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Gene: UCP2 (uncoupling protein 2) Homo sapiens
Symbol: UCP2
Name: uncoupling protein 2
Description: Predicted to have oxidative phosphorylation uncoupler activity. Involved in response to hypoxia. Localizes to mitochondrion. Implicated in carotid artery disease; diabetic neuropathy; end stage renal failure; hypertension; and obesity. Biomarker of Huntington's disease and non-alcoholic fatty liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMIQ4; body mass index quantitative trait 4; mitochondrial uncoupling protein 2; SLC25A8; solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein 2 (mitochondrial, proton carrier)
Mus musculus (house mouse) : Ucp2 (uncoupling protein 2 (mitochondrial, proton carrier))  MGI  Alliance
Rattus norvegicus (Norway rat) : Ucp2 (uncoupling protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp2 (uncoupling protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP2 (uncoupling protein 2)
Canis lupus familiaris (dog) : UCP2 (uncoupling protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp2 (uncoupling protein 2)
Sus scrofa (pig) : UCP2 (uncoupling protein 2)
Chlorocebus sabaeus (African green monkey) : UCP2 (uncoupling protein 2)
Heterocephalus glaber (naked mole-rat) : Ucp2 (uncoupling protein 2)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW64_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1173,974,672 - 73,983,246 (-)EnsemblGRCh38hg38GRCh38
GRCh381173,974,671 - 73,982,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371173,685,716 - 73,693,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,363,364 - 73,371,537 (-)NCBINCBI36hg18NCBI36
Build 341173,363,363 - 73,371,537NCBI
Celera1170,992,461 - 71,000,634 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,981,482 - 69,989,655 (-)NCBIHuRef
CHM1_11173,569,569 - 73,577,739 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on UCP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69170
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.