GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GSR | affects activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine affects the activity of GSR protein | PMID:22393308 | GSR | decreases activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased activity of GSR protein | PMID:16144695 | GSR | decreases activity | ISO | Gsr (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in decreased activity of GSR protein | PMID:24144777 PMID:34726822 | GSR | decreases expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of GSR protein | PMID:32302048 | GSR | decreases expression | ISO | Gsr (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of GSR mRNA | PMID:19107877 | GSR | increases expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of GSR mRNA | PMID:19638242 | GSR | multiple interactions | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; [3,4,5,4'-tetramethoxystilbene co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of GSR mRNA; [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GSR mRNA; [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; [Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of GSR protein; citral inhibits the reaction [Diethylnitrosamine results in decreased expression of GSR protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in decreased activity of GSR protein]; Plant Oils inhibits the reaction [Diethylnitrosamine affects the activity of GSR protein]; Vitamin E inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] | PMID:16144695 PMID:16158176 PMID:16188247 PMID:20360939 PMID:22393308 PMID:27048571 PMID:30098279 PMID:32302048 | GSR | multiple interactions | ISO | Gsr (Mus musculus) | 6480464 | CTD | [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of GSR mRNA; indoleacetic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of GSR mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] | PMID:17917374 PMID:19107877 PMID:34726822 | | ||||||||||||||||||||||
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