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Gene: Tgfbr2 (transforming growth factor, beta receptor 2) Rattus norvegicus
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Symbol: Tgfbr2
Name: transforming growth factor, beta receptor 2
Description: Exhibits mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to several cellular components, including the caveola; cell surface; and integral component of plasma membrane. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: tbetaR-II; TGF-beta 2; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; Tgfbr2T; TGFR-2; transforming growth factor beta receptor 2; transforming growth factor beta receptor type II; transforming growth factor beta, receptor 2; transforming growth factor, beta receptor II; transforming growth factor, beta receptor IIT; transforming growth factor-b type II receptor; transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor
Orthologs:
Homo sapiens (human) : TGFBR2 (transforming growth factor beta receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Tgfbr2 (transforming growth factor, beta receptor II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr2 (transforming growth factor beta receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR2 (transforming growth factor beta receptor 2)
Canis lupus familiaris (dog) : TGFBR2 (transforming growth factor beta receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr2 (transforming growth factor beta receptor 2)
Sus scrofa (pig) : TGFBR2 (transforming growth factor beta receptor 2)
more info ...
Allele / Splice: Tgfbr2m2Mcwi   Tgfbr2m1Mcwi  
Genetic Models: FHH-Tgfbr2m2Mcwi BN-Tgfbr2m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)Ensembl
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tgfbr2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69651
Created: 2001-12-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.