(+)-epicatechin-3-O-gallate multiple interactions ISO RGD:736871 6480464 epicatechin gallate binds to and results in decreased activity of DHFR protein CTD PMID:20054477 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DHFR mRNA] CTD PMID:31150632 (-)-demecolcine decreases expression ISO RGD:736871 6480464 Demecolcine results in decreased expression of DHFR mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736871 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA, epigallocatechin gallate binds to and results in decreased activity of DHFR protein CTD PMID:20054477 , PMID:22079256 (S)-nicotine decreases expression ISO RGD:736871 6480464 Nicotine results in decreased expression of DHFR mRNA CTD PMID:12588870 (S)-nicotine multiple interactions ISO RGD:736871 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] more ... CTD PMID:12588870 1,1-dichloroethene decreases expression ISO RGD:10471 6480464 vinylidene chloride results in decreased expression of DHFR mRNA CTD PMID:26682919 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:10471 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:31187328 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:736871 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of DHFR mRNA CTD PMID:22101062 17alpha-ethynylestradiol increases expression ISO RGD:10471 6480464 Ethinyl Estradiol results in increased expression of DHFR mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:10471 6480464 Ethinyl Estradiol affects the expression of DHFR mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:10471 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:736871 6480464 Estradiol results in increased expression of DHFR mRNA CTD PMID:19167446 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:10471 6480464 2 more ... CTD PMID:20005886 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10471 6480464 Tetrachlorodibenzodioxin results in increased expression of DHFR mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DHFR mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10471 6480464 Tetrachlorodibenzodioxin affects the expression of DHFR mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of DHFR mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10471 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DHFR mRNA CTD PMID:16054898 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:10471 6480464 3 more ... CTD PMID:19467301 3-methylcholanthrene increases expression ISO RGD:10471 6480464 Methylcholanthrene results in increased expression of DHFR mRNA CTD PMID:20713471 4-hydroxyphenyl retinamide increases expression ISO RGD:10471 6480464 Fenretinide results in increased expression of DHFR mRNA CTD PMID:28973697 5-fluorouracil affects expression ISO RGD:736871 6480464 Fluorouracil affects the expression of DHFR mRNA CTD PMID:16557594 5-fluorouracil increases expression ISO RGD:736871 6480464 Fluorouracil results in increased expression of DHFR mRNA CTD PMID:15109396 , PMID:21814787 5-formyltetrahydrofolic acid multiple interactions ISO RGD:736871 6480464 Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid] CTD PMID:21310277 5-formyltetrahydrofolic acid increases expression ISO RGD:736871 6480464 Leucovorin results in increased expression of DHFR protein CTD PMID:16712799 6-bromoindirubin-3'-oxime multiple interactions ISO RGD:736871 6480464 [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein CTD PMID:19727391 acrylamide decreases expression ISO RGD:736871 6480464 Acrylamide results in decreased expression of DHFR mRNA CTD PMID:32763439 aflatoxin B1 decreases expression ISO RGD:10471 6480464 Aflatoxin B1 results in decreased expression of DHFR mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:736871 6480464 Aflatoxin B1 results in decreased methylation of DHFR gene CTD PMID:27153756 aflatoxin M1 decreases expression ISO RGD:736871 6480464 Aflatoxin M1 results in decreased expression of DHFR mRNA CTD PMID:30928695 all-trans-retinoic acid decreases expression ISO RGD:736871 6480464 Tretinoin results in decreased expression of DHFR mRNA CTD PMID:33167477 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DHFR mRNA CTD PMID:16483693 aristolochic acid A increases expression ISO RGD:736871 6480464 aristolochic acid I results in increased expression of DHFR protein CTD PMID:33212167 arsane affects response to substance ISO RGD:736871 6480464 DHFR gene SNP affects the susceptibility to Arsenic CTD PMID:25759212 arsane affects methylation ISO RGD:736871 6480464 Arsenic affects the methylation of DHFR gene CTD PMID:25304211 arsenic atom affects response to substance ISO RGD:736871 6480464 DHFR gene SNP affects the susceptibility to Arsenic CTD PMID:25759212 arsenic atom affects methylation ISO RGD:736871 6480464 Arsenic affects the methylation of DHFR gene CTD PMID:25304211 arsenite(3-) decreases expression ISO RGD:10471 6480464 arsenite results in decreased expression of DHFR mRNA CTD PMID:18929588 benzo[a]pyrene increases expression ISO RGD:736871 6480464 Benzo(a)pyrene results in increased expression of DHFR protein CTD PMID:18495319 benzo[a]pyrene decreases expression ISO RGD:736871 6480464 Benzo(a)pyrene results in decreased expression of DHFR mRNA CTD PMID:20064835 , PMID:26238291 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:736871 6480464 7 more ... CTD PMID:20018196 benzo[a]pyrene diol epoxide I increases expression ISO RGD:736871 6480464 7 more ... CTD PMID:19150397 benzo[e]pyrene increases methylation ISO RGD:736871 6480464 benzo(e)pyrene results in increased methylation of DHFR intron CTD PMID:30157460 beta-carotene multiple interactions ISO RGD:10471 6480464 [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 bis(2-ethylhexyl) phthalate increases expression ISO RGD:10471 6480464 Diethylhexyl Phthalate results in increased expression of DHFR mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10471 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DHFR mRNA] CTD PMID:19850644 bisphenol A affects expression ISO RGD:736871 6480464 bisphenol A affects the expression of DHFR mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:736871 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DHFR gene CTD PMID:31601247 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of DHFR mRNA CTD PMID:34947998 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DHFR mRNA CTD PMID:30816183 , PMID:32528016 bisphenol A decreases expression ISO RGD:736871 6480464 bisphenol A results in decreased expression of DHFR mRNA CTD PMID:29275510 , PMID:33670352 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of DHFR mRNA CTD PMID:33453195 captan increases expression ISO RGD:10471 6480464 Captan results in increased expression of DHFR mRNA CTD PMID:31558096 carbamazepine affects expression ISO RGD:736871 6480464 Carbamazepine affects the expression of DHFR mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:10471 6480464 Nanotubes, Carbon results in decreased expression of DHFR mRNA CTD PMID:25620056 cefazolin decreases activity ISO RGD:736871 6480464 Cefazolin results in decreased activity of DHFR protein CTD PMID:25418905 cefepime decreases activity ISO RGD:736871 6480464 cefepime results in decreased activity of DHFR protein CTD PMID:25418905 ceftazidime pentahydrate decreases activity ISO RGD:736871 6480464 Ceftazidime results in decreased activity of DHFR protein CTD PMID:25418905 ceftizoxime decreases activity ISO RGD:736871 6480464 Ceftizoxime results in decreased activity of DHFR protein CTD PMID:25418905 ceftriaxone decreases activity ISO RGD:736871 6480464 Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 chlorambucil decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Chlorambucil CTD PMID:12872145 choline multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:10471 6480464 chromium hexavalent ion affects the expression of DHFR mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:736871 6480464 Cisplatin results in increased expression of DHFR mRNA CTD PMID:27594783 cisplatin multiple interactions ISO RGD:736871 6480464 Cisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA] CTD PMID:21858171 clobetasol decreases expression ISO RGD:10471 6480464 Clobetasol results in decreased expression of DHFR mRNA CTD PMID:27462272 cobalt dichloride decreases expression ISO RGD:736871 6480464 cobaltous chloride results in decreased expression of DHFR mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:736871 6480464 [NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:736871 6480464 [NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:736871 6480464 Copper Sulfate results in decreased expression of DHFR mRNA CTD PMID:19549813 copper(II) sulfate increases expression ISO RGD:736871 6480464 Copper Sulfate results in increased expression of DHFR mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:736871 6480464 Coumestrol results in increased expression of DHFR mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:10471 6480464 Cyclosporine results in decreased expression of DHFR mRNA CTD PMID:19770486 , PMID:23308384 cytarabine increases expression ISO RGD:736871 6480464 Cytarabine results in increased expression of DHFR mRNA CTD PMID:19194470 dibenzo[a,l]pyrene decreases expression ISO RGD:736871 6480464 dibenzo(a, l)pyrene results in decreased expression of DHFR protein CTD PMID:18495319 dibutyl phthalate decreases expression ISO RGD:10471 6480464 Dibutyl Phthalate results in decreased expression of DHFR mRNA CTD PMID:17361019 , PMID:21266533 diclofenac affects expression ISO RGD:736871 6480464 Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 DISTAMYCIN A decreases expression ISO RGD:736871 6480464 stallimycin analog results in decreased expression of DHFR protein more ... CTD PMID:21814787 doxorubicin decreases expression ISO RGD:736871 6480464 Doxorubicin results in decreased expression of DHFR mRNA CTD PMID:29803840 emodin decreases expression ISO RGD:736871 6480464 Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of DHFR mRNA CTD PMID:29391264 Enterolactone increases expression ISO RGD:736871 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of DHFR mRNA CTD PMID:19167446 Enterolactone multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DHFR mRNA CTD PMID:19167446 ethanol decreases expression ISO RGD:736871 6480464 Ethanol results in decreased expression of DHFR mRNA CTD PMID:28986285 ferulic acid decreases activity ISO RGD:736871 6480464 ferulic acid results in decreased activity of DHFR protein CTD PMID:25418905 folic acid multiple interactions ISO RGD:736871 6480464 [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA more ... CTD PMID:21310277 more ... folic acid increases expression ISO RGD:736871 6480464 Folic Acid results in increased expression of DHFR mRNA CTD PMID:28724658 , PMID:31076457 folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [Methotrexate results in decreased expression of DHFR mRNA] CTD PMID:30502384 folic acid multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 folic acid affects expression ISO RGD:736871 6480464 Folic Acid affects the expression of DHFR mRNA CTD PMID:17311948 folic acid decreases abundance ISO RGD:736871 6480464 DHFR gene mutant form results in decreased abundance of Folic Acid CTD PMID:21310277 folpet increases expression ISO RGD:10471 6480464 folpet results in increased expression of DHFR mRNA CTD PMID:31558096 formaldehyde decreases expression ISO RGD:736871 6480464 Formaldehyde results in decreased expression of DHFR mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:736871 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DHFR gene CTD PMID:31601247 genistein decreases expression ISO RGD:10471 6480464 Genistein results in decreased expression of DHFR mRNA CTD PMID:21048042 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of DHFR mRNA CTD PMID:22061828 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of DHFR mRNA CTD PMID:18299717 indometacin multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA] CTD PMID:18299717 isoflavones decreases expression ISO RGD:736871 6480464 Isoflavones results in decreased expression of DHFR mRNA CTD PMID:17374662 isotretinoin decreases expression ISO RGD:736871 6480464 Isotretinoin results in decreased expression of DHFR mRNA CTD PMID:20436886 ivermectin decreases expression ISO RGD:736871 6480464 Ivermectin results in decreased expression of DHFR protein CTD PMID:32959892 L-methionine multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 lamivudine multiple interactions ISO RGD:736871 6480464 [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA CTD PMID:15784690 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of DHFR mRNA CTD PMID:24136188 levofloxacin decreases activity ISO RGD:736871 6480464 Levofloxacin results in decreased activity of DHFR protein CTD PMID:25418905 Mecamylamine decreases expression ISO RGD:736871 6480464 Mecamylamine results in decreased expression of DHFR mRNA CTD PMID:12588870 Mecamylamine multiple interactions ISO RGD:736871 6480464 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 methapyrilene increases methylation ISO RGD:736871 6480464 Methapyrilene results in increased methylation of DHFR intron CTD PMID:30157460 methotrexate decreases response to substance ISO RGD:736871 6480464 DHFR mRNA results in decreased susceptibility to Methotrexate, DHFR protein results in decreased susceptibility to Methotrexate CTD PMID:14679136 more ... methotrexate multiple interactions EXP 6480464 DHFR protein inhibits the reaction [Methotrexate results in decreased expression of CASP3 protein] more ... CTD PMID:30502384 methotrexate decreases expression ISO RGD:10471 6480464 Methotrexate results in decreased expression of DHFR mRNA, Methotrexate results in decreased expression of DHFR protein CTD PMID:30502384 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of DHFR mRNA, Methotrexate results in decreased expression of DHFR protein CTD PMID:30502384 methotrexate decreases activity ISO RGD:10471 6480464 Methotrexate results in decreased activity of DHFR protein CTD PMID:22806879 methotrexate increases expression ISO RGD:10471 6480464 Methotrexate results in increased expression of DHFR protein CTD PMID:22484375 methotrexate affects response to substance ISO RGD:736871 6480464 DHFR 3' UTR SNP affects the susceptibility to Methotrexate CTD PMID:17686970 methotrexate multiple interactions ISO RGD:736871 6480464 [[MIR125A mRNA binds to DHFR 3' UTR] which results in decreased expression of DHFR protein] which results in increased susceptibility to Methotrexate more ... CTD PMID:17686970 more ... methotrexate decreases expression ISO RGD:736871 6480464 Methotrexate results in decreased expression of DHFR mRNA CTD PMID:23897011 , PMID:24657277 methotrexate increases expression ISO RGD:736871 6480464 Methotrexate results in increased expression of DHFR mRNA, Methotrexate results in increased expression of DHFR protein CTD PMID:19570950 more ... methotrexate multiple interactions ISO RGD:10471 6480464 Methotrexate promotes the reaction [E2F1 protein binds to DHFR promoter] CTD PMID:22484375 methotrexate decreases response to substance ISO RGD:10471 6480464 DHFR mRNA results in decreased susceptibility to Methotrexate, DHFR protein results in decreased susceptibility to Methotrexate CTD PMID:16918715 methylmercury chloride decreases expression ISO RGD:736871 6480464 methylmercuric chloride results in decreased expression of DHFR mRNA CTD PMID:28001369 methylparaben decreases expression ISO RGD:736871 6480464 methylparaben results in decreased expression of DHFR mRNA CTD PMID:31745603 methylseleninic acid decreases expression ISO RGD:736871 6480464 methylselenic acid results in decreased expression of DHFR mRNA CTD PMID:12517777 N-methyl-4-phenylpyridinium decreases expression ISO RGD:736871 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of DHFR mRNA CTD PMID:24810058 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA CTD PMID:20360939 N-Nitrosopyrrolidine decreases expression ISO RGD:736871 6480464 N-Nitrosopyrrolidine results in decreased expression of DHFR mRNA CTD PMID:32234424 NADP zwitterion decreases activity ISO RGD:736871 6480464 NADP analog results in decreased activity of DHFR protein CTD PMID:22954684 NADP(+) decreases activity ISO RGD:736871 6480464 NADP analog results in decreased activity of DHFR protein CTD PMID:22954684 naringin decreases activity ISO RGD:736871 6480464 naringin results in decreased activity of DHFR protein CTD PMID:25418905 nickel atom increases expression ISO RGD:736871 6480464 Nickel results in increased expression of DHFR mRNA CTD PMID:25583101 nicotine multiple interactions ISO RGD:736871 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] more ... CTD PMID:12588870 nicotine decreases expression ISO RGD:736871 6480464 Nicotine results in decreased expression of DHFR mRNA CTD PMID:12588870 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of DHFR mRNA CTD PMID:24136188 nitrogen mustard decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:12872145 olmesartan increases expression EXP 6480464 olmesartan results in increased expression of DHFR protein CTD PMID:17170375 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of DHFR mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:10471 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of DHFR mRNA CTD PMID:34911549 paracetamol affects expression ISO RGD:10471 6480464 Acetaminophen affects the expression of DHFR mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of DHFR mRNA CTD PMID:33387578 paracetamol increases expression ISO RGD:736871 6480464 Acetaminophen results in increased expression of DHFR mRNA CTD PMID:22230336 pemetrexed multiple interactions ISO RGD:736871 6480464 [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA CTD PMID:22975265 perfluorooctanoic acid decreases expression ISO RGD:736871 6480464 perfluorooctanoic acid results in decreased expression of DHFR mRNA CTD PMID:23978341 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA CTD PMID:20360939 phenobarbital affects expression ISO RGD:10471 6480464 Phenobarbital affects the expression of DHFR mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:10471 6480464 pirinixic acid results in increased expression of DHFR mRNA CTD PMID:17426115 pirinixic acid decreases expression ISO RGD:10471 6480464 pirinixic acid results in decreased expression of DHFR mRNA CTD PMID:23811191 piroxicam decreases expression ISO RGD:736871 6480464 Piroxicam results in decreased expression of DHFR mRNA CTD PMID:21858171 piroxicam multiple interactions ISO RGD:736871 6480464 Cisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA] CTD PMID:21858171 potassium chromate increases expression ISO RGD:736871 6480464 potassium chromate(VI) results in increased expression of DHFR mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:736871 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA CTD PMID:22079256 potassium dichromate increases expression ISO RGD:736871 6480464 Potassium Dichromate results in increased expression of DHFR mRNA CTD PMID:18332044 propanal decreases expression ISO RGD:736871 6480464 propionaldehyde results in decreased expression of DHFR mRNA CTD PMID:26079696 pyrimethamine multiple interactions ISO RGD:736871 6480464 Pyrimethamine binds to and results in increased stability of DHFR protein, Pyrimethamine results in increased expression of and affects the activity of DHFR protein CTD PMID:34953855 Rebamipide multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA] CTD PMID:18299717 resveratrol multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of DHFR mRNA CTD PMID:19167446 resveratrol increases expression ISO RGD:10471 6480464 resveratrol results in increased expression of DHFR protein CTD PMID:25505154 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of DHFR mRNA CTD PMID:28374803 silicon dioxide decreases expression ISO RGD:736871 6480464 Silicon Dioxide analog results in decreased expression of DHFR mRNA CTD PMID:25895662 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of DHFR protein CTD PMID:19072884 sodium arsenite decreases expression ISO RGD:736871 6480464 sodium arsenite results in decreased expression of DHFR protein CTD PMID:30528433 sodium arsenite increases expression ISO RGD:736871 6480464 sodium arsenite results in increased expression of DHFR mRNA CTD PMID:34032870 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of DHFR protein CTD PMID:29459688 sodium arsenite increases mutagenesis ISO RGD:736871 6480464 sodium arsenite results in increased mutagenesis of DHFR gene CTD PMID:12802802 sunitinib decreases expression ISO RGD:736871 6480464 Sunitinib results in decreased expression of DHFR mRNA CTD PMID:31533062 syringic acid decreases activity ISO RGD:736871 6480464 syringic acid results in decreased activity of DHFR protein CTD PMID:25418905 tamoxifen increases expression ISO RGD:736871 6480464 Tamoxifen results in increased expression of DHFR mRNA CTD PMID:15590111 tamoxifen affects expression ISO RGD:10471 6480464 Tamoxifen affects the expression of DHFR mRNA CTD PMID:17555576 tetrachloromethane decreases expression ISO RGD:10471 6480464 Carbon Tetrachloride results in decreased expression of DHFR mRNA CTD PMID:17484886 , PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DHFR mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of DHFR mRNA CTD PMID:31150632 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of DHFR mRNA CTD PMID:34492290 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of DHFR mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA CTD PMID:25729387 trabectedin decreases expression ISO RGD:10471 6480464 trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 trimellitic anhydride increases expression ISO RGD:10471 6480464 trimellitic anhydride results in increased expression of DHFR mRNA CTD PMID:19042947 trimethoprim multiple interactions ISO RGD:10471 6480464 [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 trimetrexate decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Trimetrexate CTD PMID:12872145 triptonide increases expression ISO RGD:10471 6480464 triptonide results in increased expression of DHFR mRNA CTD PMID:33045310 tubocurarine multiple interactions ISO RGD:736871 6480464 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 tubocurarine decreases expression ISO RGD:736871 6480464 Tubocurarine results in decreased expression of DHFR mRNA CTD PMID:12588870 urethane decreases expression ISO RGD:736871 6480464 Urethane results in decreased expression of DHFR mRNA CTD PMID:28818685 valproic acid multiple interactions ISO RGD:10471 6480464 [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 valproic acid decreases methylation ISO RGD:736871 6480464 Valproic Acid results in decreased methylation of DHFR gene CTD PMID:29154799 vincristine decreases expression ISO RGD:736871 6480464 Vincristine results in decreased expression of DHFR mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:736871 6480464 vorinostat results in decreased expression of DHFR mRNA CTD PMID:20072153 zidovudine multiple interactions ISO RGD:736871 6480464 [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA CTD PMID:15784690