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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: CHEBI:7983
Term: pentobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Chemical ID: MESH:D010424
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcdecreases expressionEXP 6480464CTDPentobarbital results in decreased expression of POMC mRNAPMID:7937335
Pomcmultiple interactionsEXP 6480464CTDMuscimol promotes the reaction [Pentobarbital results in decreased expression of POMC mRNA]; Pentobarbital inhibits the reaction [Acetylcholine results in increased expression of POMC protein]PMID:7588217 PMID:7937335
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