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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityEXP 6480464CTDTetrachlorodibenzodioxin results in decreased activity of GSR proteinPMID:23152189
GSRdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GSR mRNAPMID:23152189
GSRmultiple interactionsEXP 6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSR mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSR mRNA]PMID:23152189
GSRaffects expressionISOGsr (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of GSR mRNAPMID:20702594
GSRdecreases activityISOGsr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased activity of GSR proteinPMID:12355564 PMID:12734642 PMID:21382395
GSRdecreases activityISOGsr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased activity of GSR proteinPMID:19085997
GSRdecreases expressionISOGsr (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GSR proteinPMID:19686823
GSRincreases expressionISOGsr (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of GSR mRNAPMID:18796159
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDVitamin E inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of GSR protein]PMID:12355564
GSRmultiple interactionsISOGsr (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GSR mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSR mRNAPMID:16214954 PMID:17942748
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