Prkar2b (protein kinase cAMP-dependent type II regulatory subunit beta) - Rat Genome Database

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Gene: Prkar2b (protein kinase cAMP-dependent type II regulatory subunit beta) Rattus norvegicus
Analyze
Symbol: Prkar2b
Name: protein kinase cAMP-dependent type II regulatory subunit beta
RGD ID: 3394
Description: Enables cAMP binding activity; cAMP-dependent protein kinase regulator activity; and protein domain specific binding activity. Involved in regulation of protein kinase activity; response to antipsychotic drug; and response to clozapine. Located in several cellular components, including membrane raft; neuronal cell body; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta); PARTICIPATES IN protein kinase A (PKA) signaling pathway; apoptotic cell death pathway; insulin signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-dependent protein kinase type II-beta regulatory subunit; MGC116401; protein kinase cAMP-dependent type 2 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; RATDNA; type II beta regulatory subunit of cAMP-dependent protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,563,659 - 48,653,933 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl648,563,662 - 48,653,933 (-)Ensembl
Rnor_6.0651,265,509 - 51,356,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,936,123 - 60,027,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,234,979 - 50,325,298 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,238,107 - 50,306,399 (-)NCBI
Celera647,765,297 - 47,855,503 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furan  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
hypochlorous acid  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
Salidroside  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
2. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
3. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
4. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). Feliciello A, etal., FEBS Lett 1999 Dec 31;464(3):174-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. Jahnsen T, etal., J Biol Chem 1986 Sep 15;261(26):12352-61.
8. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
9. Identification and characterization of the GC-rich and cyclic adenosine 3',5'-monophosphate (cAMP)-inducible promoter of the type II beta cAMP-dependent protein kinase regulatory subunit gene. Kurten RC, etal., Mol Endocrinol 1992 Apr;6(4):536-50.
10. Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. Manni S, etal., J Biol Chem. 2008 Aug 29;283(35):24145-54. Epub 2008 Jun 12.
11. Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. McSorley T, etal., Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft). Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
15. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Parisiadou L, etal., Nat Neurosci. 2014 Mar;17(3):367-76. doi: 10.1038/nn.3636. Epub 2014 Jan 26.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Molecular cloning, cDNA structure and deduced amino acid sequence for the hormone-induced regulatory subunit (RII beta) of cAMP-dependent protein kinase from rat ovarian granulosa cells. Sandberg M, etal., Biochem Biophys Res Commun 1988 Jul 29;154(2):705-11.
21. Occurrence of A-kinase anchor protein and associated cAMP-dependent protein kinase in the inner compartment of mammalian mitochondria. Sardanelli AM, etal., FEBS Lett. 2006 Oct 16;580(24):5690-6. Epub 2006 Sep 18.
22. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
23. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. Zawadzki KM and Taylor SS, J Biol Chem. 2004 Feb 20;279(8):7029-36. Epub 2003 Nov 18.
24. Subcellular dynamics of type II PKA in neurons. Zhong H, etal., Neuron. 2009 May 14;62(3):363-74. doi: 10.1016/j.neuron.2009.03.013.
Additional References at PubMed
PMID:7775586   PMID:8757131   PMID:8889548   PMID:9570795   PMID:11342137   PMID:12477932   PMID:14967031   PMID:15483123   PMID:16641100   PMID:19236309   PMID:19748511   PMID:21399614  
PMID:21423175   PMID:21502359   PMID:21812984   PMID:22007132   PMID:22323819   PMID:22871113   PMID:23533145   PMID:25112875   PMID:26158466   PMID:30053369  


Genomics

Comparative Map Data
Prkar2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,563,659 - 48,653,933 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl648,563,662 - 48,653,933 (-)Ensembl
Rnor_6.0651,265,509 - 51,356,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,936,123 - 60,027,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,234,979 - 50,325,298 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,238,107 - 50,306,399 (-)NCBI
Celera647,765,297 - 47,855,503 (-)NCBICelera
Cytogenetic Map6q16NCBI
PRKAR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387107,044,705 - 107,161,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7107,044,705 - 107,161,811 (+)EnsemblGRCh38hg38GRCh38
GRCh377106,685,150 - 106,802,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,472,414 - 106,589,492 (+)NCBINCBI36hg18NCBI36
Build 347106,279,128 - 106,396,206NCBI
Celera7101,490,496 - 101,607,543 (+)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7101,045,272 - 101,162,795 (+)NCBIHuRef
CHM1_17106,618,759 - 106,735,827 (+)NCBICHM1_1
T2T-CHM13v2.07108,360,790 - 108,477,853 (+)NCBI
CRA_TCAGchr7v27106,046,282 - 106,163,333 (+)NCBI
Prkar2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,008,449 - 32,111,647 (-)NCBIGRCm39mm39
GRCm39 Ensembl1232,008,475 - 32,111,295 (-)Ensembl
GRCm381231,958,450 - 32,061,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,958,476 - 32,061,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,643,344 - 32,746,144 (-)NCBIGRCm37mm9NCBIm37
MGSCv361232,545,033 - 32,646,499 (-)NCBImm8
Celera1233,412,788 - 33,510,684 (-)NCBICelera
Cytogenetic Map12A3NCBI
Prkar2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,553,508 - 11,622,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,529,530 - 11,620,085 (+)NCBIChiLan1.0ChiLan1.0
PRKAR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17111,748,463 - 111,866,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,748,463 - 111,866,044 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0799,021,209 - 99,140,652 (+)NCBIMhudiblu_PPA_v0panPan3
PRKAR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,375,216 - 13,467,811 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,376,425 - 13,468,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,024,300 - 13,116,617 (-)NCBI
ROS_Cfam_1.01813,645,633 - 13,738,378 (-)NCBI
ROS_Cfam_1.0 Ensembl1813,646,571 - 13,738,721 (-)Ensembl
UMICH_Zoey_3.11813,461,865 - 13,554,232 (-)NCBI
UNSW_CanFamBas_1.01813,382,039 - 13,474,442 (-)NCBI
UU_Cfam_GSD_1.01813,659,873 - 13,752,991 (-)NCBI
Prkar2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,770,299 - 55,865,110 (-)NCBI
SpeTri2.0NW_00493647916,894,068 - 16,988,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,851,018 - 106,957,519 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,851,044 - 106,957,519 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,966,957 - 76,079,440 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,967,053 - 76,081,729 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604227,778,390 - 27,891,673 (-)NCBIVero_WHO_p1.0
Prkar2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,539,087 - 22,635,248 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473922,539,369 - 22,635,090 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D6Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,657,765 - 48,658,068 (+)MAPPERmRatBN7.2
Rnor_6.0651,360,215 - 51,360,517NCBIRnor6.0
Rnor_5.0660,030,865 - 60,031,167UniSTSRnor5.0
RGSC_v3.4650,329,129 - 50,329,432RGDRGSC3.4
RGSC_v3.4650,329,130 - 50,329,432UniSTSRGSC3.4
RGSC_v3.1650,332,255 - 50,332,558RGD
Celera647,859,335 - 47,859,637UniSTS
RH 3.4 Map6303.6UniSTS
RH 3.4 Map6303.6RGD
RH 2.0 Map6470.5RGD
FHH x ACI Map643.7499RGD
Cytogenetic Map6q16UniSTS
RH139912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,565,490 - 48,565,670 (+)MAPPERmRatBN7.2
Rnor_6.0651,267,341 - 51,267,520NCBIRnor6.0
Rnor_5.0659,937,955 - 59,938,134UniSTSRnor5.0
RGSC_v3.4650,236,811 - 50,236,990UniSTSRGSC3.4
Celera647,767,144 - 47,767,323UniSTS
RH 3.4 Map6321.3UniSTS
Cytogenetic Map6q16UniSTS
RH140571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,651,991 - 48,652,199 (+)MAPPERmRatBN7.2
Rnor_6.0651,354,442 - 51,354,649NCBIRnor6.0
Rnor_5.0660,025,092 - 60,025,299UniSTSRnor5.0
RGSC_v3.4650,323,357 - 50,323,564UniSTSRGSC3.4
Celera647,853,562 - 47,853,769UniSTS
RH 3.4 Map6321.3UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:165
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000012415
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 38 22 19 22 74 24 36 11
Low 1 15 8 8 8 8 10 11 5 8
Below cutoff 11 11 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012415   ⟹   ENSRNOP00000012415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,563,667 - 48,653,933 (-)Ensembl
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079719   ⟹   ENSRNOP00000074658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,565,246 - 48,614,472 (-)Ensembl
Rnor_6.0 Ensembl651,267,096 - 51,316,943 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082985   ⟹   ENSRNOP00000073412
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl648,563,662 - 48,595,009 (-)Ensembl
Rnor_6.0 Ensembl651,267,423 - 51,297,712 (-)Ensembl
RefSeq Acc Id: NM_001030020   ⟹   NP_001025191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,563,659 - 48,653,933 (-)NCBI
Rnor_6.0651,265,509 - 51,356,383 (-)NCBI
Rnor_5.0659,936,123 - 60,027,242 (-)NCBI
RGSC_v3.4650,234,979 - 50,325,298 (-)RGD
Celera647,765,297 - 47,855,503 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594037   ⟹   XP_017449526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,563,659 - 48,632,064 (-)NCBI
Rnor_6.0651,265,509 - 51,334,923 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001025191   ⟸   NM_001030020
- UniProtKB: P12369 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449526   ⟸   XM_017594037
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073412   ⟸   ENSRNOT00000082985
RefSeq Acc Id: ENSRNOP00000074658   ⟸   ENSRNOT00000079719
RefSeq Acc Id: ENSRNOP00000012415   ⟸   ENSRNOT00000012415
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12369-F1-model_v2 AlphaFold P12369 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3394 AgrOrtholog
BioCyc Gene G2FUF-37900 BioCyc
Ensembl Genes ENSRNOG00000009079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073412 ENTREZGENE
  ENSRNOP00000073412.2 UniProtKB/TrEMBL
  ENSRNOP00000074658.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079719.2 UniProtKB/TrEMBL
  ENSRNOT00000082985 ENTREZGENE
  ENSRNOT00000082985.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388087 IMAGE-MGC_LOAD
InterPro cAMP_dep_PK_reg_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24679 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116401 IMAGE-MGC_LOAD
NCBI Gene 24679 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
PhenoGen Prkar2b PhenoGen
PIRSF PK_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5G0_RAT UniProtKB/TrEMBL
  KAP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4KLG5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar2b  protein kinase cAMP-dependent type II regulatory subunit beta  Prkar2b  protein kinase cAMP-dependent type 2 regulatory subunit beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar2b  protein kinase cAMP-dependent type 2 regulatory subunit beta  Prkar2b  protein kinase, cAMP-dependent, regulatory subunit type II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar2b  protein kinase, cAMP-dependent, regulatory subunit type II beta  Prkar2b  protein kinase, cAMP dependent regulatory, type II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-24 Prkar2b  protein kinase, cAMP dependent regulatory, type II beta      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by estradiol and by follicle-stimulating hormone 727529