Plcg2 (phospholipase C, gamma 2) - Rat Genome Database

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Gene: Plcg2 (phospholipase C, gamma 2) Rattus norvegicus
Analyze
Symbol: Plcg2
Name: phospholipase C, gamma 2
RGD ID: 3348
Description: Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; response to ATP; and response to magnesium ion. Predicted to be located in several cellular components, including cytosol; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in ruffle membrane. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2); PARTICIPATES IN erythropoietin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; B cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-2; phospholipase C-gamma-2; phospholipase C-IV; PLC-gamma-2; PLC-IV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,456,196 - 62,592,684 (+)NCBIGRCr8
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1952,359,626 - 52,496,321 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,010,779 - 53,147,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,255,035 - 55,391,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
dehydroepiandrosterone  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
exemestane  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
Honokiol  (ISO)
ibrutinib  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury(1+)  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
starch  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of store-operated calcium channel activity  (ISO)
antifungal innate immune response  (IEA,ISO)
B cell activation  (ISO)
B cell differentiation  (ISO)
B cell receptor signaling pathway  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO)
cell activation  (ISO)
cellular response to calcium ion  (IEA,ISO)
cellular response to lectin  (ISO)
cellular response to lipid  (ISO)
follicular B cell differentiation  (IEA,ISO)
inositol trisphosphate biosynthetic process  (IEA,ISO)
intracellular signal transduction  (IMP,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
macrophage activation involved in immune response  (IEA,ISO)
negative regulation of programmed cell death  (IEA,ISO)
phosphatidylinositol biosynthetic process  (IEA,ISO,ISS)
phosphatidylinositol metabolic process  (IBA)
phosphatidylinositol-mediated signaling  (IBA)
phospholipid catabolic process  (IEA)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cell cycle G1/S phase transition  (IDA)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dendritic cell cytokine production  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IMP,ISO)
positive regulation of epithelial cell migration  (IBA)
positive regulation of gene expression  (IMP,ISO)
positive regulation of I-kappaB phosphorylation  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage cytokine production  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of neuroinflammatory response  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phagocytosis, engulfment  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of receptor internalization  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type I interferon production  (IEA,ISO)
programmed cell death  (IEA,ISO)
regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of lipid metabolic process  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO,ISS)
response to ATP  (IDA)
response to axon injury  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to magnesium ion  (IDA)
response to yeast  (IEA,ISO)
stimulatory C-type lectin receptor signaling pathway  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
toll-like receptor signaling pathway  (IEA,ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
intracellular vesicle  (IEA,ISO)
membrane raft  (IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (ISO,ISS,TAS)
ruffle membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Translocation of phospholipase C-gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates. Atkinson TP and Yang Q, Cell Signal. 1996 Sep;8(6):461-5.
2. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. Emori Y, etal., J Biol Chem 1989 Dec 25;264(36):21885-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. PLCG2 promotes hepatocyte proliferation in vitro via NF-κB and ERK pathway by targeting bcl2, myc and ccnd1. Ma D, etal., Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3786-3792. doi: 10.1080/21691401.2019.1669616.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Wang D, etal., Immunity 2000 Jul;13(1):25-35.
18. Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling. Watanabe D, etal., J Biol Chem. 2001 Oct 19;276(42):38595-601. Epub 2001 Aug 15.
Additional References at PubMed
PMID:8615781   PMID:9013981   PMID:10925250   PMID:11606584   PMID:12181444   PMID:12928432   PMID:15611229   PMID:15728238   PMID:20458337   PMID:20624904   PMID:22078883   PMID:27323081  
PMID:29236324   PMID:29430764  


Genomics

Comparative Map Data
Plcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,456,196 - 62,592,684 (+)NCBIGRCr8
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1952,359,626 - 52,496,321 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01953,010,779 - 53,147,507 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01955,255,035 - 55,391,742 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
PLCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,779,291 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,779,279 - 81,962,685 (+)EnsemblGRCh38hg38GRCh38
GRCh371681,812,896 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBINCBI36Build 36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBICelera
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,253 - 83,403,260 (+)NCBICHM1_1
T2T-CHM13v2.01687,843,143 - 88,026,424 (+)NCBIT2T-CHM13v2.0
Plcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)EnsemblGRCm39 Ensembl
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBIMGSCv36mm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map862.0NCBI
Plcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555224,358,233 - 4,468,986 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555224,352,890 - 4,480,735 (+)NCBIChiLan1.0ChiLan1.0
PLCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21891,495,290 - 91,707,727 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11697,414,824 - 97,627,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,812,581 - 81,984,067 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensemblpanpan1.1panPan2
PLCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,054,683 - 70,233,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,059,255 - 70,207,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,073,218 - 70,247,127 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0570,363,993 - 70,538,197 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,363,980 - 70,511,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,306,712 - 70,480,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,142,563 - 70,316,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0570,619,680 - 70,793,735 (-)NCBIUU_Cfam_GSD_1.0
Plcg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647529,248,516 - 29,377,206 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,433,153 - 6,603,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.166,433,146 - 6,603,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,994,243 - 7,071,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1567,209,268 - 67,394,865 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl567,215,459 - 67,398,990 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660478,436,871 - 8,625,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247465,682,666 - 5,821,855 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247465,678,057 - 5,824,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcg2
850 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:109
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000018678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat

Markers in Region
RH94702  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21945,683,678 - 45,683,877 (+)MAPPERmRatBN7.2
Rnor_6.01950,173,292 - 50,173,490NCBIRnor6.0
Rnor_5.01960,962,390 - 60,962,588UniSTSRnor5.0
RGSC_v3.41947,875,625 - 47,875,823UniSTSRGSC3.4
Celera1944,954,653 - 44,954,851UniSTS
RH 3.4 Map19609.8UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 38 18 57 18 9 34
Low 9 123 177 125 12 125 36 33 236 115 136 23 24
Below cutoff 18

Sequence


Ensembl Acc Id: ENSRNOT00000090165   ⟹   ENSRNOP00000069801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)Ensembl
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)Ensembl
RefSeq Acc Id: NM_017168   ⟹   NP_058864
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81962,456,196 - 62,592,684 (+)NCBI
mRatBN7.21945,547,416 - 45,683,930 (+)NCBI
Rnor_6.01950,039,425 - 50,173,543 (+)NCBI
Rnor_5.01960,828,451 - 60,962,641 (+)NCBI
RGSC_v3.41947,875,572 - 47,947,573 (-)RGD
Celera1944,819,007 - 44,954,904 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097673   ⟹   XP_038953601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81962,493,734 - 62,592,668 (+)NCBI
mRatBN7.21945,584,957 - 45,683,915 (+)NCBI
RefSeq Acc Id: NP_058864   ⟸   NM_017168
- UniProtKB: P24135 (UniProtKB/Swiss-Prot),   A0A0G2JWA2 (UniProtKB/TrEMBL),   A6IZH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069801   ⟸   ENSRNOT00000090165
RefSeq Acc Id: XP_038953601   ⟸   XM_039097673
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWA2 (UniProtKB/TrEMBL),   A6IZH5 (UniProtKB/TrEMBL)
Protein Domains
C2   PH   PI-PLC X-box   PI-PLC Y-box   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24135-F1-model_v2 AlphaFold P24135 1-1265 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3348 AgrOrtholog
BioCyc Gene G2FUF-5544 BioCyc
Ensembl Genes ENSRNOG00000051986 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090165.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma_C-SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-gamma_N-SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCgamma2_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29337 UniProtKB/Swiss-Prot
NCBI Gene 29337 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PLCG2 RGD
PhenoGen Plcg2 PhenoGen
PIRSF PLC-gamma UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051986 RatGTEx
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202295
UniProt A0A0G2JWA2 ENTREZGENE, UniProtKB/TrEMBL
  A6IZH5 ENTREZGENE, UniProtKB/TrEMBL
  P24135 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Plcg2  phospholipase C, gamma 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in several tissues with high expression in spleen 69934