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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityISOGsr (Rattus norvegicus)6480464CTDnimesulide results in decreased activity of GSR proteinPMID:22509279
GSRdecreases expressionISOGsr (Rattus norvegicus)6480464CTDnimesulide results in decreased expression of GSR mRNAPMID:22509279
GSRincreases expressionISOGsr (Rattus norvegicus)6480464CTDnimesulide results in increased expression of GSR mRNAPMID:24136188
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased activity of GSR protein]; [camphene co-treated with geraniol] inhibits the reaction [nimesulide results in decreased expression of GSR mRNA]; Silymarin inhibits the reaction [nimesulide results in decreased activity of GSR protein]; Silymarin inhibits the reaction [nimesulide results in decreased expression of GSR mRNA]PMID:22509279
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