Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tilorone
go back to main search page
Accession:CHEBI:147347 term browser browse the term
Definition:A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Synonyms:exact_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
 related_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone;   Formula=C25H34N2O3;   InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3;   InChIKey=MPMFCABZENCRHV-UHFFFAOYSA-N;   SMILES=C1=2C=3C(C(C1=CC(=CC2)OCCN(CC)CC)=O)=CC(=CC3)OCCN(CC)CC;   tilorona;   tiloronum
 alt_id: CHEBI:109553
 xref: CAS:27591-97-5;   LINCS:LSM-20974
 xref_mesh: MESH:D013994
 xref: PMID:17571857;   PMID:18157163;   PMID:22281189;   PMID:23665799;   PMID:29133569;   PMID:29655797;   PMID:30463695;   PMID:30537230;   PMID:30880776;   PMID:32205350;   PMID:32215760;   Wikipedia:Tilorone
 cyclic_relationship: is_conjugate_base_of CHEBI:147355



show annotations for term's descendants           Sort by:
tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        anti-inflammatory agent 16605
          tilorone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            organic hydride 18674
                              organic fundamental parent 18674
                                hydrocarbon 18410
                                  cyclic hydrocarbon 17225
                                    arene 17205
                                      polycyclic arene 17035
                                        ortho-fused polycyclic arene 9817
                                          fluorene 559
                                            fluorenes 431
                                              fluoren-9-ones 4
                                                tilorone 1
paths to the root