetaminophen promotes the reaction [Arsenic results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; isocytisoside inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; sodium arsenite inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] | PMID:15707775 PMID:19932728 PMID:21219961 PMID:22093918 PMID:22120977 | GSR | multiple interactions | ISO | Gsr (Mus musculus) | 6480464 | CTD | Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; Biflavonoids inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; Farnesol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; N-Acetylcysteinamide inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; OGT gene mutant form promotes the reaction [Acetaminophen results in increased expression of GSR mRNA]; Rosiglitazone inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] | PMID:22683606 PMID:26265018 PMID:26602168 PMID:27161652 PMID:27866976 PMID:29325178 PMID:37458150 | |
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