(R,R,R)-alpha-tocopherol multiple interactions ISO RGD:736049 6480464 alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] CTD PMID:14642406 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of GPX4 protein CTD PMID:17337753 1,2-dimethylhydrazine multiple interactions ISO RGD:736050 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GPX4 mRNA CTD PMID:22206623 12(S)-HPETE increases chemical synthesis ISO RGD:736049 6480464 GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 17beta-estradiol decreases expression ISO RGD:736049 6480464 Estradiol results in decreased expression of GPX4 mRNA CTD PMID:23019147 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:736050 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:736050 6480464 2 more ... CTD PMID:30294300 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:736050 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of GPX4 mRNA CTD PMID:21215274 , PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GPX4 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of GPX4 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736050 6480464 Tetrachlorodibenzodioxin affects the expression of GPX4 mRNA CTD PMID:21570461 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of GPX4 mRNA CTD PMID:21346803 2,4-dinitrophenol decreases response to substance EXP 6480464 GPX4 protein results in decreased susceptibility to 2, 4-Dinitrophenol CTD PMID:19818760 2-deoxy-D-glucose multiple interactions EXP 6480464 GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein] CTD PMID:10506188 4,4'-diaminodiphenylmethane decreases expression ISO RGD:736050 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of GPX4 mRNA CTD PMID:18648102 4-hydroxy-TEMPO increases expression ISO RGD:736050 6480464 tempol results in increased expression of GPX4 mRNA CTD PMID:22221582 4-nitroquinoline N-oxide increases expression ISO RGD:736049 6480464 4-Nitroquinoline-1-oxide results in increased expression of GPX4 protein CTD PMID:32942007 4-nitroquinoline N-oxide multiple interactions ISO RGD:736049 6480464 4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein] CTD PMID:32942007 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of GPX4 mRNA CTD PMID:19483382 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of GPX4 mRNA CTD PMID:31068541 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of GPX4 mRNA CTD PMID:31881176 acrolein decreases expression ISO RGD:736049 6480464 Acrolein results in decreased expression of GPX4 mRNA CTD PMID:33421550 acrolein multiple interactions ISO RGD:736049 6480464 Buthionine Sulfoximine promotes the reaction [Acrolein results in decreased expression of GPX4 mRNA] CTD PMID:33421550 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of GPX4 protein CTD PMID:34116104 aldehydo-D-glucose increases expression ISO RGD:736049 6480464 Glucose results in increased expression of GPX4 protein CTD PMID:32942007 aldehydo-D-glucose multiple interactions ISO RGD:736049 6480464 4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein] CTD PMID:32942007 all-trans-retinoic acid decreases activity ISO RGD:736050 6480464 Tretinoin results in decreased activity of GPX4 protein CTD PMID:16445905 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of GPX4 mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GPX4 mRNA CTD PMID:16483693 apocynin multiple interactions ISO RGD:736050 6480464 acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 arachidonic acid multiple interactions ISO RGD:736049 6480464 [Iodoacetates results in decreased activity of GPX4 protein] which affects the metabolism of Arachidonic Acid, Arachidonic Acid promotes the reaction [Sodium Selenite results in increased expression of and results in increased activity of GPX4 protein] CTD PMID:11115402 , PMID:14642406 Aroclor 1254 increases expression ISO RGD:736050 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of GPX4 mRNA CTD PMID:23650126 arsenic acid increases expression ISO RGD:736050 6480464 arsenic acid results in increased expression of GPX4 mRNA, arsenic acid results in increased expression of GPX4 protein CTD PMID:19429247 arsenite(3-) increases expression ISO RGD:736050 6480464 arsenite results in increased expression of GPX4 mRNA, arsenite results in increased expression of GPX4 protein CTD PMID:19429247 arsenous acid increases expression ISO RGD:736049 6480464 Arsenic Trioxide results in increased expression of GPX4 mRNA CTD PMID:20458559 artesunate decreases activity ISO RGD:736049 6480464 Artesunate results in decreased activity of GPX4 protein CTD PMID:30551460 artesunate multiple interactions ISO RGD:736050 6480464 Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] CTD PMID:30551460 astemizole increases expression EXP 6480464 Astemizole results in increased expression of GPX4 mRNA CTD PMID:20221588 atorvastatin calcium multiple interactions ISO RGD:736050 6480464 Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein] CTD PMID:32976958 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of GPX4 mRNA CTD PMID:19483382 benzo[a]pyrene increases expression ISO RGD:736050 6480464 Benzo(a)pyrene results in increased expression of GPX4 mRNA CTD PMID:20504355 benzo[a]pyrene decreases methylation ISO RGD:736049 6480464 Benzo(a)pyrene results in decreased methylation of GPX4 exon CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:736050 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX4 mRNA, AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GPX4 mRNA] CTD PMID:22228805 , PMID:25820237 benzo[a]pyrene diol epoxide I increases expression ISO RGD:736049 6480464 7 more ... CTD PMID:19150397 benzoates decreases expression ISO RGD:736049 6480464 Benzoates analog results in decreased expression of GPX4 mRNA CTD PMID:29472718 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of GPX4 mRNA CTD PMID:16648578 bisphenol A increases expression ISO RGD:736050 6480464 bisphenol A results in increased expression of GPX4 protein CTD PMID:25772901 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GPX4 mRNA CTD PMID:33296240 bisphenol A multiple interactions ISO RGD:736050 6480464 [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 bisphenol A affects expression ISO RGD:736049 6480464 bisphenol A affects the expression of GPX4 mRNA CTD PMID:30903817 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of GPX4 mRNA CTD PMID:30903817 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GPX4 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of GPX4 mRNA CTD PMID:26496021 busulfan decreases expression ISO RGD:736050 6480464 Busulfan results in decreased expression of GPX4 protein CTD PMID:32416107 busulfan multiple interactions ISO RGD:736050 6480464 Busulfan results in decreased expression of and results in decreased activity of GPX4 protein more ... CTD PMID:32416107 butan-1-ol multiple interactions ISO RGD:736049 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of GPX4 mRNA CTD PMID:29432896 cadmium atom decreases response to substance ISO RGD:736050 6480464 GPX4 results in decreased susceptibility to Cadmium CTD PMID:18206984 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of GPX4 mRNA CTD PMID:25388156 cadmium dichloride multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA] CTD PMID:20643113 cadmium dichloride increases expression ISO RGD:736050 6480464 Cadmium Chloride results in increased expression of GPX4 mRNA CTD PMID:17499415 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of GPX4 mRNA CTD PMID:20643113 caffeine multiple interactions ISO RGD:736050 6480464 [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 Calcimycin decreases expression ISO RGD:736049 6480464 Calcimycin results in decreased expression of GPX4 protein CTD PMID:10432307 camptothecin decreases response to substance ISO RGD:736049 6480464 GPX4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 capsaicin multiple interactions ISO RGD:736050 6480464 Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA] CTD PMID:18926900 captan increases expression ISO RGD:736050 6480464 Captan results in increased expression of GPX4 mRNA CTD PMID:31558096 carbon monoxide multiple interactions ISO RGD:736050 6480464 Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 cerium trichloride affects expression ISO RGD:736049 6480464 cerous chloride affects the expression of GPX4 mRNA CTD PMID:28954213 chloropicrin decreases expression ISO RGD:736049 6480464 chloropicrin results in decreased expression of GPX4 mRNA CTD PMID:26352163 chloroquine multiple interactions ISO RGD:736050 6480464 Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA] CTD PMID:23607047 chloroquine decreases expression ISO RGD:736050 6480464 Chloroquine results in decreased expression of GPX4 mRNA CTD PMID:23607047 chlorpyrifos affects expression EXP 6480464 Chlorpyrifos affects the expression of GPX4 mRNA CTD PMID:17452286 choline multiple interactions ISO RGD:736050 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GPX4 gene CTD PMID:20938992 chromium(6+) multiple interactions ISO RGD:736050 6480464 [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GPX4 mRNA CTD PMID:25820237 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of GPX4 mRNA CTD PMID:19483382 clothianidin decreases expression ISO RGD:736050 6480464 clothianidin results in decreased expression of GPX4 protein CTD PMID:25960033 cobalt dichloride decreases expression ISO RGD:736049 6480464 cobaltous chloride results in decreased expression of GPX4 protein CTD PMID:29673971 conjugated linoleic acid multiple interactions ISO RGD:736049 6480464 Linoleic Acids, Conjugated promotes the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] CTD PMID:14642406 copper atom decreases expression EXP 6480464 Copper deficiency results in decreased expression of GPX4 protein CTD PMID:21781943 copper(0) decreases expression EXP 6480464 Copper deficiency results in decreased expression of GPX4 protein CTD PMID:21781943 CU-O LINKAGE decreases expression ISO RGD:736050 6480464 cupric oxide results in decreased expression of GPX4 mRNA CTD PMID:25701151 CU-O LINKAGE multiple interactions ISO RGD:736050 6480464 trans-sodium crocetinate inhibits the reaction [cupric oxide results in decreased expression of GPX4 mRNA] CTD PMID:25701151 cumene hydroperoxide decreases response to substance ISO RGD:736050 6480464 GPX4 results in decreased susceptibility to cumene hydroperoxide CTD PMID:18206984 cyclophosphamide increases expression ISO RGD:736049 6480464 Cyclophosphamide results in increased expression of GPX4 protein CTD PMID:17475930 cypermethrin increases expression ISO RGD:736050 6480464 cypermethrin results in increased expression of GPX4 mRNA CTD PMID:21142847 , PMID:32214279 cyproconazole increases expression ISO RGD:736050 6480464 cyproconazole results in increased expression of GPX4 mRNA CTD PMID:22334560 D-glucose increases expression ISO RGD:736049 6480464 Glucose results in increased expression of GPX4 protein CTD PMID:32942007 D-glucose multiple interactions ISO RGD:736049 6480464 4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein] CTD PMID:32942007 DDE decreases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of GPX4 protein CTD PMID:25410718 DDE increases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of GPX4 mRNA CTD PMID:25410718 desferrioxamine B multiple interactions ISO RGD:736050 6480464 Deferoxamine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein] CTD PMID:32416107 diarsenic trioxide increases expression ISO RGD:736049 6480464 Arsenic Trioxide results in increased expression of GPX4 mRNA CTD PMID:20458559 diazinon affects expression EXP 6480464 Diazinon affects the expression of GPX4 mRNA CTD PMID:17452286 dibutyl phthalate increases expression ISO RGD:736050 6480464 Dibutyl Phthalate results in increased expression of GPX4 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:736050 6480464 Dibutyl Phthalate results in decreased expression of GPX4 mRNA CTD PMID:17361019 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of GPX4 mRNA CTD PMID:21266533 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of GPX4 mRNA CTD PMID:21266533 dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of GPX4 mRNA CTD PMID:19440498 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of GPX4 mRNA CTD PMID:17679765 dimethyl fumarate increases metabolic processing ISO RGD:736049 6480464 Dimethyl Fumarate results in increased metabolism of GPX4 protein CTD PMID:29917289 diquat decreases response to substance ISO RGD:736049 6480464 GPX4 protein alternative form results in decreased susceptibility to Diquat CTD PMID:19744930 diquat increases expression ISO RGD:736050 6480464 Diquat results in increased expression of GPX4 mRNA CTD PMID:16962985 diquat multiple interactions ISO RGD:736049 6480464 GPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein], GPX4 protein inhibits the reaction [Diquat results in increased cleavage of CASP3 protein] CTD PMID:15496407 disodium selenite multiple interactions ISO RGD:736049 6480464 alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] more ... CTD PMID:14642406 , PMID:18400727 disodium selenite increases expression ISO RGD:736049 6480464 Sodium Selenite results in increased expression of GPX4 mRNA CTD PMID:14642406 , PMID:18514395 disodium selenite multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of GPX4 mRNA] CTD PMID:20643113 disodium selenite affects expression ISO RGD:736049 6480464 Sodium Selenite affects the expression of GPX4 protein polymorphism CTD PMID:18400727 disodium selenite affects activity ISO RGD:736049 6480464 Sodium Selenite affects the activity of GPX4 protein polymorphism CTD PMID:18400727 disodium selenite affects response to substance ISO RGD:736049 6480464 GPX4 gene SNP affects the susceptibility to Sodium Selenite CTD PMID:18400727 diuron decreases expression EXP 6480464 Diuron results in decreased expression of GPX4 mRNA CTD PMID:21551480 doxorubicin multiple interactions ISO RGD:736050 6480464 Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 doxorubicin increases expression ISO RGD:736049 6480464 Doxorubicin results in increased expression of GPX4 mRNA CTD PMID:29803840 doxorubicin decreases expression ISO RGD:736050 6480464 Doxorubicin results in decreased expression of GPX4 protein CTD PMID:18037988 elemental selenium increases activity ISO RGD:736049 6480464 Selenium analog results in increased activity of GPX4 protein CTD PMID:11673642 elemental selenium multiple interactions EXP 6480464 [2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] which results in increased expression of GPX4 protein CTD PMID:34116104 elemental selenium decreases expression EXP 6480464 Selenium deficiency results in decreased expression of GPX4 mRNA CTD PMID:12031252 more ... elemental selenium increases expression EXP 6480464 Selenium results in increased expression of GPX4 mRNA CTD PMID:15792362 , PMID:19022953 elemental selenium decreases activity EXP 6480464 Selenium deficiency results in decreased activity of GPX4 protein CTD PMID:12031252 elemental selenium affects activity EXP 6480464 Selenium affects the activity of GPX4 protein CTD PMID:19106321 elemental selenium increases activity EXP 6480464 Selenium results in increased activity of GPX4 protein CTD PMID:19022953 elemental selenium decreases abundance ISO RGD:736050 6480464 GPX4 gene mutant form results in decreased abundance of Selenium CTD PMID:16246897 elemental selenium multiple interactions ISO RGD:736049 6480464 Selenium results in increased expression of and results in increased activity of GPX4 protein CTD PMID:17150329 elemental selenium increases expression ISO RGD:736049 6480464 Selenium results in increased expression of GPX4 mRNA, Selenium results in increased expression of GPX4 protein CTD PMID:17052796 , PMID:19244175 elemental selenium decreases expression ISO RGD:736049 6480464 Selenium deficiency results in decreased expression of GPX4 mRNA CTD PMID:15670848 enzyme inhibitor multiple interactions ISO RGD:736049 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GPX4 protein CTD PMID:23301498 epoxiconazole increases expression ISO RGD:736050 6480464 epoxiconazole results in increased expression of GPX4 mRNA CTD PMID:22334560 erastin decreases expression ISO RGD:736049 6480464 erastin results in decreased expression of GPX4 protein CTD PMID:31323261 erastin multiple interactions ISO RGD:736049 6480464 SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] CTD PMID:31323261 erastin decreases expression EXP 6480464 erastin results in decreased expression of GPX4 protein CTD PMID:32937103 ethanol multiple interactions ISO RGD:736050 6480464 Capsaicin inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA], Plant Extracts inhibits the reaction [Ethanol results in decreased expression of GPX4 mRNA] CTD PMID:18926900 , PMID:18992320 ethanol multiple interactions ISO RGD:736049 6480464 [CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of GPX4 protein, FXN protein affects the reaction [[CYP2E1 protein affects the susceptibility to Ethanol] which affects the expression of GPX4 protein] CTD PMID:33017621 ethanol affects splicing ISO RGD:736050 6480464 Ethanol affects the splicing of GPX4 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of GPX4 mRNA, Ethanol results in increased expression of GPX4 protein CTD PMID:23155471 ethanol decreases expression ISO RGD:736050 6480464 Ethanol results in decreased expression of GPX4 mRNA, Ethanol results in decreased expression of GPX4 protein CTD PMID:18926900 more ... ethylene glycol dimethacrylate increases expression ISO RGD:736049 6480464 ethylene dimethacrylate results in increased expression of GPX4 CTD PMID:29107684 fenofibrate multiple interactions ISO RGD:736050 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA] CTD PMID:31241159 fenvalerate affects expression EXP 6480464 fenvalerate affects the expression of GPX4 protein CTD PMID:33656234 ferrostatin-1 multiple interactions ISO RGD:736050 6480464 ferrostatin-1 inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 ferrostatin-1 multiple interactions ISO RGD:736049 6480464 ferrostatin-1 inhibits the reaction [sodium arsenite results in decreased expression of GPX4 protein] CTD PMID:32593899 flutamide increases expression EXP 6480464 Flutamide results in increased expression of GPX4 mRNA CTD PMID:17679765 folic acid multiple interactions ISO RGD:736050 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 folic acid decreases expression ISO RGD:736050 6480464 Folic Acid deficiency results in decreased expression of GPX4 CTD PMID:25384423 folpet increases expression ISO RGD:736050 6480464 folpet results in increased expression of GPX4 mRNA CTD PMID:31558096 fructose decreases expression EXP 6480464 Fructose results in decreased expression of GPX4 protein CTD PMID:21781943 Gastrodin multiple interactions ISO RGD:736050 6480464 gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA], gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein] CTD PMID:31698019 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of GPX4 mRNA CTD PMID:22061828 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of GPX4 mRNA CTD PMID:33387578 ginkgolide B multiple interactions ISO RGD:736050 6480464 ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein] CTD PMID:32976958 ginkgolide B multiple interactions ISO RGD:736049 6480464 ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein] CTD PMID:32976958 Ginsenoside Rh4 multiple interactions ISO RGD:736050 6480464 ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPX4 mRNA] CTD PMID:33359794 glucose increases expression ISO RGD:736049 6480464 Glucose results in increased expression of GPX4 protein CTD PMID:32942007 glucose multiple interactions ISO RGD:736049 6480464 4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein] CTD PMID:32942007 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of GPX4 mRNA CTD PMID:28027979 hexadecanoic acid multiple interactions ISO RGD:736049 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein more ... CTD PMID:32976958 hydrogen peroxide decreases response to substance ISO RGD:736049 6480464 GPX4 protein results in decreased susceptibility to Hydrogen Peroxide CTD PMID:14660625 hydrogen peroxide decreases response to substance ISO RGD:736050 6480464 GPX4 protein results in decreased susceptibility to Hydrogen Peroxide, GPX4 results in decreased susceptibility to Hydrogen Peroxide CTD PMID:12566075 , PMID:18206984 hydrogen peroxide increases response to substance ISO RGD:736050 6480464 GPX4 gene mutant form results in increased susceptibility to Hydrogen Peroxide CTD PMID:12566075 hypochlorous acid decreases expression ISO RGD:736050 6480464 Hypochlorous Acid results in decreased expression of GPX4 mRNA CTD PMID:19376150 Iodine aqueous multiple interactions ISO RGD:736049 6480464 Lugol's solution inhibits the reaction [potassium perchlorate results in decreased expression of GPX4 protein] CTD PMID:29673971 ivermectin decreases expression ISO RGD:736049 6480464 Ivermectin results in decreased expression of GPX4 protein CTD PMID:32959892 ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of GPX4 mRNA CTD PMID:17679765 L-ascorbic acid increases expression EXP 6480464 Ascorbic Acid results in increased expression of GPX4 mRNA CTD PMID:15372504 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of GPX4 mRNA CTD PMID:19483382 L-glutamic acid multiple interactions ISO RGD:736050 6480464 gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA], gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein] CTD PMID:31698019 L-glutamic acid decreases expression ISO RGD:736050 6480464 Glutamic Acid results in decreased expression of GPX4 mRNA, Glutamic Acid results in decreased expression of GPX4 protein CTD PMID:31698019 L-methionine multiple interactions ISO RGD:736050 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GPX4 gene CTD PMID:20938992 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of GPX4 mRNA CTD PMID:15014207 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of GPX4 mRNA CTD PMID:33862172 limonene increases expression EXP 6480464 limonene results in increased expression of GPX4 mRNA CTD PMID:12815608 lycopene decreases expression ISO RGD:736049 6480464 lycopene results in decreased expression of GPX4 mRNA CTD PMID:16886892 maneb increases expression ISO RGD:736050 6480464 Maneb results in increased expression of GPX4 mRNA CTD PMID:23764462 maneb multiple interactions ISO RGD:736049 6480464 [Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein CTD PMID:30797899 maneb multiple interactions ISO RGD:736050 6480464 [Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein more ... CTD PMID:23764462 , PMID:30797899 microcystin-LR increases expression ISO RGD:736050 6480464 cyanoginosin LR results in increased expression of GPX4 mRNA CTD PMID:17654400 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA CTD PMID:28659758 N-acetyl-L-cysteine multiple interactions ISO RGD:736049 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA] CTD PMID:12208374 N-methyl-4-phenylpyridinium decreases expression ISO RGD:736049 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 mRNA CTD PMID:24399507 naphthalene decreases expression ISO RGD:736050 6480464 naphthalene results in decreased expression of GPX4 mRNA CTD PMID:31020322 naphthalenes decreases expression EXP 6480464 Naphthalenes results in decreased expression of GPX4 protein CTD PMID:17337753 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of GPX4 mRNA CTD PMID:24136188 nerolidol multiple interactions EXP 6480464 [nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein CTD PMID:33212213 nickel atom multiple interactions EXP 6480464 [nickel sulfate results in increased abundance of Nickel] which results in decreased expression of GPX4 mRNA CTD PMID:31734292 nickel sulfate increases expression ISO RGD:736049 6480464 nickel sulfate results in increased expression of GPX4 mRNA CTD PMID:18651567 nickel sulfate multiple interactions EXP 6480464 [nickel sulfate results in increased abundance of Nickel] which results in decreased expression of GPX4 mRNA CTD PMID:31734292 nitrogen dioxide affects expression EXP 6480464 Nitrogen Dioxide affects the expression of GPX4 mRNA CTD PMID:16049373 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of GPX4 mRNA CTD PMID:17679765 ochratoxin A multiple interactions ISO RGD:736049 6480464 [ochratoxin A results in increased acetylation of GPX4 promoter] which results in increased expression of GPX4 mRNA CTD PMID:29098329 ochratoxin A increases acetylation ISO RGD:736049 6480464 ochratoxin A results in increased acetylation of GPX4 promoter CTD PMID:29098329 ochratoxin A increases expression ISO RGD:736049 6480464 ochratoxin A results in increased expression of GPX4 mRNA CTD PMID:29098329 oleic acid multiple interactions ISO RGD:736049 6480464 [Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein more ... CTD PMID:32976958 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 paracetamol increases expression ISO RGD:736049 6480464 Acetaminophen results in increased expression of GPX4 mRNA CTD PMID:25704631 paraquat increases response to substance ISO RGD:736050 6480464 GPX4 gene mutant form results in increased susceptibility to Paraquat CTD PMID:12566075 paraquat multiple interactions ISO RGD:736050 6480464 [Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein, acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 paraquat multiple interactions ISO RGD:736049 6480464 [Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein CTD PMID:30797899 paraquat increases expression ISO RGD:736050 6480464 Paraquat results in increased expression of GPX4 mRNA CTD PMID:12732627 paraquat decreases response to substance ISO RGD:736050 6480464 GPX4 protein results in decreased susceptibility to Paraquat CTD PMID:12566075 PCB138 multiple interactions ISO RGD:736050 6480464 [2 more ... CTD PMID:25510870 pentachlorophenol increases expression ISO RGD:736050 6480464 Pentachlorophenol results in increased expression of GPX4 mRNA CTD PMID:23892564 perfluorooctanoic acid affects expression ISO RGD:736050 6480464 perfluorooctanoic acid affects the expression of GPX4 mRNA CTD PMID:18281256 perfluorooctanoic acid increases expression ISO RGD:736049 6480464 perfluorooctanoic acid results in increased expression of GPX4 protein CTD PMID:26879310 permethrin multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA CTD PMID:28659758 phenylhydrazine decreases expression ISO RGD:736050 6480464 phenylhydrazine results in decreased expression of GPX4 protein CTD PMID:31323261 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of GPX4 mRNA CTD PMID:15215175 PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of GPX4 mRNA CTD PMID:33945839 phorbol 13-acetate 12-myristate decreases expression ISO RGD:736049 6480464 Tetradecanoylphorbol Acetate results in decreased expression of GPX4 protein CTD PMID:10432307 phosphatidylcholine multiple interactions ISO RGD:736049 6480464 GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite], GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of GPX4 mRNA CTD PMID:19483382 pirinixic acid increases expression ISO RGD:736050 6480464 pirinixic acid results in increased expression of GPX4 mRNA CTD PMID:17950772 , PMID:23811191 pirinixic acid multiple interactions ISO RGD:736050 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of GPX4 mRNA] CTD PMID:17950772 propiconazole increases expression ISO RGD:736050 6480464 propiconazole results in increased expression of GPX4 mRNA CTD PMID:22334560 Pyridostigmine bromide multiple interactions EXP 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of GPX4 mRNA CTD PMID:28659758 pyrimethamine increases expression ISO RGD:736050 6480464 Pyrimethamine results in increased expression of GPX4 mRNA CTD PMID:20193682 pyrimidifen increases expression ISO RGD:736049 6480464 pyrimidifen results in increased expression of GPX4 mRNA CTD PMID:33512557 quercetin multiple interactions ISO RGD:736050 6480464 Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA] CTD PMID:23607047 resveratrol increases expression ISO RGD:736050 6480464 resveratrol results in increased expression of GPX4 mRNA, resveratrol results in increased expression of GPX4 protein CTD PMID:22610192 , PMID:25505154 rotenone multiple interactions EXP 6480464 GPX4 protein inhibits the reaction [Rotenone results in increased expression of MT1 mRNA], GPX4 protein inhibits the reaction [Rotenone results in increased expression of MT2 mRNA] CTD PMID:19818760 rotenone increases expression ISO RGD:736049 6480464 Rotenone results in increased expression of GPX4 mRNA CTD PMID:33512557 rotenone decreases response to substance EXP 6480464 GPX4 protein results in decreased susceptibility to Rotenone CTD PMID:19818760 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:736049 6480464 Buthionine Sulfoximine promotes the reaction [Acrolein results in decreased expression of GPX4 mRNA] CTD PMID:33421550 Se-methyl-L-selenocysteine increases expression ISO RGD:736049 6480464 selenomethylselenocysteine results in increased expression of GPX4 mRNA CTD PMID:18514395 Se-methylselenocysteine increases expression ISO RGD:736049 6480464 selenomethylselenocysteine results in increased expression of GPX4 mRNA CTD PMID:18514395 selenium atom increases activity ISO RGD:736049 6480464 Selenium analog results in increased activity of GPX4 protein CTD PMID:11673642 selenium atom multiple interactions EXP 6480464 [2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] which results in increased expression of GPX4 protein CTD PMID:34116104 selenium atom decreases expression EXP 6480464 Selenium deficiency results in decreased expression of GPX4 mRNA CTD PMID:12031252 more ... selenium atom increases expression EXP 6480464 Selenium results in increased expression of GPX4 mRNA CTD PMID:15792362 , PMID:19022953 selenium atom decreases activity EXP 6480464 Selenium deficiency results in decreased activity of GPX4 protein CTD PMID:12031252 selenium atom affects activity EXP 6480464 Selenium affects the activity of GPX4 protein CTD PMID:19106321 selenium atom increases activity EXP 6480464 Selenium results in increased activity of GPX4 protein CTD PMID:19022953 selenium atom decreases abundance ISO RGD:736050 6480464 GPX4 gene mutant form results in decreased abundance of Selenium CTD PMID:16246897 selenium atom multiple interactions ISO RGD:736049 6480464 Selenium results in increased expression of and results in increased activity of GPX4 protein CTD PMID:17150329 selenium atom increases expression ISO RGD:736049 6480464 Selenium results in increased expression of GPX4 mRNA, Selenium results in increased expression of GPX4 protein CTD PMID:17052796 , PMID:19244175 selenium atom decreases expression ISO RGD:736049 6480464 Selenium deficiency results in decreased expression of GPX4 mRNA CTD PMID:15670848 sodium arsenite decreases expression ISO RGD:736049 6480464 sodium arsenite results in decreased expression of GPX4 mRNA, sodium arsenite results in decreased expression of GPX4 protein CTD PMID:12208374 , PMID:32593899 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of GPX4 protein CTD PMID:32593899 sodium arsenite decreases response to substance ISO RGD:736049 6480464 GPX4 results in decreased susceptibility to sodium arsenite CTD PMID:12208374 sodium arsenite multiple interactions ISO RGD:736049 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA] more ... CTD PMID:12208374 , PMID:32593899 sodium arsenite increases expression ISO RGD:736050 6480464 sodium arsenite results in increased expression of GPX4 mRNA CTD PMID:21396911 sodium fluoride decreases expression ISO RGD:736050 6480464 Sodium Fluoride results in decreased expression of GPX4 mRNA, Sodium Fluoride results in decreased expression of GPX4 protein CTD PMID:28918527 stavudine decreases expression EXP 6480464 Stavudine results in decreased expression of GPX4 mRNA CTD PMID:18299183 streptozocin multiple interactions ISO RGD:736050 6480464 [Dietary Fats co-treated with Streptozocin] results in decreased expression of GPX4 mRNA, ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPX4 mRNA] CTD PMID:33359794 sulforaphane multiple interactions ISO RGD:736050 6480464 sulforaphane inhibits the reaction [Busulfan results in decreased expression of and results in decreased activity of GPX4 protein] CTD PMID:32416107 sulforaphane increases expression ISO RGD:736050 6480464 sulforaphane results in increased expression of GPX4 protein CTD PMID:32416107 sulforaphane decreases expression ISO RGD:736049 6480464 sulforaphane results in decreased expression of GPX4 mRNA CTD PMID:31838189 temozolomide decreases expression ISO RGD:736049 6480464 Temozolomide results in decreased expression of GPX4 mRNA CTD PMID:31758290 tert-butyl hydroperoxide multiple interactions ISO RGD:736049 6480464 GPX4 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein] CTD PMID:15496407 tert-butyl hydroperoxide decreases response to substance ISO RGD:736049 6480464 GPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:15496407 tert-butyl hydroperoxide increases response to substance ISO RGD:736050 6480464 GPX4 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide CTD PMID:12566075 tert-butyl hydroperoxide decreases response to substance ISO RGD:736050 6480464 GPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide CTD PMID:12566075 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of GPX4 mRNA CTD PMID:26496021 tetrachloromethane increases expression ISO RGD:736050 6480464 Carbon Tetrachloride results in increased expression of GPX4 protein CTD PMID:30551460 tetrachloromethane multiple interactions ISO RGD:736050 6480464 Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein] CTD PMID:30551460 tetracycline decreases expression ISO RGD:736050 6480464 Tetracycline results in decreased expression of GPX4 mRNA CTD PMID:16917069 tetrahydropalmatine decreases expression ISO RGD:736049 6480464 tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of GPX4 mRNA CTD PMID:19483382 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of GPX4 mRNA CTD PMID:26277626 toluene affects expression EXP 6480464 Toluene affects the expression of GPX4 mRNA CTD PMID:21827849 Triptolide increases expression ISO RGD:736050 6480464 triptolide results in increased expression of GPX4 mRNA CTD PMID:31241159 Triptolide multiple interactions ISO RGD:736050 6480464 Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA] CTD PMID:31241159 triptonide increases expression ISO RGD:736050 6480464 triptonide results in increased expression of GPX4 mRNA CTD PMID:33045310 tungsten increases expression ISO RGD:736050 6480464 Tungsten results in increased expression of GPX4 mRNA CTD PMID:30912803 valproic acid affects expression ISO RGD:736050 6480464 Valproic Acid affects the expression of GPX4 mRNA CTD PMID:17963808 valproic acid increases methylation ISO RGD:736049 6480464 Valproic Acid results in increased methylation of GPX4 gene CTD PMID:29154799
