Tgfbr2 (transforming growth factor beta receptor 2) - Rat Genome Database

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Gene: Tgfbr2 (transforming growth factor beta receptor 2) Ictidomys tridecemlineatus
Analyze
Symbol: Tgfbr2
Name: transforming growth factor beta receptor 2
RGD ID: 12475525
Description: ENCODES a protein that exhibits glycosaminoglycan binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); SMAD binding (ortholog); INVOLVED IN activation of protein kinase activity (ortholog); aging (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; ASSOCIATED WITH Aneurysm (ortholog); aortic aneurysm (ortholog); arteriosclerosis (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: TGF-beta receptor type-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aneurysm  (ISO)
aortic aneurysm  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Neoplasms  (ISO)
carcinoma  (ISO)
cholangiocarcinoma  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
Dissecting Aneurysm  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Abnormalities  (ISO)
familial temporal lobe epilepsy 7  (ISO)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Fatigue  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary nonpolyposis colorectal cancer type 6  (ISO)
Hyperplasia  (ISO)
inguinal hernia  (ISO)
kidney disease  (ISO)
Loeys-Dietz syndrome  (ISO)
Loeys-Dietz syndrome 1  (ISO)
Loeys-Dietz syndrome 2  (ISO)
Loeys-Dietz Syndrome, Type 1b  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Microsatellite Instability  (ISO)
migraine  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Reperfusion Injury  (ISO)
thoracic aortic aneurysm  (ISO)
type 2 diabetes mellitus  (ISO)
vasculogenic impotence  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
aging  (ISO)
animal organ morphogenesis  (ISO)
animal organ regeneration  (ISO)
apoptotic process  (ISO)
atrioventricular valve morphogenesis  (ISO)
brain development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
bronchus development  (ISO)
bronchus morphogenesis  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell proliferation involved in endocardial cushion morphogenesis  (ISO)
common-partner SMAD protein phosphorylation  (ISO)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic hemopoiesis  (ISO)
endocardial cushion fusion  (ISO)
gastrulation  (ISO)
growth plate cartilage chondrocyte growth  (ISO)
growth plate cartilage development  (ISO)
heart development  (ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
inferior endocardial cushion morphogenesis  (ISO)
lens development in camera-type eye  (ISO)
lens fiber cell apoptotic process  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung morphogenesis  (ISO)
mammary gland morphogenesis  (ISO)
membranous septum morphogenesis  (ISO)
miRNA transport  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell population proliferation  (ISO)
Notch signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pathway-restricted SMAD protein phosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of B cell tolerance induction  (ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of NK T cell differentiation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of skeletal muscle tissue regeneration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell tolerance induction  (ISO)
positive regulation of tolerance induction to self antigen  (ISO)
protein phosphorylation  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to cholesterol  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
secondary palate development  (ISO)
smoothened signaling pathway  (ISO)
superior endocardial cushion morphogenesis  (ISO)
trachea formation  (ISO)
trachea morphogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
tricuspid valve morphogenesis  (ISO)
vasculogenesis  (ISO)
ventricular septum morphogenesis  (ISO)
wound healing  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Tgfbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl330,606,601 - 30,694,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl330,606,502 - 30,694,142 (+)EnsemblGRCh38hg38GRCh38
GRCh38330,606,472 - 30,694,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37330,647,994 - 30,735,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36330,622,998 - 30,710,638 (+)NCBINCBI36hg18NCBI36
Build 34330,623,041 - 30,708,147NCBI
Celera330,584,920 - 30,672,564 (+)NCBI
Cytogenetic Map3p24.1NCBI
HuRef330,590,599 - 30,678,240 (+)NCBIHuRef
CHM1_1330,598,177 - 30,685,783 (+)NCBICHM1_1
Tgfbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399115,916,763 - 116,004,431 (-)NCBIGRCm39mm39
GRCm39 Ensembl9115,913,361 - 116,004,428 (-)Ensembl
GRCm389116,087,695 - 116,175,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9116,084,293 - 116,175,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv379115,996,813 - 116,084,481 (-)NCBIGRCm37mm9NCBIm37
MGSCv369115,936,405 - 116,023,987 (-)NCBImm8
Celera9116,548,860 - 116,637,499 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map968.39NCBI
Tgfbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28115,794,537 - 115,883,615 (-)NCBI
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
Tgfbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543021,932,553 - 22,001,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543021,919,338 - 21,999,688 (+)NCBIChiLan1.0ChiLan1.0
TGFBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1330,854,071 - 30,941,378 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl330,854,460 - 30,938,856 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0330,536,187 - 30,623,653 (+)NCBIMhudiblu_PPA_v0panPan3
TGFBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12313,886,869 - 13,946,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2313,889,000 - 13,977,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2313,869,985 - 13,959,686 (-)NCBI
ROS_Cfam_1.02314,182,445 - 14,272,114 (-)NCBI
UMICH_Zoey_3.12313,979,792 - 14,069,422 (-)NCBI
UNSW_CanFamBas_1.02314,125,731 - 14,215,435 (-)NCBI
UU_Cfam_GSD_1.02314,144,194 - 14,234,152 (-)NCBI
TGFBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1316,784,491 - 16,878,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11316,784,370 - 16,875,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21318,707,787 - 18,712,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11575,112,903 - 75,200,263 (+)NCBI
ChlSab1.1 Ensembl1575,112,561 - 75,197,711 (+)Ensembl
Tgfbr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247888,447,679 - 8,535,821 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005317310   ⟹   XP_005317367
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118188,186,157 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,735 - 21,409,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005317311   ⟹   XP_005317368
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317367 (Get FASTA)   NCBI Sequence Viewer  
  XP_005317368 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005317368   ⟸   XM_005317311
- Peptide Label: isoform X2
- UniProtKB: I3NH44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005317367   ⟸   XM_005317310
- Peptide Label: isoform X1
- UniProtKB: A0A287CU99 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000019376 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000023691 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000024905 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028455 UniProtKB/TrEMBL
  ENSSTOT00000037765 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/TrEMBL
  Transforming_GF_b_rcpt_2_ecto UniProtKB/TrEMBL
NCBI Gene Tgfbr2 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
Pfam ecTbetaR2 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF TGFRII UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CU99 ENTREZGENE, UniProtKB/TrEMBL
  I3NH44 ENTREZGENE, UniProtKB/TrEMBL