Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide) - Rat Genome Database

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Gene: Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide) Mus musculus
Symbol: Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
RGD ID: 10206
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; locomotory exploration behavior; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atp; Atpa-3; AW060654; mKIAA0778; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391172,099,276 - 172,125,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,099,276 - 172,125,631 (-)Ensembl
GRCm381172,271,709 - 172,298,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,271,709 - 172,298,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,201,840 - 174,228,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,108,384 - 174,134,739 (-)NCBImm8
Celera1175,123,792 - 175,151,771 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonia  (EXP)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
calcitriol  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
digoxin  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
Ethylenethiourea  (ISO)
etoposide  (ISO)
folic acid  (EXP)
gamma-tocopherol  (EXP)
genistein  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
losartan  (ISO)
lycopene  (EXP)
mancozeb  (ISO)
mechlorethamine  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylene blue  (EXP)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
nickel atom  (ISO)
ouabain  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium cyanide  (EXP)
sunitinib  (ISO)
tebuconazole  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (ISO)
titanium dioxide  (EXP)
tocopherol  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tyrphostin AG 1478  (EXP)
undecane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
amygdala development  (IMP)
ATP metabolic process  (ISO)
behavioral fear response  (IMP)
cation transmembrane transport  (ISO)
cellular potassium ion homeostasis  (IBA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to steroid hormone stimulus  (IDA,ISO)
cellular sodium ion homeostasis  (IBA,ISO)
establishment or maintenance of transmembrane electrochemical gradient  (IBA)
ion transport  (IEA)
locomotion  (IMP)
locomotory exploration behavior  (IMP)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of calcium:sodium antiporter activity  (ISO)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of heart contraction  (IMP)
negative regulation of striated muscle contraction  (IMP)
neurotransmitter uptake  (IMP)
olfactory cortex development  (IMP)
potassium ion import across plasma membrane  (IBA,ISO)
potassium ion transmembrane transport  (IBA,ISO)
potassium ion transport  (ISO)
proton transmembrane transport  (IBA,ISO)
regulation of blood pressure  (IGI)
regulation of cardiac muscle cell contraction  (ISO)
regulation of muscle contraction  (IMP)
regulation of respiratory gaseous exchange by nervous system process  (IMP)
regulation of smooth muscle contraction  (IMP)
regulation of striated muscle contraction  (IMP)
regulation of the force of heart contraction  (IMP)
regulation of vasoconstriction  (IGI,IMP)
response to auditory stimulus  (IMP)
response to glycoside  (IMP,ISO)
response to nicotine  (ISO)
sodium ion export across plasma membrane  (IBA,ISO)
sodium ion transmembrane transport  (IBA,ISO)
sodium ion transport  (ISO)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

References - curated
1. Adir Y, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1233-7. Epub 2008 Apr 18.
2. Baek M and Weiss M, J Pharmacol Exp Ther. 2005 May;313(2):731-9. Epub 2005 Jan 11.
3. Dostanic-Larson I, etal., Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15845-50. Epub 2005 Oct 21.
4. Eddleston J, etal., Genomics 1999 Mar 1;56(2):149-59.
5. Glenn BS, etal., Am J Epidemiol. 2001 Mar 15;153(6):537-45.
6. Herrera VL, etal., J Cell Biol 1987 Oct;105(4):1855-65.
7. James PF, etal., Mol Cell 1999 May;3(5):555-63.
8. Kawakami K, etal., Obes Res. 2005 Oct;13(10):1661-71.
9. Lee YH, etal., Diabetologia. 2003 Nov;46(11):1567-75. Epub 2003 Oct 24.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
13. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
14. OMIM Disease Annotation Pipeline
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Pipeline to import SMPDB annotations from SMPDB into RGD
17. RGD automated import pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Scherer EB, etal., Mol Cell Biochem. 2013 Jun;378(1-2):91-7. doi: 10.1007/s11010-013-1598-6. Epub 2013 Mar 7.
21. Tian G, etal., Hypertens Res. 2001 Nov;24(6):729-34.
22. Vanmolkot KR, etal., Ann Neurol 2003 Sep;54(3):360-6.
23. Yasue M, etal., Genomics 1992 Apr;12(4):659-64.
Additional References at PubMed
PMID:1301170   PMID:1693656   PMID:2574151   PMID:2591369   PMID:2842249   PMID:2885848   PMID:6324196   PMID:7573462   PMID:7797269   PMID:8203495   PMID:8288230   PMID:8747931  
PMID:8889548   PMID:9107685   PMID:9727067   PMID:9933565   PMID:10349636   PMID:10555956   PMID:10837135   PMID:10920231   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11401431  
PMID:11431695   PMID:11507009   PMID:11557593   PMID:11709546   PMID:12397396   PMID:12458206   PMID:12466851   PMID:12477932   PMID:12763872   PMID:12805306   PMID:12819125   PMID:14559919  
PMID:14610273   PMID:14627611   PMID:14681479   PMID:14730696   PMID:15253893   PMID:15458945   PMID:15485817   PMID:15489334   PMID:15564586   PMID:15781423   PMID:16141072   PMID:16141073  
PMID:16166162   PMID:16292983   PMID:16524882   PMID:16602821   PMID:16870707   PMID:16985003   PMID:17111813   PMID:17114649   PMID:17234593   PMID:17552883   PMID:17634366   PMID:17641813  
PMID:17674100   PMID:17690149   PMID:17911089   PMID:17947306   PMID:17989297   PMID:18044013   PMID:18192219   PMID:18287559   PMID:18487447   PMID:18799693   PMID:19196986   PMID:19244589  
PMID:19376779   PMID:19376809   PMID:19570895   PMID:19638348   PMID:20114047   PMID:20861386   PMID:20936682   PMID:20940714   PMID:20952666   PMID:21094218   PMID:21267068   PMID:21386911  
PMID:21491433   PMID:21632957   PMID:21731499   PMID:21849490   PMID:21856907   PMID:21856916   PMID:21873635   PMID:22258333   PMID:22696220   PMID:22739122   PMID:22916088   PMID:23192345  
PMID:23436327   PMID:23652595   PMID:24154525   PMID:24662047   PMID:24674304   PMID:24952961   PMID:25344630   PMID:26079812   PMID:26468207   PMID:26911348   PMID:26930384   PMID:26932671  
PMID:27097562   PMID:27624940   PMID:27814792   PMID:28378742   PMID:28489004   PMID:28634551   PMID:28787093   PMID:28886701   PMID:30446731   PMID:30457570   PMID:30562941   PMID:30819023  
PMID:30949686   PMID:31065682   PMID:32237043   PMID:32293933   PMID:32325033   PMID:32843655   PMID:33268780   PMID:33321071   PMID:33544780  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391172,099,276 - 172,125,631 (-)NCBIGRCm39mm39
GRCm39 Ensembl1172,099,276 - 172,125,631 (-)Ensembl
GRCm381172,271,709 - 172,298,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,271,709 - 172,298,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,201,840 - 174,228,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361174,108,384 - 174,134,739 (-)NCBImm8
Celera1175,123,792 - 175,151,771 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.6NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1160,115,759 - 160,143,591 (+)EnsemblGRCh38hg38GRCh38
GRCh381160,115,759 - 160,143,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371160,085,549 - 160,113,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,352,172 - 158,380,005 (+)NCBINCBI36hg18NCBI36
Build 341156,898,620 - 156,926,445NCBI
Celera1133,154,306 - 133,182,156 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,442,647 - 131,470,507 (+)NCBIHuRef
CHM1_11161,480,881 - 161,508,729 (+)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21384,729,597 - 84,754,544 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1384,729,601 - 84,754,544 (-)Ensembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495546811,898,915 - 11,922,400 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,898,786 - 11,924,341 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11139,390,549 - 139,418,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,390,549 - 139,418,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,469,495 - 135,497,303 (+)NCBIMhudiblu_PPA_v0panPan3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244050586,240,258 - 6,264,320 (+)NCBI
SpeTri2.0NW_004936740489,357 - 514,235 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl490,291,344 - 90,396,160 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,341,316 - 90,371,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,282,712 - 98,312,416 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1203,801,044 - 3,828,680 (-)NCBI
ChlSab1.1 Ensembl203,802,887 - 3,828,692 (-)Ensembl
Vero_WHO_p1.0NW_0236660382,858,128 - 2,886,182 (-)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,274,496 - 172,274,579UniSTSGRCm38
MGSCv371174,204,627 - 174,204,710UniSTSGRCm37
Celera1175,126,580 - 175,126,663UniSTS
Cytogenetic Map1H3UniSTS
cM Map194.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,275,969 - 172,276,205UniSTSGRCm38
MGSCv371174,206,100 - 174,206,336UniSTSGRCm37
Celera1175,128,048 - 175,128,284UniSTS
Cytogenetic Map1H3UniSTS
cM Map194.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,286,100 - 172,286,312UniSTSGRCm38
MGSCv371174,216,231 - 174,216,443UniSTSGRCm37
Celera1175,139,800 - 175,140,012UniSTS
Cytogenetic Map1H3UniSTS
cM Map194.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,275,112 - 172,275,334UniSTSGRCm38
MGSCv371174,205,243 - 174,205,465UniSTSGRCm37
Celera1175,127,182 - 175,127,406UniSTS
Cytogenetic Map1H3UniSTS
cM Map194.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381172,284,167 - 172,284,364UniSTSGRCm38
MGSCv371174,214,298 - 174,214,495UniSTSGRCm37
Celera1175,137,867 - 175,138,064UniSTS
Cytogenetic Map1H3UniSTS
cM Map194.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139774467173774646Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141405603175405702Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145317638179317756Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157628733191628870Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155893961189895041Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156774467189571420Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141405603175405702Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139774467173774646Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157628733191628870Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162317638194429220Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157628733191628870Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143457095177457233Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152211172186211344Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167730317195471971Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167730317195471971Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1168222387195471971Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139774467173774646Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112081092175641372Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159435007193435127Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9148047933182048047Mouse
1300837Vmbic1_mventral midbrain iron content 1 (mouse)Not determined1139624618173624738Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158641251192641372Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139774467173774646Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164315658190802075Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155888654189888802Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139774467173774646Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150317922188627115Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167730317195471971Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141405603175405702Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1156004198190004325Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144703778178704023Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139774467173774646Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171804480192998742Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157628733191628870Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139774467173774646Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157628733191628870Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150317922188627115Mouse
1301016Szs1_mseizure susceptibility 1 (mouse)Not determined1171051174174628870Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152211172186211344Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147249520183092234Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1172250913195471971Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152211172186211344Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155699229189699330Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157628733191628870Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150929168184929353Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167929168189571420Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1166092111195471971Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158641251192641372Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157628733191628870Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169211172177550021Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168481626195471971Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1156004198190004325Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170647303195471971Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156774467189571420Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142661973176662164Mouse
1301164Tir3c_mtrypansomiasis infection response 3c (mouse)Not determined1154804480188804689Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147249520189251027Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139624618173624738Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined156004198190004325Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152211172186211344Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1163149528186261999Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160285202194285317Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151358674185358833Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155888654189888802Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161373696195373830Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150317922188627115Mouse
4142119Bpq21_mblood pressure QTL 21 (mouse)Not determined1152211172186211344Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153681660175641372Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined152007542186007711Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155706491186261999Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152211172186211344Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171804480189571420Mouse
4142417Emrq1_memotional reactivity QTL 1 (mouse)Not determined171804480172888802Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1148047933182048047Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154582944188582944Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158641251192641372Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153848421187848536Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153885284187885284Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152919071186706423Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155698056189699966Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
10412205Bbaa30_mB.burgdorferi-associated arthritis 30 (mouse)Not determined1169211172174628870Mouse
4141878Qrr1_mQTL rich region on chromosome 1 (mouse)Not determined171051174175492500Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141267440175267586Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128800000181500000Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117600000180000000Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158641251192641372Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158641251192641372Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147391821181391821Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155888654189888802Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145250061179250061Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160269591194269591Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160269591194269591Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152305175186305175Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169310000179820000Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167758517191493284Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152305175186305175Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139774467173774646Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147391821181391821Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156774467176435127Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141405603175405702Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155175373189175373Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144621573178621573Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155175373189175373Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155175373189175373Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158641251192641372Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1156004198190004325Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1867
Count of miRNA genes:697
Interacting mature miRNAs:928
Transcripts:ENSMUST00000085913, ENSMUST00000097464, ENSMUST00000131751, ENSMUST00000137679
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Nucleotide Sequences
RefSeq Transcripts NM_178405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC074311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY780072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G42024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G42053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G42054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G42057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000085913   ⟹   ENSMUSP00000083077
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,099,276 - 172,125,631 (-)Ensembl
GRCm38.p6 Ensembl1172,271,709 - 172,298,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000097464   ⟹   ENSMUSP00000095072
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,105,650 - 172,125,631 (-)Ensembl
GRCm38.p6 Ensembl1172,278,083 - 172,298,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131751
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,102,110 - 172,125,631 (-)Ensembl
GRCm38.p6 Ensembl1172,274,543 - 172,298,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137679
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,111,876 - 172,125,631 (-)Ensembl
GRCm38.p6 Ensembl1172,284,309 - 172,298,064 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191781
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1172,103,485 - 172,104,045 (-)Ensembl
GRCm38.p6 Ensembl1172,275,918 - 172,276,478 (-)Ensembl
RefSeq Acc Id: NM_178405   ⟹   NP_848492
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391172,099,276 - 172,125,631 (-)NCBI
GRCm381172,271,709 - 172,298,064 (-)ENTREZGENE
MGSCv371174,201,840 - 174,228,195 (-)RGD
Celera1175,123,792 - 175,151,771 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_848492   ⟸   NM_178405
- UniProtKB: Q6PIE5 (UniProtKB/Swiss-Prot),   Q3UHK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000083077   ⟸   ENSMUST00000085913
RefSeq Acc Id: ENSMUSP00000095072   ⟸   ENSMUST00000097464
Protein Domains
Cation_ATPase_C   Cation_ATPase_N

RGD ID:6875750
Promoter ID:EPDNEW_M1326
Type:multiple initiation site
Description:Mus musculus ATPase, Na+/K+ transporting, alpha 2 polypeptide, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381172,297,999 - 172,298,059EPDNEW
RGD ID:6817392
Promoter ID:MM_KWN:2908
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   Lung
Transcripts:ENSMUST00000097464,   NM_178405,   OTTMUST00000051817,   OTTMUST00000051818
Mouse AssemblyChrPosition (strand)Source
MGSCv361174,227,706 - 174,228,472 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88106 AgrOrtholog
Ensembl Genes ENSMUSG00000007097 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000083077 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000095072 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085913 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000097464 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:98660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cation_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp1a2 PhenoGen
SMART Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATPase-IIC_X-K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AT1A2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q80UZ8 UniProtKB/Swiss-Prot