Ccn1 (cellular communication network factor 1) - Rat Genome Database

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Gene: Ccn1 (cellular communication network factor 1) Rattus norvegicus
Symbol: Ccn1
Name: cellular communication network factor 1
RGD ID: 620763
Description: Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of cellular senescence; and positive regulation of cytokine production. Located in cytosol and membrane. Biomarker of intracranial aneurysm. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human CCN1 (cellular communication network factor 1); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: CCN family member 1; Cyr61; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; cysteine-rich, angiogenic inducer, 61; IBP-10; IGF-binding protein 10; IGFBP-10; insulin-like growth factor-binding protein 10; MGC93040
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22234,562,410 - 234,565,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,562,408 - 234,565,484 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,360,176 - 242,363,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,250,731 - 240,253,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,117,804 - 235,120,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,529,354 - 251,532,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,529,354 - 251,532,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,055,954 - 270,058,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42243,824,303 - 243,827,262 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12243,811,042 - 243,814,002 (-)NCBI
Celera2226,551,241 - 226,554,210 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
ampicillin  (ISO)
antimycin A  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
bacitracin  (EXP)
bazedoxifene  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
casticin  (ISO)
chelerythrine  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
cyanidin cation  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
estriol  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geranylgeraniol  (ISO)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
rifampicin  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sclareol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
verteporfin  (ISO)
vinclozolin  (EXP)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
apoptotic process involved in heart morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
cell adhesion  (IDA,ISO)
cell-cell adhesion  (ISO)
cellular response to angiotensin  (IEP)
cellular response to hypoxia  (IEP)
cellular response to norepinephrine stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
chemotaxis  (IDA)
chondroblast differentiation  (ISO)
chorio-allantoic fusion  (ISO)
extracellular matrix organization  (ISO)
intussusceptive angiogenesis  (ISO)
labyrinthine layer blood vessel development  (ISO)
negative regulation of apoptotic process  (ISO)
osteoblast differentiation  (ISO)
positive regulation of angiogenesis  (TAS)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of cartilage development  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (IEA,ISO,TAS)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of cellular senescence  (IEP)
positive regulation of ceramide biosynthetic process  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IMP)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of interleukin-17 production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
reactive oxygen species metabolic process  (ISO)
regulation of ERK1 and ERK2 cascade  (IEA,ISO)
signal transduction  (IEA)
ventricular septum development  (ISO)
wound healing, spreading of cells  (IEA,ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction. Chaqour B, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E765-74.
2. Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion. Cui S, etal., J Am Heart Assoc. 2018 Sep 18;7(18):e009111. doi: 10.1161/JAHA.118.009111.
3. Relationship between cellular communication network factor 1 (CCN1) and carotid atherosclerosis in patients with rheumatoid arthritis. Esaily HA, etal., Med J Malaysia. 2021 May;76(3):311-317.
4. Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes. Feng B, etal., Cardiovasc Diabetol. 2020 Nov 22;19(1):194. doi: 10.1186/s12933-020-01171-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Grzeszkiewicz TM, etal., Endocrinology 2002 Apr;143(4):1441-50.
8. Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation. Hilfiker-Kleiner D, etal., Circulation. 2004 May 11;109(18):2227-33. doi: 10.1161/01.CIR.0000127952.90508.9D. Epub 2004 Apr 26.
9. Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice. Hsu PL and Mo FE, Oncotarget. 2016 Jun 14;7(24):36698-36710. doi: 10.18632/oncotarget.9162.
10. Extracellular matrix protein CCN1 regulates cardiomyocyte apoptosis in mice with stress-induced cardiac injury. Hsu PL, etal., Cardiovasc Res. 2013 Apr 1;98(1):64-72. doi: 10.1093/cvr/cvt001. Epub 2013 Jan 16.
11. Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis. Hsu PL, etal., Circulation. 2019 Jun 18;139(25):2877-2891. doi: 10.1161/CIRCULATIONAHA.118.033895. Epub 2019 Mar 28.
12. DDR2-CYR61-MMP1 Signaling Pathway Promotes Bone Erosion in Rheumatoid Arthritis Through Regulating Migration and Invasion of Fibroblast-Like Synoviocytes. Huang TL, etal., J Bone Miner Res. 2017 Feb;32(2):407-418. doi: 10.1002/jbmr.2993. Epub 2016 Nov 3.
13. CYR61/CCN1 overexpression in the myeloma microenvironment is associated with superior survival and reduced bone disease. Johnson SK, etal., Blood. 2014 Sep 25;124(13):2051-60. doi: 10.1182/blood-2014-02-555813. Epub 2014 Jul 24.
14. Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. Kim KH, etal., J Biol Chem 2003 Apr 18;278(16):13847-54.
15. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
16. Association between CCN1 gene polymorphism and acute coronary syndrome in Chinese Han and Uygur populations. Li YH, etal., Hereditas. 2021 Apr 27;158(1):16. doi: 10.1186/s41065-021-00180-2.
17. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
18. CYR61/CCN1 stimulates proliferation and differentiation of osteoblasts in vitro and contributes to bone remodeling in vivo in myeloma bone disease. Liu H, etal., Int J Oncol. 2017 Feb;50(2):631-639. doi: 10.3892/ijo.2016.3815. Epub 2016 Dec 22.
19. CCN family member 1 (CCN1) is an early marker of infarct size and left ventricular dysfunction in STEMI patients. Mahendiran T, etal., Atherosclerosis. 2021 Oct;335:77-83. doi: 10.1016/j.atherosclerosis.2021.09.019. Epub 2021 Sep 17.
20. Determination of a potential role of the CCN family of growth regulators in connexin43 transfected C6 glioma cells. McLeod TL, etal., Cell Commun Adhes 2001;8(4-6):441-5.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. The matricellular protein CCN1 is essential for cardiac development. Mo FE and Lau LF, Circ Res. 2006 Oct 27;99(9):961-9. doi: 10.1161/01.RES.0000248426.35019.89. Epub 2006 Oct 5.
23. CYR61 (CCN1) is essential for placental development and vascular integrity. Mo FE, etal., Mol Cell Biol 2002 Dec;22(24):8709-20.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Induction of CCN1 in Growing Saccular Aneurysms: A Potential Marker Predicting Unstable Lesions. Shimizu K, etal., J Neuropathol Exp Neurol. 2021 Aug 11;80(7):695-704. doi: 10.1093/jnen/nlab037.
28. Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data. Sigala F, etal., Eur J Vasc Endovasc Surg. 2006 Sep;32(3):238-45. doi: 10.1016/j.ejvs.2006.01.026. Epub 2006 Jun 13.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. Up-regulation of cyr61 in vascular smooth muscle cells of spontaneously hypertensive rats. Unoki H, etal., Lab Invest 2003 Jul;83(7):973-82.
31. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
32. Hypoxia-Induced Cyr61/CCN1 Production in Infantile Hemangioma. Wu P, etal., Plast Reconstr Surg. 2021 Mar 1;147(3):412e-423e. doi: 10.1097/PRS.0000000000007672.
33. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Xie D, etal., Cancer Res. 2004 Mar 15;64(6):1987-96. doi: 10.1158/0008-5472.can-03-0666.
34. Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy. Zhang X, etal., Graefes Arch Clin Exp Ophthalmol. 2012 May;250(5):661-8. doi: 10.1007/s00417-011-1882-7. Epub 2011 Dec 13.
35. Prognostic Significance of Serum Cysteine-Rich Protein 61 in Patients with Acute Heart Failure. Zhao J, etal., Cell Physiol Biochem. 2018;48(3):1177-1187. doi: 10.1159/000491984. Epub 2018 Jul 25.
Additional References at PubMed
PMID:9441684   PMID:10852911   PMID:12707386   PMID:12826661   PMID:16581771   PMID:17234971   PMID:18004727   PMID:18187544   PMID:18388330   PMID:18755182   PMID:18757743   PMID:19364818  
PMID:19698122   PMID:20458273   PMID:20675382   PMID:20830586   PMID:21212405   PMID:22206666   PMID:22334618   PMID:23239110   PMID:23362279   PMID:23624342   PMID:23658023   PMID:23798676  
PMID:24006456   PMID:24196529   PMID:24487063   PMID:24631528   PMID:25106095   PMID:25446180   PMID:26515130   PMID:28824319   PMID:28898718   PMID:33827416   PMID:36199215   PMID:36527644  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22234,562,410 - 234,565,370 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,562,408 - 234,565,484 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,360,176 - 242,363,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,250,731 - 240,253,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,117,804 - 235,120,769 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,529,354 - 251,532,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,529,354 - 251,532,312 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,055,954 - 270,058,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42243,824,303 - 243,827,262 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12243,811,042 - 243,814,002 (-)NCBI
Celera2226,551,241 - 226,554,210 (-)NCBICelera
Cytogenetic Map2q44NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38185,580,761 - 85,583,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl185,580,761 - 85,584,589 (+)EnsemblGRCh38hg38GRCh38
GRCh37186,046,444 - 86,049,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,819,048 - 85,821,978 (+)NCBINCBI36Build 36hg18NCBI36
Build 34185,758,480 - 85,761,410NCBI
Celera184,290,551 - 84,293,757 (+)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef184,157,232 - 84,160,438 (+)NCBIHuRef
CHM1_1186,161,864 - 86,165,070 (+)NCBICHM1_1
T2T-CHM13v2.0185,421,570 - 85,424,759 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393145,352,726 - 145,355,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3145,352,731 - 145,355,736 (-)EnsemblGRCm39 Ensembl
GRCm383145,646,971 - 145,649,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,646,976 - 145,649,981 (-)EnsemblGRCm38mm10GRCm38
MGSCv373145,309,935 - 145,312,949 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363145,584,362 - 145,587,367 (-)NCBIMGSCv36mm8
Celera3152,099,713 - 152,102,726 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map370.18NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554238,413,725 - 8,419,166 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554238,416,498 - 8,419,029 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11140,504,343 - 140,507,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,138,739 - 118,141,681 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1186,994,296 - 86,997,147 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl186,994,296 - 86,997,147 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1662,443,285 - 62,446,246 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl662,443,675 - 62,445,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha665,092,607 - 65,095,413 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0662,984,109 - 62,986,915 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl662,984,096 - 62,986,819 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1662,514,247 - 62,517,060 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0662,482,278 - 62,484,463 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0662,986,500 - 62,989,314 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505896,150,919 - 96,153,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936608151,838 - 155,358 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936608152,174 - 155,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl4130,392,407 - 130,395,150 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14130,392,404 - 130,395,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24142,924,666 - 142,927,450 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12047,783,270 - 47,786,216 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2047,783,935 - 47,785,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603370,022,961 - 70,025,930 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474211,882,907 - 11,885,667 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474211,882,815 - 11,885,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ccn1
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:198
Interacting mature miRNAs:238
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,562,666 - 234,562,851 (+)MAPPERmRatBN7.2
Rnor_6.02251,529,611 - 251,529,793NCBIRnor6.0
Rnor_5.02270,056,211 - 270,056,393UniSTSRnor5.0
RGSC_v3.42243,824,560 - 243,824,743UniSTSRGSC3.4
Celera2226,551,498 - 226,551,691UniSTS
Cytogenetic Map2q44UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,562,562 - 234,562,689 (+)MAPPERmRatBN7.2
Rnor_6.02251,529,507 - 251,529,633NCBIRnor6.0
Rnor_5.02270,056,107 - 270,056,233UniSTSRnor5.0
RGSC_v3.42243,824,456 - 243,824,582UniSTSRGSC3.4
Celera2226,551,394 - 226,551,520UniSTS
Cytogenetic Map2q44UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 36 6 4 9 4 4 7 10 29 30 11 4
Low 2 7 51 37 10 37 4 4 64 6 11 4
Below cutoff


RefSeq Acc Id: ENSRNOT00000019501   ⟹   ENSRNOP00000019501
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2234,562,408 - 234,565,484 (-)Ensembl
Rnor_6.0 Ensembl2251,529,354 - 251,532,312 (-)Ensembl
RefSeq Acc Id: NM_031327   ⟹   NP_112617
Rat AssemblyChrPosition (strand)Source
mRatBN7.22234,562,410 - 234,565,370 (-)NCBI
Rnor_6.02251,529,354 - 251,532,312 (-)NCBI
Rnor_5.02270,055,954 - 270,058,912 (-)NCBI
RGSC_v3.42243,824,303 - 243,827,262 (-)RGD
Celera2226,551,241 - 226,554,210 (-)RGD
Protein Sequences
Protein RefSeqs NP_112617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG14964 (Get FASTA)   NCBI Sequence Viewer  
  AAH81689 (Get FASTA)   NCBI Sequence Viewer  
  BAA78339 (Get FASTA)   NCBI Sequence Viewer  
  EDL82406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019501.3
GenBank Protein Q9ES72 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112617   ⟸   NM_031327
- Peptide Label: precursor
- UniProtKB: Q9ES72 (UniProtKB/Swiss-Prot),   Q66HT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019501   ⟸   ENSRNOT00000019501
Protein Domains
CTCK   IGFBP N-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES72-F1-model_v2 AlphaFold Q9ES72 1-379 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691808
Promoter ID:EPDNEW_R2333
Type:multiple initiation site
Description:cysteine-rich, angiogenic inducer, 61
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02251,532,317 - 251,532,377EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620763 AgrOrtholog
BioCyc Gene G2FUF-50925 BioCyc
Ensembl Genes ENSRNOG00000014350 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019501.5 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_CNN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83476 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_CCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccn1 PhenoGen
PROSITE CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014350 RatGTEx
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CYR61_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-22 Ccn1  cellular communication network factor 1  Cyr61  cysteine-rich, angiogenic inducer, 61  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cyr61  cysteine-rich, angiogenic inducer, 61  Cyr61  cysteine rich protein 61  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cyr61  cysteine rich protein 61      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cyr61  cysteine rich protein 61      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increased protein levels are detected after balloon angioplasty 727633
gene_process induces angiogenesis 727633
gene_process induces vascular smooth muscle cell chemotaxis 727633