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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: CHEBI:10650
Term: sumatriptan
Definition: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Chemical ID: MESH:D018170
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcmultiple interactionsEXP 6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein] Sumatriptan inhibits the reaction [Capsaicin results in increased expression of POMC protein]

PMID:22150557
Pomcdecreases expressionISORGD:13520976480464CTDSumatriptan results in decreased expression of POMC protein modified form

PMID:7640145
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