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Gene: Pomc (pro-opiomelanocortin-alpha) Mus musculus
Symbol: Pomc
Name: pro-opiomelanocortin-alpha
Description: Exhibits hormone activity. Involved in several processes, including glucose homeostasis; regulation of corticosterone secretion; and regulation of glycogen metabolic process. Localizes to the extracellular space and secretory granule. Used to study obesity. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Is expressed in several structures, including nervous system; skin; and trophoblast giant cell. Orthologous to human POMC (proopiomelanocortin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACTH; adrenal corticotropic hormone; adrenocorticotropic hormone; alpha-melanocyte stimulating hormone; alpha-MSH; alphaMSH; BE; beta-endorphin; Beta-LPH; beta-melanocyte stimulating hormone; beta-MSH; Clip; corticotropin-like intermediary peptide; corticotropin-lipotropin; Gamma-LPH; gamma-melanocyte stimulating hormone; gamma-MSH; melanotropin gamma; met-enkephalin; Npp; Pomc-1; Pomc1; pro-opiomelanocortin
Homo sapiens (human) : POMC (proopiomelanocortin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pomc (proopiomelanocortin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pomc (proopiomelanocortin)
Pan paniscus (bonobo/pygmy chimpanzee) : POMC (proopiomelanocortin)
Canis lupus familiaris (dog) : POMC (proopiomelanocortin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pomc (proopiomelanocortin)
Sus scrofa (pig) : POMC (proopiomelanocortin)
Chlorocebus sabaeus (African green monkey) : POMC (proopiomelanocortin)
Heterocephalus glaber (naked mole-rat) : Pomc (proopiomelanocortin)
more info ...
Related Pseudogenes: Pomc-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl123,954,951 - 3,960,642 (+)Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBImm8
Celera123,882,688 - 3,888,382 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pomc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1331975
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.