Gene: Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Rattus norvegicus
Analyze
Symbol:
Atp1a2
Name:
ATPase Na+/K+ transporting subunit alpha 2
Description:
Exhibits several functions, including ATP binding activity; protein heterodimerization activity; and sodium:potassium-exchanging ATPase activity. Predicted to contribute to ATPase activity; alkali metal ion binding activity; and drug binding activity. Involved in several processes, including cellular response to mechanical stimulus; monovalent inorganic cation transport; and negative regulation of calcium:sodium antiporter activity. Localizes to several cellular components, including T-tubule; intercalated disc; and sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
ATPase Na+K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 2 polypeptide; na(+)/K(+) ATPase alpha(+) subunit; na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; RATATPA2; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101966570 (sodium/potassium-transporting ATPase subunit alpha-2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoFinder|OrthoInspector|Hieranoid)
Homo sapiens (human):
ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoFinder|HGNC|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Atpalpha
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|PANTHER|OrthoFinder|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
eat-6
Alliance
DIOPT (InParanoid|PhylomeDB|OMA|PANTHER|OrthoFinder|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
ENA1
Alliance
DIOPT (OMA|Ensembl Compara)
Saccharomyces cerevisiae (baker's yeast):
ENA2
Alliance
DIOPT (OMA|Ensembl Compara)
Saccharomyces cerevisiae (baker's yeast):
ENA5
Alliance
DIOPT (OMA|Ensembl Compara)
Caenorhabditis elegans (roundworm):
catp-2
Alliance
DIOPT (OMA|Ensembl Compara|PANTHER)
Caenorhabditis elegans (roundworm):
catp-3
Alliance
DIOPT (OMA|Ensembl Compara|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
PMA2
Alliance
DIOPT (OMA|Ensembl Compara)
Saccharomyces cerevisiae (baker's yeast):
PMA1
Alliance
DIOPT (OMA|Ensembl Compara)
Is Marker For:
QTLs:
Bp80
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 13 90,651,682 - 90,676,629 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 90,651,686 - 90,676,629 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 13 95,173,343 - 95,198,290 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 88,258,993 - 88,283,918 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 88,447,876 - 88,472,802 (-) NCBI Celera 13 84,339,662 - 84,364,561 (-) NCBI Celera Cytogenetic Map 13 q24 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:26467025 , PMID:28492532 alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:15174025 more ... alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:18056581 , PMID:28492532 alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:25741868 alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:28492532 alternating hemiplegia of childhood ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood ClinVar PMID:25741868 , PMID:28492532 Alternating Hemiplegia of Childhood 1 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood 1 ClinVar PMID:25741868 , PMID:26467025 Alternating Hemiplegia of Childhood 1 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood 1 ClinVar PMID:14667076 more ... Alternating Hemiplegia of Childhood 1 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood 1 ClinVar PMID:11439943 more ... Alternating Hemiplegia of Childhood 1 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood 1 ClinVar PMID:25741868 , PMID:28492532 Alternating Hemiplegia of Childhood 1 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Alternating hemiplegia of childhood 1 ClinVar PMID:25741868 epilepsy ISO RGD:736008 8554872 ClinVar Annotator: match by term: Epilepsy ClinVar PMID:30690204 epilepsy ISO RGD:736008 8554872 ClinVar Annotator: match by term: Epilepsy ClinVar PMID:25741868 Familial Basilar Migraine ISO RGD:736008 8554872 ClinVar Annotator: match by null ClinVar PMID:16344534 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:1361034 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:28492532 , PMID:29062094 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:24396618 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:27226003 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:21352219 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:20837964 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:15174025 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:19874388 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:15174025 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:18513263 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:18414213 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:23954377 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:19874388 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:11439943 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:18056581 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:17473835 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:15159495 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:16088919 more ... familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:26467025 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:25741868 , PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:28492532 familial hemiplegic migraine ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine ClinVar PMID:25741868 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:25741868 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:25326635 , PMID:25741868 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:17473835 , PMID:28492532 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:15159495 , PMID:28492532 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:16088919 more ... familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:12953268 more ... familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:12953268 more ... familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:15159495 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:25138102 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:15133718 more ... familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:15459825 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:17877748 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:17473835 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by OMIM:602481 ClinVar PMID:12539047 familial hemiplegic migraine 2 ISO RGD:736008 8554872 ClinVar Annotator: match by term: Familial hemiplegic migraine type 2 ClinVar PMID:26467025 , PMID:28492532 Generalized Epilepsy ISO RGD:736008 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy ClinVar PMID:25741868 genetic disease ISO RGD:736008 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:1361034 more ... genetic disease ISO RGD:736008 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:1361034 more ... Polymicrogyria ISO RGD:736008 8554872 ClinVar Annotator: match by term: Polymicrogyria ClinVar PMID:25741868
Imported Annotations - CTD
alternating hemiplegia of childhood ISO RGD:736008 11554173 CTD Direct Evidence: marker/mechanism CTD familial hemiplegic migraine 2 ISO RGD:736008 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23954377 hypertension ISO RGD:736008 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16166162 , PMID:16243970 Imported Annotations - MGI
familial hemiplegic migraine ISS RGD:736008 13592920 OMIM:141500 more ... MouseDO Imported Annotations - OMIM
Alternating Hemiplegia of Childhood 1 ISO RGD:736008 7240710 OMIM familial hemiplegic migraine 2 ISO RGD:736008 7240710 OMIM
(S)-amphetamine decreases expression ISO RGD:10206 6480464 Dextroamphetamine results in decreased expression of ATP1A2 mRNA CTD PMID:12558987 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of ATP1A2 mRNA CTD PMID:30723492 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of ATP1A2 mRNA CTD PMID:15834898 more ... 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of ATP1A2 mRNA CTD PMID:20170705 , PMID:26865667 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of ATP1A2 mRNA CTD PMID:26945725 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736008 6480464 Tetrachlorodibenzodioxin results in increased expression of ATP1A2 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10206 6480464 Tetrachlorodibenzodioxin affects the expression of ATP1A2 mRNA CTD PMID:21570461 3,4-methylenedioxymethamphetamine increases expression ISO RGD:10206 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ATP1A2 mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:736008 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases expression ISO RGD:10206 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of ATP1A2 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide decreases expression ISO RGD:10206 6480464 Fenretinide results in decreased expression of ATP1A2 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:736008 6480464 Decitabine affects the expression of ATP1A2 mRNA CTD PMID:23300844 aflatoxin B1 affects expression ISO RGD:736008 6480464 Aflatoxin B1 affects the expression of ATP1A2 protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:736008 6480464 Aflatoxin B1 results in decreased methylation of ATP1A2 exon CTD PMID:30157460 aflatoxin B1 increases methylation ISO RGD:736008 6480464 Aflatoxin B1 results in increased methylation of ATP1A2 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:736008 6480464 Aflatoxin B1 results in decreased expression of ATP1A2 mRNA CTD PMID:22100608 all-trans-retinoic acid decreases expression ISO RGD:736008 6480464 Tretinoin results in decreased expression of ATP1A2 mRNA CTD PMID:21934132 amiodarone decreases expression EXP 6480464 Amiodarone results in decreased expression of ATP1A2 mRNA, Amiodarone results in decreased expression of ATP1A2 protein CTD PMID:12479229 more ... ammonia multiple interactions ISO RGD:10206 6480464 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3 more ... CTD PMID:20447429 ammonia increases expression ISO RGD:10206 6480464 Ammonia results in increased expression of ATP1A2 mRNA, Ammonia results in increased expression of ATP1A2 protein CTD PMID:20447429 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ATP1A2 mRNA CTD PMID:16483693 atrazine multiple interactions ISO RGD:10206 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A2 mRNA] CTD PMID:27112537 atrazine decreases expression ISO RGD:10206 6480464 Atrazine results in decreased expression of ATP1A2 mRNA CTD PMID:27112537 benzo[a]pyrene increases expression ISO RGD:736008 6480464 Benzo(a)pyrene results in increased expression of ATP1A2 mRNA CTD PMID:20106945 benzo[e]pyrene decreases methylation ISO RGD:736008 6480464 benzo(e)pyrene results in decreased methylation of ATP1A2 exon CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:736008 6480464 Diethylhexyl Phthalate results in decreased expression of ATP1A2 mRNA CTD PMID:31163220 bisphenol A affects expression ISO RGD:736008 6480464 bisphenol A affects the expression of ATP1A2 mRNA CTD PMID:20170705 bisphenol A increases expression ISO RGD:10206 6480464 bisphenol A results in increased expression of ATP1A2 mRNA CTD PMID:30951980 bisphenol A increases methylation ISO RGD:10206 6480464 bisphenol A results in increased methylation of ATP1A2 promoter CTD PMID:27312807 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ATP1A2 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol F increases expression ISO RGD:10206 6480464 bisphenol F results in increased expression of ATP1A2 mRNA CTD PMID:30951980 calcitriol increases expression ISO RGD:736008 6480464 Calcitriol results in increased expression of ATP1A2 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:736008 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ATP1A2 mRNA CTD PMID:21592394 carbamazepine affects expression ISO RGD:736008 6480464 Carbamazepine affects the expression of ATP1A2 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:10206 6480464 Nanotubes, Carbon analog results in decreased expression of ATP1A2 mRNA, Nanotubes, Carbon results in decreased expression of ATP1A2 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:10206 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA CTD PMID:20938992 cisplatin affects expression ISO RGD:736008 6480464 Cisplatin affects the expression of ATP1A2 mRNA CTD PMID:23300844 clothianidin decreases expression ISO RGD:736008 6480464 clothianidin results in decreased expression of ATP1A2 mRNA CTD PMID:29044138 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of ATP1A2 mRNA CTD PMID:24386269 copper atom increases expression EXP 6480464 Copper results in increased expression of ATP1A2 mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of ATP1A2 mRNA CTD PMID:30556269 copper(II) sulfate decreases expression ISO RGD:736008 6480464 Copper Sulfate results in decreased expression of ATP1A2 mRNA CTD PMID:19549813 daunorubicin decreases expression ISO RGD:736008 6480464 Daunorubicin results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 , PMID:28940058 dexamethasone multiple interactions ISO RGD:736008 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA CTD PMID:28628672 dibenz[a,h]anthracene increases expression ISO RGD:10206 6480464 1 more ... CTD PMID:26377693 dibutyl phthalate increases expression ISO RGD:10206 6480464 Dibutyl Phthalate results in increased expression of ATP1A2 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:10206 6480464 Dibutyl Phthalate results in decreased expression of ATP1A2 mRNA CTD PMID:21266533 dichloroacetic acid decreases expression ISO RGD:10206 6480464 Dichloroacetic Acid results in decreased expression of ATP1A2 mRNA CTD PMID:28962523 digoxin decreases expression EXP 6480464 Digoxin results in decreased expression of ATP1A2 mRNA CTD PMID:19687166 digoxin multiple interactions EXP 6480464 N-(2-methyl-4, 5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in decreased expression of ATP1A2 mRNA] CTD PMID:19687166 dimethyl sulfoxide increases expression EXP 6480464 Dimethyl Sulfoxide results in increased expression of ATP1A2 mRNA CTD PMID:22193206 dioxygen multiple interactions ISO RGD:10206 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ATP1A2 mRNA CTD PMID:30529165 diuron decreases expression EXP 6480464 Diuron results in decreased expression of ATP1A2 mRNA CTD PMID:25152437 dorsomorphin multiple interactions ISO RGD:736008 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:736008 6480464 Doxorubicin results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 more ... enalapril increases expression EXP 6480464 Enalapril results in increased expression of ATP1A2 mRNA, Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of ATP1A2 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:10206 6480464 Ethanol affects the expression of and affects the splicing of ATP1A2 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:10206 6480464 Ethanol results in increased expression of ATP1A2 mRNA CTD PMID:30319688 etoposide decreases expression ISO RGD:736008 6480464 Etoposide results in decreased expression of ATP1A2 mRNA CTD PMID:29397400 folic acid multiple interactions ISO RGD:10206 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA CTD PMID:20938992 gamma-tocopherol increases expression ISO RGD:10206 6480464 Tocopherols results in increased expression of ATP1A2 mRNA CTD PMID:17654050 genistein decreases expression ISO RGD:736008 6480464 Genistein results in decreased expression of ATP1A2 mRNA CTD PMID:26865667 indometacin multiple interactions ISO RGD:736008 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ATP1A2 mRNA CTD PMID:28628672 ketamine increases expression EXP 6480464 Ketamine results in increased expression of ATP1A2 mRNA CTD PMID:20080153 L-methionine multiple interactions ISO RGD:10206 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ATP1A2 mRNA CTD PMID:20938992 lithium atom multiple interactions ISO RGD:736008 6480464 Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] CTD PMID:19995221 lithium hydride multiple interactions ISO RGD:736008 6480464 Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] CTD PMID:19995221 losartan increases expression EXP 6480464 Losartan results in increased expression of ATP1A2 mRNA, Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 lycopene multiple interactions ISO RGD:10206 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A2 mRNA] CTD PMID:27112537 mechlorethamine decreases expression ISO RGD:10206 6480464 Mechlorethamine results in decreased expression of ATP1A2 mRNA CTD PMID:17107856 metformin decreases expression EXP 6480464 Metformin results in decreased expression of ATP1A2 mRNA CTD PMID:31324951 methapyrilene decreases methylation ISO RGD:736008 6480464 Methapyrilene results in decreased methylation of ATP1A2 exon CTD PMID:30157460 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of ATP1A2 mRNA CTD PMID:21782745 methylene blue multiple interactions ISO RGD:10206 6480464 Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 methylmercury chloride decreases expression ISO RGD:736008 6480464 methylmercuric chloride results in decreased expression of ATP1A2 mRNA CTD PMID:28001369 mitoxantrone decreases expression ISO RGD:736008 6480464 Mitoxantrone results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 , PMID:28940058 nickel atom decreases expression ISO RGD:736008 6480464 Nickel results in decreased expression of ATP1A2 mRNA CTD PMID:24768652 , PMID:25583101 ouabain multiple interactions ISO RGD:736008 6480464 Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] CTD PMID:19995221 ouabain increases expression EXP 6480464 Ouabain results in increased expression of ATP1A2 protein CTD PMID:16716361 , PMID:19897708 ouabain decreases expression EXP 6480464 Ouabain results in decreased expression of ATP1A2 mRNA CTD PMID:19687166 ouabain affects expression EXP 6480464 Ouabain affects the expression of ATP1A2 protein CTD PMID:11834625 ouabain multiple interactions EXP 6480464 N-(2-methyl-4, 5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA] CTD PMID:19687166 ouabain decreases activity ISO RGD:10206 6480464 Ouabain results in decreased activity of ATP1A2 protein CTD PMID:16166162 ouabain multiple interactions ISO RGD:10206 6480464 Ouabain binds to and results in decreased activity of ATP1A2 protein CTD PMID:18487447 ouabain affects response to substance ISO RGD:10206 6480464 ATP1A2 protein affects the susceptibility to Ouabain CTD PMID:15458945 , PMID:16166162 ouabain increases expression ISO RGD:736008 6480464 Ouabain results in increased expression of ATP1A2 mRNA CTD PMID:19995221 ouabain affects binding ISO RGD:736008 6480464 Ouabain binds to ATP1A2 protein CTD PMID:12479229 paracetamol decreases expression ISO RGD:736008 6480464 Acetaminophen results in decreased expression of ATP1A2 mRNA CTD PMID:29067470 paraquat affects expression EXP 6480464 Paraquat affects the expression of ATP1A2 mRNA CTD PMID:16854511 paraquat increases expression EXP 6480464 Paraquat results in increased expression of ATP1A2 mRNA CTD PMID:18198484 paraquat decreases expression ISO RGD:10206 6480464 Paraquat results in decreased expression of ATP1A2 mRNA CTD PMID:21371552 paraquat increases expression ISO RGD:10206 6480464 Paraquat results in increased expression of ATP1A2 mRNA CTD PMID:21371552 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of ATP1A2 mRNA CTD PMID:17077588 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of ATP1A2 mRNA CTD PMID:16221955 phenobarbital affects expression ISO RGD:736008 6480464 Phenobarbital affects the expression of ATP1A2 mRNA CTD PMID:19159669 pioglitazone multiple interactions ISO RGD:10206 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ATP1A2 mRNA CTD PMID:27935865 propanal increases expression ISO RGD:736008 6480464 propionaldehyde results in increased expression of ATP1A2 mRNA CTD PMID:26079696 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of ATP1A2 mRNA CTD PMID:28970091 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of ATP1A2 mRNA CTD PMID:27900601 , PMID:28374803 SB 431542 multiple interactions ISO RGD:736008 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA CTD PMID:27188386 sodium cyanide multiple interactions ISO RGD:10206 6480464 [Sodium Cyanide results in increased activity of PRKCE protein] which results in increased phosphorylation of ATP1A2 protein, Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 sodium cyanide increases phosphorylation ISO RGD:10206 6480464 Sodium Cyanide results in increased phosphorylation of ATP1A2 protein CTD PMID:31173149 sunitinib decreases expression ISO RGD:736008 6480464 Sunitinib results in decreased expression of ATP1A2 mRNA CTD PMID:31533062 tebuconazole increases expression EXP 6480464 tebuconazole results in increased expression of ATP1A2 mRNA CTD PMID:28970091 testosterone multiple interactions ISO RGD:736008 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ATP1A2 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:736008 6480464 Testosterone results in increased expression of ATP1A2 mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of ATP1A2 mRNA CTD PMID:12832660 tetradecane decreases expression EXP 6480464 n-tetradecane results in decreased expression of ATP1A2 protein CTD PMID:17337753 titanium dioxide decreases expression ISO RGD:10206 6480464 titanium dioxide results in decreased expression of ATP1A2 mRNA CTD PMID:23557971 tocopherol increases expression ISO RGD:10206 6480464 Tocopherols results in increased expression of ATP1A2 mRNA CTD PMID:17654050 trichostatin A increases expression ISO RGD:736008 6480464 trichostatin A results in increased expression of ATP1A2 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:736008 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP1A2 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:736008 6480464 Triclosan results in decreased expression of ATP1A2 mRNA CTD PMID:30510588 trimellitic anhydride decreases expression ISO RGD:10206 6480464 trimellitic anhydride results in decreased expression of ATP1A2 mRNA CTD PMID:19042947 tyrphostin AG 1478 multiple interactions ISO RGD:10206 6480464 RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA], RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein] CTD PMID:20447429 undecane increases expression EXP 6480464 undecane results in increased expression of ATP1A2 protein CTD PMID:17337753 valproic acid decreases expression ISO RGD:736008 6480464 Valproic Acid results in decreased expression of ATP1A2 mRNA CTD PMID:23179753 more ... valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ATP1A2 mRNA CTD PMID:29427782 valproic acid increases expression ISO RGD:736008 6480464 Valproic Acid results in increased expression of ATP1A2 mRNA CTD PMID:24935251 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of ATP1A2 mRNA CTD PMID:23034163 XL147 multiple interactions ISO RGD:10206 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ATP1A2 mRNA CTD PMID:27935865
Biological Process adult locomotory behavior ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:3696486 , PMID:17234593) RGD MGI:MGI:3696486 , PMID:17234593 amygdala development ISO RGD:10206 1624291 (MGI:MGI:2664023, PMID:12805306) RGD MGI:MGI:2664023 , PMID:12805306 ATP metabolic process ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 behavioral fear response ISO RGD:10206 1624291 (MGI:MGI:2664023, PMID:12805306) RGD MGI:MGI:2664023 , PMID:12805306 cardiac muscle contraction IC GO:1903170 6903343 PMID:17442282 BHF-UCL cation transmembrane transport ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:19372756), (PMID:20100892) RGD PMID:19372756 , PMID:20100892 cellular potassium ion homeostasis ISO RGD:736008 1624291 (PMID:10636900) RGD PMID:10636900 cellular potassium ion homeostasis IBA PANTHER:PTN000643123 more ... 13792537 PMID:21873635 GO_Central cellular response to mechanical stimulus IDA 6903221 RGD cellular response to mechanical stimulus IEP 1581763 RGD cellular response to steroid hormone stimulus ISO RGD:736008 1624291 (PMID:14742675) RGD PMID:14742675 cellular response to steroid hormone stimulus IMP 6903343 PMID:17442282 BHF-UCL cellular response to steroid hormone stimulus ISO RGD:10206 1624291 (MGI:MGI:3608241, PMID:16243970) RGD MGI:MGI:3608241 , PMID:16243970 cellular sodium ion homeostasis ISO RGD:736008 1624291 (PMID:10636900) RGD PMID:10636900 cellular sodium ion homeostasis IBA MGI:MGI:88107 more ... 13792537 PMID:21873635 GO_Central energy coupled proton transmembrane transport, against electrochemical gradient TAS 727361 RGD establishment or maintenance of transmembrane electrochemical gradient IEA GO:0005391 1600115 GO_REF:0000108 GOC GO_REF:0000108 locomotion ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:2450206 , PMID:12458206) RGD MGI:MGI:2450206 , PMID:12458206 locomotory exploration behavior ISO RGD:10206 1624291 (MGI:MGI:6368078, PMID:20936682) RGD MGI:MGI:6368078 , PMID:20936682 negative regulation of calcium ion transmembrane transport IMP 6903343 PMID:17442282 BHF-UCL negative regulation of calcium:sodium antiporter activity IMP 6903343 PMID:17442282 BHF-UCL negative regulation of cytosolic calcium ion concentration ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:1337471 , PMID:10360172) RGD MGI:MGI:1337471 , PMID:10360172 negative regulation of heart contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:1337471 , PMID:10360172) RGD MGI:MGI:1337471 , PMID:10360172 negative regulation of striated muscle contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:3688972 , PMID:11507009) RGD MGI:MGI:3688972 , PMID:11507009 neurotransmitter uptake ISO RGD:10206 1624291 MGI:MGI:2664907 (MGI:MGI:2664023 , PMID:12805306) RGD MGI:MGI:2664023 , PMID:12805306 olfactory cortex development ISO RGD:10206 1624291 (MGI:MGI:2664023, PMID:12805306) RGD MGI:MGI:2664023 , PMID:12805306 potassium ion import across plasma membrane ISO RGD:736008 1624291 (PMID:10636900) RGD PMID:10636900 potassium ion import across plasma membrane IBA PANTHER:PTN000643123 more ... 13792537 PMID:21873635 GO_Central potassium ion transmembrane transport ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:18728015) RGD PMID:18728015 potassium ion transport IDA 631775 ; 2302992 RGD proton transmembrane transport IBA PANTHER:PTN000643123 , RGD:2168 13792537 PMID:21873635 GO_Central proton transmembrane transport IMP 1299865 RGD regulation of blood pressure ISO RGD:10206 1624291 MGI:MGI:97742 (MGI:MGI:3608241 , PMID:16243970) RGD MGI:MGI:3608241 , PMID:16243970 regulation of cardiac muscle cell contraction IMP 6903343 RGD regulation of cardiac muscle contraction by calcium ion signaling IC GO:1903170 6903343 PMID:17442282 BHF-UCL regulation of muscle contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:1337471 , PMID:10360172) RGD MGI:MGI:1337471 , PMID:10360172 regulation of respiratory gaseous exchange by nervous system process ISO RGD:10206 1624291 MGI:MGI:2451291 more ... RGD MGI:MGI:2450206 more ... regulation of smooth muscle contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:3525892 , PMID:14627611) RGD MGI:MGI:3525892 , PMID:14627611 regulation of striated muscle contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:3577656 , PMID:15253893) RGD MGI:MGI:3577656 , PMID:15253893 regulation of the force of heart contraction ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:1337471 , PMID:10360172) RGD MGI:MGI:1337471 , PMID:10360172 regulation of vasoconstriction ISO RGD:10206 1624291 MGI:MGI:2451291 more ... RGD MGI:MGI:3525892 , PMID:14627611 relaxation of cardiac muscle IC GO:1903170 6903343 PMID:17442282 BHF-UCL response to auditory stimulus ISO RGD:10206 1624291 (MGI:MGI:6368078, PMID:20936682) RGD MGI:MGI:6368078 , PMID:20936682 response to glycoside ISO RGD:10206 1624291 (MGI:MGI:3608241, PMID:16243970) RGD MGI:MGI:3608241 , PMID:16243970 response to glycoside IMP 6903343 PMID:17442282 BHF-UCL response to nicotine IDA 6903341 RGD sodium ion export across plasma membrane ISO RGD:736008 1624291 (PMID:10636900) RGD PMID:10636900 sodium ion export across plasma membrane IBA MGI:MGI:88107 more ... 13792537 PMID:21873635 GO_Central sodium ion transmembrane transport ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:18728015) RGD PMID:18728015 sodium ion transport IDA 631775 ; 2302992 RGD visual learning ISO RGD:10206 1624291 MGI:MGI:2451291 (MGI:MGI:3696486 , PMID:17234593) RGD MGI:MGI:3696486 , PMID:17234593 Cellular Component caveola IDA 2302992 RGD cell projection ISO RGD:10206 1624291 (MGI:MGI:2450206 more ... RGD MGI:MGI:2450206 more ... cytoplasm ISO RGD:736008 1624291 (PMID:12539047) RGD PMID:12539047 dendritic spine IDA 727361 RGD endosome IDA 1581763 RGD exocytic vesicle ISO RGD:12180621 1624291 (PMID:18504258) RGD PMID:18504258 intercalated disc IDA 6903343 PMID:17442282 BHF-UCL membrane ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 membrane IDA 14995309 PMID:28787093 ARUK-UCL neuron projection IDA 727361 RGD neuronal cell body ISO RGD:10206 1624291 (MGI:MGI:2450206 more ... RGD MGI:MGI:2450206 more ... organelle membrane ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:19751721) RGD PMID:19751721 plasma membrane ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:12539047), (PMID:19372756), (PMID:19751721) RGD PMID:12539047 more ... sarcolemma IDA 6903343 RGD sarcolemma ISO RGD:10206 1624291 (MGI:MGI:3525392 more ... RGD MGI:MGI:3525392 more ... sodium:potassium-exchanging ATPase complex IDA 2302992 ; 631775 RGD sodium:potassium-exchanging ATPase complex IDA 14995309 PMID:28787093 ARUK-UCL sodium:potassium-exchanging ATPase complex ISO RGD:736008 1624291 UniProtKB:P05027 (PMID:10636900), (PMID:18052210), (PMID:23954377) RGD PMID:10636900 more ... synapse IDA 727361 RGD T-tubule IDA 6903343 RGD T-tubule ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:19751721) RGD PMID:19751721 T-tubule ISO RGD:10206 1624291 (MGI:MGI:3610760, PMID:16292983) RGD MGI:MGI:3610760 , PMID:16292983 Molecular Function ATP binding contributes_to ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 ATP binding IMP 1299865 RGD ATPase activity contributes_to ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 ATPase-coupled cation transmembrane transporter activity ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:18728015), (PMID:19372756), (PMID:20100892) RGD PMID:18728015 more ... ATPase-coupled cation transmembrane transporter activity IMP 1299865 RGD chaperone binding ISO RGD:736008 1624291 UniProtKB:P05026 more ... RGD PMID:10636900 drug binding contributes_to ISO RGD:736008 1624291 CHEBI:472805 (PMID:23954377) RGD PMID:23954377 potassium ion binding contributes_to ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 protein binding ISO RGD:736008 1624291 UniProtKB:P05026 (PMID:23954377) RGD PMID:23954377 protein binding IPI RGD:620830 631775 RGD protein binding ISO RGD:10206 1624291 PR:P70414 more ... RGD MGI:MGI:3525392 more ... protein heterodimerization activity IPI UniProtKB:P13638 14995309 PMID:28787093 ARUK-UCL sodium ion binding contributes_to ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 sodium:potassium-exchanging ATPase activity IDA 2302992 RGD sodium:potassium-exchanging ATPase activity IBA FB:FBgn0002921 more ... 13792537 PMID:21873635 GO_Central sodium:potassium-exchanging ATPase activity ISO RGD:736008 1624291 UniProtKB:P05026 , UniProtKB:P05027 (PMID:10636900), (PMID:12539047), (PMID:18052210), (PMID:18728015), (PMID:20100892) RGD PMID:10636900 more ... sodium:potassium-exchanging ATPase activity contributes_to ISO RGD:736008 1624291 (PMID:23954377) RGD PMID:23954377 steroid hormone binding ISO RGD:736008 1624291 (PMID:14742675) RGD PMID:14742675 steroid hormone binding IDA 6903343 PMID:17442282 BHF-UCL
Gene-Chemical Interaction Annotations
