Gene: Hmbs (hydroxymethylbilane synthase) Rattus norvegicus
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Symbol: Hmbs
Name: hydroxymethylbilane synthase
Description: Exhibits several functions, including amine binding activity, carboxylic acid binding activity, and coenzyme binding activity; involved in several processes, including animal organ regeneration, astrocyte differentiation, and cellular response to amine stimulus; localizes to the axon, cytoplasm, and nucleus; colocalizes with the condensed chromosome; biomarker of bilirubin metabolic disorder; orthologous to human HMBS (hydroxymethylbilane synthase); PARTICIPATES IN heme biosynthetic pathway; acute intermittent porphyria pathway; erythropoietic porphyria pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alternative name: porphobilinogen deaminase; hemC; MGC108753; PBG-D; PBGD; Porphobilinogen deaminase; pre-uroporphyrinogen synthase; URO-S; uroporphyrinogen I synthase
Orthologs:
Homo sapiens (human) : HMBS (hydroxymethylbilane synthase)  HGNC  Alliance
Mus musculus (house mouse) : Hmbs (hydroxymethylbilane synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmbs (hydroxymethylbilane synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMBS (hydroxymethylbilane synthase)
Canis lupus familiaris (dog) : HMBS (hydroxymethylbilane synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmbs (hydroxymethylbilane synthase)
Sus scrofa (pig) : HMBS (hydroxymethylbilane synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0848,667,278 - 48,674,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0847,286,249 - 47,293,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,314,235 - 47,321,604 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1847,323,010 - 47,328,455 (-)NCBI
Celera844,259,787 - 44,267,156 (-)NCBICelera
Cytogenetic Map8q22NCBI
RH 3.4 Map8428.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

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Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Hmbs
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2801
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.