Dbh (dopamine beta-hydroxylase) - Rat Genome Database

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Gene: Dbh (dopamine beta-hydroxylase) Rattus norvegicus
Analyze
Symbol: Dbh
Name: dopamine beta-hydroxylase
RGD ID: 2489
Description: Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular biogenic amine metabolic process; cellular response to manganese ion; and cellular response to nicotine. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH 2,4-D; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dopamine beta hydroxylase; Dopamine beta hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-monooxygenase; DOPBHY
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,488,260 - 10,505,245 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)Ensembl
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
2,4-D  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
amitraz  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (EXP)
bromocriptine  (ISO)
bupropion  (ISO)
C60 fullerene  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
cyanazine  (EXP)
D-mannitol  (ISO)
desipramine  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
dieldrin  (EXP)
disulfiram  (ISO)
dobutamine  (ISO)
dopamine  (EXP,ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
Fusaric acid  (EXP)
hydrogen sulfide  (ISO)
lamotrigine  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyllycaconitine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nimodipine  (EXP)
paracetamol  (ISO)
Pargyline  (ISO)
paroxetine  (ISO)
procymidone  (EXP)
reboxetine  (ISO)
reserpine  (EXP)
rotenone  (ISO)
sarin  (ISO)
serotonin  (ISO)
sertraline  (ISO)
simazine  (EXP)
tamoxifen  (EXP)
taurine  (ISO)
testosterone  (EXP)
triazines  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function
copper ion binding  (IBA,IEA,IMP,ISO,ISS)
dopamine beta-monooxygenase activity  (IBA,IDA,IEA,IMP,ISO,TAS)
L-ascorbic acid binding  (IEA)
protein binding  (ISO)

References

References - curated
1. Bianco LE, etal., J Neurochem. 2008 Jul;106(1):205-15. Epub 2008 Jul 1.
2. Brown ST, etal., J Neurochem. 2009 Jul;110(2):622-30. Epub 2009 May 8.
3. Buller KM, etal., Pediatr Res. 2008 Apr;63(4):364-9.
4. Chen Y, etal., Am J Hypertens. 2011 Jan;24(1):24-32. Epub 2010 Sep 2.
5. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
6. Coll M, etal., Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
7. Cragg SJ, etal., Eur J Neurosci. 2004 Oct;20(7):1788-802.
8. Dina OA, etal., Eur J Neurosci. 2008 Sep;28(6):1180-90. Epub 2008 Sep 9.
9. Erdos B, etal., Exp Gerontol. 2008 Aug;43(8):806-9. Epub 2008 Apr 27.
10. Fernandez F, etal., J Neurol Sci. 2006 Dec 21;251(1-2):118-23. Epub 2006 Nov 7.
11. Freire MT, etal., J Neural Transm. 2005 Sep;112(9):1269-74.
12. Fuzesi T, etal., Brain Res. 2009 Oct 19;1294:38-44. Epub 2009 Aug 6.
13. Gajda M, etal., Cells Tissues Organs. 2010;191(6):489-99. Epub 2010 Jan 14.
14. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Gavrilovic L, etal., Braz J Med Biol Res. 2009 Dec;42(12):1185-90. Epub 2009 Nov 6.
16. GOA data from the GO Consortium
17. Guevara-Guzman R, etal., Neuroscience. 2009 Mar 31;159(3):940-50. Epub 2009 Jan 31.
18. Healy DG, etal., Ann Neurol 2004 Mar;55(3):443-6.
19. Inouye KE, etal., Endocrinology. 2006 Apr;147(4):1860-70. Epub 2006 Jan 5.
20. Kaasinen SK, etal., Int J Dev Neurosci. 2008 Oct;26(6):625-34. Epub 2008 Apr 7.
21. Kim Y, etal., Nutr Res Pract. 2010 Aug;4(4):270-5. Epub 2010 Aug 31.
22. Kitayama IT, etal., Ann N Y Acad Sci. 2008 Dec;1148:95-8.
23. Kohnke MD, etal., J Neural Transm. 2006 Jul;113(7):869-76. Epub 2005 Oct 27.
24. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
25. Lamouroux A, etal., EMBO J 1987 Dec 20;6(13):3931-7.
26. Li AJ, etal., J Neurosci. 2009 Jan 7;29(1):280-7.
27. Marques Pereira P, etal., J Neurochem. 2008 Dec;107(5):1325-34. Epub 2008 Sep 24.
28. McMahon A, etal., J Neurosci Res 1990 Mar;25(3):395-404.
29. MGD data from the GO Consortium
30. Micutkova L, etal., Endocr Regul 2001 Dec;35(4):195-200.
31. Min MY, etal., Neuroscience. 2008 Jun 2;153(4):1020-33. Epub 2008 Mar 19.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Nelson KT and Prohaska JR, Br J Nutr. 2009 Jul;102(1):18-28. Epub 2008 Dec 15.
34. Northrop LE, etal., J Neuroendocrinol. 2010 Oct;22(10):1061-71. doi: 10.1111/j.1365-2826.2010.02049.x.
35. OMIM Disease Annotation Pipeline
36. Patil J, etal., Regul Pept. 2011 Feb 25;167(1):31-41. Epub 2010 Dec 9.
37. Patterson-Buckendahl P, etal., Alcohol. 2005 Nov;37(3):157-66.
38. Pearson RJ, etal., Auton Neurosci. 2007 Oct 30;136(1-2):31-42. Epub 2007 Jun 14.
39. Petrovic N, etal., Physiol Res. 2001;50(3):289-97.
40. Pipeline to import KEGG annotations from KEGG into RGD
41. Pipeline to import SMPDB annotations from SMPDB into RGD
42. Pohorecky LA, etal., Neuroendocrinology. 2004;80(1):42-51. Epub 2004 Sep 2.
43. Potes CS, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R623-31. Epub 2010 Jun 16.
44. Prohaska JR and Brokate B, J Nutr. 1999 Dec;129(12):2147-53.
45. RGD automated data pipeline
46. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. RGD automated import pipeline for gene-chemical interactions
48. Sato T, etal., J Mol Neurosci. 2011 Feb;43(2):193-9. Epub 2010 Jul 2.
49. Serova L, etal., Neuroendocrinology 2002 Mar;75(3):193-200.
50. Smith KM, etal., Am J Med Genet B Neuropsychiatr Genet 2003 May 15;119(1):77-85.
51. Spasojevic N, etal., Auton Autacoid Pharmacol. 2010 Oct;30(4):213-7. doi: 10.1111/j.1474-8673.2010.00458.x. Epub 2010 Jul 5.
52. Swoap SJ, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R108-13. Epub 2003 Sep 11.
53. Takahashi S Tohoku J Exp Med. 2008 Nov;216(3):239-48.
54. Temel S, etal., Endocrinology 2002 Oct;143(10):3974-83.
55. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
56. Thomas SA and Palmiter RD, Nature. 1997 May 1;387(6628):94-7. doi: 10.1038/387094a0.
57. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
58. Zhang Y, etal., Neuroscience. 2010 Sep 1;169(3):1421-37. Epub 2010 May 15.
Additional References at PubMed
PMID:7715704   PMID:7961964   PMID:8889548   PMID:9189272   PMID:9393852   PMID:9603211   PMID:10051631   PMID:10777779   PMID:11805341   PMID:12370425   PMID:12959968   PMID:15066288  
PMID:15231500   PMID:15849236   PMID:16033425   PMID:16100957   PMID:16614076   PMID:19112418   PMID:19482560   PMID:21062376   PMID:21488089   PMID:21763404   PMID:21777029   PMID:22546625  
PMID:23160224   PMID:27148966   PMID:27152332   PMID:27959576   PMID:28473232   PMID:28726094  


Genomics

Comparative Map Data
Dbh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,488,260 - 10,505,245 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)Ensembl
Rnor_6.035,709,236 - 5,731,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,073,477 - 11,095,363 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,052,706 - 6,069,826 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,053,005 - 6,070,129 (+)NCBI
Celera35,285,082 - 5,302,054 (+)NCBICelera
Cytogenetic Map3p12NCBI
DBH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9133,636,363 - 133,659,329 (+)EnsemblGRCh38hg38GRCh38
GRCh389133,636,363 - 133,659,329 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,501,485 - 136,524,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,491,306 - 135,514,287 (+)NCBINCBI36hg18NCBI36
Build 349133,531,038 - 133,554,020NCBI
Celera9107,048,360 - 107,071,346 (+)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9106,002,148 - 106,025,141 (+)NCBIHuRef
CHM1_19136,651,448 - 136,674,425 (+)NCBICHM1_1
Dbh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,055,519 - 27,073,216 (+)NCBIGRCm39mm39
GRCm39 Ensembl227,055,245 - 27,073,212 (+)Ensembl
GRCm38227,165,507 - 27,183,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,165,233 - 27,183,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv37227,021,027 - 27,038,724 (+)NCBIGRCm37mm9NCBIm37
MGSCv36226,987,242 - 27,004,928 (+)NCBImm8
Celera226,868,411 - 26,886,118 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.29NCBI
Dbh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,918,286 - 2,932,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,918,085 - 2,932,481 (+)NCBIChiLan1.0ChiLan1.0
DBH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19133,371,818 - 133,394,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,371,821 - 133,393,697 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09104,761,504 - 104,784,445 (+)NCBIMhudiblu_PPA_v0panPan3
DBH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,004,806 - 50,024,130 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,004,806 - 50,024,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,285,838 - 49,305,131 (+)NCBI
ROS_Cfam_1.0950,879,184 - 50,898,677 (+)NCBI
UMICH_Zoey_3.1949,640,508 - 49,659,973 (+)NCBI
UNSW_CanFamBas_1.0949,982,444 - 50,001,971 (+)NCBI
UU_Cfam_GSD_1.0950,060,855 - 50,080,372 (+)NCBI
Dbh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,048,835 - 200,073,044 (+)NCBI
SpeTri2.0NW_0049366693,302,014 - 3,326,233 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,204,400 - 273,225,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,204,407 - 273,225,562 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,178,237 - 307,199,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
DBH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,474,041 - 4,498,942 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl124,474,958 - 4,498,910 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666058490,145 - 515,071 (+)NCBIVero_WHO_p1.0
Dbh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247602,016,066 - 2,030,240 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH135117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,504,894 - 10,505,087 (+)MAPPERmRatBN7.2
Rnor_6.035,731,545 - 5,731,737NCBIRnor6.0
Rnor_5.0311,095,013 - 11,095,205UniSTSRnor5.0
RGSC_v3.436,069,476 - 6,069,668UniSTSRGSC3.4
Celera35,301,704 - 5,301,896UniSTS
RH 3.4 Map319.3UniSTS
Cytogenetic Map3p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:286
Count of miRNA genes:170
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000061201, ENSRNOT00000070887
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 2 8
Low 2 43 4 4 8 4 28 8 7 11
Below cutoff 1 21 13 11 13 6 7 32 9 13 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061201   ⟹   ENSRNOP00000057915
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,488,260 - 10,505,248 (+)Ensembl
Rnor_6.0 Ensembl35,709,236 - 5,731,898 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000070887   ⟹   ENSRNOP00000065474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl35,709,242 - 5,731,511 (+)Ensembl
RefSeq Acc Id: NM_013158   ⟹   NP_037290
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,488,260 - 10,505,245 (+)NCBI
Rnor_6.035,709,236 - 5,731,895 (+)NCBI
Rnor_5.0311,073,477 - 11,095,363 (+)NCBI
RGSC_v3.436,052,706 - 6,069,826 (+)RGD
Celera35,285,082 - 5,302,054 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037290 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93440 (Get FASTA)   NCBI Sequence Viewer  
  Q05754 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037290   ⟸   NM_013158
- Sequence:
RefSeq Acc Id: ENSRNOP00000065474   ⟸   ENSRNOT00000070887
RefSeq Acc Id: ENSRNOP00000057915   ⟸   ENSRNOT00000061201
Protein Domains
DOMON

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2489 AgrOrtholog
Ensembl Genes ENSRNOG00000006641 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057915 UniProtKB/TrEMBL
  ENSRNOP00000065474 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061201 UniProtKB/TrEMBL
  ENSRNOT00000070887 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cu2_ascorb_mOase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_CS-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_ascorb_mOase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_monoox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHM/PNGase_F_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tbh/DBH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25699 UniProtKB/Swiss-Prot
NCBI Gene 25699 ENTREZGENE
PANTHER PTHR10157 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cu2_monoox_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu2_monooxygen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbh PhenoGen
PRINTS DBMONOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CU2_MONOOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOMON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DoH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC222723
UniProt DOPO_RAT UniProtKB/Swiss-Prot
  G3V9S4_RAT UniProtKB/TrEMBL
  M0R7P2_RAT UniProtKB/TrEMBL
  Q05754 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Dbh  dopamine beta-hydroxylase  Dbh  dopamine beta-hydroxylase (dopamine beta-monooxygenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Dbh  dopamine beta-hydroxylase (dopamine beta-monooxygenase)  Dbh  dopamine beta hydroxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dbh  dopamine beta hydroxylase    Dopamine beta hydroxylase (dopamine beta-monooxygenase)  Name updated 625702 APPROVED
2002-06-10 Dbh  Dopamine beta hydroxylase (dopamine beta-monooxygenase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression basal levels of mRNA is expressed by norepinephrine (NE) and epinephrine neurons,expression is higher in young animals during the steroid induced surge 628385
gene_process regulates norepinephrine synthesis 628385
gene_regulation expression is regulated by estrogens 727567
gene_regulation gene expression is stimulated by estrogen 727567