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Gene: Mlh1 (mutL homolog 1) Rattus norvegicus
Symbol: Mlh1
Name: mutL homolog 1
RGD ID: 620937
Description: Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in several processes, including cellular response to organic cyclic compound; response to hypoxia; and spermatogenesis. Localizes to synaptonemal complex. Used to study lung carcinoma. Human ortholog(s) of this gene implicated in Lynch syndrome; Muir-Torre syndrome; colorectal cancer; hereditary nonpolyposis colorectal cancer type 2; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide.
Type: protein-coding
Also known as: DNA mismatch repair protein Mlh1; mismatch repair protein; mismatch repair protein 1; mutL homolog 1 (E. coli); mutL homolog 1, colon cancer, nonpolyposis type 2; mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); mutL protein homolog 1
Homo sapiens (human) : MLH1 (mutL homolog 1)  HGNC  Alliance
Mus musculus (house mouse) : Mlh1 (mutL homolog 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlh1 (mutL homolog 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MLH1 (mutL homolog 1)
Canis lupus familiaris (dog) : MLH1 (mutL homolog 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlh1 (mutL homolog 1)
Sus scrofa (pig) : MLH1 (mutL homolog 1)
Chlorocebus sabaeus (African green monkey) : MLH1 (mutL homolog 1)
Heterocephalus glaber (naked mole-rat) : Mlh1 (mutL homolog 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08119,486,655 - 119,523,716 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,486,691 - 119,523,964 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,828,172 - 118,865,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,616,396 - 115,653,471 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,635,850 - 115,672,920 (-)NCBI
Celera8110,478,307 - 110,515,168 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)