ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) - Rat Genome Database

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Gene: ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2) Pan paniscus
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Symbol: ATP1A2
Name: ATPase Na+/K+ transporting subunit alpha 2
RGD ID: 11848130
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); ATPase-coupled cation transmembrane transporter activity (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amygdala development (ortholog); ATP metabolic process (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 1 (ortholog); Benign Familial Infantile Seizures, 3 (ortholog); FOUND IN caveola (ortholog); cell projection (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sodium/potassium-transporting ATPase subunit alpha-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,390,549 - 139,418,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,390,549 - 139,418,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,469,495 - 135,497,303 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
amygdala development  (ISO)
ATP metabolic process  (ISO)
behavioral fear response  (ISO)
cation transmembrane transport  (ISO)
cellular potassium ion homeostasis  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular sodium ion homeostasis  (ISO)
locomotion  (ISO)
locomotory exploration behavior  (ISO)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of calcium:sodium antiporter activity  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of striated muscle contraction  (ISO)
neurotransmitter uptake  (ISO)
olfactory cortex development  (ISO)
potassium ion import across plasma membrane  (ISO)
potassium ion transmembrane transport  (ISO)
potassium ion transport  (ISO)
proton transmembrane transport  (ISO)
regulation of blood pressure  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of muscle contraction  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of smooth muscle contraction  (ISO)
regulation of striated muscle contraction  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of vasoconstriction  (ISO)
response to auditory stimulus  (ISO)
response to glycoside  (ISO)
response to nicotine  (ISO)
sodium ion export across plasma membrane  (ISO)
sodium ion transmembrane transport  (ISO)
sodium ion transport  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
ATP1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,390,549 - 139,418,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,390,549 - 139,418,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,469,495 - 135,497,303 (+)NCBIMhudiblu_PPA_v0panPan3
ATP1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1160,115,759 - 160,143,591 (+)EnsemblGRCh38hg38GRCh38
GRCh381160,115,759 - 160,143,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371160,085,549 - 160,113,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,352,172 - 158,380,005 (+)NCBINCBI36hg18NCBI36
Build 341156,898,620 - 156,926,445NCBI
Celera1133,154,306 - 133,182,156 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,442,647 - 131,470,507 (+)NCBIHuRef
CHM1_11161,480,881 - 161,508,729 (+)NCBICHM1_1
Atp1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,099,276 - 172,125,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,099,276 - 172,125,631 (-)Ensembl
GRCm381172,271,709 - 172,298,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,271,709 - 172,298,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,201,840 - 174,228,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,108,384 - 174,134,739 (-)NCBImm8
Celera1175,123,792 - 175,151,771 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.6NCBI
Atp1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,729,597 - 84,754,544 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1384,729,601 - 84,754,544 (-)Ensembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
Atp1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,898,915 - 11,922,400 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,898,786 - 11,924,341 (+)NCBIChiLan1.0ChiLan1.0
Atp1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,240,258 - 6,264,320 (+)NCBI
SpeTri2.0NW_004936740489,357 - 514,235 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,291,344 - 90,396,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,341,316 - 90,371,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,282,712 - 98,312,416 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,801,044 - 3,828,680 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl203,802,887 - 3,828,692 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660382,858,128 - 2,886,182 (-)NCBIVero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003811890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000045241   ⟹   ENSPPAP00000022431
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1139,390,549 - 139,418,303 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000045257   ⟹   ENSPPAP00000022447
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1139,395,579 - 139,416,051 (+)Ensembl
RefSeq Acc Id: XM_003811890   ⟹   XP_003811938
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11139,390,549 - 139,418,311 (+)NCBI
Mhudiblu_PPA_v01135,469,495 - 135,497,303 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003811938 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003811938   ⟸   XM_003811890
- Sequence:
RefSeq Acc Id: ENSPPAP00000022431   ⟸   ENSPPAT00000045241
RefSeq Acc Id: ENSPPAP00000022447   ⟸   ENSPPAT00000045257


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034264 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000022431 ENTREZGENE
NCBI Gene ATP1A2 ENTREZGENE