Gpx4 (glutathione peroxidase 4) - Rat Genome Database

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Gene: Gpx4 (glutathione peroxidase 4) Rattus norvegicus
Analyze
Symbol: Gpx4
Name: glutathione peroxidase 4
RGD ID: 69226
Description: Enables glutathione peroxidase activity; phospholipid-hydroperoxide glutathione peroxidase activity; and selenium binding activity. Involved in several processes, including aging; glutathione metabolic process; and response to estradiol. Predicted to be located in cytosol and nuclear envelope. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4); PARTICIPATES IN glutathione metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Gpx-4; Gshpx-4; Phgpx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGpx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2   Gpx4-ps3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIRnor_WKY
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
12(S)-HPETE  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrophenol  (EXP)
2-deoxy-D-glucose  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxy-TEMPO  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
butan-1-ol  (ISO)
butein  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon monoxide  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
cyclophosphamide  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (EXP)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erastin  (EXP,ISO)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferrostatin-1  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
Gastrodin  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
Iodine aqueous  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
Leonurine  (EXP)
limonene  (EXP)
lycopene  (ISO)
maneb  (ISO)
melatonin  (EXP)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (EXP)
nerolidol  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
nitrogen dioxide  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylhydrazine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
stavudine  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP)
toluene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
verteporfin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO,ISS)
mitochondrion  (IBA,ISO)
nuclear envelope  (ISO)
nucleolus  (IEA)
nucleus  (IBA,ISO,ISS)
protein-containing complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Bermano G, etal., Genes Nutr. 2007 Nov;2(2):225-32. doi: 10.1007/s12263-007-0052-3. Epub 2007 Oct 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression. Imai H, etal., J Biochem (Tokyo) 1995 Nov;118(5):1061-7.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Lan X, etal., Biol Trace Elem Res. 2017 Jul;178(1):22-28. doi: 10.1007/s12011-016-0908-8. Epub 2016 Dec 13.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Genetic variants in selenoprotein genes increase risk of colorectal cancer. M├ęplan C, etal., Carcinogenesis. 2010 Jun;31(6):1074-9. doi: 10.1093/carcin/bgq076. Epub 2010 Apr 8.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. Pfeifer H, etal., FASEB J 2001 May;15(7):1236-8.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Rat phospholipid-hydroperoxide glutathione peroxidase. cDNA cloning and identification of multiple transcription and translation start sites. Pushpa-Rekha TR, etal., J Biol Chem 1995 Nov 10;270(45):26993-9.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. Sakamoto H, etal., J Biol Chem 2002 Dec 27;277(52):50431-8.
17. Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. Sunde RA, etal., J Nutr. 2005 Sep;135(9):2144-50.
18. Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. Weir CP and Robaire B, J Androl. 2007 Mar-Apr;28(2):229-40. Epub 2006 Oct 4.
19. Expression of selenium-containing proteins in human colon carcinoma tissue. Yagublu V, etal., Anticancer Res. 2011 Sep;31(9):2693-8.
20. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Yant LJ, etal., Free Radic Biol Med 2003 Feb 15;34(4):496-502.
21. Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. Zhang L, etal., J Hypertens. 2007 Feb;25(2):407-14.
Additional References at PubMed
PMID:1556123   PMID:2386798   PMID:8135530   PMID:8878533   PMID:9988735   PMID:10464096   PMID:11115402   PMID:11903656   PMID:12533403   PMID:12724282   PMID:12819198   PMID:12865426  
PMID:14575705   PMID:14583338   PMID:14651853   PMID:15670826   PMID:15757501   PMID:15821744   PMID:15888450   PMID:15901730   PMID:16159880   PMID:17603929   PMID:17630701   PMID:17997296  
PMID:18614015   PMID:19056867   PMID:19398061   PMID:19723078   PMID:19890015   PMID:21630459   PMID:22614831   PMID:23376485   PMID:23816523   PMID:25402683   PMID:25922076   PMID:26071777  
PMID:26163004   PMID:28709976   PMID:29290465   PMID:30205109   PMID:31685805   PMID:32376803   PMID:33415582   PMID:34699317   PMID:35320827   PMID:35653908  


Genomics

Comparative Map Data
Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,650,186 - 9,652,982 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,533,042 - 12,535,860 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,408,380 - 14,411,198 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,269,509 - 12,272,287 (-)NCBIRnor_WKY
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl191,103,994 - 1,106,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,103,993 - 1,106,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,529 - 1,106,380 (+)NCBICHM1_1
T2T-CHM13v2.0191,068,660 - 1,071,445 (+)NCBIT2T-CHM13v2.0
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,883,000 - 79,892,273 (+)EnsemblGRCm39 Ensembl
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBIMGSCv36mm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,082,917 - 1,085,538 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,443,525 - 57,445,796 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,383,449 - 58,385,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,383,450 - 58,385,689 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,438,781 - 57,441,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,918,275 - 57,920,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,121,304 - 58,123,564 (-)NCBIUU_Cfam_GSD_1.0
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588506,147 - 508,101 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,931 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660817,991,488 - 7,994,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,534,449 - 7,536,586 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpx4
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000018691
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat

Markers in Region
RH137289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,433 - 35,338,615 (+)MAPPERmRatBN7.2
mRatBN7.279,650,550 - 9,651,548 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,723 - 12,517,720NCBIRnor6.0
Rnor_6.01437,904,806 - 37,904,987NCBIRnor6.0
Rnor_5.01437,715,064 - 37,715,245UniSTSRnor5.0
Rnor_5.0712,686,826 - 12,687,823UniSTSRnor5.0
RGSC_v3.41437,742,061 - 37,742,242UniSTSRGSC3.4
RGSC_v3.4711,162,887 - 11,163,884UniSTSRGSC3.4
Celera77,826,407 - 7,827,404UniSTS
Celera1434,593,349 - 34,593,530UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS
RH143516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,652,690 - 9,652,829 (+)MAPPERmRatBN7.2
Rnor_6.0712,518,863 - 12,519,001NCBIRnor6.0
Rnor_5.0712,688,966 - 12,689,104UniSTSRnor5.0
RGSC_v3.4711,165,027 - 11,165,165UniSTSRGSC3.4
Celera77,828,547 - 7,828,685UniSTS
RH 3.4 Map740.6UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:237712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,650,401 - 9,650,571 (+)MAPPERmRatBN7.2
Rnor_6.0712,516,574 - 12,516,743NCBIRnor6.0
Rnor_5.0712,686,677 - 12,686,846UniSTSRnor5.0
RGSC_v3.4711,162,738 - 11,162,907UniSTSRGSC3.4
Celera77,826,258 - 7,826,427UniSTS
Cytogenetic Map7q11UniSTS
Gpx4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,112 - 35,338,614 (+)MAPPERmRatBN7.2
Rnor_6.01437,904,485 - 37,904,986NCBIRnor6.0
Rnor_5.01437,714,743 - 37,715,244UniSTSRnor5.0
RGSC_v3.41437,741,740 - 37,742,241UniSTSRGSC3.4
Celera1434,593,028 - 34,593,529UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 2 35 48 39 4 39 4 7 74 35 37 9 4
Low 1 8 9 2 15 2 4 4 2 2 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF274028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ537598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY570513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB582508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ087247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018691   ⟹   ENSRNOP00000018691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,518,684 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077681   ⟹   ENSRNOP00000072552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,519,154 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,359 - 12,517,335 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093376   ⟹   ENSRNOP00000076198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,650,185 - 9,652,982 (-)Ensembl
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093426   ⟹   ENSRNOP00000076309
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,650,186 - 9,652,512 (-)Ensembl
Rnor_6.0 Ensembl712,516,363 - 12,518,684 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093632
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,358 - 12,517,901 (-)Ensembl
RefSeq Acc Id: NM_001039849   ⟹   NP_001034938
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,512 (-)NCBI
Rnor_6.0712,516,357 - 12,518,684 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368043   ⟹   NP_001354972
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,890 (-)NCBI
RefSeq Acc Id: NM_017165   ⟹   NP_058861
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0712,516,357 - 12,519,154 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,838 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058861   ⟸   NM_017165
- Peptide Label: isoform A precursor
- UniProtKB: Q91XR8 (UniProtKB/Swiss-Prot),   P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001034938   ⟸   NM_001039849
- Peptide Label: isoform B
- UniProtKB: P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018691   ⟸   ENSRNOT00000018691
RefSeq Acc Id: ENSRNOP00000072552   ⟸   ENSRNOT00000077681
RefSeq Acc Id: ENSRNOP00000076198   ⟸   ENSRNOT00000093376
RefSeq Acc Id: ENSRNOP00000076309   ⟸   ENSRNOT00000093426
RefSeq Acc Id: NP_001354972   ⟸   NM_001368043
- Peptide Label: isoform C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695040
Promoter ID:EPDNEW_R5561
Type:initiation region
Name:Gpx4_2
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5562  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,518,684 - 12,518,744EPDNEW
RGD ID:13695039
Promoter ID:EPDNEW_R5562
Type:initiation region
Name:Gpx4_1
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5561  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,519,059 - 12,519,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69226 AgrOrtholog
BioCyc Gene G2FUF-34914 BioCyc
BioCyc Pathway PWY-4081 [glutathione-peroxide redox reactions] BioCyc
Ensembl Genes ENSRNOG00000013604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000076198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076309 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093376 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000093426 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:29328 UniProtKB/Swiss-Prot
NCBI Gene 29328 ENTREZGENE
PANTHER PTHR11592 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx4 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt GPX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91XR8 ENTREZGENE
UniProt Secondary Q6PZ55 UniProtKB/Swiss-Prot
  Q76LU9 UniProtKB/Swiss-Prot
  Q91XR8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx4  glutathione peroxidase 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression inhibits synthesis of platelet activating factor 728699