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Gene: Cxcr4 (C-X-C motif chemokine receptor 4) Rattus norvegicus
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Description: Exhibits C-X-C chemokine receptor activity and drug binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Localizes to endosome; nucleus; and plasma membrane. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-X-C chemokine receptor type 4; chemokine (C-X-C motif) receptor 4; Chemokine receptor (LCR1); CXC chemokine receptor; CXC-R4; CXCR-4; fusin; LESTR; leukocyte-derived seven transmembrane domain receptor; MGC108696; SDF-1 receptor; stromal cell-derived factor 1 receptor
Homo sapiens (human) : CXCR4 (C-X-C motif chemokine receptor 4)  HGNC  Alliance
Mus musculus (house mouse) : Cxcr4 (chemokine (C-X-C motif) receptor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cxcr4 (C-X-C motif chemokine receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CXCR4 (C-X-C motif chemokine receptor 4)
Canis lupus familiaris (dog) : CXCR4 (C-X-C motif chemokine receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cxcr4 (C-X-C motif chemokine receptor 4)
Sus scrofa (pig) : CXCR4 (C-X-C motif chemokine receptor 4)
Chlorocebus sabaeus (African green monkey) : CXCR4 (C-X-C motif chemokine receptor 4)
Heterocephalus glaber (naked mole-rat) : Cxcr4 (C-X-C motif chemokine receptor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01345,314,952 - 45,318,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,394,128 - 50,398,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,308,286 - 41,312,190 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11341,322,328 - 41,326,213 (-)NCBI
Celera1340,447,190 - 40,451,093 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cxcr4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620465
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.