Gngt1 (G protein subunit gamma transducin 1) - Rat Genome Database

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Gene: Gngt1 (G protein subunit gamma transducin 1) Rattus norvegicus
Analyze
Symbol: Gngt1
Name: G protein subunit gamma transducin 1
RGD ID: 1595475
Description: Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in photoreceptor inner segment and photoreceptor outer segment. Part of heterotrimeric G-protein complex. Orthologous to human GNGT1 (G protein subunit gamma transducin 1); PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH bisphenol A; methoxychlor; 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; guanine nucleotide binding protein, gamma transducing activity polypeptide 1; guanine nucleotide-binding protein G(T) subunit gamma-T1; heterotrimeric guanine nucleotide-binding protein 3g1; Hg3g1; LOC680149; similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,960,945 - 32,963,930 (+)NCBIGRCr8
mRatBN7.2432,006,267 - 32,009,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl432,006,267 - 32,009,252 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx436,978,973 - 36,981,963 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,905,099 - 32,908,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0431,269,587 - 31,272,586 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,972,339 - 28,975,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,972,434 - 28,975,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0428,880,061 - 28,883,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4428,831,171 - 28,834,156 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera427,392,552 - 27,395,537 (+)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, etal., J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.
7. Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin. Seiler MJ, etal., Vision Res. 1999 Jul;39(15):2589-96.
8. Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. Sokolov M, etal., Neuron. 2002 Mar 28;34(1):95-106.
Additional References at PubMed
PMID:18367617  


Genomics

Comparative Map Data
Gngt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,960,945 - 32,963,930 (+)NCBIGRCr8
mRatBN7.2432,006,267 - 32,009,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl432,006,267 - 32,009,252 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx436,978,973 - 36,981,963 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,905,099 - 32,908,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0431,269,587 - 31,272,586 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,972,339 - 28,975,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,972,434 - 28,975,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0428,880,061 - 28,883,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4428,831,171 - 28,834,156 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera427,392,552 - 27,395,537 (+)NCBICelera
Cytogenetic Map4q13NCBI
GNGT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38793,906,567 - 93,911,265 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl793,591,573 - 93,911,265 (+)EnsemblGRCh38hg38GRCh38
GRCh37793,535,879 - 93,540,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36793,373,756 - 93,378,421 (+)NCBINCBI36Build 36hg18NCBI36
Build 34793,180,470 - 93,185,039NCBI
Celera788,234,120 - 88,238,785 (+)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef788,143,534 - 88,148,199 (+)NCBIHuRef
CHM1_1793,466,052 - 93,470,717 (+)NCBICHM1_1
T2T-CHM13v2.0795,143,218 - 95,147,911 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2792,864,986 - 92,869,650 (+)NCBI
Gngt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3963,989,082 - 3,997,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl63,993,792 - 3,997,436 (+)EnsemblGRCm39 Ensembl
GRCm3863,989,082 - 3,997,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl63,993,792 - 3,997,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv3763,944,012 - 3,947,436 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3663,944,012 - 3,947,436 (+)NCBIMGSCv36mm8
Celera64,140,623 - 4,144,045 (+)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.81NCBI
Gngt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543210,643,674 - 10,658,933 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543210,653,508 - 10,657,811 (+)NCBIChiLan1.0ChiLan1.0
GNGT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26111,743,081 - 111,747,788 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17160,007,723 - 160,012,430 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0785,839,639 - 85,859,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1799,446,623 - 99,451,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl799,446,623 - 99,451,185 (+)Ensemblpanpan1.1panPan2
GNGT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11419,081,676 - 19,420,261 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1419,415,510 - 19,420,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1418,975,305 - 18,979,836 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01418,894,814 - 19,234,730 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1419,213,599 - 19,234,733 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11419,382,144 - 19,386,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01419,117,968 - 19,122,498 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01419,375,285 - 19,379,818 (+)NCBIUU_Cfam_GSD_1.0
Gngt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511832,714,879 - 32,731,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680367,608 - 71,541 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493680367,933 - 71,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNGT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl973,403,740 - 73,719,161 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1973,403,647 - 73,717,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2980,665,797 - 80,677,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gngt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624813590,580 - 594,085 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624813579,173 - 594,039 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gngt1
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:89
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000014219
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 7 1
Below cutoff 9 9 2 9 1 21 2 8 1

Sequence


RefSeq Acc Id: ENSRNOT00000014219   ⟹   ENSRNOP00000014219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl432,006,267 - 32,009,252 (+)Ensembl
Rnor_6.0 Ensembl428,972,434 - 28,975,419 (+)Ensembl
RefSeq Acc Id: NM_001135777   ⟹   NP_001129249
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8432,960,945 - 32,963,930 (+)NCBI
mRatBN7.2432,006,267 - 32,009,252 (+)NCBI
Rnor_6.0428,972,434 - 28,975,419 (+)NCBI
Rnor_5.0428,880,061 - 28,883,215 (+)NCBI
RGSC_v3.4428,831,171 - 28,834,156 (+)RGD
Celera427,392,552 - 27,395,537 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001129249 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAG9553626 (Get FASTA)   NCBI Sequence Viewer  
  EDL84393 (Get FASTA)   NCBI Sequence Viewer  
  EDL84395 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014219
  ENSRNOP00000014219.4
RefSeq Acc Id: NP_001129249   ⟸   NM_001135777
- UniProtKB: D4AAI1 (UniProtKB/TrEMBL),   A6K2B2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014219   ⟸   ENSRNOT00000014219
Protein Domains
G protein gamma

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAI1-F1-model_v2 AlphaFold D4AAI1 1-74 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692855
Promoter ID:EPDNEW_R3379
Type:single initiation site
Name:Gngt1_1
Description:G protein subunit gamma transducin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0428,972,487 - 28,972,547EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595475 AgrOrtholog
BioCyc Gene G2FUF-45729 BioCyc
Ensembl Genes ENSRNOG00000010546 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014219 ENTREZGENE
  ENSRNOT00000014219.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.10 UniProtKB/TrEMBL
InterPro G-protein_gamma-like UniProtKB/TrEMBL
  GGL_sf UniProtKB/TrEMBL
  Gprotein-gamma UniProtKB/TrEMBL
KEGG Report rno:680149 UniProtKB/TrEMBL
NCBI Gene 680149 ENTREZGENE
PANTHER Gprotein-gamma UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT GAMMA-T1 UniProtKB/TrEMBL
Pfam G-gamma UniProtKB/TrEMBL
PhenoGen Gngt1 PhenoGen
PRINTS GPROTEING UniProtKB/TrEMBL
PROSITE G_PROTEIN_GAMMA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010546 RatGTEx
SMART G_gamma UniProtKB/TrEMBL
  GGL UniProtKB/TrEMBL
Superfamily-SCOP G-protein_gamma-like UniProtKB/TrEMBL
UniProt A6K2B2 ENTREZGENE, UniProtKB/TrEMBL
  D4AAI1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gngt1  G protein subunit gamma transducin 1  Gngt1  guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-22 Gngt1  guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1  LOC680149  similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680149  similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)  LOC683332  similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)  Data merged from RGD:1588037 1643240 APPROVED
2006-11-20 LOC680149  similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683332  similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)      Symbol and Name status set to provisional 70820 PROVISIONAL