Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) - Rat Genome Database
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Gene: Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Atp1a2
Name: ATPase Na+/K+ transporting subunit alpha 2
RGD ID: 2168
Description: Exhibits several functions, including ATP binding activity; protein heterodimerization activity; and sodium:potassium-exchanging ATPase activity. Predicted to contribute to ATPase activity; alkali metal ion binding activity; and drug binding activity. Involved in several processes, including cellular response to mechanical stimulus; monovalent inorganic cation transport; and negative regulation of calcium:sodium antiporter activity. Localizes to several cellular components, including T-tubule; intercalated disc; and sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Na+K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 2 polypeptide; na(+)/K(+) ATPase alpha(+) subunit; na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; RATATPA2; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp80  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
digoxin  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
losartan  (EXP)
lycopene  (ISO)
mechlorethamine  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylene blue  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
nickel atom  (ISO)
ouabain  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pioglitazone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium cyanide  (ISO)
sunitinib  (ISO)
tebuconazole  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetradecane  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tyrphostin AG 1478  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
amygdala development  (ISO)
ATP metabolic process  (ISO)
behavioral fear response  (ISO)
cardiac muscle contraction  (IC)
cation transmembrane transport  (ISO)
cellular potassium ion homeostasis  (IBA,ISO)
cellular response to mechanical stimulus  (IDA,IEP)
cellular response to steroid hormone stimulus  (IMP,ISO)
cellular sodium ion homeostasis  (IBA,ISO)
energy coupled proton transmembrane transport, against electrochemical gradient  (TAS)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
locomotion  (ISO)
locomotory exploration behavior  (ISO)
negative regulation of calcium ion transmembrane transport  (IMP)
negative regulation of calcium:sodium antiporter activity  (IMP)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of striated muscle contraction  (ISO)
neurotransmitter uptake  (ISO)
olfactory cortex development  (ISO)
potassium ion import across plasma membrane  (IBA,ISO)
potassium ion transmembrane transport  (ISO)
potassium ion transport  (IDA)
proton transmembrane transport  (IBA,IMP)
regulation of blood pressure  (ISO)
regulation of cardiac muscle cell contraction  (IMP)
regulation of cardiac muscle contraction by calcium ion signaling  (IC)
regulation of muscle contraction  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of smooth muscle contraction  (ISO)
regulation of striated muscle contraction  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of vasoconstriction  (ISO)
relaxation of cardiac muscle  (IC)
response to auditory stimulus  (ISO)
response to glycoside  (IMP,ISO)
response to nicotine  (IDA)
sodium ion export across plasma membrane  (IBA,ISO)
sodium ion transmembrane transport  (ISO)
sodium ion transport  (IDA)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
1. Adir Y, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1233-7. Epub 2008 Apr 18.
2. Baek M and Weiss M, J Pharmacol Exp Ther. 2005 May;313(2):731-9. Epub 2005 Jan 11.
3. Beguin P, etal., EMBO J 2002 Jul 1;21(13):3264-73.
4. Blanco G and Mercer RW, Am J Physiol. 1998 Nov;275(5 Pt 2):F633-50.
5. Chibalin AV, etal., PLoS One. 2012;7(3):e33719. Epub 2012 Mar 19.
6. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
7. Dostanic-Larson I, etal., Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15845-50. Epub 2005 Oct 21.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Glenn BS, etal., Am J Epidemiol. 2001 Mar 15;153(6):537-45.
10. Helwig B, etal., J Appl Physiol 2003 Jun;94(6):2225-36.
11. Kawakami K, etal., Obes Res. 2005 Oct;13(10):1661-71.
12. Lee YH, etal., Diabetologia. 2003 Nov;46(11):1567-75. Epub 2003 Oct 24.
13. Liu L and Askari A, Am J Physiol Cell Physiol. 2006 Oct;291(4):C569-78. Epub 2006 Apr 19.
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline
17. Pierre SV, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1066-74.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Pipeline to import SMPDB annotations from SMPDB into RGD
20. RGD automated data pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Scherer EB, etal., Mol Cell Biochem. 2013 Jun;378(1-2):91-7. doi: 10.1007/s11010-013-1598-6. Epub 2013 Mar 7.
24. Segall L, etal., J Biol Chem 2003 Mar 14;278(11):9027-34. Epub 2003 Jan 14.
25. Shull GE, etal., Biochemistry 1986 Dec 16;25(25):8125-32.
26. Stoica A, etal., Glia. 2017 Nov;65(11):1777-1793. doi: 10.1002/glia.23194. Epub 2017 Aug 8.
27. Swift F, etal., Cardiovasc Res. 2007 Jul 1;75(1):109-17. Epub 2007 Mar 24.
28. Tian G, etal., Hypertens Res. 2001 Nov;24(6):729-34.
29. Vanmolkot KR, etal., Ann Neurol 2003 Sep;54(3):360-6.
30. Yuan X, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):750-7. Epub 2006 Jul 31.
31. Yuan X, etal., J Cell Physiol. 2007 Aug;212(2):509-18.
Additional References at PubMed
PMID:2170235   PMID:8889548   PMID:9757068   PMID:10360172   PMID:10636900   PMID:11507009   PMID:12458206   PMID:12477932   PMID:12539047   PMID:12805306   PMID:14593108   PMID:14627611  
PMID:14742675   PMID:15253893   PMID:15327400   PMID:15485817   PMID:15489334   PMID:15528469   PMID:15564586   PMID:16037212   PMID:16292983   PMID:16524882   PMID:17008770   PMID:17234593  
PMID:17392375   PMID:17468335   PMID:17634366   PMID:18052210   PMID:18203708   PMID:18418421   PMID:18504258   PMID:18586859   PMID:18728015   PMID:19366873   PMID:19372756   PMID:19751721  
PMID:20100892   PMID:20595385   PMID:20936682   PMID:22871113   PMID:23045463   PMID:23954377   PMID:24218169   PMID:24356962   PMID:24769233   PMID:24903141   PMID:25002582   PMID:25274047  
PMID:25654120   PMID:25988879   PMID:26108663   PMID:26316108   PMID:26924456   PMID:29118027   PMID:29394489   PMID:29476059   PMID:29480968   PMID:30949686  


Genomics

Comparative Map Data
Atp1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
ATP1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1160,115,759 - 160,143,591 (+)EnsemblGRCh38hg38GRCh38
GRCh381160,115,759 - 160,143,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371160,085,520 - 160,113,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,352,172 - 158,380,005 (+)NCBINCBI36hg18NCBI36
Build 341156,898,620 - 156,926,445NCBI
Celera1133,154,306 - 133,182,156 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,442,647 - 131,470,507 (+)NCBIHuRef
CHM1_11161,480,881 - 161,508,729 (+)NCBICHM1_1
Atp1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,099,276 - 172,125,631 (-)NCBIGRCm39mm39
GRCm381172,271,709 - 172,298,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,271,709 - 172,298,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,201,840 - 174,228,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,108,384 - 174,134,739 (-)NCBImm8
Celera1175,123,792 - 175,151,771 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.6NCBI
Atp1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,898,915 - 11,922,400 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,898,786 - 11,924,341 (+)NCBIChiLan1.0ChiLan1.0
ATP1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,390,549 - 139,418,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,390,549 - 139,418,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,469,495 - 135,497,303 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101966570
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936740489,357 - 514,235 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,291,344 - 90,396,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,341,316 - 90,371,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,282,712 - 98,312,416 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1A2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,801,044 - 3,828,680 (-)NCBI
ChlSab1.1 Ensembl203,802,887 - 3,828,692 (-)Ensembl

Position Markers
D13Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,675,363 - 90,675,596NCBIRnor6.0
Rnor_5.01395,197,024 - 95,197,257UniSTSRnor5.0
RGSC_v3.41388,282,666 - 88,282,900RGDRGSC3.4
RGSC_v3.41388,282,667 - 88,282,900UniSTSRGSC3.4
RGSC_v3.11388,471,550 - 88,471,784RGD
Celera1384,363,343 - 84,363,576UniSTS
Cytogenetic Map13q24-q26UniSTS
FHH x ACI Map1341.61UniSTS
FHH x ACI Map1341.61RGD
D13Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,675,199 - 90,675,595NCBIRnor6.0
Rnor_5.01395,196,860 - 95,197,256UniSTSRnor5.0
RGSC_v3.41388,282,502 - 88,282,899RGDRGSC3.4
RGSC_v3.41388,282,503 - 88,282,899UniSTSRGSC3.4
RGSC_v3.11388,471,386 - 88,471,783RGD
Celera1384,363,179 - 84,363,575UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map13557.0UniSTS
RH 3.4 Map13557.0RGD
RH 2.0 Map13609.7RGD
D13Mgh14  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,677,404 - 90,677,641NCBIRnor6.0
Rnor_5.01395,199,065 - 95,199,302UniSTSRnor5.0
RGSC_v3.41388,284,707 - 88,284,945RGDRGSC3.4
RGSC_v3.41388,284,708 - 88,284,945UniSTSRGSC3.4
RGSC_v3.11388,473,591 - 88,473,829RGD
Celera1384,365,336 - 84,365,573UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map13556.9UniSTS
RH 3.4 Map13556.9RGD
RH 2.0 Map13609.6RGD
D13Arb13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,653,152 - 90,653,283NCBIRnor6.0
Rnor_5.01395,174,813 - 95,174,944UniSTSRnor5.0
RGSC_v3.41388,260,454 - 88,260,586RGDRGSC3.4
RGSC_v3.41388,260,455 - 88,260,586UniSTSRGSC3.4
RGSC_v3.11388,449,338 - 88,449,470RGD
Celera1384,341,132 - 84,341,263UniSTS
Cytogenetic Map13q24-q26UniSTS
FHH x ACI Map1340.5UniSTS
FHH x ACI Map1340.5RGD
D13Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,652,874 - 90,652,984NCBIRnor6.0
Rnor_5.01395,174,535 - 95,174,645UniSTSRnor5.0
RGSC_v3.41388,260,176 - 88,260,287RGDRGSC3.4
RGSC_v3.41388,260,177 - 88,260,287UniSTSRGSC3.4
RGSC_v3.11388,449,060 - 88,449,171RGD
Celera1384,340,854 - 84,340,964UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map13554.6RGD
RH 3.4 Map13554.6UniSTS
RH 2.0 Map13607.5RGD
D13Got72  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,659,615 - 90,659,868NCBIRnor6.0
Rnor_5.01395,181,276 - 95,181,529UniSTSRnor5.0
RGSC_v3.41388,266,917 - 88,267,171RGDRGSC3.4
RGSC_v3.41388,266,918 - 88,267,171UniSTSRGSC3.4
RGSC_v3.11388,455,802 - 88,456,055RGD
Celera1384,347,595 - 84,347,848UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map13553.4RGD
RH 3.4 Map13553.4UniSTS
RH 2.0 Map13609.0RGD
RH127315  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,651,819 - 90,652,026NCBIRnor6.0
Rnor_5.01395,173,480 - 95,173,687UniSTSRnor5.0
RGSC_v3.41388,259,122 - 88,259,329UniSTSRGSC3.4
Celera1384,339,799 - 84,340,006UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map13553.5UniSTS
Atp1a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,654,800 - 90,655,070NCBIRnor6.0
Rnor_5.01395,176,461 - 95,176,731UniSTSRnor5.0
RGSC_v3.41388,262,103 - 88,262,373UniSTSRGSC3.4
Celera1384,342,780 - 84,343,050UniSTS
Cytogenetic Map13q24-q26UniSTS
RH135069  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01390,653,504 - 90,654,788NCBIRnor6.0
Rnor_5.01395,175,165 - 95,176,449UniSTSRnor5.0
RGSC_v3.41388,260,807 - 88,262,091UniSTSRGSC3.4
Celera1384,341,484 - 84,342,768UniSTS
Cytogenetic Map13q24-q26UniSTS
RH 3.4 Map18713.9UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136500824591629354Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137456837892916783Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137456837892916783Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137456837892916783Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)138040355991629354Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)139065287492916783Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:169
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000058143
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 2 37 15 8 8 10 64 11 29 11 8
Low 1 6 22 21 11 21 10 24 12
Below cutoff 18 18 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058143   ⟹   ENSRNOP00000054947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)Ensembl
RefSeq Acc Id: NM_012505   ⟹   NP_036637
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,651,682 - 90,676,629 (-)NCBI
Rnor_5.01395,173,343 - 95,198,290 (-)NCBI
RGSC_v3.41388,258,993 - 88,283,918 (-)RGD
Celera1384,339,662 - 84,364,561 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036637 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40776 (Get FASTA)   NCBI Sequence Viewer  
  AAH85764 (Get FASTA)   NCBI Sequence Viewer  
  CAA07526 (Get FASTA)   NCBI Sequence Viewer  
  EDL94697 (Get FASTA)   NCBI Sequence Viewer  
  P06686 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036637   ⟸   NM_012505
- Peptide Label: precursor
- UniProtKB: P06686 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054947   ⟸   ENSRNOT00000058143

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699024
Promoter ID:EPDNEW_R9549
Type:single initiation site
Name:Atp1a2_1
Description:ATPase Na+/K+ transporting subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,676,623 - 90,676,683EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2168 AgrOrtholog
Ensembl Genes ENSRNOG00000007290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000054947 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058143 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190910 IMAGE-MGC_LOAD
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIC UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
KEGG Report rno:24212 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93650 IMAGE-MGC_LOAD
NCBI Gene 24212 ENTREZGENE
Pfam Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
PhenoGen Atp1a2 PhenoGen
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGRFAMs ATPase-IIC_X-K UniProtKB/Swiss-Prot
  ATPase_P-type UniProtKB/Swiss-Prot
UniGene Rn.1042 ENTREZGENE
  Rn.214222 ENTREZGENE
UniProt AT1A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1a2  ATPase Na+/K+ transporting subunit alpha 2  Atp1a2  ATPase, Na+/K+ transporting, alpha 2 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Atp1a2  ATPase, Na+/K+ transporting, alpha 2 polypeptide    ATPase, Na+K+ transporting, alpha 2  Name updated 1299863 APPROVED
2002-06-10 Atp1a2  ATPase, Na+K+ transporting, alpha 2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains central isoform-specific region (ISR) mediates PKC response but not K+ deocclusion 628463
gene_domains contains an ATP binding domain 1299865
gene_expression predominant in neural and muscle tissues  
gene_expression expressed in brain and kidney 1298554
gene_function catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ & K+ ions across the plasma membrane 628463
gene_process required for Na+ and K+ gradient maintenance across plasma membrane 628463
gene_process creates the electrochemical gradient of Na+ & K+, providing the energy for active transport of various nutrients 628463
gene_process mediates the ionic gradients across the plasma membrane 628463
gene_protein contains the binding sites for ions and substrates 628463