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Gene: Dbh (dopamine beta-hydroxylase) Rattus norvegicus
Symbol: Dbh
Name: dopamine beta-hydroxylase
RGD ID: 2489
Description: Exhibits copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular response to manganese ion; cellular response to nicotine; and norepinephrine biosynthetic process. Localizes to several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH 2,4-D; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dopamine beta hydroxylase; Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-monooxygenase; DOPBHY
Homo sapiens (human) : DBH (dopamine beta-hydroxylase)  HGNC  Alliance
Mus musculus (house mouse) : Dbh (dopamine beta hydroxylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dbh (dopamine beta-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DBH (dopamine beta-hydroxylase)
Canis lupus familiaris (dog) : DBH (dopamine beta-hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dbh (dopamine beta-hydroxylase)
Sus scrofa (pig) : DBH (dopamine beta-hydroxylase)
Chlorocebus sabaeus (African green monkey) : DBH (dopamine beta-hydroxylase)
Heterocephalus glaber (naked mole-rat) : Dbh (dopamine beta-hydroxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dbh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2489
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.