EDN1 (endothelin 1) - Rat Genome Database
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Gene: EDN1 (endothelin 1) Sus scrofa
Analyze
Symbol: EDN1
Name: endothelin 1
RGD ID: 13915338
Description: ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN blood vessel morphogenesis (ortholog); cell-cell signaling (ortholog); cellular response to calcium ion (ortholog); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; inflammatory response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN basal part of cell (ortholog); rough endoplasmic reticulum lumen (ortholog); Weibel-Palade body (ortholog); INTERACTS WITH 6-oxoprostaglandin F1alpha; ambrisentan; carvedilol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: EDN; endothelin-1; ET-1; ET1; PPET1; preproendothelin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
angle-closure glaucoma  (ISO)
anterolateral myocardial infarction  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Auriculocondylar Syndrome  (ISO)
Auriculocondylar Syndrome 3  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
Bradycardia  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
cartilage disease  (ISO)
cerebrovascular disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinitis  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Craniofacial Abnormalities  (ISO)
cystic fibrosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gastrointestinal Diseases  (ISO)
heart disease  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
Hyperalgesia  (ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypogonadism  (ISO)
Hypotension  (ISO)
impotence  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
membranoproliferative glomerulonephritis  (ISO)
metabolic acidosis  (ISO)
middle cerebral artery infarction  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular glaucoma  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
optic nerve disease  (ISO)
Optic Nerve Injuries  (ISO)
Oral Ulcer  (ISO)
ovarian carcinoma  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
peptic ulcer disease  (ISO)
pneumonia  (ISO)
Pneumoperitoneum  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Question Mark Ears, Isolated  (ISO)
renal artery disease  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Slow Coronary Flow  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Urinary Retention  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA)
artery smooth muscle contraction  (IEA)
blood vessel morphogenesis  (ISO)
body fluid secretion  (IEA)
branching involved in blood vessel morphogenesis  (IEA)
calcium-mediated signaling  (IEA)
cartilage development  (IEA)
cell surface receptor signaling pathway  (IEA)
cell-cell signaling  (ISO)
cellular calcium ion homeostasis  (IBA)
cellular response to calcium ion  (ISO)
cellular response to drug  (ISO)
cellular response to fatty acid  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
dorsal/ventral pattern formation  (IEA)
endothelin receptor signaling pathway  (IEA,ISS)
epithelial fluid transport  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heart development  (IEA)
histamine secretion  (ISO)
in utero embryonic development  (IEA)
inositol phosphate-mediated signaling  (IEA)
intracellular signal transduction  (ISO)
maternal process involved in parturition  (ISO)
membrane depolarization  (ISO)
middle ear morphogenesis  (IEA)
multicellular organism aging  (ISO)
negative regulation of cellular protein metabolic process  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell development  (IEA)
neutrophil chemotaxis  (ISO)
nitric oxide transport  (IEA)
peptide hormone secretion  (IEA)
phosphatidylinositol 3-kinase signaling  (IEA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell size  (IEA)
positive regulation of chemokine-mediated signaling pathway  (IEA)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of heart rate  (IEA)
positive regulation of hormone secretion  (IEA)
positive regulation of JUN kinase activity  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of prostaglandin-endoperoxide synthase activity  (IBA)
positive regulation of renal sodium excretion  (IEA)
positive regulation of sarcomere organization  (IEA)
positive regulation of signaling receptor activity  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of smooth muscle contraction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of urine volume  (IEA)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
prostaglandin biosynthetic process  (IEA)
protein kinase C deactivation  (IEA)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IEA)
regulation of blood pressure  (ISO)
regulation of glucose transmembrane transport  (IEA)
regulation of pH  (IEA)
regulation of sensory perception of pain  (ISO)
regulation of systemic arterial blood pressure by endothelin  (IBA)
regulation of vasoconstriction  (IEA)
respiratory gaseous exchange by respiratory system  (IEA)
response to activity  (ISO)
response to amino acid  (ISO)
response to dexamethasone  (ISO)
response to drug  (ISO)
response to hypoxia  (IEA)
response to leptin  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle stretch  (ISO)
response to nicotine  (ISO)
response to ozone  (ISO)
response to prostaglandin F  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to transforming growth factor beta  (ISO)
rhythmic excitation  (IEA)
sensory perception of pain  (ISO)
skeletal system development  (ISO)
superoxide anion generation  (ISO)
vasoconstriction  (ISO)
vein smooth muscle contraction  (IBA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2205205   PMID:2451132   PMID:2665739   PMID:2669747   PMID:6524708   PMID:14681463   PMID:15458948   PMID:16043243   PMID:16782700   PMID:16820591   PMID:17145712   PMID:18019273  
PMID:18278064   PMID:18331442   PMID:18405606   PMID:18814226   PMID:18840580   PMID:18844577   PMID:19188658   PMID:19623039   PMID:19783117   PMID:21792912   PMID:21801588   PMID:21884347  
PMID:21953705   PMID:22221604   PMID:23327561   PMID:23717659   PMID:24611481   PMID:25380860   PMID:26211713   PMID:27443965  


Genomics

Comparative Map Data
EDN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.178,752,018 - 8,758,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.279,120,519 - 9,159,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.3-p1.2NCBI
EDN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl612,290,361 - 12,297,194 (+)EnsemblGRCh38hg38GRCh38
GRCh38612,256,463 - 12,297,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37612,290,529 - 12,297,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36612,398,515 - 12,405,413 (+)NCBINCBI36hg18NCBI36
Build 34612,398,644 - 12,404,761NCBI
Celera613,518,582 - 13,525,484 (+)NCBI
Cytogenetic Map6p24.1NCBI
HuRef612,222,160 - 12,229,052 (+)NCBIHuRef
CHM1_1612,292,671 - 12,299,570 (+)NCBICHM1_1
Edn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391342,454,952 - 42,461,466 (+)NCBIGRCm39mm39
GRCm381342,301,476 - 42,307,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1342,301,476 - 42,307,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371342,396,639 - 42,403,358 (+)NCBIGRCm37mm9NCBIm37
MGSCv361342,312,448 - 42,318,962 (+)NCBImm8
Celera1343,379,939 - 43,386,658 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1320.82NCBI
Edn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01722,136,814 - 22,143,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1722,137,324 - 22,143,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01724,117,499 - 24,124,188 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41728,303,886 - 28,309,775 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11728,306,726 - 28,312,616 (-)NCBI
Celera1722,134,975 - 22,140,901 (-)NCBICelera
Cytogenetic Map17p13NCBI
Edn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554652,287,798 - 2,314,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554652,287,906 - 2,314,945 (-)NCBIChiLan1.0ChiLan1.0
EDN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1612,405,538 - 12,503,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl612,462,718 - 12,503,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0612,076,312 - 12,142,861 (+)NCBIMhudiblu_PPA_v0panPan3
EDN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3511,808,892 - 11,815,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13511,808,892 - 11,815,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Edn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936534885,489 - 892,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1759,853,699 - 59,861,198 (-)Ensembl
ChlSab1.11759,854,186 - 59,861,319 (-)NCBI
Edn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475613,842,482 - 13,849,003 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 4 1 17 3 3
Below cutoff 1 2 3 1 1 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061675   ⟹   ENSSSCP00000043269
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl78,751,695 - 8,758,348 (+)Ensembl
RefSeq Acc Id: NM_213882   ⟹   NP_999047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.178,752,018 - 8,758,354 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999047 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAL46023 (Get FASTA)   NCBI Sequence Viewer  
  CAA30296 (Get FASTA)   NCBI Sequence Viewer  
  P09558 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999047   ⟸   NM_213882
- Peptide Label: preproprotein
- UniProtKB: P09558 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043269   ⟸   ENSSSCT00000061675
Protein Domains
END


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00065027852 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000043269 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00065015808 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000061675 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00065037539 UniProtKB/Swiss-Prot
InterPro Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothelin_toxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endothln-like_toxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396915 UniProtKB/Swiss-Prot
NCBI Gene EDN1 ENTREZGENE
PANTHER PTHR13874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endothelin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ENDOTHELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART END UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.9364 ENTREZGENE
UniProt A0A287AHA8_PIG UniProtKB/TrEMBL
  EDN1_PIG UniProtKB/Swiss-Prot, ENTREZGENE