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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tilorone
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Accession:CHEBI:147347 term browser browse the term
Definition:A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
Synonyms:exact_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
 related_synonym: 2,7-bis[2-(diethylamino)ethoxy]-9-fluorenone;   Formula=C25H34N2O3;   InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3;   InChIKey=MPMFCABZENCRHV-UHFFFAOYSA-N;   SMILES=C1=2C=3C(C(C1=CC(=CC2)OCCN(CC)CC)=O)=CC(=CC3)OCCN(CC)CC;   tilorona;   tiloronum
 alt_id: CHEBI:109553
 xref: CAS:27591-97-5;   LINCS:LSM-20974
 xref_mesh: MESH:D013994
 xref: PMID:17571857;   PMID:18157163;   PMID:22281189;   PMID:23665799;   PMID:29133569;   PMID:29655797;   PMID:30463695;   PMID:30537230;   PMID:30880776;   PMID:32205350;   PMID:32215760;   Wikipedia:Tilorone
 cyclic_relationship: is_conjugate_base_of CHEBI:147355


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tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      application 19412
        anti-inflammatory agent 15759
          tilorone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    main group molecular entity 19669
                      s-block molecular entity 19434
                        hydrogen molecular entity 19429
                          hydrides 18757
                            organic hydride 18355
                              organic fundamental parent 18355
                                hydrocarbon 18074
                                  cyclic hydrocarbon 17090
                                    arene 17086
                                      polycyclic arene 16907
                                        ortho-fused polycyclic arene 9665
                                          fluorene 558
                                            fluorenes 428
                                              fluoren-9-ones 4
                                                tilorone 1
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