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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: CHEBI:28857
Term: (Z)-hex-3-en-1-ol
Definition: A hex-3-en-1-ol in which the double bond adopts a Z-configuration. Also known as leaf alcohol, it is emitted by green plants upon mechanical damage. Used as a flavourant in tea.
Chemical ID: MESH:C051918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcmultiple interactionsEXP 6480464CTD[2, 5-dihydro-2, 4, 5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein, [3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2, 5-dihydro-2, 4, 5-trimethylthiazoline results in decreased expression of POMC protein], [3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC

PMID:19103229, PMID:21515296
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.