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Gene: Gsr (glutathione reductase) Mus musculus
Symbol: Gsr
Name: glutathione reductase
RGD ID: 732222
Description: Exhibits glutathione-disulfide reductase activity. Predicted to be involved in several processes, including cell redox homeostasis; glutathione metabolic process; and spermatogenesis. Localizes to external side of plasma membrane. Is expressed in brain ventricular layer; gut; lung; metanephros; and retina. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (RS)-coclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI325518; D8Ertd238; D8Ertd238e; glutathione reductase 1; glutathione reductase, mitochondrial; GR; Gr-; Gr-1; Gr1; GRase
Homo sapiens (human) : GSR (glutathione-disulfide reductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gsr (glutathione-disulfide reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsr (glutathione-disulfide reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GSR (glutathione-disulfide reductase)
Canis lupus familiaris (dog) : GSR (glutathione-disulfide reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsr (glutathione-disulfide reductase)
Sus scrofa (pig) : GSR (glutathione-disulfide reductase)
Chlorocebus sabaeus (African green monkey) : GSR (glutathione-disulfide reductase)
Heterocephalus glaber (naked mole-rat) : Gsr (glutathione-disulfide reductase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl833,652,523 - 33,698,163 (+)EnsemblGRCm38mm10GRCm38
GRCm38833,653,238 - 33,698,162 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37834,763,710 - 34,808,634 (+)NCBIGRCm37mm9NCBIm37
MGSCv36832,569,577 - 32,614,657 (+)NCBImm8
MGSCv36835,119,173 - 35,164,097 (+)NCBImm8
Celera836,289,529 - 36,337,457 (+)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gsr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732222
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.