(-)-epigallocatechin 3-gallate decreases expression ISO RGD:1352097 6480464 epigallocatechin gallate results in decreased expression of POMC mRNA CTD PMID:20706672 (20S)-20-hydroxypregn-4-en-3-one multiple interactions ISO RGD:1331975 6480464 Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 (20S)-20-hydroxypregn-4-en-3-one increases secretion ISO RGD:1331975 6480464 POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone CTD PMID:8299002 (S)-colchicine increases secretion EXP 6480464 Colchicine results in increased secretion of POMC protein CTD PMID:2453250 (S)-nicotine affects response to substance ISO RGD:1331975 6480464 POMC protein affects the susceptibility to Nicotine CTD PMID:19376143 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of POMC protein CTD PMID:28555334 (S)-nicotine affects expression EXP 6480464 Nicotine affects the expression of POMC protein CTD PMID:22975262 (S)-nicotine multiple interactions ISO RGD:1331975 6480464 POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine] CTD PMID:15689546 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of POMC protein alternative form CTD PMID:23623838 (Z)-hex-3-en-1-ol multiple interactions EXP 6480464 [2 more ... CTD PMID:19103229 , PMID:21515296 1,2-dimethylhydrazine increases expression ISO RGD:1331975 6480464 1, 2-Dimethylhydrazine results in increased expression of POMC mRNA CTD PMID:22206623 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expression ISO RGD:1352097 6480464 Citalopram results in increased expression of POMC protein CTD PMID:20414043 11-deoxycorticosterone increases abundance ISO RGD:1352097 6480464 POMC protein results in increased abundance of Desoxycorticosterone CTD PMID:3015796 17alpha-ethynylestradiol increases expression ISO RGD:1331975 6480464 Ethinyl Estradiol results in increased expression of POMC mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1331975 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POMC mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 Estradiol affects the reaction [Dronabinol results in increased expression of POMC mRNA], Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form] CTD PMID:11528220 , PMID:22265196 17beta-estradiol decreases expression ISO RGD:1331975 6480464 Estradiol results in decreased expression of POMC mRNA CTD PMID:29092056 18-hydroxycortisol increases abundance ISO RGD:1352097 6480464 POMC protein results in increased abundance of 18-hydroxycortisol CTD PMID:3015796 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:21394737 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid increases secretion ISO RGD:1331975 6480464 hexadecafluoro-nonanoic acid results in increased secretion of POMC protein alternative form CTD PMID:18583369 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1331975 6480464 Tetrachlorodibenzodioxin results in increased expression of POMC mRNA, Tetrachlorodibenzodioxin results in increased expression of POMC protein CTD PMID:12520768 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of POMC mRNA CTD PMID:15093705 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of POMC mRNA CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1331975 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POMC mRNA CTD PMID:17942748 2,3-bis(4-hydroxyphenyl)propionitrile multiple interactions ISO RGD:1331975 6480464 [4 more ... CTD PMID:29092056 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:1331975 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of POMC mRNA CTD PMID:25307695 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of POMC protein CTD PMID:11959675 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of POMC mRNA CTD PMID:21346803 2-hexenal multiple interactions EXP 6480464 [2 more ... CTD PMID:19103229 , PMID:21515296 20-HETE multiple interactions EXP 6480464 HET0016 inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5 more ... CTD PMID:19458537 20-HETE increases abundance EXP 6480464 POMC protein results in increased abundance of 20-hydroxy-5 more ... CTD PMID:18067589 , PMID:19458537 3',5'-cyclic AMP increases abundance ISO RGD:1331975 6480464 POMC protein modified form results in increased abundance of Cyclic AMP CTD PMID:26586997 3',5'-cyclic AMP multiple interactions EXP 6480464 [Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP, INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP] CTD PMID:4306506 3',5'-cyclic AMP multiple interactions ISO RGD:1331975 6480464 Quercetin analog inhibits the reaction [POMC protein modified form results in increased abundance of Cyclic AMP] CTD PMID:26586997 3',5'-cyclic GMP affects abundance EXP 6480464 POMC protein affects the abundance of Cyclic GMP CTD PMID:11193135 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:32119087 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1331975 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of POMC mRNA CTD PMID:19523041 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:1331975 6480464 naltrindole inhibits the reaction [N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of POMC mRNA] CTD PMID:19523041 4,4'-sulfonyldiphenol increases expression ISO RGD:1331975 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of POMC mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1352097 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of POMC gene CTD PMID:31601247 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of POMC mRNA CTD PMID:24780913 , PMID:25825206 7,12-dimethyltetraphene multiple interactions EXP 6480464 POMC protein promotes the reaction [CYP1B1 protein results in increased metabolism of 9 more ... CTD PMID:7588239 8-OH-DPAT multiple interactions EXP 6480464 [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form, Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form] CTD PMID:22265196 acetaldehyde increases expression EXP 6480464 Acetaldehyde results in increased expression of POMC mRNA, Acetaldehyde results in increased expression of POMC protein CTD PMID:7704432 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of POMC mRNA CTD PMID:31881176 acetylcholine increases expression EXP 6480464 Acetylcholine results in increased expression of POMC mRNA, Acetylcholine results in increased expression of POMC protein CTD PMID:7588217 acetylcholine multiple interactions EXP 6480464 Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein], Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 acrylamide increases expression ISO RGD:1331975 6480464 Acrylamide results in increased expression of POMC mRNA, Acrylamide results in increased expression of POMC protein CTD PMID:15003292 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of POMC mRNA CTD PMID:23630614 Aflatoxin B2 alpha increases methylation ISO RGD:1352097 6480464 aflatoxin B2 results in increased methylation of POMC polyA tail CTD PMID:30157460 aldehydo-D-glucose multiple interactions ISO RGD:1331975 6480464 POMC inhibits the reaction [INS1 results in increased uptake of Glucose] CTD PMID:18310442 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of POMC mRNA CTD PMID:18627777 aldehydo-D-glucose increases response to substance ISO RGD:1331975 6480464 Glucose results in increased susceptibility to POMC protein CTD PMID:19489000 aldosterone multiple interactions ISO RGD:1352097 6480464 Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone] CTD PMID:3015796 aldosterone increases secretion EXP 6480464 POMC results in increased secretion of Aldosterone CTD PMID:1659878 aldosterone increases abundance ISO RGD:1352097 6480464 POMC protein results in increased abundance of Aldosterone CTD PMID:3015796 aldosterone decreases abundance ISO RGD:1352097 6480464 POMC protein results in decreased abundance of Aldosterone CTD PMID:2551692 all-trans-retinol increases expression EXP 6480464 Vitamin A results in increased expression of POMC protein CTD PMID:17373634 AM-251 multiple interactions EXP 6480464 AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA] CTD PMID:26468265 AM-251 multiple interactions ISO RGD:1331975 6480464 AM 251 inhibits the reaction [Dietary Fats results in decreased expression of POMC mRNA] more ... CTD PMID:27071101 AM-251 increases expression EXP 6480464 AM 251 results in increased expression of POMC mRNA CTD PMID:26468265 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of POMC mRNA CTD PMID:16483693 apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes] CTD PMID:16053986 arachidonyl-2'-chloroethylamide multiple interactions EXP 6480464 arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA] CTD PMID:26468265 arachidonyl-2'-chloroethylamide decreases expression EXP 6480464 arachidonyl-2-chloroethylamide results in decreased expression of POMC mRNA CTD PMID:26468265 Aroclor 1254 multiple interactions EXP 6480464 [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1242 co-treated with aroclor 1248] results in decreased expression of POMC mRNA CTD PMID:29879404 aspartame increases expression ISO RGD:1352097 6480464 Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 astressin 2B increases secretion EXP 6480464 astressin-2B results in increased secretion of POMC protein alternative form CTD PMID:12746300 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of POMC protein CTD PMID:29574565 atrazine increases secretion EXP 6480464 Atrazine results in increased secretion of POMC protein modified form CTD PMID:19690231 more ... atrazine multiple interactions EXP 6480464 lycopene inhibits the reaction [Atrazine results in increased secretion of POMC protein modified form] CTD PMID:27102619 atropine multiple interactions EXP 6480464 Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 Aurothioglucose decreases expression ISO RGD:1331975 6480464 Aurothioglucose results in decreased expression of POMC mRNA CTD PMID:9794456 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of POMC mRNA CTD PMID:21839799 benzo[a]pyrene affects methylation ISO RGD:1352097 6480464 Benzo(a)pyrene affects the methylation of POMC promoter CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1352097 6480464 Benzo(a)pyrene results in increased methylation of POMC 5' UTR CTD PMID:27901495 Benzylphosphonic acid decreases activity ISO RGD:1331975 6480464 benzylphosphonic acid results in decreased activity of POMC protein CTD PMID:12530643 Benzylphosphonic acid multiple interactions ISO RGD:1331975 6480464 [benzylphosphonic acid results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone CTD PMID:12530643 beta-hexachlorocyclohexane multiple interactions ISO RGD:1331975 6480464 [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA CTD PMID:16758953 bezafibrate decreases expression ISO RGD:1331975 6480464 Bezafibrate results in decreased expression of POMC mRNA CTD PMID:18787029 bis(2-chloroethyl) sulfide increases expression ISO RGD:1352097 6480464 Mustard Gas results in increased expression of POMC protein alternative form CTD PMID:8299707 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of POMC mRNA CTD PMID:28871463 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of POMC protein CTD PMID:25812946 , PMID:26060449 bisphenol A decreases methylation ISO RGD:1352097 6480464 bisphenol A results in decreased methylation of POMC gene CTD PMID:31601247 bisphenol A multiple interactions ISO RGD:1331975 6480464 GNRH1 protein inhibits the reaction [bisphenol A results in increased expression of POMC mRNA] more ... CTD PMID:30149043 bisphenol A increases secretion ISO RGD:1331975 6480464 bisphenol A results in increased secretion of POMC protein modified form CTD PMID:30149043 bisphenol A increases expression ISO RGD:1331975 6480464 bisphenol A results in increased expression of POMC mRNA CTD PMID:30149043 more ... bisphenol A decreases expression ISO RGD:1331975 6480464 bisphenol A results in decreased expression of POMC mRNA CTD PMID:29092056 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of POMC mRNA CTD PMID:24323913 , PMID:24857958 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of POMC mRNA CTD PMID:25181051 more ... bisphenol F increases expression ISO RGD:1331975 6480464 bisphenol F results in increased expression of POMC mRNA CTD PMID:30951980 bromocriptine decreases expression EXP 6480464 Bromocriptine results in decreased expression of POMC protein alternative form CTD PMID:6274577 bromocriptine increases expression ISO RGD:1352097 6480464 Bromocriptine results in increased expression of POMC mRNA, Bromocriptine results in increased expression of POMC protein modified form CTD PMID:1325994 bromocriptine multiple interactions EXP 6480464 Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone] CTD PMID:12742521 bucladesine increases expression ISO RGD:1352097 6480464 Bucladesine results in increased expression of POMC mRNA, Bucladesine results in increased expression of POMC protein modified form CTD PMID:1325994 buspirone increases expression ISO RGD:1352097 6480464 Buspirone results in increased expression of POMC protein CTD PMID:19762159 buspirone multiple interactions ISO RGD:1352097 6480464 Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 Butylparaben multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA CTD PMID:34383603 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of POMC protein CTD PMID:20652474 cadmium dichloride multiple interactions ISO RGD:1331975 6480464 Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 caffeine increases secretion EXP 6480464 Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of POMC mRNA CTD PMID:31941059 cannabigerol decreases expression EXP 6480464 cannabigerol results in decreased expression of POMC mRNA CTD PMID:31941059 capsaicin multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein] more ... CTD PMID:22150557 more ... capsaicin increases secretion EXP 6480464 Capsaicin results in increased secretion of POMC protein CTD PMID:8925284 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of POMC protein CTD PMID:22150557 capsazepine multiple interactions EXP 6480464 capsazepine inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 capsazepine multiple interactions ISO RGD:1331975 6480464 capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 carbamazepine affects expression ISO RGD:1352097 6480464 Carbamazepine affects the expression of POMC mRNA CTD PMID:25979313 celecoxib multiple interactions EXP 6480464 Celecoxib inhibits the reaction [docetaxel results in increased expression of POMC mRNA] CTD PMID:22902858 CGP 52608 multiple interactions ISO RGD:1352097 6480464 CGP 52608 promotes the reaction [RORA protein binds to POMC gene] CTD PMID:28238834 chloroquine multiple interactions EXP 6480464 Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 chlorpyrifos multiple interactions ISO RGD:1352097 6480464 [APOE gene polymorphism affects the susceptibility to Chlorpyrifos] which affects the expression of POMC mRNA CTD PMID:31472362 citalopram increases expression ISO RGD:1352097 6480464 Citalopram results in increased expression of POMC protein CTD PMID:20414043 clofibrate increases expression ISO RGD:1331975 6480464 Clofibrate results in increased expression of POMC mRNA CTD PMID:17585979 clonidine increases expression ISO RGD:1352097 6480464 Clonidine results in increased expression of POMC protein CTD PMID:2455169 , PMID:6089027 clonidine multiple interactions EXP 6480464 [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein more ... CTD PMID:10898105 , PMID:2846107 clonidine increases secretion EXP 6480464 Clonidine results in increased secretion of POMC protein alternative form CTD PMID:10898105 clonidine decreases expression EXP 6480464 Clonidine results in decreased expression of POMC protein CTD PMID:3039113 clonidine multiple interactions ISO RGD:1352097 6480464 [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone CTD PMID:6089027 clonidine (amino form) increases expression ISO RGD:1352097 6480464 Clonidine results in increased expression of POMC protein CTD PMID:2455169 , PMID:6089027 clonidine (amino form) multiple interactions EXP 6480464 [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein more ... CTD PMID:10898105 , PMID:2846107 clonidine (amino form) increases secretion EXP 6480464 Clonidine results in increased secretion of POMC protein alternative form CTD PMID:10898105 clonidine (amino form) decreases expression EXP 6480464 Clonidine results in decreased expression of POMC protein CTD PMID:3039113 clonidine (amino form) multiple interactions ISO RGD:1352097 6480464 [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone CTD PMID:6089027 clonidine (imino form) increases expression ISO RGD:1352097 6480464 Clonidine results in increased expression of POMC protein CTD PMID:2455169 , PMID:6089027 clonidine (imino form) multiple interactions EXP 6480464 [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein more ... CTD PMID:10898105 , PMID:2846107 clonidine (imino form) increases secretion EXP 6480464 Clonidine results in increased secretion of POMC protein alternative form CTD PMID:10898105 clonidine (imino form) decreases expression EXP 6480464 Clonidine results in decreased expression of POMC protein CTD PMID:3039113 clonidine (imino form) multiple interactions ISO RGD:1352097 6480464 [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone CTD PMID:6089027 cobalt dichloride multiple interactions ISO RGD:1331975 6480464 Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]] more ... CTD PMID:24412703 cocaine increases secretion ISO RGD:1352097 6480464 Cocaine results in increased secretion of POMC protein CTD PMID:11750770 cocaine increases expression EXP 6480464 Cocaine results in increased expression of POMC protein, Cocaine results in increased expression of POMC protein alternative form CTD PMID:17001283 more ... cocaine increases response to substance EXP 6480464 POMC results in increased susceptibility to Cocaine CTD PMID:19279569 cocaine multiple interactions EXP 6480464 [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine], eticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein] CTD PMID:17001283 , PMID:19279569 cocaine increases response to substance ISO RGD:1331975 6480464 POMC results in increased susceptibility to Cocaine CTD PMID:18176854 corticosterone multiple interactions EXP 6480464 Bromocriptine inhibits the reaction [POMC protein results in decreased secretion of Corticosterone] more ... CTD PMID:10518784 more ... corticosterone increases secretion ISO RGD:1331975 6480464 POMC protein modified form results in increased secretion of Corticosterone CTD PMID:27052214 corticosterone multiple interactions ISO RGD:1331975 6480464 lipopolysaccharide more ... CTD PMID:27052214 corticosterone increases abundance EXP 6480464 POMC protein results in increased abundance of Corticosterone CTD PMID:10518784 , PMID:7588239 corticosterone decreases abundance EXP 6480464 POMC protein results in decreased abundance of Corticosterone CTD PMID:11518849 corticosterone increases secretion EXP 6480464 POMC protein modified form results in increased secretion of Corticosterone more ... CTD PMID:11132610 more ... corticosterone decreases secretion EXP 6480464 Corticosterone results in decreased secretion of POMC protein, POMC protein results in decreased secretion of Corticosterone CTD PMID:12742521 , PMID:3015567 cortisol increases response to substance ISO RGD:1352097 6480464 POMC protein results in increased susceptibility to Hydrocortisone CTD PMID:3015460 cortisol increases abundance ISO RGD:1352097 6480464 POMC protein results in increased abundance of Hydrocortisone CTD PMID:21332028 , PMID:9881897 cortisol multiple interactions ISO RGD:1352097 6480464 Lead inhibits the reaction [POMC protein modified form results in increased secretion of Hydrocortisone], Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone] CTD PMID:21332028 , PMID:22112310 cortisol increases secretion ISO RGD:1352097 6480464 POMC protein results in increased secretion of Hydrocortisone CTD PMID:11082157 , PMID:1321309 CP-96345(1+) multiple interactions EXP 6480464 CP 96345 inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 cyanamide multiple interactions EXP 6480464 [Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA more ... CTD PMID:11139417 , PMID:16375214 cyanamide increases expression EXP 6480464 Cyanamide results in increased expression of POMC mRNA CTD PMID:10978654 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of POMC protein CTD PMID:15276878 cyproheptadine decreases secretion ISO RGD:1352097 6480464 Cyproheptadine results in decreased secretion of POMC protein CTD PMID:642945 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of POMC mRNA CTD PMID:18627777 D-glucose increases response to substance ISO RGD:1331975 6480464 Glucose results in increased susceptibility to POMC protein CTD PMID:19489000 D-glucose multiple interactions ISO RGD:1331975 6480464 POMC inhibits the reaction [INS1 results in increased uptake of Glucose] CTD PMID:18310442 DDE multiple interactions ISO RGD:1331975 6480464 [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA CTD PMID:16758953 DDE multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA CTD PMID:34383603 DDT multiple interactions ISO RGD:1352097 6480464 [Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC CTD PMID:16329587 deethylatrazine increases secretion EXP 6480464 deethylatrazine results in increased secretion of POMC protein modified form CTD PMID:19690231 dehydroepiandrosterone sulfate increases abundance ISO RGD:1352097 6480464 POMC results in increased abundance of Dehydroepiandrosterone Sulfate CTD PMID:2161262 deisopropylatrazine increases secretion EXP 6480464 6-deisopropylatrazine results in increased secretion of POMC protein modified form CTD PMID:19690231 , PMID:19710361 dexamethasone multiple interactions ISO RGD:1352097 6480464 Dexamethasone inhibits the reaction [Crack Cocaine results in increased secretion of POMC protein], Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone] CTD PMID:10780258 , PMID:3015796 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of POMC mRNA, Dexamethasone results in decreased expression of POMC protein CTD PMID:32445661 dexamethasone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of POMC mRNA] CTD PMID:32445661 dexamethasone affects response to substance ISO RGD:1352097 6480464 POMC affects the susceptibility to Dexamethasone CTD PMID:1459535 dexamethasone decreases expression ISO RGD:1352097 6480464 Dexamethasone results in decreased expression of POMC protein CTD PMID:174842 dexamethasone decreases secretion ISO RGD:1352097 6480464 Dexamethasone results in decreased secretion of POMC protein CTD PMID:9253312 dichlorvos multiple interactions EXP 6480464 Dichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 dichlorvos increases secretion EXP 6480464 Dichlorvos results in increased secretion of POMC protein modified form CTD PMID:6245657 dimethyl sulfoxide decreases expression ISO RGD:1331975 6480464 Dimethyl Sulfoxide results in decreased expression of POMC protein CTD PMID:15680486 dinitrogen oxide increases secretion EXP 6480464 Nitrous Oxide results in increased secretion of POMC protein CTD PMID:2846107 dioxygen increases secretion EXP 6480464 Oxygen results in increased secretion of POMC protein CTD PMID:2846107 diprotium oxide multiple interactions EXP 6480464 [Water deficiency co-treated with Sodium Chloride more ... CTD PMID:26468265 disodium cromoglycate multiple interactions EXP 6480464 Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone] CTD PMID:1659878 disulfiram decreases expression EXP 6480464 Disulfiram results in decreased expression of POMC protein alternative form CTD PMID:8246921 dizocilpine maleate multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 dodecane increases expression EXP 6480464 n-dodecane results in increased expression of POMC protein modified form CTD PMID:19152832 dopachrome multiple interactions ISO RGD:1331975 6480464 [POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome, Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] CTD PMID:26586997 dopamine multiple interactions ISO RGD:1331975 6480464 POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine] CTD PMID:15689546 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of POMC mRNA CTD PMID:29391264 enzacamene multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA CTD PMID:34383603 ethanol decreases expression ISO RGD:1352097 6480464 Ethanol results in decreased expression of POMC mRNA CTD PMID:17934066 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of POMC protein CTD PMID:32437893 ethanol affects response to substance EXP 6480464 POMC protein affects the susceptibility to Ethanol CTD PMID:20021565 ethanol increases expression EXP 6480464 Ethanol results in increased expression of POMC mRNA, Ethanol results in increased expression of POMC protein CTD PMID:16925589 more ... ethanol decreases secretion EXP 6480464 Ethanol results in decreased secretion of POMC protein alternative form CTD PMID:12746300 ethanol multiple interactions EXP 6480464 [Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA more ... CTD PMID:11139417 more ... ethanol multiple interactions ISO RGD:1352097 6480464 fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 ether increases secretion EXP 6480464 Ether results in increased secretion of POMC protein CTD PMID:2846107 eticlopride(1+) multiple interactions EXP 6480464 eticlopride inhibits the reaction [Cocaine results in increased expression of POMC protein] CTD PMID:17001283 fentanyl decreases expression ISO RGD:1352097 6480464 Fentanyl results in decreased expression of POMC protein alternative form CTD PMID:20084599 fentanyl multiple interactions ISO RGD:1352097 6480464 [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form CTD PMID:20084599 finasteride multiple interactions ISO RGD:1352097 6480464 [Finasteride results in increased susceptibility to IL1B protein] which results in increased secretion of POMC protein CTD PMID:19458216 fludrocortisone multiple interactions ISO RGD:1352097 6480464 [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of POMC mRNA, Fluoxetine results in increased expression of POMC protein CTD PMID:18359080 fluoxetine decreases expression EXP 6480464 Fluoxetine results in decreased expression of POMC mRNA CTD PMID:15936043 , PMID:16042082 fomepizole multiple interactions ISO RGD:1352097 6480464 fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 formaldehyde increases expression ISO RGD:1331975 6480464 Formaldehyde results in increased expression of POMC mRNA, Formaldehyde results in increased expression of POMC protein CTD PMID:15196973 , PMID:15805735 fructose decreases expression EXP 6480464 Fructose results in decreased expression of POMC mRNA CTD PMID:18627777 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]] CTD PMID:20837582 fulvestrant multiple interactions ISO RGD:1352097 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in increased methylation of POMC gene CTD PMID:31601247 gamma-hexachlorocyclohexane multiple interactions ISO RGD:1352097 6480464 [Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC CTD PMID:16329587 genistein decreases expression ISO RGD:1352097 6480464 Genistein results in decreased expression of POMC mRNA CTD PMID:20706672 gentamycin multiple interactions EXP 6480464 POMC protein inhibits the reaction [Gentamicins results in increased activity of MPO protein] CTD PMID:17216604 glucose decreases expression EXP 6480464 Glucose results in decreased expression of POMC mRNA CTD PMID:18627777 glucose increases response to substance ISO RGD:1331975 6480464 Glucose results in increased susceptibility to POMC protein CTD PMID:19489000 glucose multiple interactions ISO RGD:1331975 6480464 POMC inhibits the reaction [INS1 results in increased uptake of Glucose] CTD PMID:18310442 Glutathione ethyl ester multiple interactions EXP 6480464 S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA] CTD PMID:24792324 glycerol increases secretion ISO RGD:1352097 6480464 POMC protein alternative form results in increased secretion of Glycerol CTD PMID:8429757 GTP multiple interactions ISO RGD:1352097 6480464 [Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form more ... CTD PMID:2550106 GTP multiple interactions ISO RGD:1331975 6480464 [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 guanosine 5'-[beta,gamma-imido]triphosphate multiple interactions ISO RGD:1331975 6480464 [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 guanosine 5'-[beta,gamma-imido]triphosphate multiple interactions ISO RGD:1352097 6480464 [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 halothane increases secretion EXP 6480464 Halothane results in increased secretion of POMC protein CTD PMID:2846107 herbicide multiple interactions EXP 6480464 [[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluoro-n-nonanoic acid] which results in decreased expression of POMC protein modified form CTD PMID:25588985 HET0016 multiple interactions EXP 6480464 HET0016 inhibits the reaction [POMC protein affects the abundance of 20-hydroxy-5 more ... CTD PMID:19458537 imipramine multiple interactions ISO RGD:1352097 6480464 Imipramine inhibits the reaction [Buspirone results in increased expression of POMC protein] CTD PMID:19762159 indometacin multiple interactions EXP 6480464 Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form], Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form] CTD PMID:10898105 isoprenaline increases secretion EXP 6480464 Isoproterenol results in increased secretion of POMC protein alternative form CTD PMID:10898105 ketoconazole decreases expression ISO RGD:1331975 6480464 Ketoconazole results in decreased expression of POMC protein modified form CTD PMID:25808816 lansoprazole increases expression ISO RGD:1352097 6480464 Lansoprazole results in increased expression of POMC protein CTD PMID:16524691 lead(0) multiple interactions ISO RGD:1352097 6480464 Lead inhibits the reaction [POMC protein modified form results in increased secretion of Hydrocortisone] CTD PMID:22112310 lead(2+) multiple interactions ISO RGD:1352097 6480464 Lead inhibits the reaction [POMC protein modified form results in increased secretion of Hydrocortisone] CTD PMID:22112310 lidocaine multiple interactions EXP 6480464 Lidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 linsidomine multiple interactions EXP 6480464 CRH protein affects the reaction [linsidomine results in increased secretion of POMC protein alternative form] CTD PMID:10460269 linsidomine increases secretion EXP 6480464 linsidomine results in increased secretion of POMC protein alternative form CTD PMID:10460269 linuron multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA CTD PMID:34383603 lipopolysaccharide affects expression ISO RGD:1331975 6480464 Lipopolysaccharides affects the expression of POMC mRNA CTD PMID:15667454 lipopolysaccharide increases secretion EXP 6480464 Lipopolysaccharides results in increased secretion of POMC protein modified form CTD PMID:29958987 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of POMC protein, Lipopolysaccharides results in increased expression of POMC protein alternative form CTD PMID:12207160 , PMID:16522730 lipopolysaccharide decreases secretion EXP 6480464 Lipopolysaccharides results in decreased secretion of POMC protein alternative form CTD PMID:12746300 lipopolysaccharide multiple interactions EXP 6480464 astressin B inhibits the reaction [Lipopolysaccharides results in decreased secretion of POMC protein alternative form] more ... CTD PMID:12207160 , PMID:12746300 lithium atom multiple interactions ISO RGD:1352097 6480464 [Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form CTD PMID:2550106 lithium hydride multiple interactions ISO RGD:1352097 6480464 [Guanosine Triphosphate co-treated with Lithium] results in decreased activity of POMC protein modified form CTD PMID:2550106 lycopene multiple interactions EXP 6480464 lycopene inhibits the reaction [Atrazine results in increased secretion of POMC protein modified form] CTD PMID:27102619 magnesium atom multiple interactions EXP 6480464 Phentolamine inhibits the reaction [POMC results in increased uptake of Magnesium] CTD PMID:191614 magnesium atom increases uptake EXP 6480464 POMC results in increased uptake of Magnesium CTD PMID:191614 magnesium atom decreases uptake EXP 6480464 POMC modified form results in decreased uptake of Magnesium CTD PMID:191614 melanins increases chemical synthesis ISO RGD:1331975 6480464 POMC protein modified form results in increased chemical synthesis of Melanins CTD PMID:26586997 melanins multiple interactions ISO RGD:1331975 6480464 Quercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins] CTD PMID:26586997 melatonin multiple interactions EXP 6480464 [Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein CTD PMID:11478929 melatonin multiple interactions ISO RGD:1352097 6480464 Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone], Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone] CTD PMID:21332028 melatonin decreases response to substance ISO RGD:1352097 6480464 Melatonin results in decreased susceptibility to POMC protein CTD PMID:19301769 metformin multiple interactions ISO RGD:1331975 6480464 Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 methamidophos increases expression EXP 6480464 methamidophos results in increased expression of POMC protein alternative form CTD PMID:11048668 methyl methanesulfonate increases expression ISO RGD:1352097 6480464 Methyl Methanesulfonate results in increased expression of POMC mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1331975 6480464 methylmercuric chloride results in increased expression of POMC mRNA CTD PMID:29850906 methylmercury chloride affects expression ISO RGD:1331975 6480464 methylmercuric chloride affects the expression of POMC mRNA CTD PMID:33338554 methylmercury chloride multiple interactions ISO RGD:1331975 6480464 LEP protein affects the reaction [methylmercuric chloride affects the expression of POMC mRNA] CTD PMID:33338554 metyrapone increases expression ISO RGD:1352097 6480464 Metyrapone results in increased expression of POMC protein CTD PMID:16566900 metyrapone increases expression EXP 6480464 Metyrapone results in increased expression of POMC CTD PMID:638031 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of POMC mRNA] CTD PMID:32445661 monosodium L-glutamate decreases expression ISO RGD:1331975 6480464 Sodium Glutamate results in decreased expression of POMC mRNA CTD PMID:9794456 monosodium L-glutamate decreases secretion EXP 6480464 Sodium Glutamate results in decreased secretion of POMC protein CTD PMID:8071649 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of POMC mRNA, Sodium Glutamate results in increased expression of POMC protein CTD PMID:9662721 morphine multiple interactions ISO RGD:1352097 6480464 [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form CTD PMID:20084599 morphine increases secretion EXP 6480464 Morphine deficiency results in increased secretion of POMC protein modified form CTD PMID:24398105 morphine multiple interactions EXP 6480464 [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein more ... CTD PMID:24398105 , PMID:2846107 morphine multiple interactions ISO RGD:1331975 6480464 [Zymosan co-treated with Morphine] results in increased expression of POMC mRNA CTD PMID:15979727 morphine increases expression ISO RGD:1331975 6480464 Morphine results in increased expression of POMC mRNA CTD PMID:20144693 Morroniside increases expression EXP 6480464 morroniside results in increased expression of POMC mRNA alternative form CTD PMID:32595037 muscimol decreases expression EXP 6480464 Muscimol results in decreased expression of POMC mRNA CTD PMID:7937335 muscimol multiple interactions EXP 6480464 Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA] CTD PMID:7937335 N-acetyl-L-cysteine multiple interactions ISO RGD:1331975 6480464 Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]] CTD PMID:24412703 naloxone multiple interactions ISO RGD:1352097 6480464 [Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone, Naloxone binds to and results in increased activity of POMC protein alternative form CTD PMID:3157294 , PMID:6089027 naloxone increases secretion EXP 6480464 Naloxone results in increased secretion of POMC protein modified form CTD PMID:24398105 naloxone multiple interactions EXP 6480464 [Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein more ... CTD PMID:24398105 , PMID:2846107 naloxone increases expression ISO RGD:1352097 6480464 Naloxone results in increased expression of POMC protein alternative form CTD PMID:2255747 Naltrindole multiple interactions ISO RGD:1331975 6480464 naltrindole inhibits the reaction [N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of POMC mRNA] CTD PMID:19523041 naproxen multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein], Naproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein] CTD PMID:22150557 nickel atom increases expression EXP 6480464 Nickel results in increased expression of POMC mRNA CTD PMID:20682304 nicotine affects response to substance ISO RGD:1331975 6480464 POMC protein affects the susceptibility to Nicotine CTD PMID:19376143 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of POMC protein CTD PMID:28555334 nicotine affects expression EXP 6480464 Nicotine affects the expression of POMC protein CTD PMID:22975262 nicotine multiple interactions ISO RGD:1331975 6480464 POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine] CTD PMID:15689546 nicotine increases expression EXP 6480464 Nicotine results in increased expression of POMC protein alternative form CTD PMID:23623838 nitric oxide multiple interactions EXP 6480464 CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form] CTD PMID:10460269 nitric oxide decreases abundance EXP 6480464 POMC protein results in decreased abundance of Nitric Oxide CTD PMID:11193135 , PMID:11703388 nitric oxide increases secretion EXP 6480464 Nitric Oxide results in increased secretion of POMC protein alternative form CTD PMID:10460269 nitroprusside multiple interactions EXP 6480464 Corticosterone inhibits the reaction [Nitroprusside results in increased secretion of POMC protein] more ... CTD PMID:20837582 , PMID:3015567 nitroprusside increases secretion EXP 6480464 Nitroprusside results in increased secretion of POMC protein CTD PMID:3015567 nonane increases expression EXP 6480464 nonane results in increased expression of POMC protein modified form CTD PMID:19152832 Nonylphenol multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [POMC protein modified form results in increased secretion of Corticosterone]] more ... CTD PMID:20837582 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of POMC protein CTD PMID:22765982 NS-398 multiple interactions EXP 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [docetaxel results in increased expression of POMC mRNA] CTD PMID:22902858 olanzapine decreases expression EXP 6480464 olanzapine results in decreased expression of POMC protein CTD PMID:21695181 olanzapine decreases expression ISO RGD:1331975 6480464 Olanzapine results in decreased expression of POMC mRNA CTD PMID:32652086 olanzapine multiple interactions ISO RGD:1331975 6480464 capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] more ... CTD PMID:32652086 Osajin decreases expression ISO RGD:1352097 6480464 osajin results in decreased expression of POMC mRNA CTD PMID:20706672 oxidopamine multiple interactions EXP 6480464 Levodopa promotes the reaction [Oxidopamine results in increased expression of POMC protein] CTD PMID:16325000 oxidopamine increases expression EXP 6480464 Oxidopamine results in increased expression of POMC protein CTD PMID:16325000 paracetamol decreases expression ISO RGD:1352097 6480464 Acetaminophen results in decreased expression of POMC protein CTD PMID:16449370 paracetamol multiple interactions EXP 6480464 [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] affects the expression of POMC mRNA CTD PMID:34383603 Pentagastrin increases expression ISO RGD:1352097 6480464 Pentagastrin results in increased expression of POMC protein alternative form CTD PMID:10481831 pentobarbital multiple interactions EXP 6480464 Muscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA], Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 , PMID:7937335 pentobarbital decreases expression EXP 6480464 Pentobarbital results in decreased expression of POMC mRNA CTD PMID:7937335 perfluorononanoic acid multiple interactions EXP 6480464 [[Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides] affects the susceptibility to perfluoro-n-nonanoic acid] which results in decreased expression of POMC protein modified form CTD PMID:25588985 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of POMC mRNA CTD PMID:24440345 perfluorooctane-1-sulfonic acid decreases secretion EXP 6480464 perfluorooctane sulfonic acid results in decreased secretion of POMC protein CTD PMID:24440345 perfluorooctanoic acid decreases expression ISO RGD:1331975 6480464 perfluorooctanoic acid results in decreased expression of POMC protein CTD PMID:29721586 phentolamine multiple interactions EXP 6480464 Phentolamine inhibits the reaction [POMC results in increased uptake of Magnesium] CTD PMID:191614 phenylarsine oxide decreases activity ISO RGD:1331975 6480464 oxophenylarsine results in decreased activity of POMC protein CTD PMID:12530643 phenylarsine oxide multiple interactions ISO RGD:1331975 6480464 [oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone CTD PMID:12530643 phenylarsine oxide multiple interactions EXP 6480464 oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone] CTD PMID:10518784 phenylephrine multiple interactions EXP 6480464 Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form] CTD PMID:10898105 phenylephrine increases response to substance ISO RGD:1352097 6480464 POMC protein results in increased susceptibility to Phenylephrine CTD PMID:2822310 , PMID:3015460 phenylephrine increases secretion EXP 6480464 Phenylephrine results in increased secretion of POMC protein alternative form CTD PMID:10898105 phenylpropanolamine increases expression EXP 6480464 Phenylpropanolamine results in increased expression of POMC mRNA, Phenylpropanolamine results in increased expression of POMC protein CTD PMID:17684035 , PMID:24792324 phenylpropanolamine multiple interactions EXP 6480464 S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA], STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA] CTD PMID:24792324 Pomiferin decreases expression ISO RGD:1352097 6480464 pomiferin results in decreased expression of POMC mRNA CTD PMID:20706672 potassium atom decreases abundance EXP 6480464 POMC protein modified form results in decreased abundance of Potassium CTD PMID:10100081 potassium atom multiple interactions ISO RGD:1352097 6480464 [Guanosine Triphosphate co-treated with Potassium] results in decreased activity of POMC protein modified form CTD PMID:2550106 potassium atom affects abundance EXP 6480464 POMC protein affects the abundance of Potassium CTD PMID:2157753 , PMID:9535146 potassium atom multiple interactions EXP 6480464 Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium] CTD PMID:10100081 prednisolone decreases expression EXP 6480464 Prednisolone results in decreased expression of POMC protein, Prednisolone results in decreased expression of POMC protein modified form CTD PMID:14694204 , PMID:9625448 prednisolone multiple interactions EXP 6480464 sairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form] CTD PMID:9625448 prednisone decreases expression ISO RGD:1352097 6480464 Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 progesterone multiple interactions ISO RGD:1331975 6480464 [benzylphosphonic acid results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone more ... CTD PMID:12530643 , PMID:19489000 progesterone increases abundance ISO RGD:1331975 6480464 POMC protein results in increased abundance of Progesterone CTD PMID:19489000 progesterone increases abundance ISO RGD:1352097 6480464 POMC protein results in increased abundance of Progesterone CTD PMID:21332028 progesterone multiple interactions ISO RGD:1352097 6480464 Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone] CTD PMID:21332028 propazine increases secretion EXP 6480464 propazine results in increased secretion of POMC protein modified form CTD PMID:19690231 pyridoxal 5'-phosphate decreases secretion ISO RGD:1331975 6480464 Pyridoxal Phosphate results in decreased secretion of POMC protein CTD PMID:16690808 quercetin multiple interactions ISO RGD:1331975 6480464 Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] more ... CTD PMID:21290442 , PMID:26586997 rabeprazole increases expression ISO RGD:1352097 6480464 Rabeprazole results in increased expression of POMC protein CTD PMID:16524691 reactive nitrogen species increases abundance EXP 6480464 POMC protein results in increased abundance of Reactive Nitrogen Species CTD PMID:15554453 reserpine increases expression EXP 6480464 Reserpine results in increased expression of POMC mRNA, Reserpine results in increased expression of POMC protein alternative form CTD PMID:20504635 , PMID:8479280 reserpine multiple interactions EXP 6480464 POMC protein alternative form inhibits the reaction [Reserpine results in decreased expression of PNMT mRNA] CTD PMID:20504635 resveratrol multiple interactions ISO RGD:1331975 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone]] CTD PMID:27052214 Rosavin decreases expression ISO RGD:1352097 6480464 rosavin results in decreased expression of POMC mRNA CTD PMID:20706672 ruthenium red multiple interactions ISO RGD:1331975 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 sarin decreases expression EXP 6480464 Sarin results in decreased expression of POMC protein CTD PMID:17301067 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [POMC protein modified form results in increased secretion of Corticosterone] CTD PMID:20837582 simazine increases secretion EXP 6480464 Simazine results in increased secretion of POMC protein modified form CTD PMID:19690231 sodium atom multiple interactions EXP 6480464 Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] CTD PMID:10100081 sodium atom affects abundance EXP 6480464 POMC protein affects the abundance of Sodium CTD PMID:2157753 , PMID:9535146 sodium atom increases abundance EXP 6480464 POMC protein modified form results in increased abundance of Sodium CTD PMID:10100081 sodium chloride multiple interactions ISO RGD:1352097 6480464 [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form, [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 sodium chloride multiple interactions ISO RGD:1331975 6480464 [Guanosine Triphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form, [Guanylyl Imidodiphosphate co-treated with Sodium Chloride] results in decreased activity of POMC protein modified form CTD PMID:2550106 spironolactone multiple interactions EXP 6480464 Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium], Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] CTD PMID:10100081 streptozocin multiple interactions EXP 6480464 INS protein inhibits the reaction [Streptozocin results in decreased expression of POMC mRNA] CTD PMID:20219977 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of POMC mRNA CTD PMID:20219977 sufentanil decreases expression ISO RGD:1352097 6480464 Sufentanil results in decreased expression of POMC protein modified form CTD PMID:15714323 sumatriptan decreases expression ISO RGD:1352097 6480464 Sumatriptan results in decreased expression of POMC protein modified form CTD PMID:7640145 sumatriptan multiple interactions EXP 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein], Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein] CTD PMID:22150557 superoxide increases abundance EXP 6480464 POMC protein results in increased abundance of Superoxides CTD PMID:16620303 tetrachloromethane multiple interactions ISO RGD:1331975 6480464 POMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] more ... CTD PMID:16508911 tetracycline increases expression ISO RGD:1331975 6480464 Tetracycline results in increased expression of POMC mRNA CTD PMID:16917069 theophylline multiple interactions EXP 6480464 [Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP, INS1 protein inhibits the reaction [[Theophylline co-treated with POMC protein] results in increased abundance of Cyclic AMP] CTD PMID:4306506 thimerosal increases expression ISO RGD:1331975 6480464 Thimerosal results in increased expression of POMC mRNA, Thimerosal results in increased expression of POMC protein CTD PMID:24675092 thioacetamide multiple interactions ISO RGD:1331975 6480464 POMC protein alternative form inhibits the reaction [Thioacetamide results in increased degradation of NFKBIA protein] more ... CTD PMID:15313186 , PMID:16511523 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of POMC mRNA CTD PMID:34492290 toluene increases expression EXP 6480464 Toluene results in increased expression of POMC protein CTD PMID:15707876 triadimefon decreases expression EXP 6480464 triadimefon results in decreased expression of POMC protein CTD PMID:34508824 triamcinolone decreases response to substance ISO RGD:1352097 6480464 Triamcinolone results in decreased susceptibility to POMC protein modified form CTD PMID:7788158 triclosan decreases expression ISO RGD:1352097 6480464 Triclosan results in decreased expression of POMC mRNA CTD PMID:30510588 trilostane decreases expression ISO RGD:1331975 6480464 trilostane results in decreased expression of POMC protein CTD PMID:19117688 triphenyl phosphate multiple interactions ISO RGD:1331975 6480464 [tris(1, 3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of POMC mRNA CTD PMID:29112739 triphenylstannane decreases expression EXP 6480464 triphenyltin results in decreased expression of POMC protein CTD PMID:32504733 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions EXP 6480464 Atropine inhibits the reaction [Acetylcholine results in increased expression of POMC protein] CTD PMID:7588217 trovafloxacin increases expression ISO RGD:1331975 6480464 trovafloxacin results in increased expression of POMC mRNA CTD PMID:35537566 urethane increases secretion EXP 6480464 Urethane results in increased secretion of POMC protein CTD PMID:2846107 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of POMC protein CTD PMID:7816191 water multiple interactions EXP 6480464 [Water deficiency co-treated with Sodium Chloride more ... CTD PMID:26468265
