RGD Reference Report - [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. - Rat Genome Database

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[Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1].

Authors: Zhou, Y  Gu, J  Xu, LM 
Citation: Zhou Y, etal., Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):61-4.
RGD ID: 4892595
Pubmed: (View Article at PubMed) PMID:17214938

OBJECTIVE: To investigate the effects of salvianolic acid B (SA-B) on portal hypertension induced by endothelin-1 in rats. METHODS: Twenty-eight Sprague-Dawley rats were randomly divided into four groups: ET-1 group, ET-1+SA-B group, ET-1+ET(A)R blocker (BQ-123) group and ET-1+ET(B)R blocker (BQ-788) group. The rats of ET-1+SA-B group underwent intragastrical administration of salvianolic acid B for five days before ET-1 injection, while in three other groups' drinking water was given. In BQ-123 group or BQ-788 group, an intravenous injection of BQ-123 or BQ-788 via femoral vein was administered 30 minutes prior to ET-1 injection. Then changes of portal pressure, cervical artery pressure and heart rate were monitored continuously. RESULTS: After ET-1 injection, the portal pressure of all rats in the ET-1 group increased significantly, while slightly in groups that pretreated with SA-B, BQ-123 or BQ-788. CONCLUSION: SA-B can attenuate the elevated portal pressure induced by ET-1 with effect similar to ETR blocker.

Annotation

Disease Annotations    
portal hypertension  (IDA,IMP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)
Ednra  (endothelin receptor type A)
Ednrb  (endothelin receptor type B)

Genes (Mus musculus)
Edn1  (endothelin 1)
Ednra  (endothelin receptor type A)
Ednrb  (endothelin receptor type B)

Genes (Homo sapiens)
EDN1  (endothelin 1)
EDNRA  (endothelin receptor type A)
EDNRB  (endothelin receptor type B)


Additional Information