Edn1 (endothelin 1) - Rat Genome Database

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Gene: Edn1 (endothelin 1) Rattus norvegicus
Symbol: Edn1
Name: endothelin 1
RGD ID: 2532
Description: Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1722,330,779 - 22,336,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,934,458 - 23,940,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01722,266,095 - 22,271,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (IDA,IEP,ISO)
Albuminuria  (IEP)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aortic atherosclerosis  (ISO)
aspiration pneumonia  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (IEP)
bronchiolitis obliterans  (ISO)
bronchopulmonary dysplasia  (IEP)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (IDA)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (IEP)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
coronary artery disease  (IMP,ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
heart disease  (IEP)
hepatopulmonary syndrome  (IEP)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (IEP,ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
Hypertrophy  (ISO)
hypogonadism  (IEP)
Hypotension  (ISO)
impotence  (IEP,ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (ISO)
kidney disease  (ISO)
kidney failure  (IEP,ISO)
Left Ventricular Hypertrophy  (IDA,IEP,ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (IEP)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (IEP,IMP)
metabolic acidosis  (IDA)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (IEP)
nephrosis  (IEP,ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (IEP,ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (IEP)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
overactive bladder syndrome  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (IEP)
portal hypertension  (IDA)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (IEP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (IEP)
Reperfusion Injury  (IEP,ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (IEP)
ureteral obstruction  (IEP,ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (EXP)
atropine  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caesium chloride  (ISO)
caffeine  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP)
Candesartan cilexetil  (EXP)
capsaicin  (ISO)
carbon atom  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chelerythrine  (EXP)
chenodeoxycholic acid  (EXP)
chetomin  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cicaprost  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
dapsone  (ISO)
daunorubicin  (EXP)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental carbon  (EXP)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
glycidol  (EXP)
glycoursodeoxycholic acid  (ISO)
GW 4064  (EXP)
heparin  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
ICI 118551  (ISO)
indometacin  (EXP,ISO)
iodixanol  (EXP)
iopromide  (EXP)
irbesartan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
isoquinoline-1,5-diol  (EXP)
isorhamnetin  (EXP)
isosorbide dinitrate  (ISO)
ivermectin  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-mimosine  (EXP,ISO)
lamivudine  (ISO)
leflunomide  (ISO)
leukotriene C4  (ISO)
levamisole  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
Meglumine sodium amidotrizoate  (EXP)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
Mibefradil  (EXP)
microcystin-LR  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
montelukast  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nisoldipine  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
olodaterol  (ISO)
orotic acid  (EXP)
oroxylin A  (EXP)
ouabain  (EXP,ISO)
Oxotremorine  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
PD123319  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (EXP)
phosphoramide mustard  (EXP)
phosphoramidon  (EXP)
picrotoxin  (EXP)
potassium atom  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
RES-701-1  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 31-8220  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
ruxolitinib  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-methyl-L-thiocitrulline  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
sodium dodecyl sulfate  (ISO)
sorafenib  (EXP)
stattic  (EXP)
staurosporine  (EXP)
steviol  (ISO)
stevioside  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (EXP,ISO)
Sucralfate  (EXP)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
teprenone  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracosanoic acid  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
tiotropium bromide  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
torcetrapib  (EXP)
trans-caffeic acid  (ISO)
trans-stilbene-4,4'-diol  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
water  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
artery smooth muscle contraction  (IDA,ISO)
axon extension  (ISO)
axon guidance  (ISO)
axonogenesis involved in innervation  (ISO)
blood vessel morphogenesis  (ISO)
body fluid secretion  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
calcium ion transmembrane transport  (ISO)
calcium-mediated signaling  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cartilage development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (ISO)
cellular response to calcium ion  (IEP)
cellular response to fatty acid  (IEP)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to human chorionic gonadotropin stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (IEP)
cellular response to organic substance  (ISO)
cellular response to peptide hormone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
cellular response to xenobiotic stimulus  (IEP)
dorsal/ventral pattern formation  (ISO)
embryonic heart tube development  (ISO)
endothelin receptor signaling pathway  (ISO,ISS)
endothelin receptor signaling pathway involved in heart process  (ISO)
epithelial fluid transport  (IDA)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (ISO)
glomerular endothelium development  (ISO)
glomerular filtration  (ISO)
heart development  (ISO)
heart process  (ISO)
histamine secretion  (IDA)
in utero embryonic development  (ISO)
intracellular calcium ion homeostasis  (IBA,ISO)
intracellular signal transduction  (IDA)
MAPK cascade  (ISO)
maternal process involved in parturition  (IEP)
meiotic cell cycle process involved in oocyte maturation  (ISO)
membrane depolarization  (IMP)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of hormone secretion  (IDA)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of protein metabolic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (ISO)
neuron projection development  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (ISO)
noradrenergic neuron differentiation  (ISO)
peptide hormone secretion  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
podocyte differentiation  (ISO)
positive regulation of artery morphogenesis  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (ISO)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of heart rate  (ISO)
positive regulation of hormone secretion  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neutrophil chemotaxis  (IDA)
positive regulation of non-canonical NF-kappaB signal transduction  (IDA)
positive regulation of odontogenesis  (IDA)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of protein localization to nucleus  (ISO,ISS)
positive regulation of renal sodium excretion  (ISO)
positive regulation of sarcomere organization  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (IDA,IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of urine volume  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
prostaglandin biosynthetic process  (ISO)
protein kinase A signaling  (ISO)
protein kinase C deactivation  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood pressure  (IMP,ISO)
regulation of glucose transmembrane transport  (ISO)
regulation of pH  (ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA,ISO)
regulation of vasoconstriction  (IEA)
renal sodium ion absorption  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to amphetamine  (ISO)
response to dexamethasone  (IEP)
response to hypoxia  (IEP,ISO)
response to leptin  (IEP)
response to lipopolysaccharide  (IEP)
response to muscle stretch  (IEP)
response to nicotine  (IEP)
response to ozone  (IEP)
response to prostaglandin F  (IEP)
response to salt  (IEP)
response to testosterone  (IEP)
response to transforming growth factor beta  (IEP)
response to xenobiotic stimulus  (IEP)
rhythmic excitation  (ISO)
semaphorin-plexin signaling pathway involved in axon guidance  (ISO)
skeletal system development  (ISO)
smooth muscle contraction  (ISO)
superoxide anion generation  (IDA)
sympathetic neuron axon guidance  (ISO)
thyroid gland development  (ISO)
transcription by RNA polymerase II  (ISO)
vasoconstriction  (IDA,ISO)
vein smooth muscle contraction  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
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130. ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors. Perry MG, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2680-6.
131. Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load. Pikkarainen S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1639-45. Epub 2006 Jan 12.
132. Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors. Pikkarainen S, etal., J Biol Chem 2003 Feb 7;278(6):3969-75.
133. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
134. Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts. Piuhola J, etal., Hypertension 2003 Jan;41(1):93-8.
135. Differential effects of ET-1, ET-2, and ET-3 on pancreatic microcirculation, tissue integrity, and inflammation. Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51.
136. Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives. Popov AF, etal., Coron Artery Dis. 2008 Nov;19(7):429-34. doi: 10.1097/MCA.0b013e32830936e5.
137. Glucocorticoids increase preproendothelin-1 expression in rat aorta. Provencher PH, etal., Endocr Res. 1998 Aug-Nov;24(3-4):737-41.
138. A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats. Qi MY, etal., J Cardiovasc Pharmacol. 2006 Jun;47(6):729-35.
139. Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. Qi MY, etal., J Pharm Pharmacol. 2008 Dec;60(12):1687-94.
140. Endothelin-1 antagonism and nitric oxide augmentation prevents cyclosporine-induced vasomotor impairment. Ramzy D, etal., J Heart Lung Transplant. 2010 Sep 17.
141. Insulin preincubation effects on rat vessel contractile responses: role of the endothelium. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
142. GOA pipeline RGD automated data pipeline
143. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
144. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
145. Endothelin-1 as a potential marker of melatonin's therapeutic effects in smoking-induced vasculopathy. Rodella LF, etal., Life Sci. 2010 Sep 18.
146. Retinal detachment and proliferative vitreoretinopathy: central retinal artery blood velocities, intraocular pressure, and endothelin 1. Roldan-Pallares M, etal., Retina. 2013 Sep;33(8):1528-39. doi: 10.1097/IAE.0b013e318285cbef.
147. Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis. Ruiz-Ortega M, etal., J Am Soc Nephrol. 1997 May;8(5):756-68.
148. Autocrine regulation of the endothelin-1 gene in rat endothelial cells. Saito S, etal., J Cardiovasc Pharmacol. 1995;26 Suppl 3:S84-7.
149. cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA. Sakurai T, etal., Biochem Biophys Res Commun 1991 Feb 28;175(1):44-7.
150. Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion. Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70.
151. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Schuetz P, etal., Crit Care. 2010;14(3):R106. Epub 2010 Jun 8.
152. The cardiac endothelin system in established pressure overload left ventricular hypertrophy. Schunkert H, etal., J Mol Med (Berl). 1999 Aug;77(8):623-30.
153. Local antinociception induced by endothelin-1 in the hairy skin of the rat's back. Shrestha S, etal., J Pain. 2009 Jul;10(7):702-14.
154. Release of endothelin in the oleic acid-induced respiratory distress syndrome in rats. Simmet T, etal., Eur J Pharmacol. 1992 Feb 18;211(3):319-22.
155. Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation. Someya A, etal., Eur J Pharmacol. 2006 Aug 14;543(1-3):14-20. Epub 2006 Jun 27.
156. Pulmonary release and coronary and peripheral consumption of big endothelin and endothelin-1 in severe heart failure: acute effects of vasodilator therapy. Stangl K, etal., Circulation. 2000 Sep 5;102(10):1132-8.
157. Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1). Stow LR, etal., J Biol Chem. 2009 Oct 30;284(44):30087-96. doi: 10.1074/jbc.M109.030718. Epub 2009 Jul 28.
158. Identification of two nuclear factor of activated T-cells (NFAT)-response elements in the 5'-upstream regulatory region of the ET-1 promoter. Strait KA, etal., J Biol Chem. 2010 Sep 10;285(37):28520-8. Epub 2010 Jul 20.
159. Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum. Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18.
160. Plasma endothelin-1 and thrombomodulin levels in coronary sinus during right atrial pacing and percutaneous transluminal coronary angioplasty. Suzuki H, etal., Int J Cardiol. 2000 Jun 12;74(1):15-23.
161. Elevated plasma endothelin in patients with diabetes mellitus. Takahashi K, etal., Diabetologia. 1990 May;33(5):306-10.
162. Divergent expression of EtA and EtB receptors in response to cyclosporine in mesangial cells. Takeda M, etal., Am J Pathol. 1994 Mar;144(3):473-9.
163. Pulmonary disease models induced by in vivo hemagglutinating virus of Japan liposome-mediated endothelin-1 gene transfer. Takeda S, etal., J Cardiovasc Pharmacol. 1998;31 Suppl 1:S336-8.
164. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
165. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
166. Tissue-specific modulation of endothelin receptors in a rat model of hypertension. Telemaque-Potts S, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S122-3.
167. Vascular endothelin-1 gene expression and synthesis and effect on renal type I collagen synthesis and nephroangiosclerosis during nitric oxide synthase inhibition in rats. Tharaux PL, etal., Circulation. 1999 Apr 27;99(16):2185-91.
168. Differential regulation of the lung endothelin system by urban particulate matter and ozone. Thomson E, etal., Toxicol Sci. 2005 Nov;88(1):103-13. Epub 2005 Aug 4.
169. [Renoprotective effects of nonselective endothelin receptor antagonist bosentan on rats with interstitial fibrosis following unilateral ureteral obstruction]. Tian XF, etal., Zhonghua Yi Xue Za Zhi. 2003 Mar 25;83(6):510-4.
170. The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients. Tomic M, etal., Coll Antropol. 2008 Mar;32(1):93-8.
171. Endothelin-1 and endothelin receptors in light-induced retinal degeneration. Torbidoni V, etal., Exp Eye Res. 2005 Sep;81(3):265-75.
172. Relationship between transcardiac gradient of endothelin-1 and left ventricular remodelling in patients with first anterior myocardial infarction. Tsutamoto T, etal., Eur Heart J. 2003 Feb;24(4):346-55.
173. Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese. Uchida Y, etal., Laryngoscope. 2009 May;119(5):938-43. doi: 10.1002/lary.20181.
174. Plasma endothelin-1 levels in Behcet's disease. Uslu T, etal., Clin Rheumatol. 1997 Jan;16(1):59-61.
175. Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats. Vanourkova Z, etal., Physiol Res. 2010;59(3):339-45.
176. Endothelin-1 plasma concentrations in patients with retinitis pigmentosa. Vingolo EM, etal., Regul Pept. 2010 Feb 25;160(1-3):64-7. doi: 10.1016/j.regpep.2009.12.006. Epub 2009 Dec 11.
177. The endothelin axis influences enteric glia cell functions. von Boyen GB, etal., Med Sci Monit. 2010 Jun;16(6):BR161-7.
178. Big endothelin-1 as a predictor of atrial fibrillation recurrence after primary ablation only in patients with paroxysmal atrial fibrillation. Wang H, etal., Herz. 2012 Dec;37(8):919-25. doi: 10.1007/s00059-012-3626-9. Epub 2012 Jun 6.
179. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7.
180. Endothelin in human congestive heart failure. Wei CM, etal., Circulation. 1994 Apr;89(4):1580-6.
181. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
182. Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats. Wu Y, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.
183. MicroRNA-27a/b mediates endothelin-1-induced PPAR¿ reduction and proliferation of pulmonary artery smooth muscle cells. Xie X, etal., Cell Tissue Res. 2017 Sep;369(3):527-539. doi: 10.1007/s00441-017-2625-9. Epub 2017 May 8.
184. PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. Xu B, etal., Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
185. Rescue Treatment with a Rho-Kinase Inhibitor Normalizes Right-Ventricular Function and Reverses Remodeling in Juvenile Rats with Chronic Pulmonary Hypertension. Xu EZ, etal., Am J Physiol Heart Circ Physiol. 2010 Oct 1.
186. Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model. Yamaguchi A, etal., J Heart Lung Transplant. 2002 Apr;21(4):417-24.
187. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
188. Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia. Yang RX, etal., Acta Pharmacol Sin. 2010 Oct;31(10):1395-400. Epub 2010 Sep 27.
189. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Yin JJ, etal., Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10954-9. Epub 2003 Aug 26.
190. Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat. Yoshimura A, etal., Kidney Int. 1995 Oct;48(4):1290-7.
191. Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. Zanatta CM, etal., Diabetes Res Clin Pract. 2008 May;80(2):299-304. Epub 2008 Mar 17.
192. IL-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E2. Zarpelon AC, etal., Br J Pharmacol. 2013 May;169(1):90-101. doi: 10.1111/bph.12110.
193. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. Zeidan A, etal., J Pharmacol Exp Ther. 2005 Dec;315(3):1075-84. Epub 2005 Sep 6.
194. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Zeiher AM, etal., Lancet. 1994 Nov 19;344(8934):1405-6.
195. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
196. Anti-IgE Therapy with Omalizumab Decreases Endothelin-1 in Exhaled Breath Condensate of Patients with Severe Persistent Allergic Asthma. Zietkowski Z, etal., Respiration. 2010 Jun 26.
197. Plasma endothelin-1 in patients with stable or unstable angina. Zuk-Popiolek I, etal., Kardiol Pol. 2003 Jun;58(6):429-37; discussion 436-7.
Additional References at PubMed
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21722,454,924 - 22,460,812 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1722,330,779 - 22,336,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01723,934,458 - 23,940,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01722,266,095 - 22,271,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38612,230,516 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36Build 36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBICelera
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
T2T-CHM13v2.0612,098,871 - 12,165,580 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1342,454,952 - 42,461,466 (+)EnsemblGRCm39 Ensembl
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBIMGSCv36mm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1622,843,513 - 22,941,706 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3511,760,401 - 11,766,891 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03511,907,692 - 11,914,182 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3511,907,494 - 11,914,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13511,736,723 - 11,743,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03511,786,346 - 11,792,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03513,110,983 - 13,117,475 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494612,616,525 - 12,623,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936534885,287 - 891,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11759,854,186 - 59,861,319 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604412,341,006 - 12,348,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475613,842,164 - 13,849,029 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Edn1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:75
Interacting mature miRNAs:86
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01724,122,311 - 24,122,488NCBIRnor5.0
Rnor_5.01724,122,310 - 24,122,487NCBIRnor5.0
RGSC_v3.41728,308,076 - 28,308,253RGDRGSC3.4
RGSC_v3.41728,308,077 - 28,308,254UniSTSRGSC3.4
RGSC_v3.11728,310,917 - 28,311,094RGD
Celera1722,139,165 - 22,139,380UniSTS
Cytogenetic Map17p12UniSTS

Related Rat Strains
The following Strains have been annotated to Edn1


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 2 11 11
Low 2 41 41 28 17 28 7 9 74 35 29 7
Below cutoff 16 13 2 13 1 2 1 1


RefSeq Acc Id: ENSRNOT00000019361   ⟹   ENSRNOP00000019361
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1722,454,420 - 22,460,885 (-)Ensembl
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)Ensembl
RefSeq Acc Id: NM_012548   ⟹   NP_036680
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21722,454,924 - 22,460,812 (-)NCBI
Rnor_6.01722,137,324 - 22,143,324 (-)NCBI
Rnor_5.01724,117,499 - 24,124,188 (-)NCBI
RGSC_v3.41728,303,886 - 28,309,775 (-)RGD
Celera1722,134,975 - 22,140,901 (-)RGD
Protein Sequences
Protein RefSeqs NP_036680 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41129 (Get FASTA)   NCBI Sequence Viewer  
  AAF31762 (Get FASTA)   NCBI Sequence Viewer  
  EDL98206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019361
GenBank Protein P22388 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036680   ⟸   NM_012548
- Peptide Label: preproprotein
- UniProtKB: P22388 (UniProtKB/Swiss-Prot),   A6J756 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019361   ⟸   ENSRNOT00000019361
Protein Domains
Endothelin-like toxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22388-F1-model_v2 AlphaFold P22388 1-202 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700379
Promoter ID:EPDNEW_R10902
Type:single initiation site
Description:endothelin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10903  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01722,143,164 - 22,143,224EPDNEW
RGD ID:13700380
Promoter ID:EPDNEW_R10903
Type:single initiation site
Description:endothelin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10902  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01722,143,402 - 22,143,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2532 AgrOrtholog
BioCyc Gene G2FUF-9785 BioCyc
Ensembl Genes ENSRNOG00000014361 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007747 UniProtKB/Swiss-Prot
  ENSRNOG00060008487 UniProtKB/Swiss-Prot
  ENSRNOG00065008479 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019361 ENTREZGENE
  ENSRNOT00000019361.3 UniProtKB/Swiss-Prot
  ENSRNOT00055012966 UniProtKB/Swiss-Prot
  ENSRNOT00060014155 UniProtKB/Swiss-Prot
  ENSRNOT00065013446 UniProtKB/Swiss-Prot
InterPro Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24323 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13874 UniProtKB/Swiss-Prot
Pfam Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Edn1 PhenoGen
RatGTEx ENSRNOG00000014361 RatGTEx
  ENSRNOG00055007747 RatGTEx
  ENSRNOG00060008487 RatGTEx
  ENSRNOG00065008479 RatGTEx
SMART END UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Edn1  endothelin 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with chronic obstructive pulmonary disease (COPD), hypoxic pulmonary vasoconstriction (HPV), pulmonary arterial remodeling, and polycythemia 625753
gene_disease contributes to cardiovascular diseases, participates in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt-induced hypertension 625753
gene_drugs DOCA treated rats had a higher levels of renal, urinary and aortic expression which was normalized by the treatment with Ednra antagonist ABT-627 625753
gene_expression expressed in lung and cultured pulmonary artery endothelial cells 625753
gene_function acts as a vasoactive and mitogenic peptide  
gene_other intravenous administration causes a decrease in the arterial pressure 625753
gene_process acts as a vasoactive and mitogenic peptide 625753
gene_process potent vasopressor found in the vascular endothelial cells 628459
gene_process potent vasopressor found in the vascular endothelial cells 628515
gene_process potent vasopressor found in the vascular endothelial cells 628516
gene_process potent vasopressor found in the vascular endothelial cells 628517
gene_process role in the development of chronic hypoxia induced pulmonary hypertension, acts as a vasoconstrictor to augment hypoxic pulmonary vasoconstriction [HPV] 625753
gene_regulation lungs of ovariectomized (OVX) rats showed an increase in prepro- endothelin mRNA levels when exposed to hypoxia and increase was blocked by ovarian hormone 17-B-estradiol (E2B) 625753
gene_regulation gene expression is mediated by transcription factor hypoxia-inducible factor 1 (HIF-1) 625753
gene_regulation promoter activity was increased by transcriptional coactivator cAMP response element binding protein (CREB) binding protein (CBP)/p300 625753
gene_regulation increase in the plasma endothelin levels has no effect on the arterial pressure in the homozygous spotting lethal rats 625753