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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityEXP 6480464CTDAcetaminophen results in decreased activity of GSR proteinPMID:28984147
GSRincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of GSR mRNAPMID:31059760
GSRmultiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA; celastrol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]PMID:28984147 PMID:31059760
GSRaffects expressionISOGsr (Mus musculus)6480464CTDAcetaminophen affects the expression of GSR mRNAPMID:17562736
GSRdecreases activityISOGsr (Rattus norvegicus)6480464CTDAcetaminophen results in decreased activity of GSR proteinPMID:15707775 PMID:19932728 PMID:22093918
GSRdecreases activityISOGsr (Mus musculus)6480464CTDAcetaminophen results in decreased activity of GSR proteinPMID:22683606 PMID:26602168 PMID:27161652 PMID:27866976 PMID:37458150
GSRdecreases expressionISOGsr (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of GSR mRNAPMID:33387578
GSRdecreases expressionISOGsr (Mus musculus)6480464CTDAcetaminophen results in decreased expression of GSR proteinPMID:26265018
GSRincreases expressionISOGsr (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of GSR mRNAPMID:17202758 PMID:17202762
GSRincreases expressionISOGsr (Mus musculus)6480464CTDAcetaminophen results in increased expression of GSR mRNA; Acetaminophen results in increased expression of GSR proteinPMID:20933533 PMID:29325178
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDAcetaminophen promotes the reaction [Arsenic results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; isocytisoside inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; sodium arsenite inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]PMID:15707775 PMID:19932728 PMID:21219961 PMID:22093918 PMID:22120977
GSRmultiple interactionsISOGsr (Mus musculus)6480464CTDAcetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; Biflavonoids inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; Farnesol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; N-Acetylcysteinamide inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; OGT gene mutant form promotes the reaction [Acetaminophen results in increased expression of GSR mRNA]; Rosiglitazone inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]; S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]PMID:22683606 PMID:26265018 PMID:26602168 PMID:27161652 PMID:27866976 PMID:29325178 PMID:37458150
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