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Gene: Chrnb2 (cholinergic receptor nicotinic beta 2 subunit) Rattus norvegicus
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Symbol: Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Description: Exhibits acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Involved in several processes, including acetylcholine receptor signaling pathway; cholinergic synaptic transmission; and positive regulation of dopamine secretion. Localizes to cholinergic synapse; integral component of plasma membrane; and plasma membrane raft. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (E)-thiamethoxam; (S)-anabasine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cholinergic receptor nicotinic beta polypeptide 2; cholinergic receptor nicotinic beta subunit 2; cholinergic receptor, nicotinic beta 2; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2; cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); cholinergic receptor, nicotinic, beta subunit 2; N-alpha 1; neuronal acetylcholine receptor non-alpha-1 chain; neuronal acetylcholine receptor subunit beta-2
Orthologs:
Homo sapiens (human) : CHRNB2 (cholinergic receptor nicotinic beta 2 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrnb2 (cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNB2 (cholinergic receptor nicotinic beta 2 subunit)
Canis lupus familiaris (dog) : CHRNB2 (cholinergic receptor nicotinic beta 2 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
Sus scrofa (pig) : CHRNB2 (cholinergic receptor nicotinic beta 2 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNB2 (cholinergic receptor nicotinic beta 2 subunit)
Heterocephalus glaber (naked mole-rat) : Chrnb2 (cholinergic receptor nicotinic beta 2 subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02189,088,570 - 189,096,785 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,088,570 - 189,096,785 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,511,421 - 208,519,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,961,373 - 181,969,581 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,911,478 - 181,919,687 (-)NCBI
Celera2169,123,949 - 169,132,124 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Chrnb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2350
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.