PLCG2 (phospholipase C gamma 2) - Rat Genome Database
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Gene: PLCG2 (phospholipase C gamma 2) Pan paniscus
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Symbol: PLCG2
Name: phospholipase C gamma 2
RGD ID: 11752023
Description: ENCODES a protein that exhibits phosphatidylinositol phospholipase C activity (ortholog); phosphorylation-dependent protein binding (ortholog); phosphotyrosine residue binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); B cell differentiation (ortholog); B cell receptor signaling pathway (ortholog); PARTICIPATES IN erythropoietin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Orthologs:
Homo sapiens (human) : PLCG2 (phospholipase C gamma 2)  HGNC  Alliance
Mus musculus (house mouse) : Plcg2 (phospholipase C, gamma 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plcg2 (phospholipase C, gamma 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcg2 (phospholipase C gamma 2)
Canis lupus familiaris (dog) : PLCG2 (phospholipase C gamma 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcg2 (phospholipase C gamma 2)
Sus scrofa (pig) : PLCG2 (phospholipase C gamma 2)
Chlorocebus sabaeus (African green monkey) : PLCG2 (phospholipase C gamma 2)
Heterocephalus glaber (naked mole-rat) : Plcg2 (phospholipase C gamma 2)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11681,812,581 - 81,984,067 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PLCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11681,812,581 - 81,984,067 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBIMhudiblu_PPA_v0panPan3
PLCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1681,739,097 - 81,962,685 (+)EnsemblGRCh38hg38GRCh38
GRCh381681,779,291 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371681,812,899 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBINCBI36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBI
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,217 - 83,407,660 (+)NCBICHM1_1
Plcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398118,225,014 - 118,361,881 (+)NCBI
GRCm388117,498,275 - 117,635,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,498,291 - 117,635,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv378120,022,191 - 120,159,042 (+)NCBIGRCm37mm9NCBIm37
MGSCv368120,384,268 - 120,521,119 (+)NCBImm8
Celera8121,718,712 - 121,856,018 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map864.26NCBI
Plcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01950,039,410 - 50,173,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1950,045,020 - 50,173,220 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,828,451 - 60,962,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,875,572 - 47,947,573 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11947,880,452 - 47,952,454 (-)NCBI
Celera1944,819,007 - 44,954,904 (+)NCBICelera
Cytogenetic Map19q12NCBI
RH 3.4 Map19609.8RGD
Plcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555224,358,233 - 4,468,986 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555224,352,890 - 4,480,735 (+)NCBIChiLan1.0ChiLan1.0
PLCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl570,059,255 - 70,207,049 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1570,054,683 - 70,233,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Plcg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647529,248,533 - 29,377,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl66,433,153 - 6,603,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.166,433,146 - 6,603,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.266,994,243 - 7,071,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCG2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl567,215,459 - 67,398,990 (+)Ensembl
ChlSab1.1567,209,268 - 67,394,865 (+)NCBI
Plcg2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247465,678,057 - 5,824,663 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000056457   ⟹   ENSPPAP00000033581
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1681,812,565 - 81,984,064 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056464   ⟹   ENSPPAP00000033588
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1681,812,614 - 81,983,768 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056466   ⟹   ENSPPAP00000033590
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1681,901,195 - 81,983,768 (+)Ensembl
RefSeq Acc Id: XM_034940799   ⟹   XP_034796690
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01662,383,270 - 62,561,579 (+)NCBI
RefSeq Acc Id: XM_034940800   ⟹   XP_034796691
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01662,383,281 - 62,541,173 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034796690 (Get FASTA)   NCBI Sequence Viewer  
  XP_034796691 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034796690   ⟸   XM_034940799
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034796691   ⟸   XM_034940800
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000033588   ⟸   ENSPPAT00000056464
RefSeq Acc Id: ENSPPAP00000033590   ⟸   ENSPPAT00000056466
RefSeq Acc Id: ENSPPAP00000033581   ⟸   ENSPPAT00000056457
Protein Domains
C2   PH   PI-PLC Y-box   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039636 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000033581 UniProtKB/TrEMBL
  ENSPPAP00000033588 UniProtKB/TrEMBL
  ENSPPAP00000033590 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056457 UniProtKB/TrEMBL
  ENSPPAT00000056464 UniProtKB/TrEMBL
  ENSPPAT00000056466 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-gamma UniProtKB/TrEMBL
  PLC-gamma2 UniProtKB/TrEMBL
  PLC-gamma_C-SH2 UniProtKB/TrEMBL
  PLC-gamma_N-SH2 UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLCgamma2_SH3 UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report pps:100984694 UniProtKB/TrEMBL
NCBI Gene PLCG2 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF25 UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PIRSF PLC-gamma UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9BV79_PANPA UniProtKB/TrEMBL
  A0A2R9BVU6_PANPA UniProtKB/TrEMBL
  A0A2R9BYN1_PANPA UniProtKB/TrEMBL