Cxcr4 (C-X-C motif chemokine receptor 4) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cxcr4 (C-X-C motif chemokine receptor 4) Rattus norvegicus
Analyze
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
RGD ID: 620465
Description: Enables small molecule binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Located in several cellular components, including cytosol; endosome; and extracellular matrix. Used to study pulmonary hypertension and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C chemokine receptor type 4; chemokine (C-X-C motif) receptor 4; Chemokine receptor (LCR1); CXC chemokine receptor; CXC-R4; CXCR-4; fusin; LESTR; leukocyte-derived seven transmembrane domain receptor; MGC108696; SDF-1 receptor; stromal cell-derived factor 1 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp327
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21340,077,976 - 40,081,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,673,402 - 42,677,295 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,961,532 - 43,965,425 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01341,206,597 - 41,210,496 (-)NCBIRnor_WKY
Rnor_6.01345,314,952 - 45,318,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,394,128 - 50,398,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,308,286 - 41,312,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,322,328 - 41,326,213 (-)NCBI
Celera1340,447,190 - 40,451,093 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
Bone Metastasis  (ISO)
Breast Neoplasms  (ISO)
Cancer Pain  (IEP,IMP)
cardiomyopathy  (ISS)
Cerebral Hemorrhage  (IMP)
Chronic Periodontitis  (ISO)
clear cell renal cell carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISS)
COVID-19  (ISO)
esophagus squamous cell carcinoma  (ISO)
Femoral Fractures  (IMP)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
Gastrointestinal Neoplasms  (ISO)
hemangioblastoma  (ISO)
hepatocellular carcinoma  (ISO)
Hermansky-Pudlak syndrome  (ISO)
Hyperalgesia  (IMP)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (IEP)
laryngeal carcinoma  (ISO)
larynx cancer  (ISO)
leukopenia  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
MALT lymphoma  (ISO)
mucoepidermoid carcinoma  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrosclerosis  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
pancreatic adenocarcinoma  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
pulmonary hypertension  (IMP)
rectum cancer  (ISO)
rheumatoid arthritis  (ISO)
Right Ventricular Hypertrophy  (IMP)
Spinal Cord Reperfusion Injury  (IMP)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
temporal lobe epilepsy  (IMP)
ulcerative colitis  (ISO)
Vascular Remodeling  (IMP)
Waldenstroem's macroglobulinemia  (ISO)
WHIM syndrome 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylonitrile  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-cyano-4-hydroxycinnamic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzyl bromide  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
celastrol  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dapsone  (ISO)
daunorubicin  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
etodolac  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glyphosate  (EXP)
heparin  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
miconazole  (ISO)
mifepristone  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naproxen  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (ISO)
oleandrin  (ISO)
omeprazole  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (EXP)
phenylmercury acetate  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
piroxicam  (ISO)
plerixafor  (EXP,ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
probucol  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus (anhydrous)  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
tranilast  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zalcitabine  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameboidal-type cell migration  (ISO)
aorta development  (ISO)
blood vessel endothelial cell migration  (ISO)
brain development  (IBA,ISO)
branching involved in blood vessel morphogenesis  (ISO)
calcium-mediated signaling  (IBA,ISO)
cardiac muscle contraction  (IMP)
cell chemotaxis  (IBA)
cell migration  (IMP)
cellular response to cytokine stimulus  (ISO,ISS)
cellular response to organonitrogen compound  (IPI)
cellular response to xenobiotic stimulus  (IEP)
CXCL12-activated CXCR4 signaling pathway  (ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
endothelial cell differentiation  (IMP)
endothelial tube morphogenesis  (IMP)
epithelial cell development  (IMP)
G protein-coupled receptor signaling pathway  (ISO)
generation of neurons  (ISO)
germ cell development  (ISO)
germ cell migration  (ISO)
hematopoietic stem cell migration  (ISO)
immune response  (IBA)
kidney development  (ISO)
motor neuron axon guidance  (ISO)
myelin maintenance  (ISO)
neural precursor cell proliferation  (ISO)
neurogenesis  (IBA,IMP)
neuron migration  (IDA,IMP,ISO)
neuron recognition  (IEP)
osteoclast differentiation  (HEP)
positive regulation of calcium ion import  (ISO)
positive regulation of cell migration  (IMP,ISO)
positive regulation of chemotaxis  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of dendrite extension  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of macrophage migration inhibitory factor signaling pathway  (ISO)
positive regulation of mesenchymal stem cell migration  (IMP)
positive regulation of neurogenesis  (IMP)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of vascular wound healing  (IMP)
regulation of calcium ion transport  (IMP)
regulation of cell adhesion  (ISO)
regulation of cell migration  (ISO)
regulation of chemotaxis  (IMP,ISO)
regulation of neuron migration  (ISO)
regulation of programmed cell death  (IMP)
regulation of viral process  (IDA)
response to activity  (IEP)
response to hypoxia  (ISO)
response to morphine  (IEP)
response to organic cyclic compound  (IMP)
response to tacrolimus  (IPI)
response to ultrasound  (IEP)
T cell proliferation  (ISO)
telencephalon cell migration  (IMP)
ventricular septum development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. In vitro model of vasculo-angiogenesis: demonstration that bone marrow derived endothelial progenitor cells form new hybrid capillary blood vessels jointly with gastric endothelial cells. Ahluwalia A, etal., J Physiol Pharmacol. 2017 Dec;68(6):841-846.
3. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Albee LJ, etal., Open Biol. 2018 Jan;8(1). pii: rsob.170207. doi: 10.1098/rsob.170207.
4. Eculizumab treatment modifies the immune profile of PNH patients. Alfinito F, etal., Immunobiology. 2012 Jul;217(7):698-703. doi: 10.1016/j.imbio.2011.11.009. Epub 2011 Dec 3.
5. In vivo knockdown of CXCR4 using jetPEI/CXCR4 shRNA nanoparticles inhibits the pulmonary metastatic potential of B16‑F10 melanoma cells. André ND, etal., Mol Med Rep. 2015 Dec;12(6):8320-6. doi: 10.3892/mmr.2015.4487. Epub 2015 Oct 26.
6. miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4. Azar MRMH, etal., Int Immunopharmacol. 2021 Mar;92:107355. doi: 10.1016/j.intimp.2020.107355. Epub 2021 Jan 8.
7. The chemokine SDF1 regulates migration of dentate granule cells. Bagri A, etal., Development 2002 Sep;129(18):4249-60.
8. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Banisadr G, etal., Eur J Neurosci 2002 Nov;16(9):1661-71.
9. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation. Baudouin SJ, etal., Mol Cell Neurosci. 2006 Oct;33(2):160-9. Epub 2006 Sep 6.
10. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Benedicto A, etal.
11. CD4 dependence of gp120IIIB-CXCR4 interaction is cell-type specific. Bodner A, etal., J Neuroimmunol 2003 Jul;140(1-2):1-12.
12. Adenosine A2A receptor activation reduces brain metastasis via SDF-1/CXCR4 axis and protecting blood-brain barrier. Chen L, etal., Mol Carcinog. 2020 Apr;59(4):390-398. doi: 10.1002/mc.23161. Epub 2020 Feb 9.
13. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Cho BS, etal., Blood. 2015 Jul 9;126(2):222-32. doi: 10.1182/blood-2015-02-628677. Epub 2015 Jun 1.
14. The prognostic role of serum C-X-C chemokine receptor type 4 in patients with metastatic or recurrent colorectal cancer. Choi YJ, etal., Onco Targets Ther. 2016 Jun 1;9:3307-12. doi: 10.2147/OTT.S104511. eCollection 2016.
15. A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. D'Alterio C, etal., Int J Cancer. 2014 Jul 15;135(2):379-90. doi: 10.1002/ijc.28689. Epub 2014 Jan 10.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Guleng B, etal., Cancer Res. 2005 Jul 1;65(13):5864-71. doi: 10.1158/0008-5472.CAN-04-3833.
18. Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer. Guo ZJ, etal., Oncotarget. 2016 Apr 12;7(15):20999-1012. doi: 10.18632/oncotarget.8236.
19. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
20. Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4. He L, etal.
21. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Hernandez PA, etal., Nat Genet 2003 May;34(1):70-4.
22. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Hosomi S, etal., Clin Exp Immunol. 2011 Feb;163(2):215-24. doi: 10.1111/j.1365-2249.2010.04290.x. Epub 2010 Nov 19.
23. The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinoma. Hu J, etal., Clin Cancer Res. 2005 Jul 1;11(13):4658-65. doi: 10.1158/1078-0432.CCR-04-1798.
24. Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain. Hu XM, etal., Sci Rep. 2017 Jun 21;7(1):4005. doi: 10.1038/s41598-017-04198-3.
25. Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia. Jost TR, etal., J Leukoc Biol. 2016 Jun;99(6):1077-87. doi: 10.1189/jlb.5MA0915-394R. Epub 2016 Mar 1.
26. Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy. Kaemmerer D, etal., Oncotarget. 2015 Sep 29;6(29):27566-79. doi: 10.18632/oncotarget.4491.
27. Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Kim SY, etal., Clin Exp Metastasis. 2008;25(3):201-11. doi: 10.1007/s10585-007-9133-3. Epub 2007 Dec 11.
28. Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer. Koishi K, etal., World J Gastroenterol. 2006 Dec 21;12(47):7585-90. doi: 10.3748/wjg.v12.i47.7585.
29. Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. Kolodziej A, etal., J Neurosci. 2008 Apr 23;28(17):4488-500. doi: 10.1523/JNEUROSCI.4721-07.2008.
30. CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia. Konoplev S, etal., Clin Lymphoma Myeloma Leuk. 2013 Dec;13(6):686-92. doi: 10.1016/j.clml.2013.05.013. Epub 2013 Sep 11.
31. Cyclic AMP and tumor necrosis factor-alpha regulate CXCR4 gene expression in Schwann cells. Kury P, etal., Mol Cell Neurosci. 2003 Sep;24(1):1-9.
32. Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Lee HJ, etal., Int J Oncol. 2009 Feb;34(2):473-80.
33. The effect of CXCL12 on endothelial progenitor cells: potential target for angiogenesis in intracerebral hemorrhage. Li B, etal., J Interferon Cytokine Res. 2015 Jan;35(1):23-31. doi: 10.1089/jir.2014.0004. Epub 2014 Jun 23.
34. Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord. Li XQ, etal., PLoS One. 2016 Oct 19;11(10):e0163807. doi: 10.1371/journal.pone.0163807. eCollection 2016.
35. Downregulation of CXCR4 by SDF-KDEL in SBC-5 cells inhibits their migration in vitro and organ metastasis in vivo. Ma N, etal., Int J Mol Med. 2015 Feb;35(2):425-32. doi: 10.3892/ijmm.2014.2033. Epub 2014 Dec 10.
36. Nuclear expression of chemokine receptor CXCR4 indicates poorer prognosis in gastric cancer. Masuda T, etal., Anticancer Res. 2014 Nov;34(11):6397-403.
37. The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome. McDermott DH, etal., Blood. 2011 Nov 3;118(18):4957-62. Epub 2011 Sep 2.
38. Effects of miR-338 on morphine tolerance by targeting CXCR4 in a rat model of bone cancer pain. Mei HX, etal., Biosci Rep. 2017 Mar 15;37(2). pii: BSR20160517. doi: 10.1042/BSR20160517. Print 2017 Apr 30.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Minamiya Y, etal., Lung Cancer. 2010 Jun;68(3):466-71. doi: 10.1016/j.lungcan.2009.07.015. Epub 2009 Aug 27.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. Expression of CXCR-4 and IDO in human colorectal cancer: An immunohistochemical approach. Ogawa M, etal., Mol Clin Oncol. 2017 May;6(5):701-704. doi: 10.3892/mco.2017.1207. Epub 2017 Apr 4.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. Paredes MF, etal., J Neurosci. 2006 Sep 13;26(37):9404-12.
45. Acetyl-11-keto-beta-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression. Park B, etal., Int J Cancer. 2011 Jul 1;129(1):23-33. doi: 10.1002/ijc.25966. Epub 2011 Mar 29.
46. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. Peng H, etal., J Neurosci Res. 2004 Apr 1;76(1):35-50.
47. Expression of C-X-C motif chemokine receptors 4 and 7 in salivary gland neoplasms. Phattarataratip E and Dhanuthai K, Arch Oral Biol. 2017 Nov;83:136-144. doi: 10.1016/j.archoralbio.2017.07.012. Epub 2017 Jul 26.
48. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin). Pleskoff O, etal., J Virol. 1997 Apr;71(4):3259-62.
52. CXCR4 modulates contractility in adult cardiac myocytes. Pyo RT, etal., J Mol Cell Cardiol. 2006 Nov;41(5):834-44. Epub 2006 Sep 28.
53. Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer. Reiss K, etal., Neuroscience 2002;115(1):295-305.
54. GOA pipeline RGD automated data pipeline
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma. Roccaro AM, etal., Blood. 2014 Jun 26;123(26):4120-31. doi: 10.1182/blood-2014-03-564583. Epub 2014 Apr 7.
58. Estrogen induces CXCR4 overexpression and CXCR4/CXL12 pathway activation in lung adenocarcinoma cells in vitro. Rodriguez-Lara V, etal., Endocr Res. 2017 Aug;42(3):219-231. doi: 10.1080/07435800.2017.1292526. Epub 2017 Mar 20.
59. CXCR4 Has the Potential to Enhance Bone Formation in Osteopenic Rats. Sanghani A, etal., Tissue Eng Part A. 2018 Dec;24(23-24):1775-1783. doi: 10.1089/ten.TEA.2018.0121. Epub 2018 Sep 19.
60. Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development. Sarnowska E, etal., Am J Cancer Res. 2017 Nov 1;7(11):2275-2289. eCollection 2017.
61. CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Saur D, etal., Gastroenterology. 2005 Oct;129(4):1237-50. doi: 10.1053/j.gastro.2005.06.056.
62. Structural localization and expression of CXCL12 and CXCR4 in rat heart and isolated cardiac myocytes. Segret A, etal., J Histochem Cytochem. 2007 Feb;55(2):141-50. Epub 2006 Oct 16.
63. Anti-Tumor Effect of Celastrol on Hepatocellular Carcinoma by the circ_SLIT3/miR-223-3p/CXCR4 Axis. Si H, etal., Cancer Manag Res. 2021 Feb 5;13:1099-1111. doi: 10.2147/CMAR.S278023. eCollection 2021.
64. CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. Smith JM, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G316-26. Epub 2004 Sep 9.
65. Differential somatostatin and CXCR4 chemokine receptor expression in MALT-type lymphoma of gastric and extragastric origin. Stollberg S, etal., J Cancer Res Clin Oncol. 2016 Nov;142(11):2239-47. doi: 10.1007/s00432-016-2220-6. Epub 2016 Aug 20.
66. Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal Cancer. Stuckel AJ, etal., Cancers (Basel). 2020 Feb 26;12(3). pii: cancers12030539. doi: 10.3390/cancers12030539.
67. Sprouting of nervous fibers and upregulation of C-X-C chemokine receptor type 4 expression in hippocampal formation of rats with enhanced spatial learning and memory. Su B, etal., Anat Rec (Hoboken). 2012 Jan;295(1):121-6. doi: 10.1002/ar.21518. Epub 2011 Dec 5.
68. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Su L, etal., Clin Cancer Res. 2005 Dec 1;11(23):8273-80. doi: 10.1158/1078-0432.CCR-05-0537.
69. CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. Tan CT, etal., Carcinogenesis. 2008 Aug;29(8):1519-27. doi: 10.1093/carcin/bgn108. Epub 2008 May 16.
70. Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma. Tao H, etal., Tumour Biol. 2016 May;37(5):6099-105. doi: 10.1007/s13277-015-4464-1. Epub 2015 Nov 26.
71. CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways. Tian Y, etal., Mol Med Rep. 2018 Nov;18(5):4374-4380. doi: 10.3892/mmr.2018.9444. Epub 2018 Sep 3.
72. Circulating fibrocytes as biomarker of prognosis in Hermansky-Pudlak syndrome. Trimble A, etal., Am J Respir Crit Care Med. 2014 Dec 15;190(12):1395-401. doi: 10.1164/rccm.201407-1287OC.
73. Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. Tripathi A, etal., Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1659-68. doi: 10.1073/pnas.1417564112. Epub 2015 Mar 16.
74. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Tsai LK, etal., Neuropsychopharmacology. 2010 Oct;35(11):2225-37. doi: 10.1038/npp.2010.97. Epub 2010 Jul 7.
75. CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer. Tu Z, etal., Int J Oncol. 2017 Feb;50(2):505-514. doi: 10.3892/ijo.2016.3812. Epub 2016 Dec 19.
76. Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma. Uchida D, etal., Mol Cancer Res. 2007 Jul;5(7):685-94. doi: 10.1158/1541-7786.MCR-06-0368.
77. High-level C-X-C chemokine receptor type 4 expression correlates with brain-specific metastasis following complete resection of non-small cell lung cancer. Wang L, etal., Oncol Lett. 2014 Jun;7(6):1871-1876. doi: 10.3892/ol.2014.1979. Epub 2014 Mar 18.
78. Significance of CXCR4, phosphorylated STAT3 and VEGF-A expression in resected non-small cell lung cancer. Wang M, etal., Exp Ther Med. 2011 May;2(3):517-522. doi: 10.3892/etm.2011.235. Epub 2011 Mar 21.
79. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome. Wang N, etal., J Transl Med. 2005 Jun 26;3:26. doi: 10.1186/1479-5876-3-26.
80. CXCR-7 receptor promotes SDF-1alpha-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Wang Y, etal., Brain Res. 2014 Aug 5;1575:78-86. doi: 10.1016/j.brainres.2014.05.035. Epub 2014 Jun 9.
81. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. Wei FY, etal., PLoS One. 2014 Sep 2;9(9):e106722. doi: 10.1371/journal.pone.0106722. eCollection 2014.
82. Rat LCR1: cloning and cellular distribution of a putative chemokine receptor in brain. Wong ML, etal., Mol Psychiatry 1996 May;1(2):133-40.
83. PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells. Xi Y, etal., Clin Exp Metastasis. 2020 Feb;37(1):173-185. doi: 10.1007/s10585-019-09998-7. Epub 2019 Sep 30.
84. Cisatracurium regulates the CXCR4/let-7a-5p axis to inhibit colorectal cancer progression by suppressing TGF-β/SMAD2/3 signalling. Xia YZ, etal., Chem Biol Interact. 2021 Apr 25;339:109424. doi: 10.1016/j.cbi.2021.109424. Epub 2021 Feb 19.
85. microRNA-9 functions as a tumor suppressor in colorectal cancer by targeting CXCR4. Xiong WC, etal., Int J Clin Exp Pathol. 2018 Feb 1;11(2):526-536. eCollection 2018.
86. CXCR4 overexpression is correlated with poor prognosis in colorectal cancer. Xu C, etal., Life Sci. 2018 Sep 1;208:333-340. doi: 10.1016/j.lfs.2018.04.050. Epub 2018 Apr 30.
87. [Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma cells]. Xu Y, etal., Ai Zheng. 2004 Feb;23(2):136-40.
88. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
89. Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro. Yang M, etal., Blood. 2006 Mar 15;107(6):2262-70. doi: 10.1182/blood-2005-08-3365. Epub 2005 Nov 22.
90. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. Yao L, etal., FASEB J. 2014 Oct;28(10):4534-50. doi: 10.1096/fj.14-249797. Epub 2014 Jul 11.
91. Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Yu L and Hales CA, Respir Res. 2011 Feb 4;12:21.
92. [Expression of chemokine receptor CXCR4 in colorectal carcinoma and its relationship with clinicopathological parameters]. Yu L, etal., Zhonghua Wei Chang Wai Ke Za Zhi. 2008 Sep;11(5):482-6.
93. Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. Zhan LY, etal., Biomed Pharmacother. 2018 Nov;107:818-823. doi: 10.1016/j.biopha.2018.08.053. Epub 2018 Aug 22.
94. [Expression of chemokine receptor CXCR4 and CCR7 in laryngeal carcinoma]. Zhang L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(21):985-7, 991.
95. [The expression and significance of SDF-1/CXCR4 biological axis in laryngeal squamous cell carcinoma and lymph node metastasize]. Zhang L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(18):798-801.
96. C-X-C motif chemokine receptor 4 promotes tumor angiogenesis in gastric cancer via activation of JAK2/STAT3. Zhang Q, etal., Cell Biol Int. 2017 Aug;41(8):854-862. doi: 10.1002/cbin.10794. Epub 2017 Jun 8.
97. CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. Zhao BC, etal., World J Gastroenterol. 2011 May 21;17(19):2389-96. doi: 10.3748/wjg.v17.i19.2389.
98. The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways. Zheng F, etal., Anticancer Res. 2017 Aug;37(8):4361-4369. doi: 10.21873/anticanres.11830.
99. MicroRNA-381-induced down-regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Zheng GH, etal., J Cell Biochem. 2018 Apr;119(4):3149-3161. doi: 10.1002/jcb.26466. Epub 2018 Jan 2.
100. CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy. Zhou Z, etal., Behav Brain Res. 2017 Mar 30;322(Pt A):83-91. doi: 10.1016/j.bbr.2017.01.014. Epub 2017 Jan 16.
101. BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway. Zhu GD, etal., Biochem Biophys Res Commun. 2018 May 5;499(2):120-127. doi: 10.1016/j.bbrc.2018.02.178. Epub 2018 Feb 24.
102. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. Zhu H, etal., Mol Med Rep. 2014 Aug;10(2):585-92. doi: 10.3892/mmr.2014.2302. Epub 2014 Jun 5.
103. AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer. Zhu WB, etal., J Cell Physiol. 2019 Jul;234(7):11746-11759. doi: 10.1002/jcp.27831. Epub 2018 Dec 7.
Additional References at PubMed
PMID:8962122   PMID:10521508   PMID:10644702   PMID:12421915   PMID:12477932   PMID:12507773   PMID:12707343   PMID:12900445   PMID:14732474   PMID:15174142   PMID:15467356   PMID:15626744  
PMID:15731012   PMID:16005638   PMID:16129397   PMID:16166380   PMID:16469439   PMID:16553776   PMID:16702540   PMID:16837851   PMID:16841089   PMID:17520275   PMID:17530714   PMID:18031680  
PMID:18064521   PMID:18201717   PMID:18206136   PMID:18308860   PMID:18606818   PMID:18753332   PMID:18850076   PMID:18978811   PMID:19008373   PMID:19024651   PMID:19053768   PMID:19064997  
PMID:19066630   PMID:19106094   PMID:19116316   PMID:19228460   PMID:19285061   PMID:19340530   PMID:19380869   PMID:19586611   PMID:19665027   PMID:19703720   PMID:20026091   PMID:20032115  
PMID:20045921   PMID:20127490   PMID:20133817   PMID:20228059   PMID:20412823   PMID:20458337   PMID:20534485   PMID:20547684   PMID:20586815   PMID:20729750   PMID:20847314   PMID:20882566  
PMID:21171825   PMID:21418513   PMID:21438014   PMID:21540189   PMID:22058039   PMID:22159319   PMID:22166584   PMID:22265737   PMID:22280945   PMID:22345572   PMID:22355073   PMID:22694179  
PMID:22978573   PMID:23029422   PMID:23148226   PMID:23170857   PMID:23223293   PMID:23289420   PMID:23576796   PMID:23620790   PMID:23671625   PMID:23793062   PMID:23832528   PMID:23969990  
PMID:24086760   PMID:24122226   PMID:24312447   PMID:24373940   PMID:24557113   PMID:24581269   PMID:24587052   PMID:24626964   PMID:24637920   PMID:24751384   PMID:24790097   PMID:24912431  
PMID:25032954   PMID:25299045   PMID:25420576   PMID:25492872   PMID:25549045   PMID:25612609   PMID:25807483   PMID:25824297   PMID:25825119   PMID:26164455   PMID:26398409   PMID:26444377  
PMID:26597700   PMID:26818151   PMID:26886751   PMID:27011380   PMID:27269634   PMID:27340942   PMID:28002632   PMID:28233339   PMID:28412763   PMID:28585910   PMID:28903152   PMID:28978524  
PMID:29114002   PMID:29207050   PMID:29476059   PMID:29524405   PMID:29568895   PMID:29693117   PMID:29710553   PMID:30120960   PMID:30195032   PMID:30541517   PMID:30955244   PMID:31177801  
PMID:31437601   PMID:31652450   PMID:31967865   PMID:32006698   PMID:32165091   PMID:32349612   PMID:32751701   PMID:33079278   PMID:33381162   PMID:34260048   PMID:34852303   PMID:35048778  
PMID:35163700   PMID:35799894   PMID:36193608  


Genomics

Comparative Map Data
Cxcr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21340,077,976 - 40,081,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,673,402 - 42,677,295 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01343,961,532 - 43,965,425 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01341,206,597 - 41,210,496 (-)NCBIRnor_WKY
Rnor_6.01345,314,952 - 45,318,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,394,128 - 50,398,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,308,286 - 41,312,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,322,328 - 41,326,213 (-)NCBI
Celera1340,447,190 - 40,451,093 (-)NCBICelera
Cytogenetic Map13q13NCBI
CXCR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,114,349 - 136,118,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2136,114,349 - 136,119,177 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,871,919 - 136,875,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,588,389 - 136,592,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 342136,705,651 - 136,709,457NCBI
Celera2130,582,637 - 130,586,442 (-)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2128,864,423 - 128,868,228 (-)NCBIHuRef
CHM1_12136,877,321 - 136,881,126 (-)NCBICHM1_1
T2T-CHM13v2.02136,558,831 - 136,562,630 (-)NCBIT2T-CHM13v2.0
Cxcr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,515,936 - 128,520,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,515,936 - 128,520,030 (-)EnsemblGRCm39 Ensembl
GRCm381128,588,199 - 128,592,299 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,588,199 - 128,592,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,484,776 - 130,488,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,415,745 - 130,419,822 (-)NCBIMGSCv36mm8
Celera1131,222,729 - 131,226,820 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.43NCBI
Cxcr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554403,455,153 - 3,460,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554403,456,165 - 3,460,024 (-)NCBIChiLan1.0ChiLan1.0
CXCR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B140,185,803 - 140,189,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B140,181,829 - 140,189,647 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B23,744,271 - 23,748,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CXCR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,874,650 - 38,877,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1938,874,145 - 38,877,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Cxcr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303101,819,271 - 101,823,136 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646939,794,584 - 39,798,459 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493646939,794,613 - 39,798,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1515,663,494 - 15,667,232 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11515,663,652 - 15,666,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21518,125,415 - 18,128,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11020,336,470 - 20,340,308 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1020,336,247 - 20,340,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660612,116,532 - 2,120,394 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473235,472,760 - 35,477,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473235,473,740 - 35,477,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcr4
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000005143
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
2292232Pur16Proteinuria QTL 1617.2urine total protein amount (VT:0000032)urine protein level (CMO:0000591)133615572341961389Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat

Markers in Region
D13Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21340,078,310 - 40,078,623 (+)MAPPERmRatBN7.2
Rnor_6.01345,315,287 - 45,315,599NCBIRnor6.0
Rnor_5.01350,394,463 - 50,394,775UniSTSRnor5.0
RGSC_v3.41341,308,620 - 41,308,933RGDRGSC3.4
RGSC_v3.41341,308,621 - 41,308,933UniSTSRGSC3.4
RGSC_v3.11341,322,663 - 41,322,976RGD
Celera1340,447,525 - 40,447,837UniSTS
RH 2.0 Map11096.8RGD
Cytogenetic Map13q12UniSTS
RH129152  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21340,078,033 - 40,078,248 (+)MAPPERmRatBN7.2
Rnor_6.01345,315,010 - 45,315,224NCBIRnor6.0
Rnor_5.01350,394,186 - 50,394,400UniSTSRnor5.0
RGSC_v3.41341,308,344 - 41,308,558UniSTSRGSC3.4
Celera1340,447,248 - 40,447,462UniSTS
Cytogenetic Map13q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 18 2 19 2 4 4 53 21 33 11 4
Low 1 15 39 39 39 4 7 21 14 8 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005143   ⟹   ENSRNOP00000005143
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)Ensembl
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091514   ⟹   ENSRNOP00000075128
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1345,315,215 - 45,318,822 (-)Ensembl
RefSeq Acc Id: NM_022205   ⟹   NP_071541
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21340,077,976 - 40,081,883 (-)NCBI
Rnor_6.01345,314,952 - 45,318,856 (-)NCBI
Rnor_5.01350,394,128 - 50,398,032 (-)NCBI
RGSC_v3.41341,308,286 - 41,312,190 (-)RGD
Celera1340,447,190 - 40,451,093 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071541   ⟸   NM_022205
- UniProtKB: Q8VD47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005143   ⟸   ENSRNOT00000005143
RefSeq Acc Id: ENSRNOP00000075128   ⟸   ENSRNOT00000091514
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08565-F1-model_v2 AlphaFold O08565 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698797
Promoter ID:EPDNEW_R9307
Type:multiple initiation site
Name:Cxcr4_1
Description:C-X-C motif chemokine receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01345,318,870 - 45,318,930EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620465 AgrOrtholog
BioCyc Gene G2FUF-18399 BioCyc
Ensembl Genes ENSRNOG00000003866 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005143 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005143 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7380432 IMAGE-MGC_LOAD
InterPro Chemokine_CXCR4_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXCR4/ACKR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60628 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108696 IMAGE-MGC_LOAD
NCBI Gene 60628 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXCR4_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CXCR4 RGD
PhenoGen Cxcr4 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXCCHMKINER4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A9CMB9_RAT UniProtKB/TrEMBL
  CXCR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VD47 ENTREZGENE
UniProt Secondary F1LPN8 UniProtKB/Swiss-Prot
  Q8VD47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cxcr4  C-X-C motif chemokine receptor 4  Cxcr4  chemokine (C-X-C motif) receptor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcr4  chemokine (C-X-C motif) receptor 4    Chemokine receptor (LCR1)  Name updated 1299863 APPROVED
2002-08-07 Cxcr4        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adult brain, glial cells (astrocytes, microglia but not oligodendrocytes) and neurons 632605
gene_expression mRNA expressed in spleen, liver, heart, and brain 632606
gene_expression in brain, expressed at high levels in ependymal layer and lower levels in cerebral cortex, hippocampus, cerebellum, and brainstem 632606