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Ameliorative effect of acetyl-L-carnitine and/or nifedipine against selenite-induced cataractogenesis in young albino rats.

Authors: Farghaly, LM  Ghobashy, WA  Shoukry, Y  El-Azab, MF 
Citation: Farghaly LM, etal., Eur J Pharmacol. 2014 Apr 15;729:1-9. doi: 10.1016/j.ejphar.2014.02.005. Epub 2014 Feb 14.
Pubmed: (View Article at PubMed) PMID:24530554
DOI: Full-text: DOI:10.1016/j.ejphar.2014.02.005

Free radical toxicity and calcium ion overload have been identified as the major two players in the causation of cataract. The current study was carried out to investigate the anti-cataractogenic effect of single and combined treatment with acetyl-l-carnitine and nifedipine in sodium selenite-induced cataract. Rat pups were divided into 5 groups; 1st group received intraperitoneal injection (i.p.) of saline and served as normal control, 2nd group received single subcutaneous injection of sodium selenite 30nmol/g body weight on p10 (postpartum day 10), 3rd and 4th groups received either acetyl-l-carnitine (200mg/kg, i.p.) or nifedipine (0.1mg/kg, i.p.) on p9, respectively, before the administration of sodium selenite, and the treatment continued till p14. Last group received the combined treatments of acetyl-l-carnitine and nifedipine in the same regimen. All animals were examined using a slit lamp and retroillumination then sacrificed on p30. Lenses were removed and processed for biochemical analyses, histopathological and electron microscopic examination. Selenite-treated groups showed significantly (P

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RGD ID: 10401885
Created: 2015-10-09
Species: All species
Last Modified: 2015-10-09
Status: ACTIVE



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