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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityEXP 6480464CTDGlucose results in decreased activity of GSR proteinPMID:28911973
GSRmultiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with GSR protein] affects the metabolism of Glucose; [Doxorubicin co-treated with GSR protein] affects the metabolism of Glucose; [Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose; Furans analog inhibits the reaction [Glucose results in decreased activity of GSR protein]PMID:1901343 PMID:28911973
GSRdecreases expressionISOGsr (Rattus norvegicus)6480464CTDGlucose results in decreased expression of GSR mRNAPMID:23192364
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDnaringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA]PMID:23192364
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