Edn1 (endothelin 1) - Rat Genome Database
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Gene: Edn1 (endothelin 1) Rattus norvegicus
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Symbol: Edn1
Name: endothelin 1
RGD ID: 2532
Description: Exhibits endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to corticosteroid; and response to fatty acid. Localizes to several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1); PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD   F344.OLETF-(D17Mgh4-Edn1)/Tj  
QTLs:   Niddm32  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBI
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (IDA,IEP,ISO)
Albuminuria  (IEP)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aspiration pneumonia  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (IEP)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (IEP)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (IDA)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (IEP)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
coronary artery disease  (IMP,ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Diseases  (ISO)
heart disease  (IEP)
hepatopulmonary syndrome  (IEP)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (IEP,ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
Hypertrophy  (ISO)
hypogonadism  (IEP)
Hypotension  (ISO)
impotence  (IEP,ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
kidney failure  (IEP,ISO)
Left Ventricular Hypertrophy  (IDA,IEP,ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (IEP)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (IEP,IMP)
metabolic acidosis  (IDA)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (IEP)
nephrosis  (IEP,ISO)
obesity  (ISO)
obstructive sleep apnea  (IEP,ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (IEP)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (IEP)
portal hypertension  (IDA)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (IEP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (IEP)
Reperfusion Injury  (IEP,ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (IEP)
ureteral obstruction  (IEP,ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-NITROINDAZOLE  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
atrasentan  (EXP)
atropine  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
bezafibrate  (EXP,ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caesium chloride  (ISO)
caffeine  (EXP)
Calcimycin  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (EXP)
capsaicin  (ISO)
carbon atom  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chelerythrine  (EXP)
chenodeoxycholic acid  (EXP)
chetomin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cicaprost  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
dapsone  (ISO)
daunorubicin  (EXP)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
elemental carbon  (EXP)
enalapril  (EXP)
enalaprilat dihydrate  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
glycidol  (EXP)
glycoursodeoxycholic acid  (ISO)
GW 4064  (EXP)
heparin  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
ICI 118551  (ISO)
indometacin  (EXP,ISO)
iodixanol  (EXP)
iopromide  (EXP)
irbesartan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
isoquinoline-1,5-diol  (EXP)
isorhamnetin  (EXP)
isosorbide dinitrate  (ISO)
ivermectin  (ISO)
KT 5823  (EXP)
L-ascorbic acid  (ISO)
L-mimosine  (EXP,ISO)
lamivudine  (ISO)
leflunomide  (ISO)
leukotriene C4  (ISO)
levamisole  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
LY294002  (EXP)
Magnolol  (EXP)
manganese(II) chloride  (EXP)
Meglumine sodium amidotrizoate  (EXP)
melphalan  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methyl beta-cyclodextrin  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
Mibefradil  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
montelukast  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotinic acid-adenine dinucleotide phosphate  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nisoldipine  (ISO)
nitric oxide  (EXP,ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
olodaterol  (ISO)
orotic acid  (EXP)
oroxylin A  (EXP)
ouabain  (EXP,ISO)
Oxotremorine  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
PD123319  (EXP)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phosgene  (EXP)
phosphoramide mustard  (EXP)
phosphoramidon  (EXP)
picrotoxin  (EXP)
potassium atom  (ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
Ro 31-8220  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
S-methyl-L-thiocitrulline  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
sodium dodecyl sulfate  (ISO)
stattic  (EXP)
staurosporine  (EXP)
steviol  (ISO)
stevioside  (ISO)
stilbene-4,4'-diol  (ISO)
streptozocin  (EXP,ISO)
Sucralfate  (EXP)
sulfur dioxide  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
tenofovir disoproxil fumarate  (ISO)
teprenone  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracosanoic acid  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
tiotropium bromide  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
torcetrapib  (EXP)
trans-caffeic acid  (ISO)
trans-stilbene-4,4'-diol  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
water  (ISO)
wortmannin  (ISO)
Y-27632  (EXP)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
artery smooth muscle contraction  (IDA,ISO)
blood vessel morphogenesis  (ISO)
body fluid secretion  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
calcium-mediated signaling  (ISO)
cartilage development  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-cell signaling  (ISO)
cellular calcium ion homeostasis  (IBA)
cellular response to calcium ion  (IEP)
cellular response to drug  (IEP)
cellular response to fatty acid  (IEP)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to mineralocorticoid stimulus  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
dorsal/ventral pattern formation  (ISO)
endothelin receptor signaling pathway  (ISO,ISS)
epithelial fluid transport  (IDA)
G protein-coupled receptor signaling pathway  (ISO)
heart development  (ISO)
histamine secretion  (IDA)
in utero embryonic development  (ISO)
inositol phosphate-mediated signaling  (ISO)
intracellular signal transduction  (IDA)
maternal process involved in parturition  (IEP)
membrane depolarization  (IMP)
middle ear morphogenesis  (ISO)
multicellular organism aging  (IEP)
negative regulation of cellular protein metabolic process  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of hormone secretion  (IDA)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of smooth muscle cell apoptotic process  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell development  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (ISO)
peptide hormone secretion  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell size  (ISO)
positive regulation of chemokine-mediated signaling pathway  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of hormone secretion  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neutrophil chemotaxis  (IDA)
positive regulation of NIK/NF-kappaB signaling  (IDA)
positive regulation of odontogenesis  (IDA)
positive regulation of prostaglandin secretion  (IDA)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA,ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of sarcomere organization  (ISO)
positive regulation of signaling receptor activity  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (IDA,IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of urine volume  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
prostaglandin biosynthetic process  (ISO)
protein kinase C deactivation  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood pressure  (IMP,ISO)
regulation of glucose transmembrane transport  (ISO)
regulation of pH  (ISO)
regulation of sensory perception of pain  (IDA)
regulation of systemic arterial blood pressure by endothelin  (IBA,ISO)
regulation of vasoconstriction  (IEA)
respiratory gaseous exchange by respiratory system  (ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to dexamethasone  (IEP)
response to drug  (IEP)
response to hypoxia  (IEP,ISO)
response to leptin  (IEP)
response to lipopolysaccharide  (IEP)
response to muscle stretch  (IEP)
response to nicotine  (IEP)
response to ozone  (IEP)
response to prostaglandin F  (IEP)
response to salt  (IEP)
response to testosterone  (IEP)
response to transforming growth factor beta  (IEP)
rhythmic excitation  (ISO)
sensory perception of pain  (IDA)
skeletal system development  (ISO)
superoxide anion generation  (IDA)
vasoconstriction  (IDA,ISO)
vein smooth muscle contraction  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abraham DJ, etal., Am J Pathol. 1997 Sep;151(3):831-41.
2. Aggarwal PK, etal., J Hypertens. 2009 Oct;27(10):2044-50.
3. Allahdadi KJ, etal., Hypertension. 2005 Apr;45(4):705-9. Epub 2005 Feb 28.
4. Ambrose JA, etal., Surg Endosc. 2001 Feb;15(2):183-8.
5. Arai M, etal., Am J Physiol. 1995 May;268(5 Pt 2):H2084-91.
6. Arozal W, etal., Toxicology. 2010 Sep 29.
7. Bagnato A, etal., Cancer Res. 1999 Feb 1;59(3):720-7.
8. Barath A, etal., Acta Physiol Hung. 2007 Mar;94(1-2):49-66.
9. Barden AE, etal., J Hypertens. 2001 Oct;19(10):1775-82.
10. Barone FC, etal., J Cereb Blood Flow Metab. 1994 Mar;14(2):337-42.
11. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
12. Belaidi E, etal., J Am Coll Cardiol. 2009 Apr 14;53(15):1309-17.
13. Berg RM, etal., Intensive Care Med. 2009 Sep;35(9):1604-8. Epub 2009 Jun 10.
14. Boumati M, etal., Arch Biochem Biophys 2002 May 15;401(2):178-86.
15. Cai C, etal., Clin Exp Allergy. 2008 Oct;38(10):1680-7. Epub 2008 Jun 23.
16. Cavasin MA, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):636-43.
17. Cellini M, etal., Life Sci. 2012 Oct 15;91(13-14):699-702. doi: 10.1016/j.lfs.2012.02.013. Epub 2012 Mar 3.
18. Chalmers GW, etal., Eur Respir J. 1999 Jun;13(6):1288-92.
19. Chan YF, etal., Biol Reprod. 2008 Apr;78(4):773-9. Epub 2007 Dec 19.
20. Chan YF, etal., Biol Reprod. 2008 Apr;78(4):780-5. Epub 2007 Dec 19.
21. Chen HY, etal., J Glaucoma. 2013 Feb;22(2):117-22. doi: 10.1097/IJG.0b013e31822e8c65.
22. Chiu J, etal., Can J Physiol Pharmacol. 2008 Jun;86(6):365-72.
23. Chua CC, etal., Biochim Biophys Acta. 1998 Oct 21;1405(1-3):29-34.
24. Comellas AP, etal., Am J Respir Crit Care Med. 2009 Jan 15;179(2):113-22. Epub 2008 Oct 23.
25. Crestani B, etal., Eur Respir J. 1998 Feb;11(2):392-9.
26. Cybulsky AV, etal., J Am Soc Nephrol. 1993 Jan;3(7):1398-404.
27. D'Angelo G, etal., Hypertension. 2010 Aug;56(2):282-9. Epub 2010 Jun 14.
28. D'Orleans-Juste P, etal., Br J Pharmacol. 1992 Apr;105(4):773-5.
29. da Silva AA, etal., Hypertension. 2004 Feb;43(2):383-7. Epub 2004 Jan 5.
30. Di Nunzio AS, etal., Am J Physiol Regul Integr Comp Physiol 2002 Sep;283(3):R615-22.
31. Diefenbach K, etal., Cardiology. 2009;112(1):62-8. Epub 2008 Jun 26.
32. Doi Y, etal., Histol Histopathol 2002 Jan;17(1):97-105.
33. Donate PB, etal., Inflamm Res. 2012 Apr;61(4):337-48. doi: 10.1007/s00011-011-0415-5. Epub 2012 Jan 17.
34. Dumont Y, etal., J Hypertens. 2001 Aug;19(8):1479-87.
35. Earley S and Resta TC, Am J Physiol Lung Cell Mol Physiol 2002 Jul;283(1):L86-93.
36. Ebihara I, etal., Nephrol Dial Transplant. 1997 May;12(5):1001-6.
37. Ergul A, etal., Circ Res. 1995 Dec;77(6):1087-94.
38. Fabricio AS, etal., Brain Res. 2005 Dec 20;1066(1-2):92-100.
39. Fellner SK and Arendshorst W, Am J Physiol Renal Physiol. 2007 Jan;292(1):F175-84. Epub 2006 Jun 20.
40. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
41. Feron O, etal., Biochem Biophys Res Commun. 1995 Apr 6;209(1):161-6.
42. Fujii Y, etal., Proc Natl Acad Sci U S A. 1991 May 15;88(10):4235-9.
43. Fukushige H, etal., Anat Rec. 2000 Aug 1;259(4):437-45.
44. Furukawa K, etal., Am J Respir Cell Mol Biol. 1996 Mar;14(3):248-53.
45. Gambara G, etal., J Cell Physiol. 2008 Aug;216(2):396-404.
46. Gandhi CR, etal., J Gastroenterol Hepatol. 2001 Jan;16(1):61-9.
47. Gariepy CE, etal., J Clin Invest 1998 Sep 15;102(6):1092-101.
48. Gariepy CE, etal., Proc Natl Acad Sci U S A 1996 Jan 23;93(2):867-72.
49. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
50. Giaid A, etal., Lancet. 1993 Jun 19;341(8860):1550-4.
51. Girsh E and Dekel N, Mol Reprod Dev 2002 Sep;63(1):71-8.
52. Girsh E, etal., NMR Biomed. 2007 Feb;20(1):28-39.
53. Gjorup PH, etal., Am J Hypertens. 2007 Jan;20(1):44-52.
54. GOA data from the GO Consortium
55. Goel A, etal., Circ Res. 2010 Jul 23;107(2):242-51. Epub 2010 Jun 3.
56. Gogg S, etal., Diabetes. 2009 Jul 6.
57. Guimaraes CL, etal., Hypertension. 1992 Feb;19(2 Suppl):II79-86.
58. Gutte H, etal., PLoS One. 2010 Jun 14;5(6):e11111.
59. Hamzeh M and Robaire B, Endocrinology. 2010 Sep;151(9):4504-14. Epub 2010 Jul 21.
60. Hasue F, etal., Neuroscience. 2005;130(2):349-58.
61. Hernandez C, etal., J Clin Endocrinol Metab. 2009 Jun;94(6):2060-5. Epub 2009 Mar 17.
62. Hileeto D, etal., Diabetes Metab Res Rev 2002 Sep-Oct;18(5):386-94.
63. Hua H, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F303-12.
64. Iemitsu M, etal., J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S447-50.
65. Imaeda K, etal., J Smooth Muscle Res. 2004 Oct;40(4-5):199-210.
66. Immervoll T, etal., Hum Mutat. 2001 Oct;18(4):327-36.
67. Integration of LocusLink data, October 12, 2001
68. Iwabe S, etal., Curr Eye Res. 2010 Apr;35(4):287-94. doi: 10.3109/02713680903545315.
69. Iwai-Kanai E and Hasegawa K, Mol Cell Biochem. 2004 Apr;259(1-2):163-8.
70. Jankov RP, etal., Pediatr Res. 2006 Sep;60(3):245-51. Epub 2006 Jul 20.
71. Jinnouchi K ORL J Otorhinolaryngol Relat Spec. 2001 Jan-Feb;63(1):6-11.
72. Kakinuma Y, etal., Life Sci. 1999;65(16):1671-83.
73. Kanagy NL, etal., Hypertension. 2001 Feb;37(2 Part 2):511-5.
74. Kaparianos A, etal., Eur Rev Med Pharmacol Sci. 2010 Aug;14(8):705-19.
75. Kappers MH, etal., Hypertension. 2010 Oct;56(4):675-81. Epub 2010 Aug 23.
76. Kaszaki J, etal., Inflamm Res. 2008 Aug;57(8):396-402.
77. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
78. Khan SQ, etal., Am Heart J. 2007 Oct;154(4):736-42.
79. Kim D Circ Res. 1991 Jul;69(1):250-5.
80. Kisanuki YY, etal., Hypertension. 2010 Jul;56(1):121-8. Epub 2010 Jun 1.
81. Kobayashi N, etal., Eur J Pharmacol. 2001 Jun 22;422(1-3):149-57.
82. Kobayashi T, etal., Am J Physiol. 1999 Apr;276(4 Pt 2):H1197-206.
83. Koliakos GG, etal., Br J Ophthalmol. 2004 Apr;88(4):523-7.
84. Kuniyoshi KM, etal., Am J Transl Res. 2010 Jun 8;2(3):332-44.
85. Kurihara Y, etal., Nature 1994 Apr 21;368(6473):703-10.
86. Kuwaki T, etal., Am J Physiol. 1996 Jun;270(6 Pt 2):R1279-86.
87. Kwon YS, etal., J Korean Med Sci. 2010 Oct;25(10):1487-91. Epub 2010 Sep 17.
88. Langleben D, etal., Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1646-50.
89. Largo R, etal., Kidney Int. 1999 Jan;55(1):82-90.
90. Lee CH, etal., Eur J Pharmacol. 2008 Oct 24;595(1-3):100-7. Epub 2008 Aug 9.
91. Lee S and Ahn D, Korean J Physiol Pharmacol. 2008 Aug;12(4):149-53. Epub 2008 Aug 31.
92. Lee SD, etal., Pulm Pharmacol Ther. 2000;13(6):257-65.
93. Lee TM, etal., Clin Sci (Lond). 2009 Mar;116(6):497-505.
94. Li H, etal., Mol Vis. 2008 Sep 15;14:1698-704.
95. Li M, etal., Zhonghua Yi Xue Za Zhi. 1999 Feb;79(2):133-5.
96. Li T, etal., Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G948-57. doi: 10.1152/ajpgi.00359.2011. Epub 2012 Feb 2.
97. Li X, etal., Hypertension. 2009 Oct;54(4):839-44. Epub 2009 Jul 27.
98. Ling Y, etal., Hepatology. 2004 Jun;39(6):1593-602.
99. Massart PE, etal., Hypertension. 1999 Dec;34(6):1197-201.
100. Matsumoto T, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97. Epub 2009 Mar 13.
101. Matsumura Y, etal., Circulation 2000 Nov 28;102(22):2765-73.
102. Mattera GG, etal., Br J Pharmacol. 1993 Sep;110(1):331-7.
103. Mazzocchi G, etal., Endocrinology. 1997 Jun;138(6):2333-7.
104. McCarter SD, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):985-91.
105. Meens MJ, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):87-95. Epub 2009 Jul 23.
106. MGD data from the GO Consortium
107. Mi XS, etal., Invest Ophthalmol Vis Sci. 2012 Jul 20;53(8):4842-51. doi: 10.1167/iovs.12-9999.
108. Montezano AC, etal., J Am Soc Hypertens. 2007 Mar-Apr;1(2):150-60.
109. Morelli S, etal., Am J Med. 1995 Sep;99(3):255-60.
110. Morin C, etal., Biochem Biophys Res Commun. 1998 Mar 17;244(2):583-7.
111. Motta EM, etal., Neurosci Lett. 2009 Jul 3;457(3):146-50. Epub 2009 Mar 21.
112. Mundhenke M, etal., Heart. 1999 Mar;81(3):278-84.
113. Munemasa Y, etal., Vis Neurosci. 2008 Mar-Apr;25(2):197-208. doi: 10.1017/S095252380808053X.
114. NCBI rat LocusLink and RefSeq merged data July 26, 2002
115. Norata GD, etal., Atherosclerosis. 2007 Apr;191(2):265-71. Epub 2006 Jun 27.
116. Oishi K, etal., Jpn J Pharmacol. 2002 Sep;90(1):36-50.
117. Oku H, etal., Curr Eye Res. 2008 Jul;33(7):611-20.
118. OMIM Disease Annotation Pipeline
119. Ong AC, etal., Nephron Exp Nephrol. 2003;93(2):e80.
120. Onoda K, etal., J Neurosurg. 1996 Nov;85(5):846-52.
121. Orisio S, etal., Kidney Int. 1993 Feb;43(2):354-8.
122. Ornan DA, etal., Biochim Biophys Acta. 2000 Jun 15;1501(2-3):211-8.
123. Pache M, etal., Eur Neurol. 2003;49(3):164-8.
124. Park SH, etal., Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):600-8.
125. Pawlik MT, etal., Eur J Anaesthesiol. 2009 Apr;26(4):285-92.
126. Pekdemir H, etal., Int J Cardiol. 2004 Oct;97(1):35-41.
127. Pellicelli AM, etal., Angiology. 2010 Nov;61(8):802-6. Epub 2010 May 24.
128. Perry MG, etal., Am J Physiol Heart Circ Physiol 2001 Dec;281(6):H2680-6.
129. Pikkarainen S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1639-45. Epub 2006 Jan 12.
130. Pikkarainen S, etal., J Biol Chem 2003 Feb 7;278(6):3969-75.
131. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
132. Piuhola J, etal., Hypertension 2003 Jan;41(1):93-8.
133. Plusczyk T, etal., Dig Dis Sci. 2001 Jun;46(6):1343-51.
134. Popov AF, etal., Coron Artery Dis. 2008 Nov;19(7):429-34. doi: 10.1097/MCA.0b013e32830936e5.
135. Provencher PH, etal., Endocr Res. 1998 Aug-Nov;24(3-4):737-41.
136. Qi MY, etal., J Cardiovasc Pharmacol. 2006 Jun;47(6):729-35.
137. Qi MY, etal., J Pharm Pharmacol. 2008 Dec;60(12):1687-94.
138. Ramzy D, etal., J Heart Lung Transplant. 2010 Sep 17.
139. Rebolledo A, etal., Endothelium 2001;8(4):269-76.
140. RGD automated data pipeline
141. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
142. RGD automated import pipeline for gene-chemical interactions
143. Rodella LF, etal., Life Sci. 2010 Sep 18.
144. Roldan-Pallares M, etal., Retina. 2013 Sep;33(8):1528-39. doi: 10.1097/IAE.0b013e318285cbef.
145. Ruiz-Ortega M, etal., J Am Soc Nephrol. 1997 May;8(5):756-68.
146. Saito S, etal., J Cardiovasc Pharmacol. 1995;26 Suppl 3:S84-7.
147. Sakurai T, etal., Biochem Biophys Res Commun 1991 Feb 28;175(1):44-7.
148. Samson WK and Skala KD, Endocrinology. 1992 May;130(5):2964-70.
149. Schuetz P, etal., Crit Care. 2010;14(3):R106. Epub 2010 Jun 8.
150. Schunkert H, etal., J Mol Med (Berl). 1999 Aug;77(8):623-30.
151. Shrestha S, etal., J Pain. 2009 Jul;10(7):702-14.
152. Simmet T, etal., Eur J Pharmacol. 1992 Feb 18;211(3):319-22.
153. Someya A, etal., Eur J Pharmacol. 2006 Aug 14;543(1-3):14-20. Epub 2006 Jun 27.
154. Stangl K, etal., Circulation. 2000 Sep 5;102(10):1132-8.
155. Stow LR, etal., J Biol Chem. 2009 Oct 30;284(44):30087-96. doi: 10.1074/jbc.M109.030718. Epub 2009 Jul 28.
156. Strait KA, etal., J Biol Chem. 2010 Sep 10;285(37):28520-8. Epub 2010 Jul 20.
157. Sullivan AM and Morton AJ, J Neurochem. 1996 Oct;67(4):1409-18.
158. Suzuki H, etal., Int J Cardiol. 2000 Jun 12;74(1):15-23.
159. Takahashi K, etal., Diabetologia. 1990 May;33(5):306-10.
160. Takeda M, etal., Am J Pathol. 1994 Mar;144(3):473-9.
161. Takeda S, etal., J Cardiovasc Pharmacol. 1998;31 Suppl 1:S336-8.
162. Talati M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. Epub 2010 Jun 18.
163. Tawa M, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. Epub 2008 Jun 14.
164. Telemaque-Potts S, etal., J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S122-3.
165. Tharaux PL, etal., Circulation. 1999 Apr 27;99(16):2185-91.
166. Thomson E, etal., Toxicol Sci. 2005 Nov;88(1):103-13. Epub 2005 Aug 4.
167. Tian XF, etal., Zhonghua Yi Xue Za Zhi. 2003 Mar 25;83(6):510-4.
168. Tomic M, etal., Coll Antropol. 2008 Mar;32(1):93-8.
169. Torbidoni V, etal., Exp Eye Res. 2005 Sep;81(3):265-75.
170. Tsutamoto T, etal., Eur Heart J. 2003 Feb;24(4):346-55.
171. Uchida Y, etal., Laryngoscope. 2009 May;119(5):938-43. doi: 10.1002/lary.20181.
172. Uslu T, etal., Clin Rheumatol. 1997 Jan;16(1):59-61.
173. Vanourkova Z, etal., Physiol Res. 2010;59(3):339-45.
174. Vingolo EM, etal., Regul Pept. 2010 Feb 25;160(1-3):64-7. doi: 10.1016/j.regpep.2009.12.006. Epub 2009 Dec 11.
175. von Boyen GB, etal., Med Sci Monit. 2010 Jun;16(6):BR161-7.
176. Wang H, etal., Herz. 2012 Dec;37(8):919-25. doi: 10.1007/s00059-012-3626-9. Epub 2012 Jun 6.
177. Watanabe T, etal., Circ Res. 1991 Aug;69(2):370-7.
178. Wei CM, etal., Circulation. 1994 Apr;89(4):1580-6.
179. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
180. Wu Y, etal., Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.
181. Xie X, etal., Cell Tissue Res. 2017 Sep;369(3):527-539. doi: 10.1007/s00441-017-2625-9. Epub 2017 May 8.
182. Xu B, etal., Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
183. Xu EZ, etal., Am J Physiol Heart Circ Physiol. 2010 Oct 1.
184. Yamaguchi A, etal., J Heart Lung Transplant. 2002 Apr;21(4):417-24.
185. Yanagisawa H, etal., J Clin Invest 1998 Jul 1;102(1):22-33.
186. Yang RX, etal., Acta Pharmacol Sin. 2010 Oct;31(10):1395-400. Epub 2010 Sep 27.
187. Yin JJ, etal., Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10954-9. Epub 2003 Aug 26.
188. Yoshimura A, etal., Kidney Int. 1995 Oct;48(4):1290-7.
189. Zanatta CM, etal., Diabetes Res Clin Pract. 2008 May;80(2):299-304. Epub 2008 Mar 17.
190. Zarpelon AC, etal., Br J Pharmacol. 2013 May;169(1):90-101. doi: 10.1111/bph.12110.
191. Zeidan A, etal., J Pharmacol Exp Ther. 2005 Dec;315(3):1075-84. Epub 2005 Sep 6.
192. Zeiher AM, etal., Lancet. 1994 Nov 19;344(8934):1405-6.
193. Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
194. Zietkowski Z, etal., Respiration. 2010 Jun 26.
195. Zuk-Popiolek I, etal., Kardiol Pol. 2003 Jun;58(6):429-37; discussion 436-7.
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PMID:22406300   PMID:22431579   PMID:22521290   PMID:22569294   PMID:22569295   PMID:22727794   PMID:22906761   PMID:22927341   PMID:22936708   PMID:22956308   PMID:23041290   PMID:23086942  
PMID:23220478   PMID:23428131   PMID:23436727   PMID:23537435   PMID:23555567   PMID:23592126   PMID:23662699   PMID:23898483   PMID:23941276   PMID:23995100   PMID:24040253   PMID:24117217  
PMID:24140435   PMID:24291639   PMID:24304569   PMID:24392990   PMID:24447812   PMID:24499246   PMID:24641950   PMID:24657892   PMID:24731444   PMID:24735959   PMID:24854661   PMID:25014910  
PMID:25088996   PMID:25091502   PMID:25228257   PMID:25243430   PMID:25425077   PMID:25446983   PMID:25517973   PMID:25587122   PMID:25692855   PMID:25824048   PMID:25873305   PMID:25939574  
PMID:26438559   PMID:26631506   PMID:26682937   PMID:26898123   PMID:27322312   PMID:27322388   PMID:27470334   PMID:27581840   PMID:27697218   PMID:27760762   PMID:27765761   PMID:28012855  
PMID:28273940   PMID:28302570   PMID:28432001   PMID:28468962   PMID:28508833   PMID:30470661   PMID:30579678   PMID:30911278   PMID:31012341   PMID:31541683   PMID:31766450   PMID:31858571  
PMID:32107448  


Genomics

Comparative Map Data
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21722,454,924 - 22,460,812 (-)NCBI
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,594 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37612,290,529 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0panPan3
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBI
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)Ensembl
Edn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBI

Position Markers
D17Mco5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01724,122,311 - 24,122,488NCBIRnor5.0
Rnor_5.01724,122,310 - 24,122,487NCBIRnor5.0
RGSC_v3.41728,308,076 - 28,308,253RGDRGSC3.4
RGSC_v3.41728,308,077 - 28,308,254UniSTSRGSC3.4
RGSC_v3.11728,310,917 - 28,311,094RGD
Celera1722,139,165 - 22,139,380UniSTS
Cytogenetic Map17p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17333697224030841Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17333697224030841Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17341403928073589Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17471606727691136Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17471606727691136Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17519104750191047Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17519104750191047Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17982730454827304Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)171052970942542027Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171400967923316697Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171574375522711729Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171574375561036897Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171867614063676140Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171867614063676140Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095062195822Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172149095066490950Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172149095066490950Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172149095066490950Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172149095066490950Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172149095066490950Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172149095074823273Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172213681453475276Rat


Related Rat Strains
The following Strains have been annotated to Edn1

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:75
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000019361
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 11 11
Low 2 41 41 28 17 28 7 9 74 35 29 7
Below cutoff 16 13 2 13 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019361   ⟹   ENSRNOP00000019361
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)Ensembl
RefSeq Acc Id: NM_012548   ⟹   NP_036680
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21722,454,924 - 22,460,812 (-)NCBI
Rnor_6.01722,137,324 - 22,143,324 (-)NCBI
Rnor_5.01724,117,499 - 24,124,188 (-)NCBI
RGSC_v3.41728,303,886 - 28,309,775 (-)RGD
Celera1722,134,975 - 22,140,901 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600453   ⟹   XP_017455942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01722,136,814 - 22,143,745 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036680 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41129 (Get FASTA)   NCBI Sequence Viewer  
  AAF31762 (Get FASTA)   NCBI Sequence Viewer  
  EDL98206 (Get FASTA)   NCBI Sequence Viewer  
  P22388 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036680   ⟸   NM_012548
- Peptide Label: preproprotein
- UniProtKB: P22388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455942   ⟸   XM_017600453
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000019361   ⟸   ENSRNOT00000019361

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700379
Promoter ID:EPDNEW_R10902
Type:single initiation site
Name:Edn1_2
Description:endothelin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10903  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01722,143,164 - 22,143,224EPDNEW
RGD ID:13700380
Promoter ID:EPDNEW_R10903
Type:single initiation site
Name:Edn1_1
Description:endothelin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10902  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01722,143,402 - 22,143,462EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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