Gene: Edn1 (endothelin 1) Rattus norvegicus
Symbol: Edn1
Name: endothelin 1
Description: ENCODES a protein that exhibits endothelin A receptor binding; endothelin B receptor binding; cytokine activity (ortholog); INVOLVED IN artery smooth muscle contraction; cellular response to calcium ion; cellular response to drug; PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Albuminuria; Brain Ischemia; Bronchopulmonary Dysplasia; FOUND IN basal part of cell; extracellular space; rough endoplasmic reticulum lumen; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
Homo sapiens (human) : EDN1 (endothelin 1)  HGNC  AGR
Mus musculus (house mouse) : Edn1 (endothelin 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Edn1 (endothelin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN1 (endothelin 1)
Canis lupus familiaris (dog) : EDN1 (endothelin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn1 (endothelin 1)
more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Edn1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2532
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-12-05
Status: ACTIVE