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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tilorone
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Accession:CHEBI:147347 term browser browse the term
Definition:A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Synonyms:exact_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
 related_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone;   Formula=C25H34N2O3;   InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3;   InChIKey=MPMFCABZENCRHV-UHFFFAOYSA-N;   SMILES=C1=2C=3C(C(C1=CC(=CC2)OCCN(CC)CC)=O)=CC(=CC3)OCCN(CC)CC;   tilorona;   tiloronum
 alt_id: CHEBI:109553
 xref: CAS:27591-97-5;   DrugBank:DB17965;   HMDB:HMDB0259096;   LINCS:LSM-20974
 xref_mesh: MESH:D013994
 xref: PMID:17571857;   PMID:18157163;   PMID:22281189;   PMID:23665799;   PMID:29133569;   PMID:29655797;   PMID:30463695;   PMID:30537230;   PMID:30880776;   PMID:32205350;   PMID:32215760;   PMID:33400519;   PMID:33804032;   PMID:34705177;   PMID:35056541;   PMID:37012691;   PMID:37033868;   Wikipedia:Tilorone
 cyclic_relationship: is_conjugate_base_of CHEBI:147355


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tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      application 20606
        anti-inflammatory agent 16814
          tilorone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            organic hydride 19066
                              organic fundamental parent 19066
                                hydrocarbon 18723
                                  cyclic hydrocarbon 17311
                                    arene 17292
                                      polycyclic arene 17100
                                        ortho-fused polycyclic arene 9932
                                          fluorene 562
                                            fluorenes 433
                                              fluoren-9-ones 4
                                                tilorone 1
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