RGD Reference Report - Gene expression of ANP, BNP and ET-1 in the heart of rats during pulmonary embolism. - Rat Genome Database

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Gene expression of ANP, BNP and ET-1 in the heart of rats during pulmonary embolism.

Authors: Gutte, H  Oxbol, J  Kristoffersen, US  Mortensen, J  Kjaer, A 
Citation: Gutte H, etal., PLoS One. 2010 Jun 14;5(6):e11111.
RGD ID: 4144858
Pubmed: (View Article at PubMed) PMID:20559433
DOI: Full-text: DOI:10.1371/journal.pone.0011111

AIMS: Atrial natriuretic petide (ANP), brain natriuretic peptide (BNP) and endothelin-1 (ET-1) may reflect the severity of right ventricular dysfunction (RVD) in patients with pulmonary embolism (PE). The exact nature and source of BNP, ANP and ET-1 expression and secretion following PE has not previously been studied. METHODS AND RESULTS: Polystyrene microparticles were injected to induce PE in rats. Gene expression of BNP, ANP and ET-1 were determined in the 4 cardiac chambers by quantitative real time polymerase chain reaction (QPCR). Plasma levels of ANP, BNP, ET-1 and cardiac troponin I (TNI) were measured in plasma. PE dose-dependently increased gene expression of ANP and BNP in the right ventricle (RV) and increased gene expression of ANP in the right atrium (RA). In contrast PE dose-dependently decreased BNP gene expression in both the left ventricle (LV) and the left atrium (LA). Plasma levels of BNP, TNI and ET-1 levels dose-dependently increased with the degree of PE. CONCLUSION: We found a close correlation between PE degree and gene-expression of ANP, and BNP in the cardiac chambers with a selective increase in the right chambers of the heart. The present data supports the idea of natriuretic peptides as valuable biomarkers of RVD in PE.


Disease Annotations    
pulmonary embolism  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)

Additional Information