RGD Reference Report - Subcellular dynamics of type II PKA in neurons. - Rat Genome Database

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Subcellular dynamics of type II PKA in neurons.

Authors: Zhong, Haining  Sia, Gek-Ming  Sato, Takashi R  Gray, Noah W  Mao, Tianyi  Khuchua, Zaza  Huganir, Richard L  Svoboda, Karel 
Citation: Zhong H, etal., Neuron. 2009 May 14;62(3):363-74. doi: 10.1016/j.neuron.2009.03.013.
RGD ID: 12050092
Pubmed: PMID:19447092   (View Abstract at PubMed)
PMCID: PMC2702487   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2009.03.013   (Journal Full-text)

Protein kinase A (PKA) plays multiple roles in neurons. The localization and specificity of PKA are largely controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA in neurons and the roles of specific AKAPs are poorly understood. We imaged the distribution of type II PKA in hippocampal and cortical layer 2/3 pyramidal neurons in vitro and in vivo. PKA was concentrated in dendritic shafts compared to the soma, axons, and dendritic spines. This spatial distribution was imposed by the microtubule-binding protein MAP2, indicating that MAP2 is the dominant AKAP in neurons. Following cAMP elevation, catalytic subunits dissociated from the MAP2-tethered regulatory subunits and rapidly became enriched in nearby spines. The spatial gradient of type II PKA between dendritic shafts and spines was critical for the regulation of synaptic strength and long-term potentiation. Therefore, the localization and activity-dependent translocation of type II PKA are important determinants of PKA function.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
postsynapse located_inIDA 12050092PMID:19447092SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Prkar2b  (protein kinase cAMP-dependent type II regulatory subunit beta)


Additional Information