Plcg2 (phospholipase C, gamma 2) - Rat Genome Database

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Gene: Plcg2 (phospholipase C, gamma 2) Mus musculus
Analyze
Symbol: Plcg2
Name: phospholipase C, gamma 2
RGD ID: 735444
MGI Page MGI
Description: Enables phosphatidylinositol phospholipase C activity and phosphorylation-dependent protein binding activity. Involved in several processes, including immune response-regulating signaling pathway; positive regulation of cytokine production; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including activation of store-operated calcium channel activity; follicular B cell differentiation; and regulation of calcium-mediated signaling. Located in cytosol. Is expressed in several structures, including alimentary system; bone; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2); PARTICIPATES IN erythropoietin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; B cell receptor signaling pathway; INTERACTS WITH (E)-thiamethoxam; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; MGC38590; phosphoinositide phospholipase C-gamma-2; phospholipase C-gamma-2; PLC-gamma-2; Plcg; Plcg-2; PLCga; PLCgamma2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBIGRCm39mm39
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)Ensembl
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIGRCm37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBImm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
3-methylcholanthrene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
C60 fullerene  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
dehydroepiandrosterone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
exemestane  (ISO)
folic acid  (ISO)
fonofos  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
Honokiol  (ISO)
ibrutinib  (ISO)
methapyrilene  (ISO)
methylmercury(1+)  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium fluoride  (EXP)
starch  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiamethoxam  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of store-operated calcium channel activity  (IMP)
antifungal innate immune response  (IMP)
B cell differentiation  (IMP)
B cell receptor signaling pathway  (IMP,ISO)
calcium-mediated signaling  (ISO)
cell activation  (IMP)
cellular response to calcium ion  (ISO)
cellular response to lectin  (IMP)
cellular response to lipid  (ISO)
follicular B cell differentiation  (IMP)
inositol trisphosphate biosynthetic process  (IDA)
intracellular signal transduction  (IMP,ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (IMP)
negative regulation of programmed cell death  (IMP)
phosphatidylinositol biosynthetic process  (ISO)
phospholipid catabolic process  (IEA)
positive regulation of calcium-mediated signaling  (IMP)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell cytokine production  (IMP)
positive regulation of DNA-binding transcription factor activity  (IMP,ISO)
positive regulation of epithelial cell migration  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB phosphorylation  (IMP)
positive regulation of interleukin-10 production  (IMP)
positive regulation of interleukin-12 production  (IMP)
positive regulation of interleukin-2 production  (IMP)
positive regulation of interleukin-23 production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of macrophage cytokine production  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of receptor internalization  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of type I interferon production  (IMP)
regulation of calcineurin-NFAT signaling cascade  (IMP)
regulation of gene expression  (IMP)
regulation of I-kappaB kinase/NF-kappaB signaling  (IMP)
regulation of lipid metabolic process  (ISO)
release of sequestered calcium ion into cytosol  (IMP,ISO)
response to ATP  (ISO)
response to axon injury  (ISO)
response to lipopolysaccharide  (IDA)
response to magnesium ion  (ISO)
response to yeast  (IMP)
signal transduction  (IEA)
stimulatory C-type lectin receptor signaling pathway  (IMP)
T cell receptor signaling pathway  (IDA)
toll-like receptor signaling pathway  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal calcium level  (IAGP)
abnormal dendritic cell chemotaxis  (IAGP)
abnormal dendritic cell morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal endocytosis  (IAGP)
abnormal foot pad morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal trabecular bone morphology  (IAGP)
arrested B cell differentiation  (IAGP)
chronic inflammation  (IAGP)
chylous ascites  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1a cell number  (IEA)
decreased B-2 B cell number  (IAGP)
decreased body size  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased follicular B cell number  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased mature B cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased platelet aggregation  (IAGP)
decreased pre-B cell number  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased transitional stage B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IEA)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
glomerulonephritis  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1a cell number  (IAGP)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased immature B cell number  (IAGP)
increased lymphoma incidence  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased transitional stage T2 B cell number  (IAGP)
internal hemorrhage  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
osteoarthritis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
References

Additional References at PubMed
PMID:2033248   PMID:7774933   PMID:7835906   PMID:8395016   PMID:8615781   PMID:8672127   PMID:8739298   PMID:8889548   PMID:9013981   PMID:9312046   PMID:9884330   PMID:10349636  
PMID:10744659   PMID:10922068   PMID:10925250   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11389024   PMID:12411320   PMID:12446777   PMID:12466851   PMID:12471105   PMID:12477932  
PMID:12520002   PMID:12729897   PMID:12813055   PMID:12832411   PMID:12913095   PMID:12928432   PMID:14610273   PMID:14676298   PMID:14681479   PMID:15048721   PMID:15102471   PMID:15259021  
PMID:15283702   PMID:15327970   PMID:15372077   PMID:15456756   PMID:15509800   PMID:15611229   PMID:15728238   PMID:15774906   PMID:15845450   PMID:15899577   PMID:15953601   PMID:15985541  
PMID:16002670   PMID:16141072   PMID:16141073   PMID:16204312   PMID:16249387   PMID:16254207   PMID:16354682   PMID:16585562   PMID:16670270   PMID:16798839   PMID:16889948   PMID:17015722  
PMID:17015726   PMID:17030619   PMID:17053833   PMID:17164342   PMID:17202334   PMID:17372989   PMID:17374738   PMID:17579183   PMID:17591700   PMID:17634444   PMID:17932569   PMID:18203684  
PMID:18233961   PMID:18362175   PMID:18378693   PMID:18464161   PMID:18704487   PMID:18728019   PMID:18799693   PMID:19056831   PMID:19136564   PMID:19273622   PMID:19273623   PMID:19404984  
PMID:19502585   PMID:19525933   PMID:19531496   PMID:19838179   PMID:20070863   PMID:20111715   PMID:20167705   PMID:20171124   PMID:20194721   PMID:20230420   PMID:20371769   PMID:20392227  
PMID:20457868   PMID:20719962   PMID:20872577   PMID:21267068   PMID:21305534   PMID:21308776   PMID:21480213   PMID:21506110   PMID:21602433   PMID:21623346   PMID:21873635   PMID:22041900  
PMID:22078883   PMID:22158869   PMID:22245675   PMID:22291096   PMID:22683124   PMID:22761313   PMID:22837484   PMID:24038146   PMID:24081142   PMID:24127488   PMID:24868545   PMID:24907343  
PMID:25053811   PMID:25793864   PMID:25979088   PMID:26410627   PMID:26644563   PMID:26777396   PMID:26950550   PMID:26966907   PMID:27032818   PMID:27045006   PMID:27609517   PMID:28378742  
PMID:28786489   PMID:29133930   PMID:30196744   PMID:30317660   PMID:30333137   PMID:30711010   PMID:30879886   PMID:32325033   PMID:32917267   PMID:32929010   PMID:34254352  


Genomics

Comparative Map Data
Plcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBIGRCm39mm39
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)Ensembl
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIGRCm37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBImm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.26NCBI
PLCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1681,739,097 - 81,962,685 (+)EnsemblGRCh38hg38GRCh38
GRCh381681,779,291 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371681,812,896 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBINCBI36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBI
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,253 - 83,403,260 (+)NCBICHM1_1
Plcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21945,547,416 - 45,683,930 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1945,547,416 - 45,683,930 (+)Ensembl
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
Celera1944,819,007 - 44,954,904 (+)NCBICelera
RH 3.4 Map19609.8RGD
Cytogenetic Map19q12NCBI
Plcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555224,358,233 - 4,468,986 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555224,352,890 - 4,480,735 (+)NCBIChiLan1.0ChiLan1.0
PLCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11681,812,581 - 81,984,067 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0panPan3
PLCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,054,683 - 70,233,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,059,255 - 70,207,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,073,218 - 70,247,127 (-)NCBI
ROS_Cfam_1.0570,363,993 - 70,538,197 (-)NCBI
UMICH_Zoey_3.1570,306,712 - 70,480,652 (-)NCBI
UNSW_CanFamBas_1.0570,142,563 - 70,316,489 (-)NCBI
UU_Cfam_GSD_1.0570,619,680 - 70,793,735 (-)NCBI
Plcg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,211,918 - 30,340,596 (-)NCBI
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,433,153 - 6,603,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.166,433,146 - 6,603,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,994,243 - 7,071,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1567,209,268 - 67,394,865 (+)NCBI
ChlSab1.1 Ensembl567,215,459 - 67,398,990 (+)Ensembl
Vero_WHO_p1.0NW_0236660478,436,871 - 8,625,803 (-)NCBI
Plcg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247465,678,057 - 5,824,663 (-)NCBI

Position Markers
D8Mit216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388117,608,477 - 117,608,587UniSTSGRCm38
MGSCv378120,132,377 - 120,132,487UniSTSGRCm37
Celera8121,829,313 - 121,829,423UniSTS
Cytogenetic Map8E1UniSTS
cM Map861.0UniSTS
Whitehead Genetic863.4UniSTS
D8Mit276  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388117,626,099 - 117,626,309UniSTSGRCm38
MGSCv378120,149,999 - 120,150,209UniSTSGRCm37
Celera8121,846,974 - 121,847,184UniSTS
Cytogenetic Map8E1UniSTS
cM Map862.0UniSTS
Whitehead Genetic864.5UniSTS
Plcg2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS
cM Map862.0UniSTS
cM Map862.0UniSTS
UniSTS:236018  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388117,607,004 - 117,607,083UniSTSGRCm38
MGSCv378120,130,904 - 120,130,983UniSTSGRCm37
Celera8121,827,840 - 121,827,919UniSTS
Cytogenetic Map8E1UniSTS
cM Map862.0UniSTS
Plcg2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS
cM Map862.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8109688333129401213Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8109688333129401213Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8110755016129401213Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8110755016129401213Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined113712788125329141Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:124
Interacting mature miRNAs:128
Transcripts:ENSMUST00000081232
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000081232   ⟹   ENSMUSP00000079991
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8118,225,030 - 118,361,881 (+)Ensembl
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)Ensembl
RefSeq Acc Id: NM_172285   ⟹   NP_758489
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398118,225,014 - 118,361,881 (+)NCBI
GRCm388117,498,275 - 117,635,142 (+)NCBI
MGSCv378120,022,191 - 120,159,042 (+)RGD
Celera8121,718,712 - 121,856,018 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_758489   ⟸   NM_172285
- UniProtKB: Q8CIH5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000079991   ⟸   ENSMUST00000081232
Protein Domains
C2   PH   PI-PLC X-box   PI-PLC Y-box   SH2   SH3

Promoters
RGD ID:8668393
Promoter ID:EPDNEW_M12227
Type:initiation region
Name:Plcg2_1
Description:Mus musculus phospholipase C, gamma 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388117,498,280 - 117,498,340EPDNEW
RGD ID:6843618
Promoter ID:MM_KWN:55875
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:ENSMUST00000081232
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368120,022,119 - 120,022,619 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97616 AgrOrtholog
Ensembl Genes ENSMUSG00000034330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000079991 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081232 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.20.20.190 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PI-PLC_fam UniProtKB/Swiss-Prot
  PLC-gamma UniProtKB/Swiss-Prot
  PLC-gamma2 UniProtKB/Swiss-Prot
  PLC-gamma_C-SH2 UniProtKB/Swiss-Prot
  PLC-gamma_N-SH2 UniProtKB/Swiss-Prot
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  PLCgamma2_SH3 UniProtKB/Swiss-Prot
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:234779 UniProtKB/Swiss-Prot
MGD MGI:97616 ENTREZGENE
NCBI Gene 234779 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot
  PTHR10336:SF25 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
  PI-PLC-X UniProtKB/Swiss-Prot
  PI-PLC-Y UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PharmGKB PLCG2 RGD
PhenoGen Plcg2 PhenoGen
PIRSF PLC-gamma UniProtKB/Swiss-Prot
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot
  SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART PLCXc UniProtKB/Swiss-Prot
  PLCYc UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
  SSF51695 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt PLCG2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3UBA8 UniProtKB/Swiss-Prot
  Q3UQT0 UniProtKB/Swiss-Prot
  Q8VE69 UniProtKB/Swiss-Prot