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Gene: Gpx4 (glutathione peroxidase 4) Rattus norvegicus
Symbol: Gpx4
Name: glutathione peroxidase 4
Description: Exhibits glutathione peroxidase activity; phospholipid-hydroperoxide glutathione peroxidase activity; and selenium binding activity. Involved in several processes, including glutathione metabolic process; regulation of inflammatory response; and response to estradiol. Predicted to localize to several cellular components, including cytosol; mitochondrion; and nucleus. Orthologous to human GPX4 (glutathione peroxidase 4); PARTICIPATES IN glutathione metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Gpx-4; Gshpx-4; Phgpx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGpx
Homo sapiens (human) : GPX4 (glutathione peroxidase 4)  HGNC  Alliance
Mus musculus (house mouse) : Gpx4 (glutathione peroxidase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx4 (glutathione peroxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX4 (glutathione peroxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx4 (glutathione peroxidase 4)
Sus scrofa (pig) : GPX4 (glutathione peroxidase 4)
Chlorocebus sabaeus (African green monkey) : GPX4 (glutathione peroxidase 4)
Heterocephalus glaber (naked mole-rat) : Gpx4 (glutathione peroxidase 4)
more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2   Gpx4-ps3  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gpx4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69226
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.