Map2k7 (mitogen activated protein kinase kinase 7) - Rat Genome Database

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Gene: Map2k7 (mitogen activated protein kinase kinase 7) Rattus norvegicus
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Symbol: Map2k7
Name: mitogen activated protein kinase kinase 7
RGD ID: 1560043
Description: Enables several functions, including ATP binding activity; JUN kinase kinase activity; and magnesium ion binding activity. Involved in several processes, including MAPK cascade; cellular response to sorbitol; and positive regulation of JNK cascade. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK; JNKK 2; Jnkk2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; Mapkk7; MEK 7; Mek7; Mkk7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,389,032 - 7,398,377 (+)NCBIGRCr8
mRatBN7.2122,591,312 - 2,600,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,239,383 - 3,248,497 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,862,974 - 3,872,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,626,083 - 2,635,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,546,278 - 2,555,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,698,912 - 4,708,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,545,407 - 1,552,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,407,043 - 4,413,990 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-Chaconine  (ISO)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bufalin  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
deguelin  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
hydrogen peroxide  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
methamphetamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nitrates  (ISO)
obeticholic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phlorizin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
2. Combined high energy of extracorporeal shock wave and 5-FU effectively suppressed the proliferation and growth of tongue squamous cell carcinoma. Chang CL, etal., Biomed Pharmacother. 2021 Oct;142:112036. doi: 10.1016/j.biopha.2021.112036. Epub 2021 Aug 16.
3. Prognostic significance of autophagy-related genes within esophageal carcinoma. Chen C, etal., BMC Cancer. 2020 Aug 24;20(1):797. doi: 10.1186/s12885-020-07303-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
6. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
7. Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. Jia M, etal., Int J Cancer. 2017 Feb 15;140(4):807-817. doi: 10.1002/ijc.30508. Epub 2016 Nov 16.
8. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
9. Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region. Li CH, etal., J Neurochem. 2005 Apr;93(2):290-8.
10. JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. Liu J, etal., Nat Commun. 2019 May 14;10(1):2148. doi: 10.1038/s41467-019-09843-1.
11. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
12. An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer. Luo MS, etal., Medicine (Baltimore). 2020 Jul 24;99(30):e21163. doi: 10.1097/MD.0000000000021163.
13. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Pan J, etal., Neuroscience. 2005;131(1):147-59.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese. Qiu F, etal., PLoS Genet. 2016 Mar 30;12(3):e1005955. doi: 10.1371/journal.pgen.1005955. eCollection 2016 Mar.
18. A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. Ray D, etal., Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16391-16400. doi: 10.1073/pnas.2002499117. Epub 2020 Jun 29.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. Ruiz EJ, etal., JCI Insight. 2021 Jul 8;6(13). pii: e124985. doi: 10.1172/jci.insight.124985.
22. MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. Sakai H, etal., Cancer Sci. 2014 Apr;105(4):425-30. doi: 10.1111/cas.12380. Epub 2014 Mar 24.
23. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Schramek D, etal., Nat Genet. 2011 Mar;43(3):212-9. doi: 10.1038/ng.767. Epub 2011 Feb 13.
24. Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Trotter L, etal., Neurosci Lett. 2002 Mar 1;320(1-2):29-32.
25. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend DJ, etal., Cancer Res. 2005 Dec 1;65(23):10984-91.
26. Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. Vasilevskaya IA, etal., Mol Pharmacol. 2008 Jul;74(1):246-54. doi: 10.1124/mol.107.044644. Epub 2008 Apr 24.
27. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
28. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
29. POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. Xu Z, etal., EMBO J. 2003 Jan 15;22(2):252-61.
30. Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats. Zhang Q, etal., Life Sci. 2003 Nov 21;74(1):37-45.
31. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
Additional References at PubMed
PMID:9405446   PMID:9535930   PMID:9891090   PMID:11959862   PMID:14615289   PMID:14697235   PMID:20633641   PMID:21406225   PMID:21531765   PMID:22088537   PMID:25100604   PMID:26270349  
PMID:28111074  


Genomics

Comparative Map Data
Map2k7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,389,032 - 7,398,377 (+)NCBIGRCr8
mRatBN7.2122,591,312 - 2,600,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,239,383 - 3,248,497 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,862,974 - 3,872,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,626,083 - 2,635,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,546,278 - 2,555,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,698,912 - 4,708,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,545,407 - 1,552,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,407,043 - 4,413,990 (+)NCBICelera
Cytogenetic Map12p12NCBI
MAP2K7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,903,877 - 7,914,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,903,843 - 7,914,478 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,968,762 - 7,979,363 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,874,765 - 7,885,363 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,874,764 - 7,885,362NCBI
Celera197,839,967 - 7,850,565 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,639,009 - 7,649,623 (+)NCBIHuRef
CHM1_1197,968,237 - 7,978,836 (+)NCBICHM1_1
T2T-CHM13v2.0197,904,832 - 7,915,433 (+)NCBIT2T-CHM13v2.0
Map2k7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,288,740 - 4,297,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,288,865 - 4,301,423 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl84,288,740 - 4,297,897 (+)EnsemblGRCm39 Ensembl
GRCm3884,238,740 - 4,247,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,238,865 - 4,251,423 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl84,238,740 - 4,247,897 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,238,740 - 4,247,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,238,990 - 4,246,173 (+)NCBIMGSCv36mm8
Celera84,439,329 - 4,448,486 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.99NCBI
Map2k7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,352,638 - 1,361,598 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,352,638 - 1,361,598 (-)NCBIChiLan1.0ChiLan1.0
MAP2K7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,586,639 - 12,597,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,702,668 - 11,714,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,205,124 - 7,215,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,058,431 - 8,068,555 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,057,598 - 8,066,512 (+)Ensemblpanpan1.1panPan2
MAP2K7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,594,450 - 52,604,236 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,594,536 - 52,602,150 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,396,989 - 52,406,782 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,122,659 - 53,132,453 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,122,690 - 53,132,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,325,934 - 52,335,725 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,770,533 - 52,780,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,001,904 - 53,011,707 (+)NCBIUU_Cfam_GSD_1.0
Map2k7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,942,983 - 212,952,496 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,882,184 - 4,892,071 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,882,191 - 4,891,807 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,298,325 - 71,308,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,299,010 - 71,308,432 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,699,410 - 71,708,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,355,387 - 7,365,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,355,434 - 7,364,398 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081448,367 - 458,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828869,425 - 878,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828869,424 - 878,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k7
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000061821
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000061821   ⟹   ENSRNOP00000058535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,591,219 - 2,600,396 (+)Ensembl
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084460   ⟹   ENSRNOP00000072160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,591,478 - 2,604,222 (+)Ensembl
Rnor_6.0 Ensembl122,548,218 - 2,555,164 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104881   ⟹   ENSRNOP00000086269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,591,219 - 2,604,222 (+)Ensembl
RefSeq Acc Id: NM_001025425   ⟹   NP_001020596
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,267 - 7,398,377 (+)NCBI
mRatBN7.2122,591,424 - 2,600,534 (+)NCBI
Rnor_6.0122,548,218 - 2,555,164 (-)NCBI
Rnor_5.0124,698,912 - 4,708,078 (-)NCBI
RGSC_v3.4121,545,407 - 1,552,353 (-)RGD
Celera124,407,043 - 4,413,990 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401207   ⟹   NP_001388136
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,267 - 7,398,377 (+)NCBI
mRatBN7.2122,591,424 - 2,600,534 (+)NCBI
RefSeq Acc Id: XM_006248769   ⟹   XP_006248831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,032 - 7,398,377 (+)NCBI
mRatBN7.2122,591,312 - 2,600,534 (+)NCBI
Rnor_6.0122,546,278 - 2,555,310 (-)NCBI
Rnor_5.0124,698,912 - 4,708,078 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768985   ⟹   XP_008767207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,389,032 - 7,398,377 (+)NCBI
mRatBN7.2122,591,313 - 2,600,534 (+)NCBI
Rnor_6.0122,546,278 - 2,555,308 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001020596   ⟸   NM_001025425
- Peptide Label: isoform 1
- UniProtKB: Q4KSH7 (UniProtKB/Swiss-Prot),   A6KQ65 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248831   ⟸   XM_006248769
- Peptide Label: isoform X1
- UniProtKB: A6KQ62 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767207   ⟸   XM_008768985
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UMW0 (UniProtKB/TrEMBL),   A6KQ63 (UniProtKB/TrEMBL),   A6KQ61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072160   ⟸   ENSRNOT00000084460
Ensembl Acc Id: ENSRNOP00000058535   ⟸   ENSRNOT00000061821
Ensembl Acc Id: ENSRNOP00000086269   ⟸   ENSRNOT00000104881
RefSeq Acc Id: NP_001388136   ⟸   NM_001401207
- Peptide Label: isoform 2
- UniProtKB: A6KQ61 (UniProtKB/TrEMBL),   D3XAM6 (UniProtKB/TrEMBL),   A6KQ64 (UniProtKB/TrEMBL),   A0A0G2K2A1 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KSH7-F1-model_v2 AlphaFold Q4KSH7 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698383
Promoter ID:EPDNEW_R8907
Type:initiation region
Name:Map2k7_1
Description:mitogen activated protein kinase kinase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,555,234 - 2,555,294EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560043 AgrOrtholog
BioCyc Gene G2FUF-20352 BioCyc
Ensembl Genes ENSRNOG00000001047 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061821 ENTREZGENE
  ENSRNOT00000061821.4 UniProtKB/TrEMBL
  ENSRNOT00000084460 ENTREZGENE
  ENSRNOT00000084460.2 UniProtKB/TrEMBL
  ENSRNOT00000104881 ENTREZGENE
  ENSRNOT00000104881.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dual_spec_MAPK_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363855 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 363855 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAP2K7 RGD
PhenoGen Map2k7 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001047 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2A1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UMW0 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ61 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ62 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ63 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ64 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ65 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ66_RAT UniProtKB/TrEMBL
  A6KQ67_RAT UniProtKB/TrEMBL
  D3XAM6 ENTREZGENE
  MP2K7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3XAM6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Map2k7  mitogen activated protein kinase kinase 7      Symbol and Name status set to provisional 70820 PROVISIONAL