Gpx4 (glutathione peroxidase 4) - Rat Genome Database

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Gene: Gpx4 (glutathione peroxidase 4) Rattus norvegicus
Analyze
Symbol: Gpx4
Name: glutathione peroxidase 4
RGD ID: 69226
Description: Exhibits glutathione peroxidase activity; phospholipid-hydroperoxide glutathione peroxidase activity; and selenium binding activity. Involved in several processes, including aging; glutathione metabolic process; and response to estradiol. Predicted to localize to several cellular components, including cytosol; mitochondrion; and nuclear envelope. Orthologous to human GPX4 (glutathione peroxidase 4); PARTICIPATES IN glutathione metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Gpx-4; Gshpx-4; Phgpx; phospholipid hydroperoxide glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear; snGpx
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gpx4-ps1   Gpx4-ps2   Gpx4-ps3  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
12(S)-HPETE  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrophenol  (EXP)
2-deoxy-D-glucose  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon monoxide  (ISO)
cerium trichloride  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
cyclophosphamide  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
DDE  (EXP)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol dimethacrylate  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
Gastrodin  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
Iodine aqueous  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
limonene  (EXP)
lycopene  (ISO)
maneb  (ISO)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (EXP)
nerolidol  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
nitrogen dioxide  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylhydrazine  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
stavudine  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
toluene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO,ISS)
mitochondrion  (IBA,ISO)
nuclear envelope  (ISO)
nucleolus  (IEA)
nucleus  (IBA,ISO,ISS)
protein-containing complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1556123   PMID:2386798   PMID:8135530   PMID:8878533   PMID:9988735   PMID:10464096   PMID:11115402   PMID:11903656   PMID:12533403   PMID:12724282   PMID:12819198   PMID:12865426  
PMID:14575705   PMID:14583338   PMID:14651853   PMID:15670826   PMID:15757501   PMID:15821744   PMID:15888450   PMID:15901730   PMID:16159880   PMID:17603929   PMID:17630701   PMID:17997296  
PMID:18614015   PMID:19056867   PMID:19398061   PMID:19723078   PMID:19890015   PMID:21630459   PMID:22614831   PMID:23376485   PMID:23816523   PMID:25402683   PMID:25922076   PMID:26071777  
PMID:26163004   PMID:28709976   PMID:29290465   PMID:30205109   PMID:31685805  


Genomics

Comparative Map Data
Gpx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0712,516,357 - 12,519,154 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0712,686,460 - 12,689,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,162,521 - 11,165,318 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1711,162,520 - 11,165,318 (-)NCBI
Celera77,826,041 - 7,828,838 (-)NCBICelera
Cytogenetic Map7q11NCBI
GPX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl191,103,926 - 1,106,791 (+)EnsemblGRCh38hg38GRCh38
GRCh38191,103,994 - 1,106,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37191,103,993 - 1,106,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,054,936 - 1,057,787 (+)NCBINCBI36hg18NCBI36
Build 34191,054,965 - 1,057,778NCBI
Celera191,036,910 - 1,039,761 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef19877,428 - 880,271 (+)NCBIHuRef
CHM1_1191,103,518 - 1,106,381 (+)NCBICHM1_1
Gpx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,883,000 - 79,892,273 (+)NCBIGRCm39mm39
GRCm39 Ensembl1079,883,000 - 79,892,273 (+)Ensembl
GRCm381080,047,166 - 80,056,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,047,166 - 80,056,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,516,255 - 79,519,184 (+)NCBIGRCm37mm9NCBIm37
MGSCv361079,456,617 - 79,459,567 (+)NCBImm8
Celera1081,068,319 - 81,071,248 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Gpx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,767,975 - 6,772,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,767,969 - 6,772,256 (-)NCBIChiLan1.0ChiLan1.0
GPX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,082,917 - 1,085,538 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01920,904 - 23,828 (-)NCBIMhudiblu_PPA_v0panPan3
GPX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,443,525 - 57,445,796 (-)NCBI
ROS_Cfam_1.02058,383,449 - 58,385,704 (-)NCBI
UMICH_Zoey_3.12057,438,781 - 57,441,040 (-)NCBI
UNSW_CanFamBas_1.02057,918,275 - 57,920,554 (-)NCBI
UU_Cfam_GSD_1.02058,121,304 - 58,123,564 (-)NCBI
Gpx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,324,770 - 217,328,696 (-)NCBI
SpeTri2.0NW_004936588506,101 - 508,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,320,464 - 77,323,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,321,568 - 77,323,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,673,720 - 77,676,083 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16873,867 - 876,225 (+)NCBI
Gpx4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248287,534,251 - 7,536,675 (-)NCBI

Position Markers
RH137289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,433 - 35,338,615 (+)MAPPER
mRatBN7.279,650,550 - 9,651,548 (+)MAPPER
Rnor_6.0712,516,723 - 12,517,720NCBIRnor6.0
Rnor_6.01437,904,806 - 37,904,987NCBIRnor6.0
Rnor_5.01437,715,064 - 37,715,245UniSTSRnor5.0
Rnor_5.0712,686,826 - 12,687,823UniSTSRnor5.0
RGSC_v3.41437,742,061 - 37,742,242UniSTSRGSC3.4
RGSC_v3.4711,162,887 - 11,163,884UniSTSRGSC3.4
Celera77,826,407 - 7,827,404UniSTS
Celera1434,593,349 - 34,593,530UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS
RH143516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,652,690 - 9,652,829 (+)MAPPER
Rnor_6.0712,518,863 - 12,519,001NCBIRnor6.0
Rnor_5.0712,688,966 - 12,689,104UniSTSRnor5.0
RGSC_v3.4711,165,027 - 11,165,165UniSTSRGSC3.4
Celera77,828,547 - 7,828,685UniSTS
RH 3.4 Map740.6UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:237712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,650,401 - 9,650,571 (+)MAPPER
Rnor_6.0712,516,574 - 12,516,743NCBIRnor6.0
Rnor_5.0712,686,677 - 12,686,846UniSTSRnor5.0
RGSC_v3.4711,162,738 - 11,162,907UniSTSRGSC3.4
Celera77,826,258 - 7,826,427UniSTS
Cytogenetic Map7q11UniSTS
Gpx4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,338,112 - 35,338,614 (+)MAPPER
Rnor_6.01437,904,485 - 37,904,986NCBIRnor6.0
Rnor_5.01437,714,743 - 37,715,244UniSTSRnor5.0
RGSC_v3.41437,741,740 - 37,742,241UniSTSRGSC3.4
Celera1434,593,028 - 34,593,529UniSTS
Cytogenetic Map14p11UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000018691
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 2 35 48 39 4 39 4 7 74 35 37 9 4
Low 1 8 9 2 15 2 4 4 2 2 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF274028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ537598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY570513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB582508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ087247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X82679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018691   ⟹   ENSRNOP00000018691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,518,684 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077681   ⟹   ENSRNOP00000072552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,357 - 12,519,154 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,359 - 12,517,335 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093376   ⟹   ENSRNOP00000076198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,352 - 12,519,154 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093426   ⟹   ENSRNOP00000076309
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,363 - 12,518,684 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093632
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,516,358 - 12,517,901 (-)Ensembl
RefSeq Acc Id: NM_001039849   ⟹   NP_001034938
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,512 (-)NCBI
Rnor_6.0712,516,357 - 12,518,684 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,368 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368043   ⟹   NP_001354972
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,890 (-)NCBI
RefSeq Acc Id: NM_017165   ⟹   NP_058861
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,650,186 - 9,652,982 (-)NCBI
Rnor_6.0712,516,357 - 12,519,154 (-)NCBI
Rnor_5.0712,686,460 - 12,689,257 (-)NCBI
RGSC_v3.4711,162,521 - 11,165,318 (-)RGD
Celera77,826,041 - 7,828,838 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058861   ⟸   NM_017165
- Peptide Label: isoform A precursor
- UniProtKB: P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001034938   ⟸   NM_001039849
- Peptide Label: isoform B
- UniProtKB: P36970 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018691   ⟸   ENSRNOT00000018691
RefSeq Acc Id: ENSRNOP00000072552   ⟸   ENSRNOT00000077681
RefSeq Acc Id: ENSRNOP00000076198   ⟸   ENSRNOT00000093376
RefSeq Acc Id: ENSRNOP00000076309   ⟸   ENSRNOT00000093426
RefSeq Acc Id: NP_001354972   ⟸   NM_001368043
- Peptide Label: isoform C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695040
Promoter ID:EPDNEW_R5561
Type:initiation region
Name:Gpx4_2
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5562  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,518,684 - 12,518,744EPDNEW
RGD ID:13695039
Promoter ID:EPDNEW_R5562
Type:initiation region
Name:Gpx4_1
Description:glutathione peroxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5561  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,519,059 - 12,519,119EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69226 AgrOrtholog
Ensembl Genes ENSRNOG00000013604 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018691 UniProtKB/TrEMBL
  ENSRNOP00000072552 UniProtKB/TrEMBL
  ENSRNOP00000076198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076309 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018691 UniProtKB/TrEMBL
  ENSRNOT00000077681 UniProtKB/TrEMBL
  ENSRNOT00000093376 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000093426 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29328 UniProtKB/Swiss-Prot
NCBI Gene 29328 ENTREZGENE
PANTHER PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpx4 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K398_RAT UniProtKB/TrEMBL
  F8WFK6_RAT UniProtKB/TrEMBL
  GPX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6PZ55 UniProtKB/Swiss-Prot
  Q76LU9 UniProtKB/Swiss-Prot
  Q91XR8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpx4  glutathione peroxidase 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression inhibits synthesis of platelet activating factor 728699