Tgfbr2 (transforming growth factor, beta receptor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tgfbr2 (transforming growth factor, beta receptor 2) Rattus norvegicus
Analyze
Symbol: Tgfbr2
Name: transforming growth factor, beta receptor 2
RGD ID: 69651
Description: Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in caveola; cell surface; and cytosol. Is integral component of plasma membrane. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: tbetaR-II; TGF-beta 2; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; Tgfbr2T; TGFR-2; transforming growth factor beta receptor 2; transforming growth factor beta receptor type II; transforming growth factor beta, receptor 2; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tgfbr2m2Mcwi   Tgfbr2m1Mcwi  
Genetic Models: FHH-Tgfbr2m2Mcwi BN-Tgfbr2m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28115,794,537 - 115,883,615 (-)NCBI
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aneurysm  (ISO)
aortic aneurysm  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Neoplasms  (ISO)
carcinoma  (ISO)
cholangiocarcinoma  (IEP)
cleft soft palate  (ISS)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISS)
Dissecting Aneurysm  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (IEP)
Experimental Liver Cirrhosis  (IDA,ISO)
Eye Abnormalities  (ISO)
familial temporal lobe epilepsy 7  (ISO)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Fatigue  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IEP)
hereditary nonpolyposis colorectal cancer type 6  (ISO)
Hyperplasia  (IEP)
inguinal hernia  (ISO)
kidney disease  (IEP)
Loeys-Dietz syndrome  (ISO)
Loeys-Dietz syndrome 1  (ISO)
Loeys-Dietz syndrome 2  (ISO)
Loeys-Dietz Syndrome, Type 1b  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
membranoproliferative glomerulonephritis  (IDA)
Microsatellite Instability  (ISO)
migraine  (ISO)
myocardial infarction  (IEP)
Neoplasm Metastasis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
prostate cancer  (ISS)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (IEP)
Radiation Injuries  (IDA)
Reperfusion Injury  (IEP)
thoracic aortic aneurysm  (ISO)
type 2 diabetes mellitus  (IEP)
vasculogenic impotence  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-nitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acteoside  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furosemide  (EXP)
galangin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
Isoangustone A  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (EXP)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
osthole  (ISO)
oxalic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salvianolic acid B  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
succimer  (ISO)
tacrolimus hydrate  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
activin receptor signaling pathway  (IEA)
aging  (IEP)
animal organ morphogenesis  (IMP)
animal organ regeneration  (IEP)
apoptotic process  (ISO)
atrioventricular valve morphogenesis  (ISO)
brain development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
bronchus development  (ISO)
bronchus morphogenesis  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell proliferation involved in endocardial cushion morphogenesis  (ISO)
cellular response to growth factor stimulus  (IBA)
common-partner SMAD protein phosphorylation  (IDA)
digestive tract development  (IEP)
embryo implantation  (IEP)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic hemopoiesis  (ISO)
endocardial cushion fusion  (ISO)
gastrulation  (ISO)
growth plate cartilage chondrocyte growth  (ISO)
growth plate cartilage development  (ISO)
heart development  (IBA,ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
inferior endocardial cushion morphogenesis  (ISO)
lens development in camera-type eye  (ISO)
lens fiber cell apoptotic process  (ISO)
lung development  (IEP,ISO)
lung lobe morphogenesis  (ISO)
lung morphogenesis  (ISO)
mammary gland morphogenesis  (ISO)
membranous septum morphogenesis  (ISO)
miRNA transport  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell population proliferation  (IGI,IMP)
Notch signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pathway-restricted SMAD protein phosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of B cell tolerance induction  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of NK T cell differentiation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of skeletal muscle tissue regeneration  (IEP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of T cell tolerance induction  (ISO)
positive regulation of tolerance induction to self antigen  (ISO)
protein phosphorylation  (IBA,ISO)
receptor-mediated endocytosis  (IDA)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to cholesterol  (ISO)
response to estrogen  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP,TAS)
response to mechanical stimulus  (IEP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (ISO)
secondary palate development  (ISO)
smoothened signaling pathway  (ISO)
superior endocardial cushion morphogenesis  (ISO)
trachea formation  (ISO)
trachea morphogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IMP,ISO,TAS)
tricuspid valve morphogenesis  (ISO)
vasculogenesis  (IEP,ISO)
ventricular septum morphogenesis  (ISO)
wound healing  (IEP)

Cellular Component

References

References - curated
1. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Battista D, etal., Eur J Neurosci. 2006 Jan;23(1):83-93.
3. Bing P, etal., Transplant Proc. 2006 Sep;38(7):2180-2.
4. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
5. Buck MB, etal., Clin Cancer Res. 2004 Jan 15;10(2):491-8.
6. Chen A Biochem J 2002 Dec 15;368(Pt 3):683-93.
7. Chen CL, etal., J Cell Sci. 2007 Oct 15;120(Pt 20):3509-21. Epub 2007 Sep 18.
8. Copland JA, etal., Oncogene. 2003 Sep 11;22(39):8053-62.
9. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
10. Gao J, etal., J Periodontal Res. 1999 Feb;34(2):113-22.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. GOA data from the GO Consortium
13. Goggins M, etal., Cancer Res. 1998 Dec 1;58(23):5329-32.
14. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
15. Gu L, etal., Zhonghua Bing Li Xue Za Zhi. 2001 Dec;30(6):439-42.
16. Guo Q, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Apr;23(4):317-9.
17. Hao J, etal., J Mol Cell Cardiol. 1999 Mar;31(3):667-78.
18. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
19. Hill C, etal., Diabetologia 2001 Apr;44(4):495-500.
20. Hosomi N, etal., Atherosclerosis. 2002 May;162(1):69-76.
21. Ijichi H, etal., Genes Dev. 2006 Nov 15;20(22):3147-60.
22. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
23. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
24. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
25. Jung B, etal., Gastroenterology. 2004 Mar;126(3):654-9.
26. Kasuga H, etal., Kidney Int. 2001 Nov;60(5):1745-55.
27. Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50.
28. Landstrom M, etal., Int J Cancer. 1996 Aug 7;67(4):573-9.
29. Li JJ, etal., Neuroscience. 2008 Oct 15;156(3):662-72. Epub 2008 Aug 6.
30. Lin HY, etal., Life Sci. 2006 May 1;78(23):2669-75. Epub 2006 Jan 19.
31. Liu A and Ballermann BJ, Kidney Int. 1998 Mar;53(3):716-25.
32. Liu J, etal., Dev Dyn. 2000 Apr;217(4):343-60.
33. Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30.
34. Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68.
35. Lu J, etal., Development. 2005 Jul;132(14):3231-42. Epub 2005 Jun 15.
36. Lu JP, etal., World J Gastroenterol 2003 Mar;9(3):590-4.
37. Lu SL, etal., Cancer Res. 1996 Oct 15;56(20):4595-8.
38. Lu Z, etal., Dig Dis Sci. 1997 Oct;42(10):2054-63.
39. Markowitz S, etal., Science. 1995 Jun 2;268(5215):1336-8.
40. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
41. Meurer SK, etal., Cell Signal. 2011 Apr;23(4):683-99. doi: 10.1016/j.cellsig.2010.12.002. Epub 2010 Dec 10.
42. MGD data from the GO Consortium
43. Mizuguchi T, etal., Nat Genet. 2004 Aug;36(8):855-60. Epub 2004 Jul 4.
44. Morath C, etal., J Am Soc Nephrol. 2001 Nov;12(11):2300-9.
45. Morrison JF, etal., Ann N Y Acad Sci. 2006 Nov;1084:267-79.
46. Mussener A, etal., Clin Exp Immunol. 1997 Jan;107(1):112-9.
47. NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23.
49. OMIM Disease Annotation Pipeline
50. Ozawa S, etal., Surgery. 2006 Apr;139(4):563-73.
51. Pannu H, etal., Circulation. 2005 Jul 26;112(4):513-20. Epub 2005 Jul 18.
52. Park DY, etal., Hepatol Res. 2003 Nov;27(3):205-213.
53. Peng B, etal., Invest Ophthalmol Vis Sci. 1997 Jan;38(1):257-60.
54. Piao M and Tokunaga O, J Atheroscler Thromb. 2006 Apr;13(2):82-9.
55. Pipeline to import KEGG annotations from KEGG into RGD
56. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
57. Rabbani ZN, etal., Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):563-72.
58. RGD automated data pipeline
59. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. RGD automated import pipeline for gene-chemical interactions
61. Riser BL, etal., Kidney Int. 1999 Aug;56(2):428-39.
62. Ryu JK, etal., Int J Androl. 2004 Feb;27(1):42-9.
63. Sakuma K, etal., Acta Neuropathol (Berl). 2000 Feb;99(2):177-85.
64. Sarkar DK, etal., Endocrinology. 2005 Oct;146(10):4179-88. Epub 2005 Jun 16.
65. Satomi Y, etal., J Toxicol Sci. 2006 Oct;31(4):345-55.
66. Sheikh F, etal., Cardiovasc Res. 2004 Dec 1;64(3):516-25.
67. Siddiqui SS, etal., Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L1016-26. Epub 2004 Jan 16.
68. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
69. Takeno S, etal., Anticancer Res. 2002 Jul-Aug;22(4):2247-52.
70. Tanaka S, etal., Br J Cancer. 2000 May;82(9):1557-60.
71. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
72. Tsuchida K, etal., Biochem Biophys Res Commun 1993 Mar 31;191(3):790-5.
73. Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30.
74. Wagner M, etal., Pancreas. 1999 Nov;19(4):370-6.
75. Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
76. Warzecha Z, etal., J Physiol Pharmacol. 2004 Dec;55(4):791-810.
77. Watkins SJ, etal., Cardiovasc Res. 2006 Feb 1;69(2):432-9. Epub 2005 Dec 19.
78. Wikstrom P, etal., Urol Res. 1997;25(2):103-11.
79. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
80. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
81. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
82. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
83. Yasuda Y, etal., Biochem Biophys Res Commun. 2001 Feb 16;281(1):71-7.
84. Zakrzewicz A, etal., Eur Respir J. 2007 Mar 28;.
85. Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9.
86. Zhao Y and Young SL, Am J Physiol. 1995 Sep;269(3 Pt 1):L419-26.
87. Zieske JD, etal., Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1465-71.
Additional References at PubMed
PMID:1326540   PMID:1333888   PMID:7852346   PMID:8264154   PMID:8774881   PMID:10030593   PMID:11157754   PMID:11641223   PMID:12015308   PMID:12459253   PMID:12773577   PMID:12975342  
PMID:15578192   PMID:15781643   PMID:16332365   PMID:16611331   PMID:16690877   PMID:16806156   PMID:16897002   PMID:16973387   PMID:17050629   PMID:17078885   PMID:17164348   PMID:17471240  
PMID:17533113   PMID:17938236   PMID:17953362   PMID:17972267   PMID:18243111   PMID:18381416   PMID:18453574   PMID:18498113   PMID:18990706   PMID:20039857   PMID:20160708   PMID:20652948  
PMID:21378033   PMID:21382347   PMID:21420963   PMID:22425884   PMID:22964853   PMID:23486519   PMID:23868260   PMID:25178280   PMID:25446530   PMID:25801897   PMID:25813266   PMID:25893292  
PMID:26284552   PMID:26362850   PMID:26459119   PMID:26788514   PMID:29196166   PMID:30468668   PMID:31147562   PMID:31315051  


Genomics

Comparative Map Data
Tgfbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28115,794,537 - 115,883,615 (-)NCBI
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
TGFBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl330,606,601 - 30,694,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38330,606,472 - 30,694,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37330,647,994 - 30,735,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36330,622,998 - 30,710,638 (+)NCBINCBI36hg18NCBI36
Build 34330,623,041 - 30,708,147NCBI
Celera330,584,920 - 30,672,564 (+)NCBI
Cytogenetic Map3p24.1NCBI
HuRef330,590,599 - 30,678,240 (+)NCBIHuRef
CHM1_1330,598,177 - 30,685,783 (+)NCBICHM1_1
Tgfbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399115,916,763 - 116,004,431 (-)NCBIGRCm39mm39
GRCm39 Ensembl9115,913,361 - 116,004,428 (-)Ensembl
GRCm389116,087,695 - 116,175,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9116,084,293 - 116,175,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv379115,996,813 - 116,084,481 (-)NCBIGRCm37mm9NCBIm37
MGSCv369115,936,405 - 116,023,987 (-)NCBImm8
Celera9116,548,860 - 116,637,499 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map968.39NCBI
Tgfbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543021,932,553 - 22,001,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543021,919,338 - 21,999,688 (+)NCBIChiLan1.0ChiLan1.0
TGFBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1330,854,071 - 30,941,378 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl330,854,460 - 30,938,856 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0330,536,187 - 30,623,653 (+)NCBIMhudiblu_PPA_v0panPan3
TGFBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12313,886,869 - 13,946,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2313,889,000 - 13,977,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2313,869,985 - 13,959,686 (-)NCBI
ROS_Cfam_1.02314,182,445 - 14,272,114 (-)NCBI
UMICH_Zoey_3.12313,979,792 - 14,069,422 (-)NCBI
UNSW_CanFamBas_1.02314,125,731 - 14,215,435 (-)NCBI
UU_Cfam_GSD_1.02314,144,194 - 14,234,152 (-)NCBI
Tgfbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1316,784,491 - 16,878,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11316,784,370 - 16,875,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21318,707,787 - 18,712,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11575,112,903 - 75,200,263 (+)NCBI
ChlSab1.1 Ensembl1575,112,561 - 75,197,711 (+)Ensembl
Vero_WHO_p1.0NW_02366604148,399,611 - 48,486,893 (+)NCBI
Tgfbr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247888,447,679 - 8,535,821 (+)NCBI

Position Markers
D8Got214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28115,876,703 - 115,876,983 (+)MAPPER
Rnor_6.08124,392,370 - 124,392,649NCBIRnor6.0
Rnor_5.08123,664,527 - 123,664,806UniSTSRnor5.0
RGSC_v3.48120,673,910 - 120,674,190RGDRGSC3.4
RGSC_v3.48120,673,911 - 120,674,190UniSTSRGSC3.4
RGSC_v3.18120,693,647 - 120,693,927RGD
Celera8115,089,982 - 115,090,261UniSTS
RH 3.4 Map81222.2UniSTS
RH 3.4 Map81222.2RGD
RH 2.0 Map8979.3RGD
Cytogenetic Map8q32UniSTS
AI715297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28115,796,930 - 115,797,071 (+)MAPPER
Rnor_6.08124,312,682 - 124,312,822NCBIRnor6.0
Rnor_5.08123,585,618 - 123,585,758UniSTSRnor5.0
RGSC_v3.48120,593,448 - 120,593,588UniSTSRGSC3.4
Celera8115,012,028 - 115,012,168UniSTS
RH 3.4 Map81230.2UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)876103982127182642Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)880697934125697934Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8107769005129956433Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8120870965127609447Rat


Genetic Models
This gene Tgfbr2 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:36
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000037883
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 31 35 34 11 8
Low 1 43 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037883   ⟹   ENSRNOP00000035501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)Ensembl
RefSeq Acc Id: NM_031132   ⟹   NP_112394
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28115,796,846 - 115,883,343 (-)NCBI
Rnor_6.08124,312,829 - 124,398,864 (-)NCBI
Rnor_5.08123,585,765 - 123,671,209 (-)NCBI
RGSC_v3.48120,593,595 - 120,680,453 (-)RGD
Celera8115,012,175 - 115,096,500 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766690   ⟹   XP_008764912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28115,794,537 - 115,883,615 (-)NCBI
Rnor_6.08124,310,288 - 124,399,345 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112394   ⟸   NM_031132
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_008764912   ⟸   XM_008766690
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000035501   ⟸   ENSRNOT00000037883
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696359
Promoter ID:EPDNEW_R6884
Type:initiation region
Name:Tgfbr2_1
Description:transforming growth factor, beta receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08124,398,828 - 124,398,888EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69651 AgrOrtholog
Ensembl Genes ENSRNOG00000013265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000035501 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037883 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transforming_GF_b_rcpt_2_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81810 UniProtKB/Swiss-Prot
NCBI Gene 81810 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ecTbetaR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Tgfbr2 PhenoGen
PIRSF TGFRII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206174
UniProt D0VED2_RAT UniProtKB/TrEMBL
  P38438 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Tgfbr2  transforming growth factor, beta receptor 2  Tgfbr2  transforming growth factor, beta receptor II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-01 Tgfbr2  transforming growth factor, beta receptor II  Tgfbr2T  transforming growth factor, beta receptor IIT  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-01 Tgfbr2T  transforming growth factor, beta receptor IIT  Tgfbr2  transforming growth factor, beta receptor II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-11 Tgfbr2T  transforming growth factor, beta receptor IIT  Tgfbr2  transforming growth factor, beta receptor II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-11 Tgfbr2  transforming growth factor, beta receptor II  Tgfbr2T  transforming growth factor, beta receptor IIT  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tgfbr2  transforming growth factor, beta receptor 2      Name updated 70584 APPROVED
2002-02-26 Tgfbr2  transforming growth factor, beta receptor II      Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in the development of diabetic nephrepathy 68928
gene_function receptor for TGF-beta and a constitutively active serine threonine kinase 68928
gene_pathway binding TGF-beta isoform leads to recruitment and phosphorylation of Tgfbr1, starting the signaling cascade to the nucleus through the Smad proteins 68928
gene_process inhibits the synthesis of collagenases and stimulates tissue production of metalloproteinase inhibitors 68928