Prkar2b (protein kinase cAMP-dependent type II regulatory subunit beta) - Rat Genome Database

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Gene: Prkar2b (protein kinase cAMP-dependent type II regulatory subunit beta) Rattus norvegicus
Analyze
Symbol: Prkar2b
Name: protein kinase cAMP-dependent type II regulatory subunit beta
RGD ID: 3394
Description: Exhibits cAMP binding activity; cAMP-dependent protein kinase regulator activity; and protein domain specific binding activity. Involved in regulation of protein kinase activity; response to antipsychotic drug; and response to clozapine. Localizes to several cellular components, including cAMP-dependent protein kinase complex; membrane raft; and neuronal cell body. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta); PARTICIPATES IN protein kinase A (PKA) signaling pathway; apoptotic cell death pathway; insulin signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP-dependent protein kinase type II-beta regulatory subunit; MGC116401; protein kinase cAMP-dependent type 2 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; RATDNA; type II beta regulatory subunit of cAMP-dependent protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,563,659 - 48,653,933 (-)NCBI
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0651,265,509 - 51,356,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0659,936,123 - 60,027,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,234,979 - 50,325,298 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,238,107 - 50,306,399 (-)NCBI
Celera647,765,297 - 47,855,503 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3',5'-cyclic AMP  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furan  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
hypochlorous acid  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
Salidroside  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
2. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
3. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
4. Feliciello A, etal., FEBS Lett 1999 Dec 31;464(3):174-8.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Jahnsen T, etal., J Biol Chem 1986 Sep 15;261(26):12352-61.
8. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
9. Kurten RC, etal., Mol Endocrinol 1992 Apr;6(4):536-50.
10. Manni S, etal., J Biol Chem. 2008 Aug 29;283(35):24145-54. Epub 2008 Jun 12.
11. McSorley T, etal., Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
15. Parisiadou L, etal., Nat Neurosci. 2014 Mar;17(3):367-76. doi: 10.1038/nn.3636. Epub 2014 Jan 26.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Sandberg M, etal., Biochem Biophys Res Commun 1988 Jul 29;154(2):705-11.
21. Sardanelli AM, etal., FEBS Lett. 2006 Oct 16;580(24):5690-6. Epub 2006 Sep 18.
22. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
23. Zawadzki KM and Taylor SS, J Biol Chem. 2004 Feb 20;279(8):7029-36. Epub 2003 Nov 18.
24. Zhong H, etal., Neuron. 2009 May 14;62(3):363-74. doi: 10.1016/j.neuron.2009.03.013.
Additional References at PubMed
PMID:7775586   PMID:8757131   PMID:8889548   PMID:9570795   PMID:11342137   PMID:12477932   PMID:14967031   PMID:15483123   PMID:16641100   PMID:19236309   PMID:19748511   PMID:21399614  
PMID:21423175   PMID:21502359   PMID:21812984   PMID:22007132   PMID:22323819   PMID:22871113   PMID:23533145   PMID:25112875   PMID:26158466   PMID:30053369  


Genomics

Comparative Map Data
Prkar2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,563,659 - 48,653,933 (-)NCBI
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0651,265,509 - 51,356,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0659,936,123 - 60,027,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,234,979 - 50,325,298 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,238,107 - 50,306,399 (-)NCBI
Celera647,765,297 - 47,855,503 (-)NCBICelera
Cytogenetic Map6q16NCBI
PRKAR2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7107,044,705 - 107,161,811 (+)EnsemblGRCh38hg38GRCh38
GRCh387107,044,705 - 107,161,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377106,685,150 - 106,802,256 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,472,414 - 106,589,492 (+)NCBINCBI36hg18NCBI36
Build 347106,279,128 - 106,396,206NCBI
Celera7101,490,496 - 101,607,543 (+)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7101,045,272 - 101,162,795 (+)NCBIHuRef
CHM1_17106,618,759 - 106,735,827 (+)NCBICHM1_1
CRA_TCAGchr7v27106,046,282 - 106,163,333 (+)NCBI
Prkar2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,008,449 - 32,111,647 (-)NCBIGRCm39mm39
GRCm39 Ensembl1232,008,475 - 32,111,295 (-)Ensembl
GRCm381231,958,450 - 32,061,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,958,476 - 32,061,296 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,643,344 - 32,746,144 (-)NCBIGRCm37mm9NCBIm37
MGSCv361232,545,033 - 32,646,499 (-)NCBImm8
Celera1233,412,788 - 33,510,684 (-)NCBICelera
Cytogenetic Map12A3NCBI
Prkar2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,553,508 - 11,622,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,529,530 - 11,620,085 (+)NCBIChiLan1.0ChiLan1.0
PRKAR2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17111,748,463 - 111,866,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,748,463 - 111,866,044 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0799,021,209 - 99,140,652 (+)NCBIMhudiblu_PPA_v0panPan3
PRKAR2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,375,216 - 13,467,811 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,376,425 - 13,468,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,024,300 - 13,116,617 (-)NCBI
ROS_Cfam_1.01813,645,633 - 13,738,378 (-)NCBI
UMICH_Zoey_3.11813,461,865 - 13,554,232 (-)NCBI
UNSW_CanFamBas_1.01813,382,039 - 13,474,442 (-)NCBI
UU_Cfam_GSD_1.01813,659,873 - 13,752,991 (-)NCBI
Prkar2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,770,299 - 55,865,110 (-)NCBI
SpeTri2.0NW_00493647916,894,068 - 16,988,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,851,018 - 106,957,519 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,851,044 - 106,957,519 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAR2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,966,957 - 76,079,440 (+)NCBI
ChlSab1.1 Ensembl2175,967,053 - 76,081,729 (+)Ensembl
Vero_WHO_p1.0NW_02366604227,778,390 - 27,891,673 (-)NCBI
Prkar2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473922,539,369 - 22,635,090 (-)NCBI

Position Markers
D6Arb12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,657,765 - 48,658,068 (+)MAPPER
Rnor_6.0651,360,215 - 51,360,517NCBIRnor6.0
Rnor_5.0660,030,865 - 60,031,167UniSTSRnor5.0
RGSC_v3.4650,329,129 - 50,329,432RGDRGSC3.4
RGSC_v3.4650,329,130 - 50,329,432UniSTSRGSC3.4
RGSC_v3.1650,332,255 - 50,332,558RGD
Celera647,859,335 - 47,859,637UniSTS
RH 3.4 Map6303.6UniSTS
RH 3.4 Map6303.6RGD
RH 2.0 Map6470.5RGD
FHH x ACI Map643.7499RGD
Cytogenetic Map6q16UniSTS
RH139912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,565,490 - 48,565,670 (+)MAPPER
Rnor_6.0651,267,341 - 51,267,520NCBIRnor6.0
Rnor_5.0659,937,955 - 59,938,134UniSTSRnor5.0
RGSC_v3.4650,236,811 - 50,236,990UniSTSRGSC3.4
Celera647,767,144 - 47,767,323UniSTS
RH 3.4 Map6321.3UniSTS
Cytogenetic Map6q16UniSTS
RH140571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2648,651,991 - 48,652,199 (+)MAPPER
Rnor_6.0651,354,442 - 51,354,649NCBIRnor6.0
Rnor_5.0660,025,092 - 60,025,299UniSTSRnor5.0
RGSC_v3.4650,323,357 - 50,323,564UniSTSRGSC3.4
Celera647,853,562 - 47,853,769UniSTS
RH 3.4 Map6321.3UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63425776653855198Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63626028860606186Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63819641260606431Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:165
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000012415
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 38 22 19 22 74 24 36 11
Low 1 15 8 8 8 8 10 11 5 8
Below cutoff 11 11 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012415   ⟹   ENSRNOP00000012415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl651,265,515 - 51,356,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079719   ⟹   ENSRNOP00000074658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl651,267,096 - 51,316,943 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082985   ⟹   ENSRNOP00000073412
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl651,267,423 - 51,297,712 (-)Ensembl
RefSeq Acc Id: NM_001030020   ⟹   NP_001025191
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,563,659 - 48,653,933 (-)NCBI
Rnor_6.0651,265,509 - 51,356,383 (-)NCBI
Rnor_5.0659,936,123 - 60,027,242 (-)NCBI
RGSC_v3.4650,234,979 - 50,325,298 (-)RGD
Celera647,765,297 - 47,855,503 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594037   ⟹   XP_017449526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2648,563,659 - 48,632,064 (-)NCBI
Rnor_6.0651,265,509 - 51,334,923 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001025191   ⟸   NM_001030020
- UniProtKB: P12369 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017449526   ⟸   XM_017594037
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073412   ⟸   ENSRNOT00000082985
RefSeq Acc Id: ENSRNOP00000074658   ⟸   ENSRNOT00000079719
RefSeq Acc Id: ENSRNOP00000012415   ⟸   ENSRNOT00000012415
Protein Domains
Cyclic nucleotide-binding

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3394 AgrOrtholog
Ensembl Genes ENSRNOG00000009079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073412 UniProtKB/TrEMBL
  ENSRNOP00000074658 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012415 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079719 UniProtKB/TrEMBL
  ENSRNOT00000082985 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7388087 IMAGE-MGC_LOAD
InterPro cAMP_dep_PK_reg_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24679 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116401 IMAGE-MGC_LOAD
NCBI Gene 24679 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
PhenoGen Prkar2b PhenoGen
PIRSF PK_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5G0_RAT UniProtKB/TrEMBL
  KAP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4KLG5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar2b  protein kinase cAMP-dependent type II regulatory subunit beta  Prkar2b  protein kinase cAMP-dependent type 2 regulatory subunit beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar2b  protein kinase cAMP-dependent type 2 regulatory subunit beta  Prkar2b  protein kinase, cAMP-dependent, regulatory subunit type II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar2b  protein kinase, cAMP-dependent, regulatory subunit type II beta  Prkar2b  protein kinase, cAMP dependent regulatory, type II beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-24 Prkar2b  protein kinase, cAMP dependent regulatory, type II beta      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by estradiol and by follicle-stimulating hormone 727529