POMC (proopiomelanocortin) - Rat Genome Database

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Gene: POMC (proopiomelanocortin) Sus scrofa
Analyze
Symbol: POMC
Name: proopiomelanocortin
RGD ID: 14209199
Description: ENCODES a protein that exhibits hormone activity; signaling receptor binding (ortholog); type 1 melanocortin receptor binding (ortholog); INVOLVED IN cortisol secretion; antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; altered energy homeostasis pathway; altered melanocortin system pathway; ASSOCIATED WITH ACTH Syndrome, Ectopic (ortholog); acute kidney failure (ortholog); acute kidney tubular necrosis (ortholog); FOUND IN cytoplasm (ortholog); extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH cortisol; diethyldithiocarbamic acid; disodium selenite
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: corticotropin-lipotropin; pro-opiomelanocortin; proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH Syndrome, Ectopic  (ISO)
acute kidney failure  (ISO)
acute kidney tubular necrosis  (ISO)
Acute Liver Failure  (ISO)
adrenal cortex disease  (ISO)
amnestic disorder  (ISO)
autistic disorder  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Bradycardia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Catalepsy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral palsy  (ISO)
cholestasis  (ISO)
chondrocalcinosis  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
constipation  (ISO)
Cushing Syndrome  (ISO)
cystitis  (ISO)
diabetes insipidus  (ISO)
diabetes mellitus  (ISO)
disease by infectious agent  (ISO)
disease of mental health  (ISO)
Edema  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Eye Pain  (ISO)
facial paralysis  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femur Head Necrosis  (ISO)
Fever  (ISO)
Gastrointestinal Diseases  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
heroin dependence  (ISO)
Hirsutism  (ISO)
Hypercalciuria  (ISO)
Hypernatremia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypocalcemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
immune system disease  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
long QT syndrome  (ISO)
melanoma  (ISO)
mental depression  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
Myoclonic Epilepsies  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephrocalcinosis  (ISO)
Neurogenic Inflammation  (ISO)
Nociceptive Pain  (ISO)
obesity  (ISO)
Oliguria  (ISO)
Opsoclonus-Myoclonus Syndrome  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreas disease  (ISO)
penile disease  (ISO)
pituitary-dependent Cushing's disease  (ISO)
pneumonia  (ISO)
Postoperative Complications  (ISO)
Proopiomelanocortin Deficiency  (ISO)
proteinuria  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
restless legs syndrome  (ISO)
Rhabdomyoma  (ISO)
Sacroiliitis  (ISO)
severe acute respiratory syndrome  (ISO)
sick sinus syndrome  (ISO)
sleep disorder  (ISO)
subvalvular aortic stenosis  (ISO)
synovitis  (ISO)
urinary tract infection  (ISO)
visual epilepsy  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
West syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
altered energy homeostasis pathway  (ISO)
altered melanocortin system pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
obesity pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:1007884   PMID:1207728   PMID:2174774   PMID:3753882   PMID:4334191   PMID:4369114   PMID:4673865   PMID:5543613   PMID:6196724   PMID:6547437   PMID:7958386   PMID:11518235  
PMID:13348631   PMID:13451616   PMID:14681463   PMID:15201064   PMID:17023126   PMID:17145712   PMID:18277703  


Genomics

Comparative Map Data
POMC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POMC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl225,160,853 - 25,168,903 (-)EnsemblGRCh38hg38GRCh38
GRCh38225,160,860 - 25,168,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37225,383,729 - 25,391,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,237,226 - 25,245,063 (-)NCBINCBI36hg18NCBI36
Build 34225,295,438 - 25,303,103NCBI
Celera225,224,014 - 25,231,854 (-)NCBI
Cytogenetic Map2p23.3NCBI
HuRef225,121,466 - 25,129,306 (-)NCBIHuRef
CHM1_1225,313,607 - 25,321,447 (-)NCBICHM1_1
Pomc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBImm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Pomc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)Ensembl
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
Celera626,415,706 - 26,421,526 (+)NCBICelera
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
Pomc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,217,363 - 7,220,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,217,233 - 7,220,401 (-)NCBIChiLan1.0ChiLan1.0
POMC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A25,258,768 - 25,266,806 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,258,768 - 25,262,706 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A25,161,668 - 25,165,600 (-)NCBIMhudiblu_PPA_v0panPan3
POMC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,431,396 - 19,438,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,431,585 - 19,434,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,328,041 - 19,334,822 (-)NCBI
ROS_Cfam_1.01719,706,608 - 19,713,398 (-)NCBI
UMICH_Zoey_3.11719,440,669 - 19,447,445 (-)NCBI
UNSW_CanFamBas_1.01719,450,362 - 19,457,130 (-)NCBI
UU_Cfam_GSD_1.01719,496,844 - 19,503,629 (-)NCBI
Pomc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,774,289 - 63,781,377 (-)NCBI
SpeTri2.0NW_0049364937,060,747 - 7,065,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POMC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,491,296 - 82,499,289 (+)NCBI
ChlSab1.1 Ensembl1482,494,323 - 82,499,447 (+)Ensembl
Vero_WHO_p1.0NW_02366604529,662,185 - 29,670,382 (-)NCBI
Pomc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247387,442,223 - 7,448,513 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High 3 3
Medium
Low 7 1 15
Below cutoff 1 2 1 1 4 2 1

Sequence


Reference Sequences
RefSeq Acc Id: NM_213858   ⟹   NP_999023
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13113,661,930 - 113,668,549 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085834   ⟹   XP_020941493
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020941493   ⟸   XM_021085834
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999023   ⟸   NM_213858
- Peptide Label: precursor
- UniProtKB: P01192 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
ACTH_domain   NPP   Op_neuropeptide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021155 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070012411 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024582 UniProtKB/TrEMBL
  ENSSSCP00000041758 UniProtKB/TrEMBL
  ENSSSCP00000049264 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062999 UniProtKB/TrEMBL
  ENSSSCP00070020088 UniProtKB/TrEMBL
  ENSSSCP00070020097 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000032500 UniProtKB/TrEMBL
  ENSSSCT00000043278 UniProtKB/TrEMBL
  ENSSSCT00000051262 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066751 UniProtKB/TrEMBL
  ENSSSCT00070024275 UniProtKB/TrEMBL
  ENSSSCT00070024284 UniProtKB/TrEMBL
InterPro Mcrtin_ACTH_cent UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melanocortin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_neuropept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMOC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396863 UniProtKB/Swiss-Prot
NCBI Gene POMC ENTREZGENE
Pfam ACTH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MELANOCORTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ACTH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287ACZ2_PIG UniProtKB/TrEMBL
  A0A287AZ74_PIG UniProtKB/TrEMBL
  A0A4X1TX77_PIG UniProtKB/TrEMBL
  A0A4X1TXQ0_PIG UniProtKB/TrEMBL
  A0A5G2QEB5_PIG UniProtKB/TrEMBL
  A8VWB5_PIG UniProtKB/TrEMBL
  COLI_PIG UniProtKB/Swiss-Prot
  I3LKG8_PIG UniProtKB/TrEMBL
  P01192 ENTREZGENE
UniProt Secondary Q95246 UniProtKB/Swiss-Prot