Creb3 (cAMP responsive element binding protein 3)

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Gene: Creb3 (cAMP responsive element binding protein 3) Rattus norvegicus

Analyze

Symbol:

Creb3

Name:

cAMP responsive element binding protein 3

RGD ID:

1308831

Description:

Predicted to enable several functions, including CCR1 chemokine receptor binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and cAMP response element binding protein binding activity. Predicted to be involved in several processes, including negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of chemotaxis; and positive regulation of defense response to virus by host. Predicted to be located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human CREB3 (cAMP responsive element binding protein 3); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cyclic AMP-responsive element-binding protein 3; LOC298400

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	57,817,865 - 57,823,233 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,817,832 - 57,824,390 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,797,695 - 59,803,062 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,616,511 - 61,621,878 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,587,974 - 61,593,343 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	59,063,532 - 59,068,196 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	59,063,531 - 59,068,188 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,588,126 - 63,592,790 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	60,040,874 - 60,045,512 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	60,041,052 - 60,045,688 (+)	NCBI
Celera	5	56,398,438 - 56,403,076 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

anauxetic dysplasia (ISO)

breast ductal carcinoma (ISO)

distal arthrogryposis type 1A (ISO)

distal spinal muscular atrophy 2 (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis-6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

primary ciliary dyskinesia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clobetasol (ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

curcumin (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (EXP)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

geraniol (ISO)

methidathion (ISO)

methotrexate (ISO)

microcystin-LR (ISO)

nefazodone (EXP)

nicotine (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

sarin (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

tamibarotene (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

DNA-templated transcription (ISO)

endoplasmic reticulum unfolded protein response (IEA,ISO)

establishment of viral latency (ISO)

induction of positive chemotaxis (ISO)

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (ISO)

positive regulation of calcium ion transport (ISO)

positive regulation of cell migration (ISO)

positive regulation of defense response to virus by host (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of monocyte chemotaxis (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of apoptotic process (ISO)

regulation of cell growth (ISO)

regulation of cell population proliferation (ISO)

regulation of transcription by RNA polymerase II (IBA)

release from viral latency (ISO)

response to endoplasmic reticulum stress (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

Golgi apparatus (ISO)

Golgi membrane (ISO)

membrane (ISO)

neuronal cell body (ISO)

nuclear body (ISO)

nucleus (IBA,ISO)

RNA polymerase II transcription regulator complex (ISO)

Molecular Function

cAMP response element binding protein binding (ISO)

CCR1 chemokine receptor binding (ISO)

chromatin binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription coregulator binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endoplasmic reticulum stress - the unfolded protein response pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	The impact of the unfolded protein response on human disease.	Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.

Additional References at PubMed

PMID:8112612	PMID:9271389	PMID:10623756	PMID:10675342	PMID:15001559	PMID:15845366	PMID:16236796	PMID:16940180	PMID:17296613	PMID:18391022	PMID:19779205	PMID:20091349
PMID:20141198	PMID:20546900	PMID:24894591	PMID:25349404	PMID:26511246	PMID:30863858	PMID:37678424

Genomics

Comparative Map Data

Creb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	57,817,865 - 57,823,233 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,817,832 - 57,824,390 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,797,695 - 59,803,062 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,616,511 - 61,621,878 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,587,974 - 61,593,343 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	59,063,532 - 59,068,196 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	59,063,531 - 59,068,188 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,588,126 - 63,592,790 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	60,040,874 - 60,045,512 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	60,041,052 - 60,045,688 (+)	NCBI
Celera	5	56,398,438 - 56,403,076 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

CREB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	35,732,666 - 35,736,999 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	35,732,598 - 35,736,999 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	35,732,663 - 35,736,996 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	35,722,317 - 35,727,005 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	35,722,316 - 35,727,004	NCBI
Celera	9	35,665,867 - 35,670,555 (+)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	35,687,941 - 35,692,625 (+)	NCBI		HuRef
CHM1_1	9	35,732,720 - 35,737,408 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	35,753,346 - 35,757,679 (+)	NCBI		T2T-CHM13v2.0

Creb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	43,562,658 - 43,567,061 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	43,562,332 - 43,567,060 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	43,562,658 - 43,567,061 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	43,562,332 - 43,567,060 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	43,575,506 - 43,579,932 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	43,583,769 - 43,587,967 (+)	NCBI		MGSCv36	mm8
Celera	4	43,596,627 - 43,601,049 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	23.05	NCBI

Creb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	564,493 - 568,491 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	564,227 - 568,708 (-)	NCBI	ChiLan1.0	ChiLan1.0

CREB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	88,855,363 - 88,862,231 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	35,583,351 - 35,587,870 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	36,385,867 - 36,390,540 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	36,385,867 - 36,390,540 (+)	Ensembl	panpan1.1		panPan2

CREB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	52,260,340 - 52,265,085 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	52,260,420 - 52,266,515 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	50,827,661 - 50,832,639 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	53,325,030 - 53,330,008 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	53,325,322 - 53,330,008 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	51,869,576 - 51,874,554 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	51,853,091 - 51,858,072 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	52,555,244 - 52,560,222 (+)	NCBI		UU_Cfam_GSD_1.0

Creb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,179,510 - 167,183,384 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	3,727,098 - 3,730,975 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	3,727,104 - 3,730,962 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	236,450,573 - 236,456,375 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	236,450,573 - 236,456,381 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	264,175,788 - 264,181,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CREB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	44,865,409 - 44,870,074 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	44,865,682 - 44,869,621 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	41,968,965 - 41,973,616 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Creb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624868	5,056,691 - 5,060,669 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624868	5,056,415 - 5,061,234 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Creb3
13 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	61
Count of miRNA genes:	52
Interacting mature miRNAs:	60
Transcripts:	ENSRNOT00000065909
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	27955440	72955440	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	27955440	72955440	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	28515489	73515489	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	28515489	73515489	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	35189153	68564008	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat

Markers in Region

RH141307

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,822,171 - 57,822,379 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	59,067,864 - 59,068,071	NCBI	Rnor6.0
Rnor_5.0	5	63,592,458 - 63,592,665	UniSTS	Rnor5.0
RGSC_v3.4	5	60,045,180 - 60,045,387	UniSTS	RGSC3.4
Celera	5	56,402,744 - 56,402,951	UniSTS
RH 3.4 Map	5	394.8	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH129387

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,820,074 - 57,820,273 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	59,065,767 - 59,065,965	NCBI	Rnor6.0
Rnor_5.0	5	63,590,361 - 63,590,559	UniSTS	Rnor5.0
RGSC_v3.4	5	60,043,083 - 60,043,281	UniSTS	RGSC3.4
Celera	5	56,400,647 - 56,400,845	UniSTS
RH 3.4 Map	5	394.3	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH134106

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,822,457 - 57,822,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	59,068,150 - 59,068,367	NCBI	Rnor6.0
Rnor_5.0	5	63,592,744 - 63,592,961	UniSTS	Rnor5.0
RGSC_v3.4	5	60,045,466 - 60,045,683	UniSTS	RGSC3.4
Celera	5	56,403,030 - 56,403,247	UniSTS
RH 3.4 Map	5	394.9	UniSTS
Cytogenetic Map	5	q22	UniSTS

BE118740

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,821,073 - 57,821,234 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	59,066,766 - 59,066,926	NCBI	Rnor6.0
Rnor_5.0	5	63,591,360 - 63,591,520	UniSTS	Rnor5.0
RGSC_v3.4	5	60,044,082 - 60,044,242	UniSTS	RGSC3.4
Celera	5	56,401,646 - 56,401,806	UniSTS
RH 3.4 Map	5	395.0	UniSTS
Cytogenetic Map	5	q22	UniSTS

PMC114562P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	57,818,024 - 57,818,440 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	59,063,717 - 59,064,132	NCBI	Rnor6.0
Rnor_5.0	5	63,588,311 - 63,588,726	UniSTS	Rnor5.0
RGSC_v3.4	5	60,041,033 - 60,041,448	UniSTS	RGSC3.4
Celera	5	56,398,597 - 56,399,012	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ817427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000065909 ⟹ ENSRNOP00000061486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	57,817,832 - 57,823,228 (+)	Ensembl
Rnor_6.0 Ensembl	5	59,063,558 - 59,068,188 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000085311 ⟹ ENSRNOP00000072482

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	57,817,832 - 57,824,390 (+)	Ensembl
Rnor_6.0 Ensembl	5	59,063,531 - 59,068,148 (+)	Ensembl

RefSeq Acc Id:

NM_001395632 ⟹ NP_001382561

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	57,817,865 - 57,823,233 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001382561	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62241	(Get FASTA)	NCBI Sequence Viewer
	AIE90091	(Get FASTA)	NCBI Sequence Viewer
	EDL98755	(Get FASTA)	NCBI Sequence Viewer
	EDL98756	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061486
	ENSRNOP00000061486.2
	ENSRNOP00000072482.2

RefSeq Acc Id:

ENSRNOP00000072482 ⟸ ENSRNOT00000085311

RefSeq Acc Id:

ENSRNOP00000061486 ⟸ ENSRNOT00000065909

RefSeq Acc Id:	NP_001382561 ⟸ NM_001395632
- UniProtKB:	F7FJV3 (UniProtKB/TrEMBL), A6IJ35 (UniProtKB/TrEMBL), A0A075FKQ4 (UniProtKB/TrEMBL)

Protein Domains

bZIP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K331-F1-model_v2	AlphaFold	A0A0G2K331	1-387	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693679

Promoter ID:

EPDNEW_R4204

Type:

initiation region

Name:

Creb3_1

Description:

cAMP responsive element binding protein 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	59,063,584 - 59,063,644	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308831	AgrOrtholog
BioCyc Gene	G2FUF-41504	BioCyc
Ensembl Genes	ENSRNOG00000016452	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065909	ENTREZGENE
	ENSRNOT00000065909.2	UniProtKB/TrEMBL
	ENSRNOT00000085311.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6887761	IMAGE-MGC_LOAD
InterPro	bZIP	UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/TrEMBL
KEGG Report	rno:298400	UniProtKB/TrEMBL
MGC_CLONE	MGC:72980	IMAGE-MGC_LOAD
NCBI Gene	298400	ENTREZGENE
PANTHER	AGAP001464-PB	UniProtKB/TrEMBL
	PTHR45996:SF4	UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/TrEMBL
PhenoGen	Creb3	PhenoGen
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016452	RatGTEx
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/TrEMBL
UniProt	A0A075FKQ4	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K331_RAT	UniProtKB/TrEMBL
	A6IJ35	ENTREZGENE, UniProtKB/TrEMBL
	A6IJ36_RAT	UniProtKB/TrEMBL
	F7FJV3	ENTREZGENE, UniProtKB/TrEMBL
	Q6P6G3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Creb3	cAMP responsive element binding protein 3	Creb3_predicted	cAMP responsive element binding protein 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Creb3_predicted	cAMP responsive element binding protein 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations