Gene: Dhfr (dihydrofolate reductase) Rattus norvegicus
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Symbol:
Dhfr
Name:
dihydrofolate reductase
Description:
Exhibits NADP binding activity; dihydrofolate reductase activity; and dihydrofolic acid binding activity. Involved in several processes, including axon regeneration; folic acid-containing compound metabolic process; and response to methotrexate. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR2 (dihydrofolate reductase 2) and DHFRP1 (dihydrofolate reductase pseudogene 1); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Dhfr1; Dihydrofolate reductase 1 (active)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DHFR (dihydrofolate reductase) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Dhfr (dihydrofolate reductase) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dhfr (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DHFR (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dhfr (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DHFR (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DHFR (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Dhfr (dihydrofolate reductase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
DHFR2 (dihydrofolate reductase 2) HGNC
EggNOG, Ensembl, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs 3
Mus musculus (house mouse):
Dhfr (dihydrofolate reductase)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|TreeFam|OrthoInspector|OrthoFinder|Hieranoid)
Homo sapiens (human):
DHFR (dihydrofolate reductase)
Alliance
DIOPT (OMA|Ensembl Compara|TreeFam|HGNC)
Homo sapiens (human):
DHFRP1 (dihydrofolate reductase pseudogene 1)
Alliance
DIOPT (InParanoid|PhylomeDB|PANTHER|OrthoFinder|OrthoInspector|Hieranoid)
Homo sapiens (human):
DHFR2 (dihydrofolate reductase 2)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|OMA|TreeFam|OrthoFinder|PANTHER)
Danio rerio (zebrafish):
dhfr (dihydrofolate reductase)
Alliance
DIOPT (PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
DFR1
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoInspector|OrthoFinder|Hieranoid)
Drosophila melanogaster (fruit fly):
Dhfr
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoInspector|OrthoFinder|TreeFam|Hieranoid)
Caenorhabditis elegans (roundworm):
dhfr-1
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoInspector|OrthoFinder|PANTHER|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 21,931,887 - 21,958,927 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 21,931,493 - 21,962,453 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 41,162,308 - 41,162,496 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Rnor_5.0 2 41,137,784 - 41,149,417 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 22,607,093 - 22,828,487 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 22,527,461 - 22,748,856 (+) NCBI Celera 2 19,675,965 - 19,700,103 (+) NCBI Celera Cytogenetic Map 2 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
cavernous sinus meningioma ISO RGD:736871 8554872 ClinVar Annotator: match by term: Cavernous Sinus Meningioma ClinVar endometrial carcinoma ISO RGD:736871 8554872 ClinVar Annotator: match by term: Endometrial carcinoma ClinVar familial adenomatous polyposis 4 ISO RGD:736871 8554872 ClinVar Annotator: match by term: Familial adenomatous polyposis 4 ClinVar PMID:28492532 gastrointestinal stromal tumor ISO RGD:736871 8554872 ClinVar Annotator: match by term: Gastrointestinal Stromal Tumors ClinVar PMID:25227144 Hereditary Neoplastic Syndromes ISO RGD:736871 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar Hereditary Neoplastic Syndromes ISO RGD:736871 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:24033266 Hereditary Neoplastic Syndromes ISO RGD:736871 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:28492532 Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency ISO RGD:736871 8554872 ClinVar Annotator: match by OMIM:613839 ClinVar PMID:21310276 Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency ISO RGD:736871 8554872 ClinVar Annotator: match by OMIM:613839 ClinVar PMID:1060915 more ... Neurodevelopmental Disorders ISO RGD:736871 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
autistic disorder ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17597297 Breast Neoplasms ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21501481 , PMID:28188287 Chemical and Drug Induced Liver Injury ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19648163 Colorectal Neoplasms ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15814641 Drug-Related Side Effects and Adverse Reactions ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21064136 Female Infertility ISO RGD:736871 11554173 CTD Direct Evidence: therapeutic CTD PMID:17519396 folic acid deficiency anemia ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21310277 inherited metabolic disorder ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21310276 , PMID:21310277 megaloblastic anemia ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21310276 , PMID:21310277 Neoplasm Metastasis ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19159907 nervous system disease ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21064136 , PMID:21310277 osteosarcoma ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19159907 pancytopenia ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21310276 rheumatoid arthritis ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23897011 Spontaneous Abortions ISO RGD:736871 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642 Imported Annotations - OMIM
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency ISO RGD:736871 7240710 OMIM
(+)-epicatechin-3-O-gallate multiple interactions ISO RGD:736871 6480464 epicatechin gallate binds to and results in decreased activity of DHFR protein CTD PMID:20054477 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DHFR mRNA] CTD PMID:31150632 (-)-demecolcine decreases expression ISO RGD:736871 6480464 Demecolcine results in decreased expression of DHFR mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736871 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA, epigallocatechin gallate binds to and results in decreased activity of DHFR protein CTD PMID:20054477 , PMID:22079256 (S)-nicotine decreases expression ISO RGD:736871 6480464 Nicotine results in decreased expression of DHFR mRNA CTD PMID:12588870 (S)-nicotine multiple interactions ISO RGD:736871 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] more ... CTD PMID:12588870 1,1-dichloroethene decreases expression ISO RGD:10471 6480464 vinylidene chloride results in decreased expression of DHFR mRNA CTD PMID:26682919 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:736871 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of DHFR mRNA CTD PMID:22101062 17alpha-ethynylestradiol increases expression ISO RGD:10471 6480464 Ethinyl Estradiol results in increased expression of DHFR mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:10471 6480464 Ethinyl Estradiol affects the expression of DHFR mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:10471 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:736871 6480464 Estradiol results in increased expression of DHFR mRNA CTD PMID:19167446 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:10471 6480464 2 more ... CTD PMID:20005886 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10471 6480464 Tetrachlorodibenzodioxin results in increased expression of DHFR mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10471 6480464 Tetrachlorodibenzodioxin affects the expression of DHFR mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of DHFR mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10471 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DHFR mRNA CTD PMID:16054898 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:10471 6480464 3 more ... CTD PMID:19467301 3-methylcholanthrene increases expression ISO RGD:10471 6480464 Methylcholanthrene results in increased expression of DHFR mRNA CTD PMID:20713471 4-hydroxyphenyl retinamide increases expression ISO RGD:10471 6480464 Fenretinide results in increased expression of DHFR mRNA CTD PMID:28973697 5-fluorouracil affects expression ISO RGD:736871 6480464 Fluorouracil affects the expression of DHFR mRNA CTD PMID:16557594 5-fluorouracil increases expression ISO RGD:736871 6480464 Fluorouracil results in increased expression of DHFR mRNA CTD PMID:15109396 , PMID:21814787 5-formyltetrahydrofolic acid multiple interactions ISO RGD:736871 6480464 Leucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid] CTD PMID:21310277 5-formyltetrahydrofolic acid increases expression ISO RGD:736871 6480464 Leucovorin results in increased expression of DHFR protein CTD PMID:16712799 6-bromoindirubin-3'-oxime multiple interactions ISO RGD:736871 6480464 [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein CTD PMID:19727391 aflatoxin B1 decreases expression ISO RGD:10471 6480464 Aflatoxin B1 results in decreased expression of DHFR mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:736871 6480464 Aflatoxin B1 results in decreased methylation of DHFR gene CTD PMID:27153756 aflatoxin M1 decreases expression ISO RGD:736871 6480464 Aflatoxin M1 results in decreased expression of DHFR mRNA CTD PMID:30928695 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DHFR mRNA CTD PMID:16483693 arsane affects response to substance ISO RGD:736871 6480464 DHFR gene SNP affects the susceptibility to Arsenic CTD PMID:25759212 arsane affects methylation ISO RGD:736871 6480464 Arsenic affects the methylation of DHFR gene CTD PMID:25304211 arsenic atom affects response to substance ISO RGD:736871 6480464 DHFR gene SNP affects the susceptibility to Arsenic CTD PMID:25759212 arsenic atom affects methylation ISO RGD:736871 6480464 Arsenic affects the methylation of DHFR gene CTD PMID:25304211 arsenite(3-) decreases expression ISO RGD:10471 6480464 arsenite results in decreased expression of DHFR mRNA CTD PMID:18929588 benzo[a]pyrene increases expression ISO RGD:736871 6480464 Benzo(a)pyrene results in increased expression of DHFR protein CTD PMID:18495319 benzo[a]pyrene decreases expression ISO RGD:736871 6480464 Benzo(a)pyrene results in decreased expression of DHFR mRNA CTD PMID:20064835 , PMID:26238291 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:736871 6480464 7 more ... CTD PMID:20018196 benzo[a]pyrene diol epoxide I increases expression ISO RGD:736871 6480464 7 more ... CTD PMID:19150397 benzo[e]pyrene increases methylation ISO RGD:736871 6480464 benzo(e)pyrene results in increased methylation of DHFR intron CTD PMID:30157460 beta-carotene multiple interactions ISO RGD:10471 6480464 [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 bis(2-ethylhexyl) phthalate increases expression ISO RGD:10471 6480464 Diethylhexyl Phthalate results in increased expression of DHFR mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10471 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DHFR mRNA] CTD PMID:19850644 bisphenol A affects expression ISO RGD:736871 6480464 bisphenol A affects the expression of DHFR mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DHFR mRNA CTD PMID:30816183 bisphenol A decreases expression ISO RGD:736871 6480464 bisphenol A results in decreased expression of DHFR mRNA CTD PMID:29275510 carbamazepine affects expression ISO RGD:736871 6480464 Carbamazepine affects the expression of DHFR mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:10471 6480464 Nanotubes, Carbon results in decreased expression of DHFR mRNA CTD PMID:25620056 cefazolin decreases activity ISO RGD:736871 6480464 Cefazolin results in decreased activity of DHFR protein CTD PMID:25418905 cefepime decreases activity ISO RGD:736871 6480464 cefepime results in decreased activity of DHFR protein CTD PMID:25418905 ceftazidime pentahydrate decreases activity ISO RGD:736871 6480464 Ceftazidime results in decreased activity of DHFR protein CTD PMID:25418905 ceftizoxime decreases activity ISO RGD:736871 6480464 Ceftizoxime results in decreased activity of DHFR protein CTD PMID:25418905 ceftriaxone decreases activity ISO RGD:736871 6480464 Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 chlorambucil decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Chlorambucil CTD PMID:12872145 choline multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:10471 6480464 chromium hexavalent ion affects the expression of DHFR mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:736871 6480464 Cisplatin results in increased expression of DHFR mRNA CTD PMID:27594783 cisplatin multiple interactions ISO RGD:736871 6480464 Cisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA] CTD PMID:21858171 clobetasol decreases expression ISO RGD:10471 6480464 Clobetasol results in decreased expression of DHFR mRNA CTD PMID:27462272 cobalt dichloride decreases expression ISO RGD:736871 6480464 cobaltous chloride results in decreased expression of DHFR mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:736871 6480464 [NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:736871 6480464 [NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:736871 6480464 Copper Sulfate results in decreased expression of DHFR mRNA CTD PMID:19549813 copper(II) sulfate increases expression ISO RGD:736871 6480464 Copper Sulfate results in increased expression of DHFR mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:736871 6480464 Coumestrol results in increased expression of DHFR mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:10471 6480464 Cyclosporine results in decreased expression of DHFR mRNA CTD PMID:19770486 , PMID:23308384 cytarabine increases expression ISO RGD:736871 6480464 Cytarabine results in increased expression of DHFR mRNA CTD PMID:19194470 dibenzo[a,l]pyrene decreases expression ISO RGD:736871 6480464 dibenzo(a, l)pyrene results in decreased expression of DHFR protein CTD PMID:18495319 dibutyl phthalate decreases expression ISO RGD:10471 6480464 Dibutyl Phthalate results in decreased expression of DHFR mRNA CTD PMID:17361019 , PMID:21266533 diclofenac affects expression ISO RGD:736871 6480464 Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 DISTAMYCIN A decreases expression ISO RGD:736871 6480464 stallimycin analog results in decreased expression of DHFR protein more ... CTD PMID:21814787 doxorubicin decreases expression ISO RGD:736871 6480464 Doxorubicin results in decreased expression of DHFR mRNA CTD PMID:29803840 emodin decreases expression ISO RGD:736871 6480464 Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of DHFR mRNA CTD PMID:29391264 Enterolactone increases expression ISO RGD:736871 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of DHFR mRNA CTD PMID:19167446 Enterolactone multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DHFR mRNA CTD PMID:19167446 ethanol decreases expression ISO RGD:736871 6480464 Ethanol results in decreased expression of DHFR mRNA CTD PMID:28986285 ferulic acid decreases activity ISO RGD:736871 6480464 ferulic acid results in decreased activity of DHFR protein CTD PMID:25418905 folic acid multiple interactions ISO RGD:736871 6480464 [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA more ... CTD PMID:21310277 more ... folic acid multiple interactions EXP 6480464 Folic Acid inhibits the reaction [Methotrexate results in decreased expression of DHFR mRNA] CTD PMID:30502384 folic acid multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 folic acid affects expression ISO RGD:736871 6480464 Folic Acid affects the expression of DHFR mRNA CTD PMID:17311948 folic acid decreases abundance ISO RGD:736871 6480464 DHFR gene mutant form results in decreased abundance of Folic Acid CTD PMID:21310277 formaldehyde decreases expression ISO RGD:736871 6480464 Formaldehyde results in decreased expression of DHFR mRNA CTD PMID:23649840 genistein decreases expression ISO RGD:10471 6480464 Genistein results in decreased expression of DHFR mRNA CTD PMID:21048042 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of DHFR mRNA CTD PMID:22061828 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of DHFR mRNA CTD PMID:18299717 indometacin multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA] CTD PMID:18299717 isoflavones decreases expression ISO RGD:736871 6480464 Isoflavones results in decreased expression of DHFR mRNA CTD PMID:17374662 isotretinoin decreases expression ISO RGD:736871 6480464 Isotretinoin results in decreased expression of DHFR mRNA CTD PMID:20436886 L-methionine multiple interactions ISO RGD:10471 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA CTD PMID:20938992 lamivudine multiple interactions ISO RGD:736871 6480464 [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA CTD PMID:15784690 leflunomide increases expression EXP 6480464 leflunomide results in increased expression of DHFR mRNA CTD PMID:24136188 levofloxacin decreases activity ISO RGD:736871 6480464 Levofloxacin results in decreased activity of DHFR protein CTD PMID:25418905 Mecamylamine decreases expression ISO RGD:736871 6480464 Mecamylamine results in decreased expression of DHFR mRNA CTD PMID:12588870 Mecamylamine multiple interactions ISO RGD:736871 6480464 Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 methapyrilene increases methylation ISO RGD:736871 6480464 Methapyrilene results in increased methylation of DHFR intron CTD PMID:30157460 methotrexate decreases response to substance ISO RGD:736871 6480464 DHFR mRNA results in decreased susceptibility to Methotrexate, DHFR protein results in decreased susceptibility to Methotrexate CTD PMID:14679136 more ... methotrexate multiple interactions EXP 6480464 DHFR protein inhibits the reaction [Methotrexate results in decreased expression of CASP3 protein] more ... CTD PMID:30502384 methotrexate decreases expression ISO RGD:10471 6480464 Methotrexate results in decreased expression of DHFR mRNA, Methotrexate results in decreased expression of DHFR protein CTD PMID:30502384 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of DHFR mRNA, Methotrexate results in decreased expression of DHFR protein CTD PMID:30502384 methotrexate decreases activity ISO RGD:10471 6480464 Methotrexate results in decreased activity of DHFR protein CTD PMID:22806879 methotrexate increases expression ISO RGD:10471 6480464 Methotrexate results in increased expression of DHFR protein CTD PMID:22484375 methotrexate affects response to substance ISO RGD:736871 6480464 DHFR 3' UTR SNP affects the susceptibility to Methotrexate CTD PMID:17686970 methotrexate multiple interactions ISO RGD:736871 6480464 [[MIR125A mRNA binds to DHFR 3' UTR] which results in decreased expression of DHFR protein] which results in increased susceptibility to Methotrexate more ... CTD PMID:17686970 more ... methotrexate decreases expression ISO RGD:736871 6480464 Methotrexate results in decreased expression of DHFR mRNA CTD PMID:23897011 , PMID:24657277 methotrexate increases expression ISO RGD:736871 6480464 Methotrexate results in increased expression of DHFR mRNA, Methotrexate results in increased expression of DHFR protein CTD PMID:19570950 more ... methotrexate multiple interactions ISO RGD:10471 6480464 Methotrexate promotes the reaction [E2F1 protein binds to DHFR promoter] CTD PMID:22484375 methotrexate decreases response to substance ISO RGD:10471 6480464 DHFR mRNA results in decreased susceptibility to Methotrexate, DHFR protein results in decreased susceptibility to Methotrexate CTD PMID:16918715 methylmercury chloride decreases expression ISO RGD:736871 6480464 methylmercuric chloride results in decreased expression of DHFR mRNA CTD PMID:28001369 methylseleninic acid decreases expression ISO RGD:736871 6480464 methylselenic acid results in decreased expression of DHFR mRNA CTD PMID:12517777 N-methyl-4-phenylpyridinium decreases expression ISO RGD:736871 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of DHFR mRNA CTD PMID:24810058 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA CTD PMID:20360939 NADP zwitterion decreases activity ISO RGD:736871 6480464 NADP analog results in decreased activity of DHFR protein CTD PMID:22954684 NADP(+) decreases activity ISO RGD:736871 6480464 NADP analog results in decreased activity of DHFR protein CTD PMID:22954684 naringin decreases activity ISO RGD:736871 6480464 naringin results in decreased activity of DHFR protein CTD PMID:25418905 nickel atom increases expression ISO RGD:736871 6480464 Nickel results in increased expression of DHFR mRNA CTD PMID:25583101 nicotine multiple interactions ISO RGD:736871 6480464 alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] more ... CTD PMID:12588870 nicotine decreases expression ISO RGD:736871 6480464 Nicotine results in decreased expression of DHFR mRNA CTD PMID:12588870 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of DHFR mRNA CTD PMID:24136188 nitrogen mustard decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compounds CTD PMID:12872145 olmesartan increases expression EXP 6480464 olmesartan results in increased expression of DHFR protein CTD PMID:17170375 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of DHFR mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:10471 6480464 Acetaminophen affects the expression of DHFR mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:736871 6480464 Acetaminophen results in increased expression of DHFR mRNA CTD PMID:22230336 pemetrexed multiple interactions ISO RGD:736871 6480464 [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA CTD PMID:22975265 perfluorooctanoic acid decreases expression ISO RGD:736871 6480464 perfluorooctanoic acid results in decreased expression of DHFR mRNA CTD PMID:23978341 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA CTD PMID:20360939 phenobarbital affects expression ISO RGD:10471 6480464 Phenobarbital affects the expression of DHFR mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:10471 6480464 pirinixic acid results in increased expression of DHFR mRNA CTD PMID:17426115 pirinixic acid decreases expression ISO RGD:10471 6480464 pirinixic acid results in decreased expression of DHFR mRNA CTD PMID:23811191 piroxicam decreases expression ISO RGD:736871 6480464 Piroxicam results in decreased expression of DHFR mRNA CTD PMID:21858171 piroxicam multiple interactions ISO RGD:736871 6480464 Cisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA] CTD PMID:21858171 potassium chromate increases expression ISO RGD:736871 6480464 potassium chromate(VI) results in increased expression of DHFR mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:736871 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA CTD PMID:22079256 potassium dichromate increases expression ISO RGD:736871 6480464 Potassium Dichromate results in increased expression of DHFR mRNA CTD PMID:18332044 propanal decreases expression ISO RGD:736871 6480464 propionaldehyde results in decreased expression of DHFR mRNA CTD PMID:26079696 Rebamipide multiple interactions EXP 6480464 rebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA] CTD PMID:18299717 resveratrol multiple interactions ISO RGD:736871 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of DHFR mRNA CTD PMID:19167446 resveratrol increases expression ISO RGD:10471 6480464 resveratrol results in increased expression of DHFR protein CTD PMID:25505154 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of DHFR mRNA CTD PMID:28374803 silicon dioxide decreases expression ISO RGD:736871 6480464 Silicon Dioxide analog results in decreased expression of DHFR mRNA CTD PMID:25895662 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of DHFR protein CTD PMID:19072884 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of DHFR protein CTD PMID:29459688 sodium arsenite increases mutagenesis ISO RGD:736871 6480464 sodium arsenite results in increased mutagenesis of DHFR gene CTD PMID:12802802 sunitinib decreases expression ISO RGD:736871 6480464 Sunitinib results in decreased expression of DHFR mRNA CTD PMID:31533062 syringic acid decreases activity ISO RGD:736871 6480464 syringic acid results in decreased activity of DHFR protein CTD PMID:25418905 tamoxifen increases expression ISO RGD:736871 6480464 Tamoxifen results in increased expression of DHFR mRNA CTD PMID:15590111 tamoxifen affects expression ISO RGD:10471 6480464 Tamoxifen affects the expression of DHFR mRNA CTD PMID:17555576 tetrachloromethane decreases expression ISO RGD:10471 6480464 Carbon Tetrachloride results in decreased expression of DHFR mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DHFR mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of DHFR mRNA CTD PMID:31150632 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of DHFR mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA CTD PMID:25729387 trabectedin decreases expression ISO RGD:10471 6480464 trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 trimellitic anhydride increases expression ISO RGD:10471 6480464 trimellitic anhydride results in increased expression of DHFR mRNA CTD PMID:19042947 trimethoprim multiple interactions ISO RGD:10471 6480464 [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 trimetrexate decreases response to substance ISO RGD:736871 6480464 DHFR protein polymorphism results in decreased susceptibility to Trimetrexate CTD PMID:12872145 tubocurarine multiple interactions ISO RGD:736871 6480464 Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 tubocurarine decreases expression ISO RGD:736871 6480464 Tubocurarine results in decreased expression of DHFR mRNA CTD PMID:12588870 urethane decreases expression ISO RGD:736871 6480464 Urethane results in decreased expression of DHFR mRNA CTD PMID:28818685 valproic acid multiple interactions ISO RGD:10471 6480464 [Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid CTD PMID:8318756 valproic acid decreases methylation ISO RGD:736871 6480464 Valproic Acid results in decreased methylation of DHFR gene CTD PMID:29154799 vincristine decreases expression ISO RGD:736871 6480464 Vincristine results in decreased expression of DHFR mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:736871 6480464 vorinostat results in decreased expression of DHFR mRNA CTD PMID:20072153 zidovudine multiple interactions ISO RGD:736871 6480464 [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA CTD PMID:15784690
Gene-Chemical Interaction Annotations
