Dhfr (dihydrofolate reductase) - Rat Genome Database

Name: Dhfr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dhfr (dihydrofolate reductase) Rattus norvegicus

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Symbol:

Dhfr

Name:

dihydrofolate reductase

Description:

ENCODES a protein that exhibits dihydrofolate reductase activity; dihydrofolic acid binding; NADP binding; INVOLVED IN axon regeneration; dihydrofolate metabolic process; folic acid metabolic process; PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; pyrimidine metabolic pathway; ASSOCIATED WITH Kidney Reperfusion Injury; Neoplasm Metastasis; Abortion, Spontaneous (ortholog); FOUND IN cytoplasm; mitochondrion; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Dhfr1; Dihydrofolate reductase 1 (active)

Orthologs:

Homo sapiens (human) : DHFR (dihydrofolate reductase) HGNC Alliance
Mus musculus (house mouse) : Dhfr (dihydrofolate reductase) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhfr (dihydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHFR (dihydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhfr (dihydrofolate reductase)
Sus scrofa (pig) : DHFR (dihydrofolate reductase)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DHFR (dihydrofolate reductase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dhfr (dihydrofolate reductase)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DHFR (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dhfr (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DHFR (dihydrofolate reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DHFR2 (dihydrofolate reductase 2)	HGNC	EggNOG, Ensembl, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Dhfr (dihydrofolate reductase)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):	DHFR (dihydrofolate reductase)	Alliance	DIOPT (Ensembl Compara, HGNC, OMA, OrthoFinder, PANTHER, TreeFam)
Homo sapiens (human):	DHFRP1 (dihydrofolate reductase pseudogene 1)	Alliance	DIOPT (Hieranoid, InParanoid, OMA, OrthoInspector, PhylomeDB)
Homo sapiens (human):	DHFR2 (dihydrofolate reductase 2)	Alliance	DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):	dhfr (dihydrofolate reductase)	Alliance	DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):	zgc:153031	Alliance	DIOPT (OrthoFinder, PANTHER, TreeFam)
Saccharomyces cerevisiae (baker's yeast):	DFR1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):	Dhfr	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):	dhfr-1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	2	21,931,887 - 21,958,927 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	41,137,784 - 41,149,417 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	41,162,308 - 41,162,496 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	22,607,093 - 22,828,487 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	22,527,461 - 22,748,856 (+)	NCBI
Celera	2	19,675,965 - 19,700,103 (+)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

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QTLs in Region (Rnor_6.0)

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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links

Nomenclature History

RGD Curation Notes

More on Dhfr
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	2500
Created:	2000-05-25
Species:	Rattus norvegicus
Last Modified:	2019-01-30
Status:	ACTIVE

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

RGD Manual Annotations

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)