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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:46245
Term: coenzyme Q10
Definition: A ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration.
Chemical ID: MESH:C024989
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRincreases expressionISOGsr (Rattus norvegicus)6480464CTDcoenzyme Q10 results in increased expression of GSR mRNAPMID:32116774
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; coenzyme Q10 inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]PMID:19958828 PMID:32116774 PMID:33393703
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