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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:147347 term browser browse the term
Definition:A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Synonyms:exact_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
 related_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone;   Formula=C25H34N2O3;   InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3;   InChIKey=MPMFCABZENCRHV-UHFFFAOYSA-N;   SMILES=C1=2C=3C(C(C1=CC(=CC2)OCCN(CC)CC)=O)=CC(=CC3)OCCN(CC)CC;   tilorona;   tiloronum
 alt_id: CHEBI:109553
 xref: CAS:27591-97-5;   LINCS:LSM-20974
 xref_mesh: MESH:D013994
 xref: PMID:17571857;   PMID:18157163;   PMID:22281189;   PMID:23665799;   PMID:29133569;   PMID:29655797;   PMID:30463695;   PMID:30537230;   PMID:30880776;   PMID:32205350;   PMID:32215760;   Wikipedia:Tilorone
 cyclic_relationship: is_conjugate_base_of CHEBI:147355

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tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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  CHEBI ontology 19908
    role 19883
      application 19717
        anti-inflammatory agent 16527
          tilorone 1
Path 2
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  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19684
                        hydrogen molecular entity 19673
                          hydrides 19150
                            organic hydride 18711
                              organic fundamental parent 18711
                                hydrocarbon 18431
                                  cyclic hydrocarbon 17240
                                    arene 17220
                                      polycyclic arene 17047
                                        ortho-fused polycyclic arene 9770
                                          fluorene 557
                                            fluorenes 429
                                              fluoren-9-ones 4
                                                tilorone 1
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