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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRdecreases activityISOGsr (Rattus norvegicus)6480464CTDIsoproterenol results in decreased activity of GSR proteinPMID:15261977 PMID:15740881 PMID:16697266 PMID:16757080 PMID:23261676 PMID:25269373 PMID:32007421 PMID:35130744 PMID:36593721
GSRdecreases expressionISOGsr (Rattus norvegicus)6480464CTDIsoproterenol results in decreased expression of GSR; Isoproterenol results in decreased expression of GSR proteinPMID:12557918 PMID:19146839
GSRincreases activityISOGsr (Rattus norvegicus)6480464CTDIsoproterenol results in increased activity of GSR proteinPMID:1840475
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDabana inhibits the reaction [Isoproterenol results in decreased expression of GSR]; allyl sulfide inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; benidipine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Catechin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; dicarbine inhibits the reaction [Isoproterenol results in increased activity of GSR protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of GSR protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; S-allylcysteine inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]; Tretinoin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]PMID:12557918 PMID:15261977 PMID:15740881 PMID:16697266 PMID:16757080 PMID:1840475 PMID:19146839 PMID:23261676 PMID:25269373 PMID:32007421 PMID:36593721
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