Bmp7 (bone morphogenetic protein 7) - Rat Genome Database

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Gene: Bmp7 (bone morphogenetic protein 7) Rattus norvegicus
Symbol: Bmp7
Name: bone morphogenetic protein 7
RGD ID: 620743
Description: Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BMP-7; bone moorphogenic protein-7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23161,639,915 - 161,716,938 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,516,462 - 161,716,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,452,682 - 165,528,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,951,623 - 174,027,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,693,437 - 171,769,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,879,972 - 170,955,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,879,973 - 170,955,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,945,362 - 177,020,745 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,723,429 - 163,799,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,630,250 - 163,704,848 (-)NCBI
Celera3160,834,683 - 160,910,334 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boron atom  (ISO)
Brevetoxin B  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
cyanamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental boron  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glycerol 2-phosphate  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
Licarin A  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
octreotide  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pasireotide  (ISO)
pentanal  (ISO)
perchlorate  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
allantois development  (ISO)
ameloblast differentiation  (ISO)
anatomical structure formation involved in morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (ISO)
BMP signaling pathway  (IBA,ISO,TAS)
branching involved in salivary gland morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
camera-type eye morphogenesis  (ISO)
cardiac muscle tissue development  (ISO)
cardiac septum morphogenesis  (ISO)
cell development  (ISO)
cell population proliferation  (ISO)
cellular response to BMP stimulus  (ISO)
chorio-allantoic fusion  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
embryonic pattern specification  (ISO)
embryonic skeletal joint morphogenesis  (ISO)
endocardial cushion formation  (ISO)
epithelial cell differentiation  (ISO)
eye development  (ISO)
heart trabecula morphogenesis  (ISO)
hindbrain development  (ISO)
kidney development  (ISO)
mesenchymal cell apoptotic process involved in nephron morphogenesis  (ISO)
mesenchymal cell differentiation  (ISO)
mesenchyme development  (ISO)
mesoderm formation  (ISO)
mesonephros development  (ISO)
metanephric mesenchymal cell proliferation involved in metanephros development  (ISO)
metanephric mesenchyme morphogenesis  (ISO)
metanephros development  (ISO)
monocyte aggregation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of glomerular mesangial cell proliferation  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of prostatic bud formation  (ISO)
nephrogenic mesenchyme morphogenesis  (ISO)
neural fold elevation formation  (ISO)
neuron projection morphogenesis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
pattern specification process  (ISO)
pericardium morphogenesis  (ISO)
pharyngeal system development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of brown fat cell differentiation  (ISO)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
positive regulation of dendrite development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heterotypic cell-cell adhesion  (ISO)
positive regulation of hyaluranon cable assembly  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of branching involved in prostate gland morphogenesis  (ISO)
regulation of phosphorylation  (IMP)
response to estradiol  (IEP)
response to peptide hormone  (IEP)
response to vitamin D  (IEP)
salivary gland morphogenesis  (ISO)
tube morphogenesis  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas. Alarmo EL, etal., Ann Oncol. 2007 Sep 24;.
2. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21.
3. Downregulation of the expression of bone morphogenetic protein 7 in experimental pyelonephritis. Biyikli NK, etal., Pediatr Nephrol. 2005 Sep;20(9):1230-6. Epub 2005 Jul 21.
4. Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer. Bobinac D, etal., Croat Med J. 2005 Jun;46(3):389-96.
5. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Doak SH, etal., Cancer Genet Cytogenet. 2007 Jul 15;176(2):161-5.
6. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Fuller ML, etal., Ann Neurol. 2007 Sep;62(3):288-300.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Differential gene expression in ovarian carcinoma: identification of potential biomarkers. Hibbs K, etal., Am J Pathol. 2004 Aug;165(2):397-414.
9. Deficient expression of mRNA for the putative inductive factor bone morphogenetic protein-7 in chemically initiated rat nephroblastomas. Higinbotham KG, etal., Mol Carcinog. 1998 Oct;23(2):53-61.
10. The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens. Huang L, etal., Dev Biol. 2005 Feb 15;278(2):396-414.
11. Heparan sulfate is required for bone morphogenetic protein-7 signaling. Irie A, etal., Biochem Biophys Res Commun 2003 Sep 5;308(4):858-65.
12. Expression of bone morphogenetic proteins, the subfamily of the transforming growth factor-beta superfamily, in renal cell carcinoma. Kwak C, etal., J Urol. 2007 Sep;178(3 Pt 1):1062-7. Epub 2007 Jul 20.
13. Increased expression of bone morphogenetic protein-7 in bone metastatic prostate cancer. Masuda H, etal., Prostate. 2003 Mar 1;54(4):268-74.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
18. Transforming growth factor-beta1, vascular endothelial growth factor, and bone morphogenic protein-7 expression in tacrolimus-induced nephrotoxicity in rats. Ogutmen B, etal., Transplant Proc. 2006 Mar;38(2):487-9.
19. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Onishi T, etal., Bone. 1998 Jun;22(6):605-12.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Daily or intermittent calcitriol administration during growth hormone therapy in rats with renal failure and advanced secondary hyperparathyroidism. Sanchez CP and He YZ, J Am Soc Nephrol. 2005 Apr;16(4):929-38. Epub 2005 Feb 23.
26. Bone growth during daily or intermittent calcitriol treatment during renal failure with advanced secondary hyperparathyroidism. Sanchez CP and He YZ, Kidney Int. 2007 Sep;72(5):582-91. Epub 2007 Jun 6.
27. Tissue remodeling in the acute otitis media mouse model. Sautter NB, etal., Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1368-71. doi: 10.1016/j.ijporl.2011.07.026. Epub 2011 Sep 1.
28. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
29. Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells. Sun N, etal., Eur J Pharmacol. 2019 Nov 15;863:172679. doi: 10.1016/j.ejphar.2019.172679. Epub 2019 Sep 19.
30. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10.
31. [Changes of bone morphogenetic protein-7 and inhibitory Smad expression in streptozotocin-induced diabetic nephropathy rat kidney.] Yang Q, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):190-6.
Additional References at PubMed
PMID:7590254   PMID:8950518   PMID:9056639   PMID:9311995   PMID:9664686   PMID:9693150   PMID:9786991   PMID:10049573   PMID:10079236   PMID:11502704   PMID:11580864   PMID:11731698  
PMID:12631064   PMID:12741987   PMID:14517293   PMID:14623234   PMID:15013323   PMID:15100360   PMID:15307210   PMID:15342483   PMID:15525533   PMID:15831470   PMID:15843411   PMID:16049014  
PMID:16154126   PMID:16324690   PMID:16325379   PMID:16801560   PMID:16828469   PMID:16854970   PMID:17244894   PMID:17699604   PMID:17878916   PMID:17977014   PMID:18326817   PMID:18436533  
PMID:18437684   PMID:18471416   PMID:18803283   PMID:19056781   PMID:19275892   PMID:19440953   PMID:19669850   PMID:19736306   PMID:19765637   PMID:20453459   PMID:21520255   PMID:21675116  
PMID:21873793   PMID:22085733   PMID:22126789   PMID:22674456   PMID:23437931   PMID:23444145   PMID:23640479   PMID:23848567   PMID:23863481   PMID:24111806   PMID:24634122   PMID:24682853  
PMID:24964906   PMID:25356047   PMID:25577291   PMID:25773679   PMID:25857705   PMID:26010756   PMID:26097554   PMID:26385023   PMID:26824865   PMID:27035233   PMID:27053343   PMID:27491681  
PMID:27923061   PMID:28062213   PMID:28124060   PMID:28415516   PMID:28765970   PMID:29512787   PMID:30442072   PMID:30459239   PMID:30872412   PMID:31127659   PMID:31539631   PMID:31590011  
PMID:31829291   PMID:32169723   PMID:33575343   PMID:34116735   PMID:34390115   PMID:36542543   PMID:36613483   PMID:36765143   PMID:36858954   PMID:37293506  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23161,639,915 - 161,716,938 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,516,462 - 161,716,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,452,682 - 165,528,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03173,951,623 - 174,027,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,693,437 - 171,769,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,879,972 - 170,955,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,879,973 - 170,955,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,945,362 - 177,020,745 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,723,429 - 163,799,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,630,250 - 163,704,848 (-)NCBI
Celera3160,834,683 - 160,910,334 (-)NCBICelera
Cytogenetic Map3q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382057,168,753 - 57,266,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2057,168,753 - 57,266,641 (-)EnsemblGRCh38hg38GRCh38
GRCh372055,743,809 - 55,841,697 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,178,962 - 55,274,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 342055,178,961 - 55,274,708NCBI
Celera2052,484,025 - 52,581,945 (-)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2052,525,580 - 52,623,004 (-)NCBIHuRef
CHM1_12055,645,001 - 55,742,816 (-)NCBICHM1_1
T2T-CHM13v2.02058,946,552 - 59,044,382 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392172,709,805 - 172,782,114 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,709,805 - 172,782,114 (-)EnsemblGRCm39 Ensembl
GRCm382172,868,012 - 172,940,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,868,012 - 172,940,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv372172,695,187 - 172,765,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,512,625 - 172,583,232 (-)NCBIMGSCv36mm8
Celera2178,834,089 - 178,904,564 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.54NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554452,153,170 - 2,235,795 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,154,057 - 2,235,594 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12062,913,422 - 63,010,356 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02053,509,484 - 53,606,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,788,974 - 54,885,015 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,788,974 - 54,885,021 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12442,203,183 - 42,294,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,204,823 - 42,294,653 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,452,207 - 41,541,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02443,068,237 - 43,159,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2443,069,877 - 43,159,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12442,155,146 - 42,244,886 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02442,294,769 - 42,384,624 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02442,952,879 - 43,042,732 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640183,162,668 - 183,234,253 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493653071,920 - 143,940 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493653071,965 - 143,940 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1757,584,956 - 57,675,986 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,567,770 - 57,676,516 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,737,755 - 64,840,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.126,856,396 - 6,954,948 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl26,856,453 - 6,954,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605054,918,476 - 55,017,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474123,658,004 - 23,737,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474123,658,214 - 23,743,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bmp7
330 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:141
Interacting mature miRNAs:164
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,695,835 - 161,695,983 (+)MAPPERmRatBN7.2
Rnor_6.03170,934,860 - 170,935,007NCBIRnor6.0
Rnor_5.03176,999,784 - 176,999,932NCBIRnor5.0
Rnor_5.03176,999,783 - 176,999,932NCBIRnor5.0
Rnor_5.03176,999,785 - 176,999,932UniSTSRnor5.0
RGSC_v3.43163,778,606 - 163,778,754RGDRGSC3.4
RGSC_v3.43163,778,607 - 163,778,754UniSTSRGSC3.4
RGSC_v3.13163,684,638 - 163,684,916RGD
Celera3160,889,373 - 160,889,520UniSTS
RH 3.4 Map31499.9UniSTS
RH 3.4 Map31499.9RGD
RH 2.0 Map31028.0RGD
SHRSP x BN Map386.3099RGD
FHH x ACI Map3103.83RGD
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03176,999,785 - 176,999,932UniSTSRnor5.0
RGSC_v3.43163,778,607 - 163,778,754UniSTSRGSC3.4
RGSC_v3.13163,684,642 - 163,684,790RGD
Celera3160,889,373 - 160,889,520UniSTS
RH 3.4 Map31499.9UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,716,033 - 161,716,287 (+)MAPPERmRatBN7.2
Rnor_6.03170,955,057 - 170,955,310NCBIRnor6.0
Rnor_5.03177,019,982 - 177,020,235UniSTSRnor5.0
RGSC_v3.43163,798,804 - 163,799,057UniSTSRGSC3.4
Celera3160,909,571 - 160,909,824UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,641,293 - 161,641,480 (+)MAPPERmRatBN7.2
Rnor_6.03170,880,302 - 170,880,488NCBIRnor6.0
Rnor_5.03176,945,674 - 176,945,860UniSTSRnor5.0
RGSC_v3.43163,723,756 - 163,723,942UniSTSRGSC3.4
Celera3160,834,979 - 160,835,165UniSTS
RH 3.4 Map3631.11UniSTS
Cytogenetic Map3q42UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 26 6 5 1 5 43 35 29
Low 2 8 51 36 18 36 8 11 31 12 11 8
Below cutoff 9


RefSeq Acc Id: ENSRNOT00000084990   ⟹   ENSRNOP00000070891
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,516,462 - 161,716,788 (-)Ensembl
Rnor_6.0 Ensembl3170,879,973 - 170,955,399 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101894   ⟹   ENSRNOP00000087993
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,516,462 - 161,716,788 (-)Ensembl
RefSeq Acc Id: NM_001191856   ⟹   NP_001178785
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.23161,640,964 - 161,716,797 (-)NCBI
Rnor_6.03170,879,972 - 170,955,820 (-)NCBI
Rnor_5.03176,945,362 - 177,020,745 (-)NCBI
Celera3160,834,683 - 160,910,334 (-)NCBI
RefSeq Acc Id: XM_039106002   ⟹   XP_038961930
Rat AssemblyChrPosition (strand)Source
mRatBN7.23161,639,915 - 161,716,938 (-)NCBI
RefSeq Acc Id: NP_001178785   ⟸   NM_001191856
- Peptide Label: precursor
- UniProtKB: G3V6W8 (UniProtKB/TrEMBL),   A6KKY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070891   ⟸   ENSRNOT00000084990
RefSeq Acc Id: XP_038961930   ⟸   XM_039106002
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A920 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087993   ⟸   ENSRNOT00000101894
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6W8-F1-model_v2 AlphaFold G3V6W8 1-430 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692709
Promoter ID:EPDNEW_R3233
Type:single initiation site
Description:bone morphogenetic protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.03170,955,401 - 170,955,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620743 AgrOrtholog
BioCyc Gene G2FUF-46525 BioCyc
Ensembl Genes ENSRNOG00000053384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084990 ENTREZGENE
  ENSRNOT00000084990.2 UniProtKB/TrEMBL
  ENSRNOT00000101894.1 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_N UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
KEGG Report rno:85272 UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PhenoGen Bmp7 PhenoGen
RatGTEx ENSRNOG00000053384 RatGTEx
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Bmp7  bone morphogenetic protein 7      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bmp7  bone morphogenetic protein 7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may act to facilitate the transition of follicles from the primordial stage to the pool of primary, preantral, and antral follicles 634724
gene_process caused an increase in DNA synthesis and proliferation of granulosa cells from small antral follicles in vitro 634724
gene_process heparin sulfate binding is necessary for signaling 737843