Cd3e (CD3 epsilon subunit of T-cell receptor complex)

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Gene: Cd3e (CD3 epsilon subunit of T-cell receptor complex) Rattus norvegicus

Analyze

Symbol:

Cd3e

Name:

CD3 epsilon subunit of T-cell receptor complex

RGD ID:

1309222

Description:

Predicted to enable SH3 domain binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in T cell differentiation in thymus; positive regulation of T cell proliferation; and response to nutrient. Predicted to be located in several cellular components, including cell body; dendritic spine; and immunological synapse. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3 epsilon subunit of T-cell receptor complex); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; Chagas disease pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CD3 antigen, epsilon polypeptide; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3e molecule; LOC315609; T-cell surface glycoprotein CD3 epsilon chain

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD3E (CD3 epsilon subunit of T-cell receptor complex)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cd3e (CD3 antigen, epsilon polypeptide)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Cd3e (CD3e molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD3E (CD3e molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD3E (CD3 epsilon subunit of T-cell receptor complex)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd3e (CD3e molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD3E (CD3 epsilon subunit of T-cell receptor complex)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD3E (CD3e molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd3e (CD3e molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CD3E (CD3 epsilon subunit of T-cell receptor complex)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Cd3e (CD3 antigen, epsilon polypeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Cd3e-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	45,303,848 - 45,315,297 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	8	45,303,852 - 45,315,022 (-)	Ensembl
Rnor_6.0	8	49,297,604 - 49,309,370 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,297,608 - 49,308,806 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	47,915,622 - 47,926,803 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	47,947,257 - 47,958,419 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	47,956,580 - 47,967,075 (-)	NCBI
Celera	8	44,888,608 - 44,901,125 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

CD3epsilon deficiency (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

congenital disorder of glycosylation Ij (ISO)

congenital myasthenic syndrome 13 (ISO)

Dwarfism (ISO)

Experimental Diabetes Mellitus (ISO)

gastrointestinal stromal tumor (ISO)

Glycogen Storage Disease IB (ISO)

immunodeficiency 17 (ISO)

immunodeficiency 18 (ISO)

immunodeficiency 19 (ISO)

Inflammation (ISO)

inflammatory bowel disease 28 (ISO)

intellectual disability (ISO)

long QT syndrome 10 (ISO)

primary immunodeficiency disease (ISO)

rheumatoid arthritis (ISO)

severe acute respiratory syndrome (ISO)

severe combined immunodeficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic AMP (ISO)

3,4-methylenedioxymethamphetamine (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

adenine (ISO)

aflatoxin B1 (EXP,ISO)

aluminium trifluoride (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

calcidiol (ISO)

calcitriol (ISO)

cycloheximide (ISO)

cyclophosphamide (ISO)

dexamethasone (ISO)

diethylstilbestrol (ISO)

fingolimod hydrochloride (ISO)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

ketoconazole (ISO)

lead diacetate (EXP)

nickel atom (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phorbol 13-acetate 12-myristate (ISO)

progesterone (EXP)

resveratrol (EXP,ISO)

scopolamine (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium fluoride (ISO)

sulfoxaflor (EXP)

testosterone (EXP,ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

apoptotic signaling pathway (ISO)

calcium-mediated signaling (ISO)

CD4-positive, alpha-beta T cell proliferation (ISO)

cell surface receptor signaling pathway (IBA,ISO)

cerebellum development (ISO)

dendrite development (ISO)

lymphocyte activation (ISO)

negative regulation of gene expression (ISO)

negative regulation of smoothened signaling pathway (ISO)

negative thymic T cell selection (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of alpha-beta T cell proliferation (ISO)

positive regulation of calcium-mediated signaling (ISO)

positive regulation of CD4-positive, alpha-beta T cell proliferation (ISO)

positive regulation of cell-cell adhesion mediated by integrin (ISO)

positive regulation of cell-matrix adhesion (ISO)

positive regulation of gene expression (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of interleukin-4 production (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of T cell activation (ISO)

positive regulation of T cell anergy (ISO)

positive regulation of T cell proliferation (IDA,ISO)

positive regulation of type II interferon production (ISO)

positive thymic T cell selection (IBA)

response to nutrient (IDA)

smoothened signaling pathway (ISO)

T cell activation (ISO)

T cell anergy (ISO)

T cell costimulation (ISO)

T cell differentiation in thymus (IEP)

T cell proliferation (ISO)

T cell receptor signaling pathway (ISO)

Cellular Component

alpha-beta T cell receptor complex (IBA,ISO)

cell body (ISO)

cell-cell junction (ISO)

cellular_component (ND)

dendritic spine (ISO)

endoplasmic reticulum (ISO)

external side of plasma membrane (IBA,ISO)

Golgi apparatus (ISO)

immunological synapse (ISO)

integral component of membrane (IEA)

plasma membrane (ISO)

T cell receptor complex (ISO)

Molecular Function

identical protein binding (ISO)

molecular_function (ND)

protein binding (ISO)

SH3 domain binding (ISO)

transmembrane signaling receptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Chagas disease pathway (IEA)

interleukin-12 signaling pathway (ISO)

interleukin-23 signaling pathway (ISO)

measles pathway (IEA)

primary immunodeficiency pathway (IEA)

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.	Bresson D, etal., J Clin Invest. 2006 May;116(5):1371-81. Epub 2006 Apr 20.
2.	Chronic marginal vitamin A status affects the distribution and function of T cells and natural T cells in aging Lewis rats.	Dawson HD and Ross AC, J Nutr. 1999 Oct;129(10):1782-90.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Binding of the Galanthus nivalis agglutinin to thymocytes reveals alterations in surface glycosylation during T-cell development.	Sinkora J, etal., Scand J Immunol. 2002 Feb;55(2):196-203.
14.	Orchitis: a complication of severe acute respiratory syndrome (SARS).	Xu J, etal., Biol Reprod. 2006 Feb;74(2):410-6. doi: 10.1095/biolreprod.105.044776. Epub 2005 Oct 19.

Additional References at PubMed

PMID:7630421	PMID:8125140	PMID:8176201	PMID:8666928	PMID:8755570	PMID:8943715	PMID:9064344	PMID:9208839	PMID:9485181	PMID:10072077	PMID:10485657	PMID:10981962
PMID:11390434	PMID:11894097	PMID:12110186	PMID:12652296	PMID:12874832	PMID:14635057	PMID:14967045	PMID:14973438	PMID:15064761	PMID:15368291	PMID:15843560	PMID:17213291
PMID:17277142	PMID:17502348	PMID:19838199	PMID:20660734	PMID:20709950	PMID:22732588	PMID:23793062	PMID:23817958

Genomics

Comparative Map Data

Cd3e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	45,303,848 - 45,315,297 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	8	45,303,852 - 45,315,022 (-)	Ensembl
Rnor_6.0	8	49,297,604 - 49,309,370 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	49,297,608 - 49,308,806 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	47,915,622 - 47,926,803 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	47,947,257 - 47,958,419 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	47,956,580 - 47,967,075 (-)	NCBI
Celera	8	44,888,608 - 44,901,125 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

CD3E
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	118,304,730 - 118,316,173 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	118,304,730 - 118,316,175 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	118,175,445 - 118,186,888 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	117,680,662 - 117,692,100 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	117,680,661 - 117,692,099	NCBI
Celera	11	115,333,175 - 115,344,768 (+)	NCBI
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	114,108,889 - 114,120,482 (+)	NCBI		HuRef
CHM1_1	11	118,061,293 - 118,072,876 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	118,321,077 - 118,332,497 (+)	NCBI

Cd3e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	44,910,033 - 44,920,961 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	44,910,038 - 44,920,925 (-)	Ensembl
GRCm38	9	44,998,735 - 45,009,663 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	44,998,740 - 45,009,627 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	44,806,826 - 44,817,673 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	44,749,738 - 44,760,585 (-)	NCBI			mm8
Celera	9	42,267,117 - 42,278,016 (-)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI
cM Map	9	24.84	NCBI

Cd3e
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	19,464,613 - 19,478,990 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	19,464,666 - 19,476,425 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD3E
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	117,074,041 - 117,085,625 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	117,074,041 - 117,085,625 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	113,142,200 - 113,153,928 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CD3E
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	15,403,724 - 15,415,259 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	15,403,710 - 15,415,260 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	15,454,474 - 15,466,079 (-)	NCBI
ROS_Cfam_1.0	5	15,346,053 - 15,357,458 (-)	NCBI
UMICH_Zoey_3.1	5	15,484,300 - 15,495,694 (-)	NCBI
UNSW_CanFamBas_1.0	5	15,387,761 - 15,399,158 (-)	NCBI
UU_Cfam_GSD_1.0	5	15,428,916 - 15,440,314 (-)	NCBI

Cd3e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	100,410,261 - 100,469,704 (+)	NCBI
SpeTri2.0	NW_004936542	3,379,361 - 3,390,677 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD3E
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	45,619,482 - 45,633,968 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	45,619,730 - 45,633,972 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	50,660,852 - 50,675,098 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CD3E
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	109,681,142 - 109,692,835 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	1	109,681,065 - 109,692,839 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666043	16,342,046 - 16,353,608 (-)	NCBI	Vero_WHO_p1.0

Cd3e
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	13,712,920 - 13,726,950 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624784	13,714,667 - 13,726,881 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH130440

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	45,303,920 - 45,304,138 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	49,297,677 - 49,297,894	NCBI	Rnor6.0
Rnor_5.0	8	47,915,695 - 47,915,912	UniSTS	Rnor5.0
RGSC_v3.4	8	47,947,326 - 47,947,543	UniSTS	RGSC3.4
Celera	8	44,888,677 - 44,888,894	UniSTS
RH 3.4 Map	8	449.9	UniSTS
Cytogenetic Map	8	q22	UniSTS

AA945909

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	8	451.8	UniSTS
Cytogenetic Map	8	q22	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	28242912	53961020	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	26644912	46711092	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	58482492	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	2097640	47097640	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	2097640	47097640	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	30848154	61290444	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	30848154	61290444	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	30848154	61290444	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	4705810	49705810	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	16290444	61290444	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	2097640	47097640	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	2097640	47097640	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	4705810	49705810	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	8736635	53736635	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	27205715	54998217	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	14906751	59906751	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	9712220	53356647	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	7670578	52670578	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	7688955	52688955	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	30848154	61290444	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	29502665	50095447	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	42692684	50095447	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	7688955	52688955	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	8736635	53736635	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	4705810	49705810	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	92
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000047291
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		8		19							3
Low	1	15	13	7		7	1	1	3	14	26	8	1
Below cutoff		12	36	34		34	7	9	22	9	6		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC136866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000047291 ⟹ ENSRNOP00000047591

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	45,303,852 - 45,315,001 (-)	Ensembl
Rnor_6.0 Ensembl	8	49,297,608 - 49,308,806 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091190 ⟹ ENSRNOP00000074900

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	45,303,852 - 45,315,022 (-)	Ensembl
Rnor_6.0 Ensembl	8	49,297,643 - 49,301,125 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119549 ⟹ ENSRNOP00000089736

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	45,303,852 - 45,314,090 (-)	Ensembl

RefSeq Acc Id:

NM_001108140 ⟹ NP_001101610

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	45,303,852 - 45,315,018 (-)	NCBI
Rnor_6.0	8	49,297,608 - 49,308,806 (-)	NCBI
Rnor_5.0	8	47,915,622 - 47,926,803 (-)	NCBI
RGSC_v3.4	8	47,947,257 - 47,958,419 (-)	RGD
Celera	8	44,888,608 - 44,901,125 (-)	RGD

Sequence:

show sequence

CTGTGTGGGGTTCAGACACTTGCCTCCCTGCCTGCTTCTGGTGCCTTCTTCAGAAATGAAGTAA
TGAGCCAGCCGTGTCCGCCATCTTAGTTGAGAGAGCATTCTAAGAGGATGCAGTGGAACGCTTT
CTGGAGCATCCTGGGCCTCAGCCTCCTAGCAGTTGGCACTTGCCAGGAAGAGTATGAAGTCTCC
ATCTCAGGAACCAGTGTAGAGCTGACGTGCCCTCTAGAGAATGAGGACAACTTAAAGTGGGAGA
AAAATGACAAAGTCCTGCCTGATAAGAATGAGAAACACCTGGTGCTAGAGGATTTCTCGGAAGT
CAAGGACAGTGGTTACTATGTCTGCTACACAGAAAGCTCAAGGAAAAACACGTACCTGTACCTG
AAAGCCAGAGTGTGCGAGAACTGCATGGAGGTGGACCTGACAGCAGTATCCATAATCATCATTG
TTGACATCTGCATCACTCTGGGCTTGCTGATGGTCGTTTATTACTGGAGCAAGAAAAGGAAGGC
CAAGGCCAAGCCTGTGACCCGAGGAACTGGTACTGGTGGCAGGCCCAGAGGTAAAGCCCAGGGG
CAAAACAAGGAGCGGCCGCCACCTGTTCCCAACCCAGACTATGAGCCCATCCGAAAAGGCCAAC
GGGACCTGTATTCTGGCCTGAATCAGAGAGCAGTCTGACAGATAGGAGGGACACTGCCTTCTGT
GGACCCATGCTATTCCTTGTTCTCTGGACAAGCGGCAGAGTCCACAGCCTTATTCTTCAGCCTC
CTGGTGAACACGCATCCTAGAACCTTCCTCTCCCACTTCCTTTGCTAGAAGCCAGTACTAGGAC
ATTGCTGACTCAGTATCCTTTGAAATATCATGACTGGTCAGATTGTCGGCCAGCCACCTTGTGG
GGATACTTTTCTCAGTTGCCCTGCTGCCATTCCCTGCCAGCTCCCCCCTTCTTCACCAATGTCA
TCTCCATATCCATCAATATACCAAGCTCTTCTTTGCTAATGCAAAAGCAATAAAGTATGTTGGT
TGG

hide sequence

RefSeq Acc Id:

XM_039081430 ⟹ XP_038937358

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	45,303,848 - 45,315,297 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101610	(Get FASTA)	NCBI Sequence Viewer
	XP_038937358	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95346	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001101610 ⟸ NM_001108140
- Peptide Label:	precursor
- Sequence:	show sequence MQWNAFWSILGLSLLAVGTCQEEYEVSISGTSVELTCPLENEDNLKWEKNDKVLPDKNEKHLVL EDFSEVKDSGYYVCYTESSRKNTYLYLKARVCENCMEVDLTAVSIIIIVDICITLGLLMVVYYW SKKRKAKAKPVTRGTGTGGRPRGKAQGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRAV hide sequence

RefSeq Acc Id:

ENSRNOP00000074900 ⟸ ENSRNOT00000091190

RefSeq Acc Id:

ENSRNOP00000047591 ⟸ ENSRNOT00000047291

RefSeq Acc Id:	XP_038937358 ⟸ XM_039081430
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000089736 ⟸ ENSRNOT00000119549

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A5M2-F1-model_v2	AlphaFold	D4A5M2	1-188	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695908

Promoter ID:

EPDNEW_R6433

Type:

initiation region

Name:

Cd3e_1

Description:

CD3e molecule

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	49,308,789 - 49,308,849	EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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CSV

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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CSV

TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309222	AgrOrtholog
BioCyc Gene	G2FUF-30688	BioCyc
Ensembl Genes	ENSRNOG00000016069	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000047591	ENTREZGENE
	ENSRNOP00000047591.4	UniProtKB/TrEMBL
	ENSRNOP00000074900.1	UniProtKB/TrEMBL
	ENSRNOP00000089736.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000047291	ENTREZGENE
	ENSRNOT00000047291.5	UniProtKB/TrEMBL
	ENSRNOT00000091190.2	UniProtKB/TrEMBL
	ENSRNOT00000119549.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	CD3_esu/gsu/dsu	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	Phos_immunorcpt_sig_ITAM	UniProtKB/TrEMBL
KEGG Report	rno:315609	UniProtKB/TrEMBL
NCBI Gene	315609	ENTREZGENE
PANTHER	PTHR10570	UniProtKB/TrEMBL
Pfam	ITAM	UniProtKB/TrEMBL
PhenoGen	Cd3e	PhenoGen
PROSITE	IG_LIKE	UniProtKB/TrEMBL
	ITAM_1	UniProtKB/TrEMBL
SMART	IGc2	UniProtKB/TrEMBL
	ITAM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A0G2K986_RAT	UniProtKB/TrEMBL
	A0A8I6AAG4_RAT	UniProtKB/TrEMBL
	D4A5M2_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-03-14	Cd3e	CD3 epsilon subunit of T-cell receptor complex	Cd3e	CD3e molecule	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-02	Cd3e	CD3e molecule	Cd3e	CD3 molecule, epsilon	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-27	Cd3e	CD3 molecule, epsilon polypeptide	Cd3e	CD3 antigen, epsilon polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Cd3e	CD3 antigen, epsilon polypeptide	Cd3e_predicted	CD3 antigen, epsilon polypeptide (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Cd3e_predicted	CD3 antigen, epsilon polypeptide (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)