Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Atp1a2
Name: ATPase Na+/K+ transporting subunit alpha 2
Description: Exhibits ATP binding activity; sodium:potassium-exchanging ATPase activity; and steroid hormone binding activity. Predicted to contribute to ATPase activity; alkali metal ion binding activity; and drug binding activity. Involved in several processes, including cellular response to mechanical stimulus; monovalent inorganic cation transport; and negative regulation of calcium:sodium antiporter activity. Localizes to several cellular components, including the T-tubule; endosome; and sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Na+K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 2 polypeptide; na(+)/K(+) ATPase alpha(+) subunit; na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; RATATPA2; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
Orthologs:
Homo sapiens (human) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966570 (sodium/potassium-transporting ATPase subunit alpha-2)
Sus scrofa (pig) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
more info ...
Is Marker For: QTLs:   Bp80  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Atp1a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2168
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.