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Strain: FHH-Tgfbr2m2Mcwi

Symbol: FHH-Tgfbr2m2Mcwi
Strain: FHH-Tgfbr2m2
Substrain: Mcwi
RGD ID: 1579685
Citation ID: RRID:RRRC_00400
Ontology ID: RS:0001121
Alleles: Tgfbr2m2Mcwi
Also known as: FHH-Tgfbr2m2Mcwi; RRRC:00400
Type: mutant
Source: PhysGen, Rat Resource and Research Center
Origin: Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. E311K mutation is generated from the codon change GAG/AAG.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28115,794,537 - 115,883,615RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.08124,310,288 - 124,399,345RGD_MAPPER_PIPELINERnor6.0
Rnor_5.08123,585,765 - 123,671,209RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.48120,593,595 - 120,680,453RGD_MAPPER_PIPELINERGSC3.4






Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
body weight
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
body length, nose to tail
body length, nose to rump
left kidney wet weight
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
serum total cholesterol level
total white blood cell count
serum total bilirubin level
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
serum globulin level

References

References - curated
1. Personal Communication with Rat Resource & Research Center
2. PhysGen strains
3. RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-25 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Symbol updated 68687 APPROVED
2017-01-25 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Name updated 68913 APPROVED
2014-03-21 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Name updated 68913 APPROVED
2014-03-21 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Symbol updated 68687 APPROVED
2012-04-17 FHH-Tgfbr2m2Mcwi    FHH-Tgfbr2m2Mcwi    Name updated 68913 APPROVED