Pdp1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) - Rat Genome Database

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Gene: Pdp1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) Rattus norvegicus
Analyze
Symbol: Pdp1
Name: pyruvate dehydrogenase phosphatase catalytic subunit 1
RGD ID: 620393
Description: Enables calcium ion binding activity; magnesium ion binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; PDP 1; PDPC 1; Ppm2c; protein phosphatase 2C, magnesium dependent, catalytic subunit; protein phosphatase 2C, magnesium-dependent, catalytic subunit; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial; pyruvate dehydrogenase phosphatase isoenzyme 1; pyruvate dehydrogenase phosphatase, catalytic subunit 1; pyruvate dehyrogenase phosphatase catalytic subunit 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2525,446,843 - 25,455,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,446,272 - 25,455,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx527,586,593 - 27,593,283 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0529,179,332 - 29,186,022 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0529,122,462 - 29,129,161 (-)NCBIRnor_WKY
Rnor_6.0525,577,593 - 25,584,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,577,451 - 25,584,288 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0530,284,064 - 30,290,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4526,234,414 - 26,240,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1526,234,515 - 26,241,115 (-)NCBI
Celera524,779,851 - 24,786,537 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
glucose  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nicotinamide  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Huang B, etal., Diabetes. 2003 Jun;52(6):1371-6.
3. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, etal., J Biol Chem 1998 Jul 10;273(28):17680-8.
4. Probing a putative active site of the catalytic subunit of pyruvate dehydrogenase phosphatase 1 (PDP1c) by site-directed mutagenesis. Karpova T, etal., Biochim Biophys Acta. 2004 Jul 1;1700(1):43-51.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Down-regulation of pyruvate dehydrogenase phosphatase in obese subjects is a defect that signals insulin resistance. Piccinini M, etal., Obes Res. 2005 Apr;13(4):678-86.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
12. Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications. Vassylyev DG and Symersky J, J Mol Biol. 2007 Jul 13;370(3):417-26. Epub 2007 May 10.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15367397   PMID:18614015   PMID:18716035   PMID:20801214   PMID:22884618   PMID:25931508   PMID:35148687  


Genomics

Comparative Map Data
Pdp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2525,446,843 - 25,455,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,446,272 - 25,455,217 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx527,586,593 - 27,593,283 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0529,179,332 - 29,186,022 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0529,122,462 - 29,129,161 (-)NCBIRnor_WKY
Rnor_6.0525,577,593 - 25,584,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,577,451 - 25,584,288 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0530,284,064 - 30,290,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4526,234,414 - 26,240,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1526,234,515 - 26,241,115 (-)NCBI
Celera524,779,851 - 24,786,537 (-)NCBICelera
Cytogenetic Map5q13NCBI
PDP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38893,916,923 - 93,926,068 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl893,857,807 - 93,926,068 (+)EnsemblGRCh38hg38GRCh38
GRCh37894,929,151 - 94,938,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36894,998,338 - 95,007,472 (+)NCBINCBI36Build 36hg18NCBI36
Build 34894,998,337 - 95,007,470NCBI
Celera891,115,139 - 91,124,357 (+)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef890,137,033 - 90,146,245 (+)NCBIHuRef
CHM1_1894,969,362 - 94,978,572 (+)NCBICHM1_1
T2T-CHM13v2.0895,042,005 - 95,051,150 (+)NCBIT2T-CHM13v2.0
Pdp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,958,183 - 11,966,450 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,958,184 - 11,966,452 (-)EnsemblGRCm39 Ensembl
GRCm38411,958,183 - 11,966,450 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,958,184 - 11,966,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv37411,885,332 - 11,893,597 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,886,958 - 11,893,567 (-)NCBIMGSCv36mm8
Celera411,768,969 - 11,777,217 (-)NCBICelera
Cytogenetic Map4A1NCBI
Pdp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,219,595 - 10,228,669 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541710,219,096 - 10,227,483 (+)NCBIChiLan1.0ChiLan1.0
PDP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1892,486,271 - 92,494,714 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl892,486,271 - 92,494,714 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0890,541,269 - 90,550,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12938,783,945 - 38,792,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2938,782,418 - 38,789,807 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2938,944,677 - 38,954,347 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02938,987,121 - 38,996,745 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2938,987,129 - 38,996,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,000,780 - 39,010,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02938,995,485 - 39,005,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02939,437,281 - 39,447,145 (+)NCBIUU_Cfam_GSD_1.0
Pdp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,775,259 - 40,783,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,009,486 - 7,018,859 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365447,008,882 - 7,017,446 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl442,764,441 - 42,777,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1442,769,232 - 42,777,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2446,190,418 - 46,199,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1888,896,049 - 88,905,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl888,897,030 - 88,903,003 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603951,943,494 - 51,952,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247631,356,588 - 1,365,726 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247631,356,193 - 1,364,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdp1
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:57
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000067823
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 18 4 16 4 8 11 72 22 41 11 8
Low 3 39 37 3 37 2 13
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067823   ⟹   ENSRNOP00000062054
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl525,448,361 - 25,454,602 (-)Ensembl
Rnor_6.0 Ensembl525,577,593 - 25,583,834 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090376   ⟹   ENSRNOP00000070525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl525,446,272 - 25,455,217 (-)Ensembl
Rnor_6.0 Ensembl525,577,451 - 25,584,288 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090579   ⟹   ENSRNOP00000069844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl525,448,361 - 25,454,395 (-)Ensembl
Rnor_6.0 Ensembl525,577,593 - 25,584,278 (-)Ensembl
RefSeq Acc Id: NM_001271108   ⟹   NP_001258037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2525,448,361 - 25,454,602 (-)NCBI
Rnor_6.0525,577,593 - 25,583,834 (-)NCBI
Rnor_5.0530,284,064 - 30,290,681 (-)NCBI
Celera524,779,851 - 24,786,092 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019372   ⟹   NP_062245
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2525,448,361 - 25,455,047 (-)NCBI
Rnor_6.0525,577,593 - 25,584,278 (-)NCBI
Rnor_5.0530,284,064 - 30,290,681 (-)NCBI
RGSC_v3.4526,234,414 - 26,240,301 (-)RGD
Celera524,779,851 - 24,786,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237907   ⟹   XP_006237969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2525,446,843 - 25,454,341 (-)NCBI
Rnor_6.0525,577,698 - 25,583,715 (-)NCBI
Rnor_5.0530,284,064 - 30,290,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237908   ⟹   XP_006237970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2525,446,843 - 25,454,931 (-)NCBI
Rnor_6.0525,577,593 - 25,583,857 (-)NCBI
Rnor_5.0530,284,064 - 30,290,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237909   ⟹   XP_006237971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2525,446,843 - 25,455,107 (-)NCBI
Rnor_6.0525,577,593 - 25,584,325 (-)NCBI
Rnor_5.0530,284,064 - 30,290,681 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062245   ⟸   NM_019372
- Peptide Label: isoform 2
- UniProtKB: A1L1J4 (UniProtKB/TrEMBL),   F1LP63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258037   ⟸   NM_001271108
- Peptide Label: isoform 1
- UniProtKB: A0A0G2QC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237971   ⟸   XM_006237909
- Peptide Label: isoform X3
- UniProtKB: A0A0G2QC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237970   ⟸   XM_006237908
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006237969   ⟸   XM_006237907
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000062054   ⟸   ENSRNOT00000067823
RefSeq Acc Id: ENSRNOP00000069844   ⟸   ENSRNOT00000090579
RefSeq Acc Id: ENSRNOP00000070525   ⟸   ENSRNOT00000090376
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88483-F1-model_v2 AlphaFold O88483 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693568
Promoter ID:EPDNEW_R4093
Type:single initiation site
Name:Pdp1_2
Description:pyruvate dehyrogenase phosphatase catalytic subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4094  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0525,583,839 - 25,583,899EPDNEW
RGD ID:13693569
Promoter ID:EPDNEW_R4094
Type:multiple initiation site
Name:Pdp1_1
Description:pyruvate dehyrogenase phosphatase catalytic subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4093  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0525,584,269 - 25,584,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620393 AgrOrtholog
BioCyc Gene G2FUF-41914 BioCyc
Ensembl Genes ENSRNOG00000016180 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062054 ENTREZGENE
  ENSRNOP00000062054.3 UniProtKB/TrEMBL
  ENSRNOP00000069844 ENTREZGENE
  ENSRNOP00000069844.2 UniProtKB/TrEMBL
  ENSRNOP00000070525 ENTREZGENE
  ENSRNOP00000070525.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067823 ENTREZGENE
  ENSRNOT00000067823.4 UniProtKB/TrEMBL
  ENSRNOT00000090376 ENTREZGENE
  ENSRNOT00000090376.2 UniProtKB/TrEMBL
  ENSRNOT00000090579 ENTREZGENE
  ENSRNOT00000090579.2 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8369880 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54705 UniProtKB/TrEMBL
MGC_CLONE MGC:156655 IMAGE-MGC_LOAD
NCBI Gene 54705 ENTREZGENE
PANTHER PTHR13832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdp1 PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWE0_RAT UniProtKB/TrEMBL
  A0A0G2QC17 ENTREZGENE, UniProtKB/TrEMBL
  A1L1J4 ENTREZGENE, UniProtKB/TrEMBL
  F1LP63 ENTREZGENE
  O88483 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1LP63 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Pdp1  pyruvate dehydrogenase phosphatase catalytic subunit 1  Pdp1  pyruvate dehyrogenase phosphatase catalytic subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Pdp1  pyruvate dehyrogenase phosphatase catalytic subunit 1  Ppm2c  protein phosphatase 2C, magnesium dependent, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppm2c  protein phosphatase 2C, magnesium-dependent, catalytic subunit  PDP1  pyruvate dehydrogenase phosphatase isoenzyme 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 PDP1  pyruvate dehydrogenase phosphatase isoenzyme 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression predominantly expressed in mitochondria from skeletal muscle 729524
gene_function Mg2+-dependent enzyme 729524